Immunotherapy Weekly articles from July 1999

Immunotherapy Weekly archives from July 1999

Active Specific Immunotherapy Mediates Tumor Regression.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Active specific immunotherapy with an autologous tumor vaccine, combined with recombinant granulocyte macrophage-colony stimulating factor (GM-CSF), either with or without interferon alfa-2B (IFN...

Sublingual-Swallow Immunotherapy Is Effective.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Sublingual-swallow immunotherapy (SLIT) is effective for asthma patients allergic to house-dust mites. J. Bousquet and colleagues from the Stallergenes SA, France, conducted a double-blind,...

TCR-Directed Immunotherapy Not Likely For Birch Pollen Allergy.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- T-cell receptor (TCR)-directed immunotherapy does not seem feasible for birch pollen allergy sufferers. Because allergen-specific CD4(+) T cells play an important regulatory role in atopic...

CTLs Circumvent Tumor Resistance To Apoptosis.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cytotoxic T lymphocytes (CTLs) circumvent tumor resistance to pas-induced death. Because Fas and Fas ligand (FasL) have been found both in lymphoid and in non-lymphoid malignancies, and are...

BCG Therapy After Radiation Is Effective.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Intravesical Bacille Calmette-Guerin (BCG) therapy after radiation is useful for the treatment of bladder cancer. J. Palou and colleagues from the University Autonoma Barcelona, Spain, evaluated...

Dysfunction in Cellular Immunity after Stem Cell Transplantation.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers report significant dysfunction in cellular immunity after stem cell transplantation in an ongoing study of breast cancer patients who received high-dose chemotherapy. D. Avigan and...

GVHD Risk Factors May Vary between Allogeneic SCT and BMT.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The risk factors for chronic graft-versus-host disease and survival may be different for allogeneic stem cell transplantation and allogeneic bone marrow transplantation. Allogeneic blood stem...

GM-CSF and IL-3 May Have Mycobactericidal Properties.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Granulocyte-macrophage colony-stimulating factor and interleukin-3 may contribute to mycobacteria-killing activity in humans, according to a report from France's Institut Pasteur. The mechanisms...

Low-Titre Antibodies in IFN Recipients Point to Complications.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Low titre auto-antibodies may be risk factors for autoimmune complications in chronic hepatitis C virus patients undergoing interferon therapy. In this study, researcher T.M. Bell and colleagues...

New Tool ID's CD4(+) T-Cell Antigens.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A new, broadly applicable technique identifies antigens recognized by CD4(+) T cells. As these so-called T-helper cells are the basis of cell-mediated immunity, the technique promises to...

T-Cell Response May Control Viremia During Vaccine Therapy.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Induction of CD4(+) T-cell responses could be important in controlling viremia during vaccine therapy of chronic hepatitis B virus carriers, according to a study from France's Institut Pasteur. ...

Marking System Gives Scientists Real View of Immune Memory Cells.
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A method of permanently marking T cells has allowed Emory University immunologists and colleagues in Atlanta, Georgia, to overcome one of the most challenging barriers to understanding just how the...

Immune Dysfunction Following Stem Cell Transplantation is Associated with a Type 2 Cytokine Storm and FasL-Mediated CD4(+) T Cells Apoptosis.
July 12, 1999... Immunology (Transplantation) "Immune Dysfunction Following Stem Cell Transplantation is Associated with a Type 2 Cytokine Storm and FasL-Mediated CD4(+) T Cells Apoptosis." J.E. Talmadge, R.K. Singh, M.L. Varney, S. Buyukberber, K. Ino,...

Active Specific Immunization with a hybrid Cell Vaccine is Effective in Patients with Advanced Renal Cell Carcinoma.
July 12, 1999... Cancer Immunotherapy "Active Specific Immunization with a hybrid Cell Vaccine is Effective in Patients with Advanced Renal Cell Carcinoma." Alexander Kugler, Gerd A. Muller, Florian Seseke, Manfred Kallerhoff, Rolf-Hermann Ringert, Peter...

Mature Dendritic Cells Induce T Helper Type 1-Dominant Immune Responses in Patients With Metastatic Renal Cell Carcinoma.
July 12, 1999... Cancer Immunotherapy "Mature Dendritic Cells Induce T Helper Type 1-Dominant Immune Responses in Patients With Metastatic Renal Cell Carcinoma." C. Rieser, R. Ramoner, L. Holtl, H. Rogatsch, C. Papesh, A. Stenzi, G. Barsch and M. Thurnher....

Zinc and Infections in Aging. Parallelism with HIV.
July 12, 1999... Disease Associations "Zinc and Infections in Aging. Parallelism with HIV." F. Mocchegiani, M. Muzzioh and R. Giacconi. Immunol. Center, INRCA, Ancona, Italy. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an abstract...

Interference of Modern Antibiotics with Bacillus-Calmette-Guerin (BCG) Viability.
July 12, 1999... TB Immunotherapy "Interference of Modern Antibiotics with Bacillus-Calmette-Guerin (BCG) Viability." Christoph Durek, Sabine Rusch-Gerdes, Dieter Jocham and Andreas Bohle. Lubeck, Germany; Borstel, Germany. (CW HENDERSON PUBLISHER...

Early Chemoprophylaxis With Trimethoprim-Sulphamethoxazole for HIV-1 Infected Adults in Abidjan, Cote d'Ivoire: A Randomised Trial.
July 12, 1999... AIDS Therapies Anglaret, X.; Chene, G.; Attia, A.; Toure, S.; Lafont, S.; Combe, P.; Manlan, K.; Ndriyoman, T.; Salamon, R. "Early Chemoprophylaxis With Trimethoprim-Sulphamethoxazole for HIV-1 Infected Adults in Abidjan, Cote d'Ivoire: A...

Review of the Efficacy of Individualized Chemotherapy Selected by in vitro Drug Sensitivity Testing for Patients With Cancer.
July 12, 1999... Chemotherapy Cortazar, P.; Johnson, B.E. "Review of the Efficacy of Individualized Chemotherapy Selected by in vitro Drug Sensitivity Testing for Patients With Cancer." Journal of Clinical Oncology, May 1999;17(5):1625-1631. (CW...

Impact of Therapeutic Research on Informed Consent and the Ethics of Clinical Trials: A Medical Oncology Perspective.
July 12, 1999... Clinical Trials Daugherty, C.K. "Impact of Therapeutic Research on Informed Consent and the Ethics of Clinical Trials: A Medical Oncology Perspective." Journal of Clinical Oncology, May 1999;17(5):1601-1617. (CW HENDERSON PUBLISHER...

Efficacy of Trimethoprim-Sulphamethoxazole Prophylaxis to Decrease Morbidity and Mortality in HIV-1 Infected Patients With Tuberculosis in Abidjan, Cote d'Ivoire: A Randomised Controlled Trial.
July 12, 1999... Coinfection Wiktor, S.Z.; Sassanmorokro, M.; Grant, A.D.; Abouya, L.; Karon, J.M.; Maurice, C.; Djomand, G.; Ackah, A.; Domoua, K.; Kadio, A.; Yapi, A.; Combe, P.; Tossou, O.; Roels, T.H.; Lackritz, E.M.; Coulibaly, D.; Decock, K.M.;...

Effects of Immunomodulation With Interferon-gamma on Hepatic Ischemia-Reperfusion Injury.
July 12, 1999... Ischemia-Reperfusion Langdale, L.A.; Wilson, L.; Jurkovich, G.J.; Liggitt, H.D. "Effects of Immunomodulation With Interferon-gamma on Hepatic Ischemia-Reperfusion Injury." Shock, May 1999;11(5):356-361. (CW HENDERSON PUBLISHER...

HPV Vaccine Enters Clinical Trial Stage.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Preliminary results from a clinical trial of a human papillomavirus (HPV) vaccine for the treatment of cervical cancer show the vaccine is well tolerated. Margaret Wojtowicz, representing...

Adoptive Immunotherapy for Melanoma Is Feasible.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Outpatient immunotherapy for melanoma patients is feasible. On the basis of their previous experience, P. Queirolo and colleagues from the University of Genoa, Italy, designed a study to...

Chemotherapy Resistance May Be Associated With Immunotherapy Resistance.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Drug resistance to vincristine may be associated with resistance to some cancer immunotherapies. M. Hirose and colleagues from the University Hospital of Tokushima, Japan, designed a study to...

Clinical Trial Tests Different Therapy Modalities.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A clinical trial compares several different therapeutic options for the treatment of patients with malignant effusion. Y. Nio and colleagues from the Himane Medical University, Japan, found that...

Radioimmunoluminography Applied With Clinical Relevance.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Radioimmunoluminography (RILG) system measures quantity and distribution of protein in tissue. G. Boxer and colleagues from the University College of London, England, explored unique...

Tolerance As Arthritis Therapy.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers are hoping to find a way to treat arthritis by inducing mucosal tolerance. Tolerance is the paradoxical phenomenon of reduced immune reactivity to an antigen by mucosal exposure to...

Nasal Immunization Elicits Ab in Lung, Urogenital Tract.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Human volunteers developed IgA and IgG antibodies in the lung and urogenital tract after intranasal vaccination with cholera toxin B subunit (CTB). Intranasal immunization is considered the most...

GM-CSF May Have Role in HCV Treatment.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Granulocyte-macrophage colony-stimulating factor may have a role in the treatment of chronic hepatitis C. Recombinant-granulocyte macrophage colony-stimulating factor has been shown to have...

Triple Therapy Shows Promise in IFN Non-Responders.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Triple antiviral therapy including interferon, ribavirin, and amantadine may be an appropriate alternative therapy for hepatitis C patients who do not respond to first-line interferon. No...

NIAID Launches Major Step in Trial of Experimental Shingles Vaccine.
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- On June 17, 1999, researchers at NIAID launched an important next step in a study of an experimental vaccine to prevent shingles (also known as herpes zoster, or just "zoster"). In the Phase III...

MHC Class I Restricted Tumor Cell Lysis in Renal Cell Carcinoma.
July 26, 1999... Cancer Vaccines "MHC Class I Restricted Tumor Cell Lysis in Renal Cell Carcinoma." R. Oberneder, P. Jantzer, E. Noner, A. Hofstetter and D.J. Schendel. Munich, Germany. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

A Retroviral Tetracycline (TET) Regulated System for in vivo Manipulation of IL-2 Expression.
July 26, 1999... Cancer Gene Therapy "A Retroviral Tetracycline (TET) Regulated System for in vivo Manipulation of IL-2 Expression." S. Pomer, C. Pitzer, B. Roseler and T. Wirth. Heidelberg, Germany. (CW HENDERSON PUBLISHER www.newsfile.com) --...

Phagocytes from Long-Term Survivor Renal Cell Carcinoma and Melanoma Patients Fail to Secrete IL-10 When Challenged With Tumor Apoptotic Cells.
July 26, 1999... Cancer Immunotherapy "Phagocytes from Long-Term Survivor Renal Cell Carcinoma and Melanoma Patients Fail to Secrete IL-10 When Challenged With Tumor Apoptotic Cells." A. Bondanza, P. Rovere, D. Pini, E. Rota Caremoli, C. Vallinoto, S....

Clinical Activity and Broken Immunologic Tolerance from ex vivo GM-CSF Gene Transduced Prostate Cancer Vaccines.
July 26, 1999... Cancer Vaccines "Clinical Activity and Broken Immunologic Tolerance from ex vivo GM-CSF Gene Transduced Prostate Cancer Vaccines." J.W. Simons, B. Mikhak, J.F. Chang, A. DeMarzo, M. Lim, M.A. Carducci, M. Goemann, F. Marshall, C. Weber, S....

Polynucleotide Vaccines for Colon Cancer and Melanoma.
July 26, 1999... Cancer Vaccines "Polynucleotide Vaccines for Colon Cancer and Melanoma." Robert M. Conry. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 5R01CA68256-04. GRANT...

The Role of Heat Shock Proteins for Vaccination Models in Renal Cell Carcinoma.
July 26, 1999... Cancer Vaccines "The Role of Heat Shock Proteins for Vaccination Models in Renal Cell Carcinoma." J. Roigas, E.S. Wallen, S.A. Loening and P.L. Moseley. Berlin, Germany. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

Antisense Oligonucleotides to Class III beta-Tubulin Sensitize Drug-Resistant Cells to Taxol.
July 26, 1999... Antisense Technology Kavallaris, M.; Burkhart, C.A.; Horwitz, S.B. "Antisense Oligonucleotides to Class III beta-Tubulin Sensitize Drug-Resistant Cells to Taxol." British Journal of Cancer, June 1999;80(7):1020-1025. (CW HENDERSON...

The Tumorigenicity of IL-2 Gene-Transfected Murine M-3D Melanoma Cells Is Determined by the Magnitude and Quality of the Host Defense Reaction: NK Cells Play a Major Role.
July 26, 1999... Cancer Immunology Schneeberger, A.; Koszik, F.; Schmidt, W.; Kutil, R.; Stingl, G. "The Tumorigenicity of IL-2 Gene-Transfected Murine M-3D Melanoma Cells Is Determined by the Magnitude and Quality of the Host Defense Reaction: NK Cells...

Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8(+) T-Cell Subpopulations in Established Pulmonary Metastases.
July 26, 1999... Cancer Immunotherapy Dobrzanski, M.J.; Reome, J.B.; Dutton, R.W. "Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8(+) T-Cell Subpopulations in Established Pulmonary Metastases." Journal of Immunology, June 1,...

Immunogene Therapy of Murine Fibrosarcoma Using IL-15 Gene With High Translation Efficiency.
July 26, 1999... Gene Transfer Kimura, K.; Nishimura, H.; Hirose, K.; Matsuguchi, T.; Nimura, Y.; Yoshikai, Y. "Immunogene Therapy of Murine Fibrosarcoma Using IL-15 Gene With High Translation Efficiency." European Journal of Immunology, May...

Safety and Efficacy Studies of Liposomes in Specific Immunotherapy.
July 26, 1999... Liposomes Galvain, S.; Andre, C.; Vatrinet, C.; Villet, B. "Safety and Efficacy Studies of Liposomes in Specific Immunotherapy." Current Therapeutic Research - Clinical and Experimental, May 1999;60(5):278-294. (CW HENDERSON PUBLISHER...

Phase II Trial of Biochemotherapy With Interferon alpha, Dacarbazine, Cisplatin and Tamoxifen in Metastatic Melanoma: A Southwest Oncology Group Trial.
July 26, 1999... Melanoma Margolin, K.A.; Liu, P.Y.; Unger, J.M.; Fletcher, W.S.; Flaherty, L.E.; Urba, W.J.; Hersh, E.M.; Hutchins, L.E.; Sosman, J.A.; Smith, J.W.; Weiss, G.R.; Sondak, V.K. "Phase II Trial of Biochemotherapy With Interferon alpha,...

Intrapatient Consistency of Imaging Biodistributions and Their Application to Predicting Therapeutic Doses in a Phase I Clinical Study of Y-90-Based Radioimmunotherapy.
July 26, 1999... Radioimmunotherapy Clarke, K.G.; Odommaryon, T.L.; Williams, L.E.; Liu, A.; Lopatin, G.; Chou, J.; Farino, G.M.; Raubitschek, A.A.; Wong, J.Y.C. "Intrapatient Consistency of Imaging Biodistributions and Their Application to Predicting...