Immunotherapy Weekly articles from February 2004

Immunotherapy Weekly archives from February 2004

Adoptive immunity fosters gene expression after cell transfection.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Adoptive immunity fosters gene expression after cell transfection. "Like cellular transplantation, gene therapy is often limited by immune rejection of the newly expressed antigen. In a model of...

Cancer researchers unlock secrets of how tumors hide.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Researchers at the H. Lee Moffitt Cancer Center & Research Institute have unlocked at least part of the mystery of how tumors flourish undetected by keeping their presence a secret from the sentries of...

Cilomilast modifies dendritic cell migration through skin.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Cilomilast modifies the dendritic cell migration through skin. According to a study from Germany, "The phosphodiesterase 4 inhibitor cilomilast demonstrated strong inhibitory effects in a model of...

Redundancy defines complex nature of cytokines and autoimmunity.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Redundancy defines the complex nature of cytokines and autoimmunity. According to recent research published in the journal Current Opinion in Immunology, "Cytokines are critical mediators in...

M. smegmatis GPLs inhibit macrophage phagocytosis.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- A group of M. smegmatis GPLs prevents macrophage phagocytosis of several mycobacterial species. "Phagocytosis by macrophages represents the early step of mycobacterial infection. It is governed...

Vaccine elicits immune response against respiratory syncytial virus.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant elicited a significant immune response to respiratory syncytial virus infection. According to a study from the United...

Lamivudine prevents rituximab-induced hepatitis B virus reactivation.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Lamivudine prevents rituximab-induced hepatitis B virus reactivation. According to researchers in Japan, "we used regimens containing rituximab in the treatment of five hepatitis B virus surface...

Scientists identify genes that regulate allergic response to diesel fumes.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The risk of developing respiratory allergies from exposure to diesel emissions depends largely on genetics, according to a study funded by the National Institute of Allergy and Infectious Diseases...

The bronchovideoscope detects increased vessel growth in new asthma patients.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The bronchovideoscope detects increased vessel growth in new asthma patients. "Hypervascularity in the bronchial wall is part of airway remodeling, but has remained an ill-defined process in asthma...

Prostaglandin may worsen lung injury induced by lipopolysaccharide.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- 15-Deoxy-Delta[superscript]12,14-prostaglandin J[subscript]2 may exacerbate acute lung injury induced by lipopolysaccharide in mice. According to recent research published in the European Journal of...

Th1 polarization underlies hematopoietic dysfunction in AAA patients.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Th1 polarization underlies hematopoietic dysfunction in AAA patients. "Immune dysfunction, which leads to the suppression of hemopoiesis by cytokines that are secreted by activated T lymphocytes,...

Ethnicity may affect allergies in children with asthma.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Puerto Rican and African American children with asthma may be at risk for multiple indoor and outdoor allergies, says a new study. The study found that Puerto Rican children with asthma were up to...

Measuring airway resistance in kids shows later asthma risk.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Measurement of airway resistance in 4-year-old children with different types of wheezing, using a new approach, could help identify those at high risk of asthma at a later date, according to researchers...

Women with systemic lupus erythematosus are at risk for losing bone density.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Women with systemic lupus erythematosus are at risk for losing bone density. According to recent research from Bulgaria, "the aim of this study was to analyze the heterogeneity of bone mineral...

Data shows CF101 to be effective in restraining growth of certain cancers.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Can-Fite BioPharma announced new preclinical study results, published in three peer reviewed, high score scientific journals: the Journal of Biological Chemistry, the British Journal of Cancer, and...

Enrollment complete for phase II clinical study in non-Hodgkin lymphoma.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Favrille, Inc., has completed enrollment for its current phase II clinical trial (FavId-04) with the company's lead investigational agent, FavId. This agent is under clinical development for the...

Granulocyte colony-stimulating factor reduces complications in elderly patients.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Further research studies are needed to identify the elderly patients who will benefit most from prophylactic granulocyte colony-stimulating factor (G-CSF). "According to recent research from Italy,...

Tumor cells plus adjuvant induced immunity against hepatoma.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Fixed tumor cells in combination with adjuvant induced protective antitumor immunity in a murine hepatoma model. According to recent research published in the journal Cancer Letters, "We previously...

To avoid detection, HIV disrupts immune cell migration.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The HIV protein Nef sparked intensive research after observations that patients with a rare strain of HIV lacking Nef took a very long time to develop AIDS symptoms. Nef has been linked to molecules...

Tomato parasite shares antigens with Trypanosoma cruzi.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Phytomonas serpens, a tomato parasite, shares antigens with Trypanosoma cruzi that are recognized by human sera and induce protective immunity in mice. According to published research from Brazil,...

ImClone gets $5 million payment relating to approval of ERBITUX in Switzerland.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- ImClone Systems, Inc., (IMCL) has achieved a milestone in its license agreement with Merck, KgaA, for development of ERBITUX outside of North America. The milestone relates to the approval in...

Company announces reimbursement for capsule endoscopy primary procedure.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Given Imaging (GIVN) announced that the Medicare carrier for the states of Ohio and West Virginia - Palmetto GBA - approved reimbursement coverage for capsule endoscopy as a primary procedure in the...

Scabies mites use novel immune evasion strategy.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Researchers describe a novel immune evasion strategy in the scabies mite Sarcoptes scabiei in a recent issue of the Journal of Investigative Dermatology. "Parasitic infestation of the skin by the...

Federal government report illustrates current diphtheria risks.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- According to the January 9 issue of the U.S. Centers for Disease Control and Prevention's (CDC) Morbidity & Mortality Weekly Report (MMWR), a recent case of fatal diphtheria was diagnosed in a U.S....

Company to transfer S. pneumoniae patent portfolio to Aventis.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Genome Therapeutics Corp. (GENE) and Aventis (AVE) have agreed to the sale of Genome Therapeutics' pending patent applications relating to the organism Streptococcus pneumoniae (S. pneumoniae) to...

Smallpox likely historic cause of CCR5-Delta32 mutation.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Contrary to conventional wisdom, smallpox is the likely historic cause of the CCR5-Delta32 mutation in Europeans. "The high frequency, recent origin, and geographic distribution of the CCR5-Delta32...

PTSD has some beneficial effects in HIV patients.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Surprisingly, PTSD appears to have some beneficial effects in HIV patients. "Previous research has reported rates of posttraumatic stress disorder (PTSD) following diagnosis with a life-threatening...

First case of ITG in HIV patient without hepatitis reported.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- A unique case of ITG in an HIV patient without hepatitis has been reported. Nephrologists in Pennsylvania described "the first case of immunotactoid glomerulopathy (ITG) in a human immunodeficiency...

Opioids can impair neuroprotective effects of retinoids.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Opioid use and abuse can counteract the neuroprotective effects of retinoids in HIV patients. "Among injection drug users, human immunodeficiency virus (HIV) type 1 infection may be associated with...

Delayed rectal viral dissemination seen in acutely SIV-infected macaques.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Surprisingly, viral activity is subdued shortly after rectal SIV infection in macaques. "Rectal infection of macaques by SIV is a model for rectal HIV transmission," according to virologists in...

HIV Vpu overcomes dominant host restriction in human cells.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The HIV Vpu protein overcomes a dominant host restriction mechanism in human cells. "Human cells resist viral infections by a variety of mechanisms. Viruses must overcome host cell restrictions to...

Mechanisms of NK cell impairment during HIV infection identified.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The molecular mechanisms of natural killer (NK) cell impairment during HIV infection have been identified. NK cells "play a central role in host defense against various pathogens," scientists in...

Viral fitness determines viral rebound during treatment interruptions.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- HIV fitness determines viral rebound during planned therapy interruptions. According to recent research from Switzerland, "Human immunodeficiency virus type 1 (HIV-1) isolates from 20 chronically...

IgG antibodies confer sterilizing protection to SHIV-infected macaques.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Transfer of neutralizing IgG antibodies to macaques 6 hours (but not 24 hours) after SHIV infection conferred sterilizing protection. According to a study from the United States, "Passive transfer...

Vaccinia virus DIs expressing SIV gag controls SHIV in monkeys.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Intravenous inoculation of replication-deficient recombinant vaccinia virus DIs expressing simian immunodeficiency virus (SIV) gag controls highly pathogenic SHIV in monkeys. "To be effective, a...

Effectiveness of preventive HPV vaccination reviewed.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Researchers review data on the effectiveness of preventive human papillomavirus (HPV) vaccination in a recent issue of the International Journal of STD and AIDS. According to a study from Finland,...

Phase III study of Actimmune published in leading journal.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- InterMune, Inc., (ITMN) announced the publication in the New England Journal of Medicine of previously presented results of the company's initial randomized, double-blind, placebo-controlled, phase III...

The pathophysiology of autoimmune hepatitis involves complex mechanisms.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The pathophysiology of autoimmune hepatitis involves complex mechanisms. According to a study from Mexico, "autoimmune hepatitis (AIH) is an inflammatory disease of unknown cause characterized by...

The proinflammatory function of VEGF involves leukocyte regulation.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The proinflammatory function of VEGF involves leukocyte regulation. "Vascular endothelial growth factor (VEGF), an established angiogenesis factor, is expressed in allografts undergoing rejection,...

Endoglin antibody works with transforming growth factor-beta to stop cancer.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Endoglin antibody works with transforming growth factor beta to stop cancer. According to recent research from the United States, "endoglin (CD105) is a proliferation-associated cell membrane...

H. pylori CagA mimicry may underlie cITP.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Molecular mimicry by the Helicobacter pylori CagA protein may underlie cITP associated with infection. H. pylori eradication "often leads to platelet recovery in patients with chronic idiopathic...

Mistrust and fears of risk keep elderly from influenza vaccination.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Fears of potential risk and mistrust of the medical system keep elderly people from obtaining influenza vaccination. "Influenza and its related illnesses remain a major cause of preventable...

Leishmania donovani with BCG protects against leishmaniasis.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Autoclaved Leishmania donovani with BCG has prophylactic potential against experimental visceral leishmaniasis. According to a study from India, "The prophylactic efficacy of autoclaved Leishmania...

Leishmania lesions affect nasal mucosa in rhesus monkey model.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Scientists describe the Leishmania chronic granulomatous cutaneous lesions that affect the nasal mucosa in a rhesus monkey model. "The present studies on infections with Leishmania (Viannia)...

MRP3 linked to drug resistance in pediatric ALL.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The MRP3 protein appears to contribute to drug resistance in pediatric ALL. According to a study from Germany, "The family of multidrug resistance-associated proteins (MRPs) belongs to the...

Diffuse large B-cell lymphoma patients should undergo aggressive treatment.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Study finds that patients with diffuse large B-cell lymphoma (DLBCL) arising in nodular lymphocyte predominant Hodgkin disease (NLPHL) have a prognosis similar to those with de novo DLBCL and should be...

DNA vaccine elicits strong immune response against malaria sporozoites.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- A novel construct containing functional domains of Plasmodium cynomolgi circumsporozoite (CS) and thrombospondin-related adhesive protein (TRAP) elicited a strong immune response in monkeys. ...

Vaccines based on Plasmodium vivax Sal I strains show promise.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Malaria vaccines based on Plasmodium vivax Sal I strains show promise in animal models. "We have previously demonstrated that mouse antisera against yeast-produced recombinant forms of the ookinete...

B. pertussis toxin induces T-cell responses against melanoma.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes. "The adenylate cyclase (CyaA) of Bordetella...

Administering topotecan weekly shows promise in the management of ovarian cancer.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Early results indicate that antitumor activity is maintained with weekly topotecan administration, researchers report. According to recent research from the United States, "Topotecan is an...

Vaccine company gets broad patent coverage for its core technology platform.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Juvaris BioTherapeutics, Inc., has received notice of allowance from the U.S. Patent Office covering its core technology platform. The company is focused on the development of a new generation of...

NCX 4016 successfully achieves primary efficacy endpoint in phase II study.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- NicOx, SA, (NICOX) announced that NCX 4016 reached its primary efficacy endpoint in a phase IIa study in patients with symptomatic peripheral arterial obstructive disease (PAOD). NCX 4016 is a...

Biotechnology company announces new member to board of directors.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Favrille, Inc., announced that Peter Barton Hutt, a leading food and drug law expert and former chief counsel for the U.S. Food and Drug Administration (FDA), has joined the company's board of...

Company announces departure of CFO Gregory S. Patrick.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) announced the departure of senior vice president and CFO Gregory S. Patrick. Commenting on Patrick's departure, David M. Mott, MedImmune's CEO, said, "We would like to thank...

Pan-pestivirus PCR primers cross-react with poliovirus genome.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Researchers report that pan-pestivirus PCR primers cross-react with the poliovirus genome. According to recent research from Slovakia and the U.K., "When several human vaccines were tested for...

NIAID awards $12.95 million for biodefense contract.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- NovaScreen Biosciences Corp. has been awarded a 5-year, $12.95 million contract by the National Institute of Allergy and Infectious Diseases (NIAID), a part of the U.S. National Institutes of Health...

Phase II clinical trial of LymphoStat-B for RA initiated.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) has begun dosing patients in a phase II clinical trial of LymphoStat-B (human monoclonal antibody to B-lymphocyte stimulator, BLyS) for the treatment of rheumatoid...

Company accelerates new oral SARS prevention program.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) is accelerating its experimental SARS treatment, including preparation of the clinical investigator's brochure and related packaging/labeling materials. The...

Unusual leukemia caused by rare combination of genes.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Two children who developed leukemia after receiving gene therapy for an inherited disease may have been victims of a rare combination of genes that is unlikely to happen in gene therapy for other...

CMV-seropositive donors might be preferable for seropositive SCT recipients.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Cytomegalovirus (CMV)-seropositive stem-cell donors may increase the safety and efficacy of transplantation for CMV-seropositive recipients. CMV infection "has been a major cause of morbidity and...

Impaired naive T-cell survival underlies post-SCT immunodeficiency.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Impaired survival of naive T cells - rather than poor thymic function - underlies the post-transplant immune dysfunction in stem-cell graft recipients. According to a study from Canada, "Allogeneic...

PBMC-PCR can facilitate tuberculous lymphadenitis diagnosis.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- PBMC-PCR testing can facilitate the diagnosis of tuberculous lymphadenitis. "Providing prompt and precise laboratory confirmation of a clinical diagnosis of tuberculous lymphadenitis is difficult...

CD40 needed for efficient T-cell priming after M. tuberculosis exposure.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- CD40 expression - but not that of its main ligand, CD40L - is needed for efficient T-cell priming during acute Mycobacterium tuberculosis infection. In a study from the United States, "CD40(-/-)...

Cantuzumab mertansine and huN901-DM1 advance to proof-of-concept studies.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- ImmunoGen, Inc., (IMGN), a biotechnology company that develops targeted anticancer products, announced that the company will advance both of its clinical stage tumor-activated prodrug (TAP) compounds -...

U.S. National Committee recommends strengthening vaccine supply.
February 4, 2004... 2004 FEB 4 - (NewsRx.com & NewsRx.net) -- The National Vaccine Advisory Committee in the United States recommends strengthening the nation's vaccine supply. According to a study from the United States, "Between late 2000 and the spring of...

To avoid detection, HIV disrupts immune cell migration.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- The HIV protein Nef sparked intensive research after observations that patients with a rare strain of HIV lacking Nef took a very long time to develop AIDS symptoms. Nef has been linked to...

Antigens shared by Aspergillus and Penicillium species identified.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Scientists have identified multiple antigens shared by Aspergillus and Penicillium species. According to published research from the United States and Poland, "Molds are ubiquitous in every...

A-beta single chain Fv antibodies isolated from immune phage library.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Amyloid-beta peptide-specific single chain Fv antibodies have been isolated from an immune phage display library. According to recent research published in the Journal of Neuroimmunology, "A...

Complete picture of a human immune pathway revealed.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- A large-scale proteomic approach has identified the complete set of protein interactions involved in a key human immune system signaling pathway implicated in a variety of disease states, including...

Intravital fluorescence microscopy assesses angiogenesis in arthritic mice.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Intravital fluorescence microscopy assesses angiogenesis in arthritic mice. "Inhibition of angiogenesis might be a therapeutic approach to prevent joint destruction caused by the overgrowing...

IL-21 triggers rapid maturation of natural killer cell precursors.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- The cytokine interleukin (IL)-21 triggers the rapid maturation of natural killer (NK) precursor cells. According to recent research from Italy, "The NK cell maturation from...

Gene product restricts HIV-1 replication in resting CD4+ lymphocytes.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. "Although human immunodeficiency virus-1 (HIV-1) infects quiescent and proliferating CD4+ lymphocytes, the virus...

Popularity of OTC allergy meds puts prescription drugs under price pressure.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Modified healthcare coverage with increased copayments and other disincentives is decreasing demand of high-priced prescription products by shifting consumer interest to lower-cost therapies such as...

Inactivated split influenza vaccine safe in children with asthma.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Inactivated split influenza vaccine is safe in children with stable asthma. "Although annual influenza vaccinations are recommended by many authorities, some doctors may be reluctant to vaccinate...

Patent granted for antiangiogenic treatments using VEGF inhibition.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals (PPHM) announced the issuance of U.S. Patent No. 6,524,583, entitled "Antibody Methods for Selectively Inhibiting VEGF," which covers methods for treating a variety of...

Contract signed with Pentagon to supply vaccine.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- BioPort Corporation announced that the Lansing-based manufacturer of the world's only U.S. Food and Drug Administration (FDA) licensed anthrax vaccine has entered into a 3-year contract to continue...

Elbow replacements are effective for the rheumatic elbow joint.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Total elbow arthroplasty is successful at 12-year follow-up, researchers report. "Management of patients with rheumatoid arthritis of the elbow has changed significantly over the last several...

Asthma drug program licensed from Abbott Laboratories.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Critical Therapeutics, Inc., a privately held biopharmaceutical company engaged in the discovery and development of products for critical care medicine, announced that it has in-licensed certain rights...

Controlled-release treatment for asthma and COPD to be developed.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- SkyePharma PLC (SKYE) announced an agreement with Critical Therapeutics Inc. (CTI) to develop a controlled-release formulation of the oral asthma drug zileuton for asthma and chronic obstructive...

Disappointing phase IIa clinical trial results reported for oral asthma drug.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Neurogen Corp. (NRGN), a small molecule drug discovery and development company, announced top-line results from its phase IIa clinical trial for asthma using NGD 2000-1, the first oral C5a antagonist...

Doubling of steroids before severe asthma attacks ineffective.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Recommendations to double inhaled steroids at the start of asthma attacks are challenged by new research findings. Doubling the dose of inhaled corticosteroid when asthma control deteriorates is...

Pregnant smokers put babies at increased risk for asthma.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Mothers who smoke during pregnancy greatly increase their child's risk of developing asthma in the first seven years of life, according to a study of almost 60,000 births. Researchers focused on...

Scientists identify cell defects that limit immune system's impact on late-stage tumors.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Although vaccines developed to help the immune system fight tumors appear to have an impact against early-stage tumors, they have little if any success in slowing the growth of tumors in later stages....

CRADA inked for pancreatic, ovarian, and lung cancer antibody development.
February 11, 2004... 2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Morphotek, Inc., announced it has signed a cooperative research and development agreement (CRADA) with the National Cancer Institute (NCI) for the development of therapeutic antibodies to a...