Immunotherapy Weekly articles from February 2003

Immunotherapy Weekly archives from February 2003

Zoledronic acid appears to have extensive uptake by, slow release from bone.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Switzerland, "Zoledronic acid is a new, highly potent bisphosphonate drug under clinical evaluation. A radioimmunoassay has been developed to determine zoledronic acid...

Combination therapy with monoclonal antibodies improves rejection-free survival.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing donor-specific tolerance in...

CD1 reactive T cells may direct dendritic cell development.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity,...

Endo2 has no role in mediating response to acute nociceptive signals.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Antibody coated microprobes, inserted into the spinal cord at the L4-5 level, were used to detect whether endomorphin-2 (Endo2) was released from spinal dorsal horns in anesthetized rats in response to...

R-halphaGalA may prevent renal failure in patients.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Fabry disease, a lysosomal storage disease caused by deficient lysosomal alpha-galactosidase A activity, is characterized by globotriaosylceramide (GL-3) accumulation in multiple cell types,...

Arthritis may be side effect of interferon beta-1b treatment.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Interferon beta (IFN-beta) is the most widely prescribed disease-modifying drug for multiple sclerosis (MS). Therapy with IFN-beta may be associated with a number of adverse reactions. The...

Piceatannol suppresses NF-kappa B activation induced by inflammatory agents.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Piceatannol is an anti-inflammatory, immunomodulatory, and antiproliferative stilbene that has been shown to interfere with the cytokine signaling...

Mannose-binding lectin genotype determines lectin levels and function.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Australia, "The mannose-binding lectin (MBL) pathway of complement activation is an important component of innate host defense. Numerous studies have described...

IFN-gamma-induced ERAP1 trims precursors to MHC class I-presented peptides.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Precursors to major histocompatibility complex (MHC) class I-presented peptides with extra NH[subscript]2-terminal residues can be efficiently trimmed to...

ER aminopeptidase ERAP1 enhances, limits supply of antigenic peptides.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major histocompatibility complex...

Former WebMD executive producer joins NewsRx.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- A former WebMD executive producer and medical editor has joined Atlanta-based NewsRx, along with three board-certified editors. Dominique Walton Brooks, MD, with WebMD until 2001, will serve as...

NIH releases landmark autoimmune disease research plan.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- The National Institutes of Health (NIH) released a comprehensive multidisciplinary, multi-agency research plan for autoimmune disease that the American Autoimmune Related Disease Association (AARDA) is...

Human detrusor smooth muscle cells may be tool for study of cholinergic pathways.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers from Italy recently explored "the morphological and biochemical aspects of human detrusor cells in culture as a tool for investigating the physiological mechanisms underlying bladder...

Changes in nitric oxide synthase activity may influence hypertrophy.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers from Sweden recently investigated "the expression and activity of nitric oxide synthase (NOS) and the localization of cyclic guanosine monophosphate (cGMP) in hypertrophied rat bladder....

Dual-specific T cells knock out tumors with double punch.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Immune system cells genetically redesigned to recognize immunogen show promise for treating cancer, United States government researchers indicate. According to a new study, "an effective immune...

Transferrin allows differentiation between alcohol abusers and teetotalers.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Measurements of carbohydrate-deficient transferrin (CDT) are used as markers of alcohol abuse. We developed a capillary zone electrophoresis (CZE) method aimed at improving accuracy of CDT testing,"...

HDAC2 may be recruited to promoter, specifically repress transcription.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "In a chicken B cell line, DT40, the disruption of HDAC2 (chHDAC2) gene causes an alteration of several gene expressions including chicken IgM light chain (chIgM-L) gene by 2D-polyacrylamide gel...

New blood treatment could help.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Draw a vial of blood from someone with advanced heart failure. Zap the blood with heat and other stresses, then inject it back in hopes the altered blood cells will trick the patient's immune system...

HEp-2, HEp-2000 comparable for fluorescence intensities, detecting specific ANAs.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers in Belgium reported: "For detection of anti-nuclear antibodies (ANAs) and antibodies to extractable nuclear antigens (ENAs), samples frequently are screened with indirect immunofluorescence...

Pseudokinase domain required for suppression of tyrosine kinases.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Finland, "Janus (Jak) tyrosine kinases contain a tyrosine kinase (JH1) domain adjacent to a catalytically inactive pseudokinase domain (JH2). The JH2 domain has been...

Researchers investigate gene expression during maturation of immature dendritic cells.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Dendritic cells (DCs) are the most important antigen-presenting cells. Many recent studies have compared the function of immature DCs (iDCs) and mature DCs...

Muscle pathology may result from MHC I overexpression.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Italy, "Dysferlin deficiency is being increasingly recognized in limb-girdle dystrophy and distal myopathy but its role in the development of muscle pathology is still...

Two-step culture system offers rapid expansion of progenitor cells.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- A two-step culture technique unravels the slow process of progenitor cell expansion. "Since dendritic cells (DC) play pivotal roles in both innate and adaptive immunity, DC can be a good target for...

HIV Nef inhibits T cell migration.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers in the United States have shed new light on the activity of the HIV Nef protein. This regulatory protein "has been shown to contribute to disease progression," according to E. Y. Choe...

NHEJ mutation could be rescued by deletion of Ku.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "There are two general pathways by which multicellular eukaryotes repair doublestranded DNA breaks (DSB): homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). All mammalian mutants...

Mumps virus' V protein disrupts alpha interferon receptor complex.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "It has been reported that mumps virus protein V or the C-terminal cysteine rich region of protein V (Vsp) is associated with blocking of the interferon (IFN) signal transduction pathway through a...

Identification of gene families containing Ig-like variable domains.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The evolutionary origin of adaptive immune receptors is not understood below the phylogenetic level of the jawed vertebrates. We describe here a...

Vectors expressing foreign peptides effective at inducing antibody responses.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Spain, "PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox polyvirus (PPV). In addition to the well-known...

Autoreactive B cells involved in autoantibody response to mouse lysozyme.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "We previously found that autoantibodies against mouse lysozyme (ML) were strongly induced in normal BALB/c mice when immunized with mutant ML that has triple...

DC-SIGN is an efficient target for delivery of T cell epitopes for MHC class II presentation.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Norway, "In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that...

Interleukin-6 involvement does not always include an antibody response.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "In the present study, we examined the effect of anti-IL-6 receptor antibody (MR16-1) on humoral and cellular immune responses in mice. MR16-1 did not affect antigen-specific antibody production in...

Leptin regulates the immune response to friend and foe.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- The hormone leptin, primarily produced in fat cells, helps regulate food intake, metabolism, and reproduction. It has also been shown to promote and sustain the body's immune response by binding to T...

Major Japanese cedar pollen antigens retain immunogenicity in a linked peptide.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "It has been demonstrated in detail that administration of a dominant T-cell determinant to animals induces activation or immunological tolerance of T cells. However, it has not been determined whether...

Microbial entry through caveolae investigated.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Caveolae and lipid rafts are increasingly being recognized as a significant portal of entry into host cells for a wide variety of pathogenic microorganisms....

Monoclonal antibody catalyzes the hydrolysis of nitrophenyl-beta-lactam.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers in England report "the first example of a monoclonal antibody-catalyzed hydrolysis of a P-lactam where the antibodies were generated by a simple transition-state analogue. A rat monoclonal...

Na,K-ATPase beta 3 subunit suppresses T and B lymphocyte activation.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "In order to identify new molecules involved in regulation of T cell proliferation, we generated various monoclonal antibodies (mAb) by immunization of mice with the T cell line Molt4. We found one mAb...

Research center study identifies specific gene required for long-term immunity.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Scientists at the Emory Vaccine Research Center show that a gene called SAP is required to generate long-term immunity. By measuring the immune responses of "knockout" mice genetically engineered...

Cyclooxygenase-2 may be involved in pathogenesis.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a report from Japan, "The expression of cyclooxygenase-2 was studied immunohistologically in specimens from lumbar disc herniation. The cultured disc cells also were examined to evaluate...

Cytokine associates with abnormal pathology of lymph nodes.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Scientists affiliated with Harvard University's Beth Israel Deaconess Medical Center say cytokines that regulate angiogenesis also modulate lymphangiogenesis. According to recent research from the...

Human lymph disease could tail off thanks to gecko.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Many lizards shed their tails, and then regrow them, as a survival mechanism - and now researchers from the University of Adelaide believe understanding this act could also help them treat a lymphatic...

Differential expression of isoforms, signaling proteins determine NKG2D function.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Optimal lymphocyte activation requires the simultaneous engagement of stimulatory and costimulatory receptors. Stimulatory immunoreceptors are usually...

Anti-inflammatory agents may not be appropriate for treatment.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Inflammation has always been thought of as detrimental in the pathophysiology of multiple sclerosis (MS). However, emerging genetic data, magnetic resonance imaging studies, and immunopathological...

IL-2 gene: no influence on susceptibility, clinical characteristics in Japanese.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Interleukin-2 (IL-2) is a cytokine intimately involved with both the function and regulation of the immune system. Genetic analysis of experimental autoimmune...

Inhibition of nitric oxide synthesis is produced by some treatment drugs.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Nitric oxide (NO) has been implicated in the etiopathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), and inhibition of NO synthesis has been...

TACE mRNA expression in peripheral mononuclear cells may precede new lesion.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from Austria, "tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of multiple sclerosis (MS). It has to be released from its cell membrane-bound precursor by...

Metastable state of IgG keeps 70% of complement-binding ability.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers in Russia report "that the human (hu) myeloma IgG1 Ser, its Fey fragment and the chimeric mouse-human monoclonal antibody (chim-mAb), containing the constant part of hu-gamma1-chain, can...

Cyclosporin A fails to rescue peripheral allografts in ongoing acute rejection.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "prevention and control of graft rejection remain essential in the investigation of peripheral nerve allotransplantation. Although use of...

Phosphorylated TIF 2 alpha localization is different in Alzheimer and CJD.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to researchers from Spain, "in vitro studies have shown that phosphorylated translation initiation factor 2alpha (TIF 2alpha) may have several functions, including regulation of protein...

5-HT1A receptor antagonists reduce cell proliferation in the dentate gyrus.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. "Three antagonists...

Regulatory T cells suppress ability to withstand central nervous system injury.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "The ability of rats or mice to withstand the consequences of injury to myelinated axons in the CNS was previously shown to depend on the ability to manifest a T cell-mediated protective immune...

Functional CcN motif regulates pro-IL-16.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The immunomodulatory cytokine interleukin-16 (IL-16) represents the secreted C-terminus of a larger precursor, pro-IL-16. Following cleavage by...

Tumors attacked by immune system respond better to therapy.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- The presence of tumor-infiltrating lymphocytes predicts the length of remission after chemotherapy and the overall survival of patients with ovarian cancer, according to researchers from the Abramson...

Nonsteroidal anti-inflammatory drug use appears to reduce colorectal adenomas.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to researchers from the United States, "observational studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal neoplasia. The mechanism of this effect...

Apoptotic epithelial cell death is prerequisite for fusion.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to research from Germany, "The aim of the present study was to investigate stage-specific changes in medial edge epithelium during in vivo fusion of embryonic palatal shelves in 25 Russian...

Crotalidae polyvalent immune Fab (ovine) antivenom appears to be efficacious.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Southern Pacific rattlesnake (Crotalus helleri) venom is not one of the four venoms used to produce Crotalidae polyvalent immune Fab (ovine)...

Improving teens' compliance must address circumstances of adolescence.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Renal transplantation restores a patient's endogenous renal function. The benefits of this restoration are especially dramatic in children....

FDA temporarily halts some gene therapy trials.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- In a precautionary measure, the U.S. Food and Drug Administration (FDA) has placed on "clinical hold" all active gene therapy trials using retroviral vectors to insert genes into blood stem cells. ...

Both systemic and local t cells are responsible for formation.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "the hallmark of Schistosoma mansoni infection is the formation of liver granulomas around deposited ova. The initiation of granuloma formation is T cell...

Patients with higher plasma fibrinogen improve when treated with apheresis.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "sudden sensorineural hearing loss (SSHL) is thought to have many different origins, including disturbances of microcirculation, autoimmune pathology, and...

Localization using MR angiography using gadomer-17 feasible.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "the goals of our study were to determine the technical feasibility of dynamic MR lymphangiography for detecting sentinel lymph nodes using Gadomer-17 contrast...

LPS-dependent leukocyte lipid bodies contain eicosanoid enzymes and cytokines.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- "Lipid bodies are rapidly inducible, specialized cytoplasmic domains for eicosanoid-forming enzyme localization, which we hypothesize to have specific roles in enhanced inflammatory mediator production...

Phagocytic cells present are not invaders, but transformed residents.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a report from Germany, "an immunohistochemical study on human autopsy lumbar intervertebral discs and surgical specimens was conducted to investigate the presence of phagocytic cells within...

Cancer therapy may offer patients new hope.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers at Johns Hopkins report success in using high doses of the anticancer drug cyclophosphamide to treat patients with moderate and severe forms of lupus, a chronic and sometimes fatal...

Cbl proteins promote clearance of engaged antigen receptor from cell surface.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "How Cbl family proteins regulate T cell responses is unclear. We found that c-Cbl Cbl-b double knockout (dKO) T cells became hyperresponsive upon anti-CD3...

Patients with implants have altered functional ability but no systemic illness.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "An undetermined number of patients with temporomandibular joint (TMJ) symptoms have been treated with intra-articular disc implants composed of Teflon...

Goal is to research about pathways of B lymphocytes and cardiac myocytes.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signaling networks. "Pathways will be...

L* protein colocalized with polyprotein, expressed in neurons.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Two subgroup strains of Theiler's murine encephalomyelitis virus (TMEV) synthesize L* protein from an alternative initiation codon. We first demonstrated L*...

Damage could be inhibited with anti-TGF beta 1 or lisinopril.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT) was used to determine the role of TGFbeta1 in fibrosis initiated by an...

Data presented on first cloned, double knock-out miniature swine.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- In a session at the annual meeting of the International Embryo Transfer Society (IETS), Randall Prather, PhD, distinguished professor of reproductive biotechnology at the University of...

Adolescence difficult time for recipients, immunosuppression needs to be optimal.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from England, "Adolescence is a difficult time for transplant recipients, who need to cope with the challenges of becoming independent from their parents, as well as taking...

Immune modulation therapy prevents renal ischemia-reperfusion injury.
February 5, 2003... 2003 FEB 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "Vasogen Inc.'s (Mississauga, Ontario, Canada) immune modulation therapy (IMT) is a therapy in which cells from the patient's own blood are modified by ex vivo...

Transplant researchers say rapamycin may help lupus, some cancers.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- Rapamycin, a drug approved for use in kidney transplant patients to prevent organ rejection, could also benefit patients with lupus and other autoimmune diseases as well as patients with blood cancers,...

Suppressing immune system reverses otherwise untreatable case of blood disease.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- Treatment with two medications that suppress the immune system, rituximab and cyclophosphamide, appears to have cured one woman of an otherwise untreatable case of the blood disease known as thrombotic...

Carbohydrate-based particles are better adjuvant than alum for allergy vaccines.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Carbohydrate-based particles (CBP) acted as an effective adjuvant for the major timothy grass pollen allergen without causing the granulomatous...

Cytotoxic T cells may role in pustule formation.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from Switzerland, "Extensive formation of nonfollicular sterile pustules on erythematous background combined with fever and peripheral blood leukocytosis are the characteristics of...

IL-15Ralpha may participate in transduction of IL-15 mitogenic signals.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The survival and expansion of effector cytotoxic T lymphocytes (CTLs) during an immunological response are critical for the successful elimination...

Gemfibrozil, a lipid-lowering drug, inhibits the induction of iNOs in astrocytes.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "Gernfibrozil, a lipid lowering drug, inhibited cytokine induced production of NO and the expression of inducible nitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astrocytes....

Histamine, cytokine modulated by an adenosine A(3) receptor agonist.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "the effects of adenosine receptor agonists on cytokine production in vivo were investigated in mouse models of endotoxemia. Selective adenosine A(3)...

Histidine residues oxidation induces superoxide dismutase misfolding/aggregation.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "the presence of intracellular aggregates that contain Cu/Zn superoxide dismutase (SOD1) in spinal cord motor neurons is a pathological hallmark of amyotrophic...

Gene expression profiling allows for understanding of mechanisms in prostate.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "Androgens are critical for prostate development, growth, and functions. In general, they support proliferation and prevent cell death of prostatic epithelial cells. Here, we studied changes of gene...

Purification of serum polyclonal antibody using unique synthetic peptide column.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- A recent study from Italy, "investigates the applicability of the protein A Mimetic (PAM) affinity ligand, obtained from the screening of a multimeric combinatorial peptide library, in immunoglobulin...

Monoclonal against a TNF receptor fights autoimmune disease and lymphadenopathy.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "humans and mice deficient in Fas, a tumor necrosis factor (TNF)receptor family member, cannot induce apoptosis of autoreactive cells, and consequently...

Antisera developed against the P. aeruginosa proteins responsible.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- "The third genes, opmE, opmD and opmB, of multidrug efflux operons deduced from the Pseudomonas aeruginosa PAO1 genome data were cloned by polymerase chain reaction. The opmB gene product showed...

Atrial natriuretic peptide prevents allergen-induced bronchial response.
February 12, 2003... 2003 FEB 12 - (NewsRx.com & NewsRx.net) -- Plasmid DNA may prevent asthma attacks that are stimulated by exposure to allergens. According to a study from the United States, "atrial natriuretic peptide (ANP) is a bronchodilator; however, the...