Immunotherapy Weekly articles from February 1999

Immunotherapy Weekly archives from February 1999

I.P. IL-2 Gene Delivery Inhibits Colon Carcinoma.
February 1, 1999... Intraperitoneal (i.p.) administration of a retrovirus harboring the interleukin-2 (IL-2) gene inhibited peritoneal dissemination of murine colon carcinoma cells. For several years researchers have explored methods of administering...

Clinical Trials Should Use Average Risk Patients.
February 1, 1999... Because patients with brain metastases from renal cell carcinoma have such poor prognosis, clinical trials should consider using patients with average risk prognostic factors in order to determine if a therapy is valid or not. S. Culine...

Potential Gene Therapy Exploits Dendritic Cells.
February 1, 1999... Gene transfer into human dendritic cells (DC) is possible using vaccinia virus and adenovirus vectors. From the perspective of exploiting DCs for cancer immunotherapy, Massimo Di Nicola and colleagues from the Istituto Nazionale Tumori,...

Renal Cell Carcinoma Produces Immunosuppressive Factors.
February 1, 1999... Renal cell carcinoma (RCC) produces immunosuppressive factors that inhibit interleukin-2 (IL-2) immunotherapy. C. Menetriercaux and colleagues from the Center Leon Berard, France, investigated the production of immunosuppressive factors by...

Early Results: Successful HAART Can End PCP Prophylaxis.
February 1, 1999... New findings suggest that people aggressively treating their HIV infections can take one fewer pill. The most deadly opportunistic infection among western AIDS patients is Pneumocystis carinii pneumonia (PCP). Trimethoprim-sulfamethoxazole...

Macrophage Migration Inhibitory Factor Induces Tumor Growth.
February 1, 1999... Macrophage migration inhibitory factor (MIF) induces tumor cell growth and may be a viable target for anticancer strategies. N. Kakahashi and colleagues from Hokkaido University, Japan, investigated the role of MIF protein in association...

Tobacco Twist: Plants Grow Cancer Cure.
February 1, 1999... In an ironic twist, tobacco plants may be used to grow therapeutic cancer vaccines. By engineering a tobacco virus, researchers at Biosource Technologies Inc. and Stanford University have found a way to cause tobacco plants to quickly...

Treatment Combination Effective for Lymphoma.
February 1, 1999... A multi-institutional clinical study led by Roswell Park Cancer Institute (RPCI), Buffalo, New York, has demonstrated the safety and effectiveness of a chemoimmunotherapy treatment for patients with non-Hodgkin's lymphoma. The overall...

"Viral Tumor Therapy in Herpes Simplex Virus-Immunized Mice Bearing Syngeneic Neuroblastoma.".
February 1, 1999... A. Chahlavi, T. Todo, S.D. Kabkin, S. Periasamy and K.L. Martuza. Department of Neurosurgery, Georgetown University Medical Center, Washington, DC. According to an abstract submitted by the authors to the 28th Annual Meeting of the Society...

"Antibody-Mediated IL-2 Gene Transfer Into Human Renal Carcinoma Cell (RCC) Lines.".
February 1, 1999... A. Durrbach, E. Angevin, G. Chavanel, B. Charpentier, A. Senik and F. Hirsch. CNRS/UPR420 and Immunotherapy Unit of the Institute Gustave Roussy, Villejuif, France. According to an abstract submitted by the authors to the 31st Annual...

"IL-12 Prolongs Survival in a Transgenic Mouse Model of Endogenously Arising Brain Tumors.".
February 1, 1999... E.J. Roy, L.A. Rund, and D.M. Kranz. Department of Biochemistry, University of Illinois, Urbana, Illinois. According to an abstract submitted by the authors to the 28th Annual Meeting of the Society for Neuroscience, held November 7-12,...

"Serologic Study of the Working Mechanisms of Immunotherapy for Children With Perennial Allergic Rhinitis." Archives of Otolaryngology - Head & Neck Surgery, December 1998;124(12):1337-1346.
February 1, 1999... Ohashi, Y.; Nakai, Y.; Tanaka, A.; Kakinoki, Y.; Washio, Y.; Kato, A.; Masamoto, T.; Yamada, K.; Hayashi, M. According to the authors' abstract of an article published in Archives of Otolaryngology - Head & Neck Surgery, "BACKGROUND:...

"Effect of Rush Immunotherapy on Airway Inflammation and Airway Hyperresponsiveness After Bronchoprovocation With Allergen in Asthma." Journal of Allergy and Clinical Immunology, December 1998;102(6 Part 1):927-934.
February 1, 1999... Kohno, Y.; Minoguchi, K.; Oda, N.; Yokoe, T.; Yamashita, N.; Sakane, T.; Adachi, M. According to the authors' abstract of an article published in Journal of Allergy and Clinical Immunology, "BACKGROUND: Rush immunotherapy (RIT) has been...

"Dose Escalation Trial of indium-111-Labeled Anti-carcinoembryonic Antigen Chimeric Monoclonal Antibody (Chimeric T84.66) in Presurgical Colorectal Cancer Patients." Journal of Nuclear Medicine, December 1998;39(12):2097-2104.
February 1, 1999... Wong, J.Y.C.; Chu, D.Z.J.; Yamauchi, D.; Odommaryon, T.L.; Williams, L.E.; Liu, A.; Esteban, J.M.; Wu, A.M.; Primus, F.J.; Beatty, J.D.; Shively, J.E.; Raubitschek, A.A. According to the authors' abstract of an article published in Journal...

"Multicenter Evaluation of the Mycobacteria Growth Indicator Tube for Testing Susceptibility of Mycobacterium tuberculosis to First-line Drugs." Journal of Clinical Microbiology, January 1999;37(1):45-48.
February 1, 1999... Ruschgerdes, S.; Domehl, C.; Nardi, G.; Gismondo, M.R.; Welscher, H.M.; Pfyffer, G.E. According to the authors' abstract of an article published in Journal of Clinical Microbiology, "In a multicenter study involving three reference centers...

"The European Directive on the Legal Protection of Biotechnological Inventions." Expert Opinion on Therapeutic Patents, December 1998;8(12):1729-1735.
February 1, 1999... Binns, R.; Driscoll, B. According to the authors' abstract of an article published in Expert Opinion on Therapeutic Patents, "The European Biotechnology Directive, which finally came into force on 30 July 1998, will clarify a number of...

"Diversity of the Fine Specificity Displayed by HLA-A*0201-restricted CTL Specific for the Immunodominant Melan-A/MART-1 Antigenic Peptide." Journal of Immunology, December 15, 1998;161(12):6956-6962.
February 1, 1999... Valmori, D.; Gervois, N.; Rimoldi, D.; Fonteneau, J.F.; Bonelo, A.; Lienard, D.; Rivoltini, L.; Jotereau, F.; Cerottini, J.C.; Romero, P. According to the authors' abstract of an article published in Journal of Immunology, "HLA-A*0201...

"Reduction of NOS2 Overexpression in Rheumatoid Arthritis Patients Treated With Anti-tumor Necrosis Factor alpha Monoclonal Antibody (CA2)." Arthritis and Rheumatism, December 1998;41(12):2205-2210.(nitric oxide synthase type 2)(Abstract)
February 1, 1999... Perkins, D.J.; Stclair, E.W.; Misukonis, M.A.; Weinberg, J.B. According to the authors' abstract of an article published in Arthritis and Rheumatism, "OBJECTIVE: Peripheral blood mononuclear cells (PBMC) from patients with rheumatoid...

"Successful Treatment of Rotavirus Diarrhea in Children With Immunoglobulin from Immunized Bovine Colostrum." Pediatric Infectious Disease Journal, December 1998;17(12):1149-1154.
February 1, 1999... Sarker, S.A.; Casswall, T.H.; Mahalanabis, D.; Alam, N.H.; Albert, M.J.; Brussow, H.; Fuchs, G.J.; Hammerstrom, L. According to the authors' abstract of an article published in Pediatric Infectious Disease Journal, "BACKGROUND: Oral...

"Priming of CD8(+) CTL Effector Cells in Mice by Immunization With a Stress Protein Influenza Virus Nucleoprotein Fusion Molecule." Vaccine, January 28, 1999;17(4):373-383.
February 1, 1999... Anthony, L.S.D.; Wu, H.C.; Sweet, H.; Turnnir, C.; Boux, L.J.; Mizzen, L.A. According to the authors' abstract of an article published in Vaccine, "Literature is accumulating which suggests the potential for stress proteins to form the...

Homing Potentials of Circulating Antibody-Secreting Cells After Administration of Oral or Parenteral Protein or Polysaccharide Vaccine in Humans.
February 1, 1999... Kantele, A.; Westerholm, M.; Kantele, J.M.; Makela, P.H.; Savilahti, E. According to the authors' abstract of an article published in Vaccine, "The site of antigen encounter influences the Ig-distribution and homing potentials of...

Influence of Maternal Antibodies on Vaccine Responses: Inhibition of Antibody But Not T-cell Responses Allows Successful Early Prime-Boost Strategies in Mice.
February 1, 1999... Siegrist, C.A.; Barrios, C.; Martinez, X.; Brandt, C.; Berney, M.; Cordova, M.; Kovarik, J.; Lambert, P.H. According to the authors' abstract of an article published in European Journal of Immunology, "The transfer of maternal antibodies...

Receptor-Mediated Gene Delivery Uses Fab Fragments.
February 8, 1999... Fab fragments of anti-epidermal growth factor receptor (EGFR) antibodies facilitate an improved immunogene approach for receptor-mediated gene delivery. In previous research, J. Chen et al. were able to target delivery of a therapeutic...

Tumor Cells Inhibit Dendritic Cell Development.
February 8, 1999... Tumor cells may escape immune recognition by hindering the development of dendritic cells (DC). A better understanding of how cancer escapes immune recognition in the patient's body may facilitate therapeutic approaches to circumvent this...

Successful Therapy Depends on Recruitment of Immune Cells.
February 8, 1999... Successful immunotherapy for cancer requires the effective recruitment of naive host immune cells to the tumor site. M. Nagoshi and colleagues from the St. Louis University School of Medicine, Missouri, explored the mechanisms behind...

TGF-(beta) Antisense Therapy Prolongs Survival.
February 8, 1999... Suppression of the immunosuppressive cytokine transforming growth factor beta (TGF-(beta)) prolongs survival in glioma tumor-bearing rats. Using an intracranial rat C6 glioma model, L.M. Liau and colleagues from the University of California...

Immunologic Monitoring Does Not Detect Rejection.
February 8, 1999... Determining the class I MHC molecules was not helpful in detecting rejection early, researchers indicated. W. Prohaska and colleagues performed a study to determine lymphocyte subset alterations during the early phase after heart...

Interleukin-2 in Patients with HIV Infection.
February 8, 1999... C. Lane. National Institutes of Health, Bethesda, Maryland. According to an abstract submitted by the author to the International Conference on the Discovery and Clinical Development of Antiretroviral Therapies, held December 13-17, 1998,...

Specific Recognition of 3TC-Resistant HIV-1 Variants By Cytotoxic T-Cells (CTL).
February 8, 1999... T. Harrer, M. Schmitt, E. Harrer, A. Goldwich, M. Bauerle, I. Graedner and J.R. Kalden. Department of Medicine III, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany. According to an abstract submitted by the...

HIV cDNA Plasmids as Immunotherapy.
February 8, 1999... B. Wahren, S. Calarota, A.C. Leandersson, A. Kjerrstrom, B. Hejdeman, A.L. Hultstrom, I. Hinkula, G. Bratt and E. Sandstrom. Swedish Institute for Infectious Disease Control, South Hospital, Karolinska Institute, Stockholm, Sweden. ...

"Inhibition of BCR-Mediated Apoptosis by IFN-(alpha).".
February 8, 1999... L. Su and M. David. University of California at San Diego, La Jolla, California. According to an abstract submitted by the authors to the 51st Annual Symposium on Fundamental Cancer Research entitled Molecular Targets for Cancer Therapy...

HIV-1 Recognition.
February 8, 1999... R.B. Moss, M.R. Wallace, W.K. Giermakowska, E. Webb, J. Savary, F. Chamberlin-Brandt, G. Theofan, R. Musil, S.P. Richier, F.C. Jensen and D.J. Carlo. The Immune Response Corporation, Carlsbad, California; U.S. Naval Medical Center, San Diego,...

Adenoviral Infection Inhibits Allergic Airways Inflammation in Mice.
February 8, 1999... Stampfli, M.R.; Ritz, S.A.; Neigh, G.S.; Sime, P.J.; Lei, X.F.; Xing, Z.; Croitoru, K.; Jordana, M. According to the authors' abstract of an article published in Clinical and Experimental Allergy, "BACKGROUND: Recent epidemiological...

Metabolism-Dependent Neutrophil Cytotoxicity of Amodiaquine: A Comparison With Pyronaridine and Related Antimalarial Drugs.
February 8, 1999... Naisbitt, D.J.; Williams, D.P.; Oneill, P.M.; Maggs, J.L.; Willock, D.J.; Pirmohamed, M.; Park, B.K. According to the authors' abstract of an article published in Chemical Research in Toxicology, "Life-threatening agranulocytosis and...

Generation of Cytokine-Induced Killer Cells Using Exogenous in Interleukin-2, -7, or -12.
February 8, 1999... Zoll, B.; Lefterova, P.; Csipai, M.; Finke, S.; Trojaneck, B.; Ebert, O.; Micka, B.; Roigk, K.; Fehlinger, M.; Schmidtwolf, G.D.; Huhn, D.; Schmidtwolf, I.G.H. According to the authors' abstract of an article published in Cancer Immunology...

Anti-tumor Activity of Interleukin-2-Producing Tumor Cells and Recombinant Interleukin 12 Against Mouse Glioma Cells Located in the Central Nervous System.(International Journal of Cancer, January 29, 1999;80(3):425-430)
February 8, 1999... Kikuchi, T.; Joki, T.; Saitoh, S.; Hata, Y.; Abe, T.; Kato, N.; Kobayashi, A.; Miyazaki, T.; Ohno, T. According to the authors' abstract of an article published in International Journal of Cancer, "Interleukin 12 (IL-12) exhibits...

Treatment of Lung Tumor Colonies With Y-90 Targeted to Blood Vessels: Comparison With the alpha-particle emitter Bi-213.(Nuclear Medicine and Biology, January 1999;26(1):149-157)
February 8, 1999... Kennel, S.J.; Stabin, M.; Yoriyaz, H.; Brechbiel, M.; Mirzadeh, S. According to the authors' abstract of an article published in Nuclear Medicine and Biology, "An in vivo lung tumor model system for radioimmunotherapy of lung metastases was...

Mutations of the beta(2)-microglobulin Gene Result in a Lack of HLA Class I Molecules on Melanoma Cells of Two Patients Immunized with MAGE Peptides.
February 8, 1999... Benitez, R.; Godelaine, D.; Lopeznevot, M.A.; Brasseur, F.; Jimenez, P.; Marchand, M.; Oliva, M.R.; Vanbaren, N.; Cabrera, T.; Andry, G.; Landry, C.; Ruizcabello, F.; Boon, T.; Garrido, F. According to the authors' abstract of an article...

Complement-Mediated Anti-HIV-1 Effect Induced by Human IgM Monoclonal Antibody Against Ganglioside GM2.
February 8, 1999... Wu, X.S.; Okada, N.; Momota, H.; Irie, R.F.; Okada, H. According to the authors' abstract of an article published in Journal of Immunology, "HIV infected cells aberrantly express a high level of antigenic glycosidic structures such as GM2...

Intranasal Immunization With Plasmid DNA-Lipid Complexes Elicits Mucosal Immunity in the Female Genital and Rectal Tracts.
February 8, 1999... Klavinskis, L.S.; Barnfield, C.; Gao, L.Q.; Parker, S. According to the authors' abstract of an article published in Journal of Immunology, "The development of vaccines against pathogens transmitted across the genito-rectal mucosa that...

HSV Amplicon Vectors Deliver Immune Effector Molecules.(herpes simplex virus)
February 15, 1999... Herpes simplex virus (HSV) amplicon vectors expressing immune effector molecules eradicate pre-established lymphoma. Research suggests that for immunotherapy of hematologic malignancies to be effective, several interventions may be required,...

Combination Therapy Induces Lung Cancer Regression.
February 15, 1999... The combination of chemotherapy and interleukin (IL)-15 administration induced permanent tumor regression in a murine lung cancer model. A.I. Chapoval and colleagues from the Mayo Clinic, Minnesota, investigated the pathogenesis...

EGF-R: A Novel Target against Cervical Cancer.(epidermal growth factor receptor)
February 15, 1999... Epidermal growth factor receptor (EGF-R) may be an interesting target for immunotherapy of cervical cancer. S. Biesterfeld and colleagues from the University of Aachen, Germany, investigated the expression of EGF-R in the prognosis of...

Ewing's Sarcoma Could Be The Next Immunotherapy Target.
February 15, 1999... Due to the expression of Fas ligand in Ewing's sarcoma, the cancer may be a future target of immunotherapeutic modalities. H.U. Kontny and colleagues from the Pediatric Oncology Branch of the National Institutes of Health, Maryland,...

Host-Mediated ADCC Facilitates Leukemia Immunotoxicity.(antibody-dependent cellular cytotoxicity)
February 15, 1999... Host-mediated antibody-dependent cellular cytotoxicity (ADCC) facilitates the therapeutic efficacy of an immunotoxin therapy against acute lymphoblastic leukemia (ALL). D.J. Flavell and colleagues from the University of Southampton,...

Peritoneal Cell Expansion May Have Therapeutic Effect.
February 15, 1999... The expansion of peritoneal cell populations via the peritoneal injection of granulocyte-macrophage colony-stimulating factor (GM-CSF) has strong antitumor potential. A.H. Klimp and colleagues from the University of Groningen, The...

Intratumoral AdV-Mediated TNF-(alpha) Induces Tumor Regression.(adenovirus, tumor necrosis factor)
February 15, 1999... Intratumoral inoculation of an adenovirus (AdV) expressing the fusion protein RM4 and tumor necrosis factor (TNF)-(alpha) induces significant solid tumor regression. TNF-(alpha) is an immunoregulatory cytokine that can enhance the cytotoxic...

Ad-Mediated Alveolar Macrophage Expansion Facilitates Immunity.(adenovirus)
February 15, 1999... In vivo expansion of alveolar macrophages (AM) by adenovirus (Ad)-mediated transfer of the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) cDNA facilitates the lungs ability to protect itself from inhaled organisms. Stefan...

Latent Virus Flush Too Toxic.
February 15, 1999... A bold clinical experiment showed that it may be a good idea to flush latent HIV from its hiding place, but that new methods will have to be found. It has become painfully clear that highly active antiretroviral therapy (HAART) regimens cannot...

Anti-E1 May Be Marker of HCV Recurrence in OLT Patients.(hepatitis C virus, orthotopic liver transplant)
February 15, 1999... Envelope-specific humoral immune response may be directly stimulated by hepatitis C virus replication in liver transplant recipients, researchers from the United Kingdom report. Patients who receive liver transplants for hepatitis C virus...

Antiviral Treatment is Useful in Post-HCV Cirrhosis Patients.(hepatitis C virus)
February 15, 1999... Patients with post-hepatitis C cirrhosis benefit from treatment with interferon and/or ribavirin, according to a report from France. Researcher T. Poynard and colleagues assessed the benefit-risk ratio of interferon and ribavirin in the...

Passively Transfused Alloantibodies After Infusions of Rho(D) Immune Globulin (WinRho).(Abstract)
February 15, 1999... "Passively Transfused Alloantibodies After Infusions of Rho(D) Immune Globulin (WinRho)." J. Rushin, D.H. Rumsey and S.G. Sandler. Georgetown University Medical Center, Washington, DC. According to an abstract submitted by the authors to...

Poor Immunogenic Features of a Small Cell Carcinoma of the Cervix.(Abstract)
February 15, 1999... "Poor Immunogenic Features of a Small Cell Carcinoma of the Cervix." R. Mirhashemi, M.F. Janicek, W.M.J. Schoell, M.A. Penalver, E.R. Podack and B. Liu. Department of Microbiology/Immunology, and Department of Obstetrics and Gynecology,...

Successful Prevention of Post-Transfusion Rh Alloimmunization by Intravenous Rho(D) Immune Globulin (WinRho).(Abstract)
February 15, 1999... "Successful Prevention of Post-Transfusion Rh Alloimmunization by Intravenous Rho(D) Immune Globulin (WinRho)." B. Anderson, A.T. Shad, J.E. Gootenberg and S.G. Sandler. Georgetown University Medical Center, Washington, DC. According to...

Correlation of Elevated Serum Interleukin-10 (IL-10) with Survival in Patients with Advanced Melanoma.(Abstract)
February 15, 1999... "Correlation of Elevated Serum Interleukin-10 (IL-10) with Survival in Patients with Advanced Melanoma." J. Nemunaitis, T. Fong, D. Martineau, F. Oldham and D. Ando. PRN Research, Inc., Dallas, Texas; Chiron Corporation, San Diego,...

Measurement of Delivery and Metabolism of Tirapazamine to Tumour Tissue Using the Multilayered Cell Culture Model.(Abstract)
February 15, 1999... Kyle, A.H.; Minchinton, A.I. "Measurement of Delivery and Metabolism of Tirapazamine to Tumour Tissue Using the Multilayered Cell Culture Model." Cancer Chemotherapy and Pharmacology, March 1998;43(3):213-220. According to the authors'...

Reversal of Tamoxifen Resistance of Human Breast Carcinomas in vivo by Neutralizing Antibodies to Transforming Growth Factor-beta.(Abstract)
February 15, 1999... Arteaga, C.L.; Koli, K.M.; Dugger, T.C.; Clarke, R. "Reversal of Tamoxifen Resistance of Human Breast Carcinomas in vivo by Neutralizing Antibodies to Transforming Growth Factor-beta." Journal of the National Cancer Institute, January 6,...

Treatment of Multiple Sclerosis with Copolymer-1 (Copaxone (R)): Implicating Mechanisms of Th1 to Th2/Th3 Immune-Deviation.(Abstract)
February 15, 1999... Miller, A.; Shapiro, S.; Gershtein, R.; Kinarty, A.; Rawashdeh, H.; Honigman, S.; Lahat, N. "Treatment of Multiple Sclerosis with Copolymer-1 (Copaxone (R)): Implicating Mechanisms of Th1 to Th2/Th3 Immune-Deviation." Journal of...

Improving Monoclonal Antibody Pharmacokinetics Via Chemical Modification.(Abstract)
February 15, 1999... Sharifi, J.; Khawli, L.A.; Hornick, J.L.; Epstein, A.L. "Improving Monoclonal Antibody Pharmacokinetics Via Chemical Modification." Quarterly Journal of Nuclear Medicine, December 1998;42(4):242-249. According to the authors' abstract of...

Effects of Linker Chemistry on the Pharmacokinetics of Radioimmunoconjugates.(Abstract)
February 15, 1999... Quadri, S.M.; Vriesendorp, H.M. "Effects of Linker Chemistry on the Pharmacokinetics of Radioimmunoconjugates." Quarterly Journal of Nuclear Medicine, December 1998;42(4):250-261. According to the authors' abstract of an article...

Administration Route Affects Efficacy of IL-12 Therapy.
February 22, 1999... The antitumor activity of interleukin-12 (IL-12) is influenced by the route of administration. Numerous mouse models have demonstrated the antitumor activity of recombinant murine IL-12 (rIL-12). However, the exact mechanisms are still not...

Early Results of INF-(alpha) for Renal Carcinoma are Mixed.
February 22, 1999... Benefits of subcutaneous administration of interferon alpha (INF-(alpha)) for metastatic renal carcinoma need to be balanced with the risks. A. Ritchie and colleagues from the Cancer Trials Office, England, reported early clinical trial...

Monoclonal Antibodies Studied as Immune Effectors.
February 22, 1999... Monoclonal antibodies undergo scrutiny as therapeutic modalities for microscopic tumors. J.Y. Douillard and colleagues from the Site Hospital Nord Nantes, France, examined the immune effector capabilities of monoclonal antibodies...

CEA mAb Enhances Tumor Uptake in Radioimmunotherapy Protocol.
February 22, 1999... Stabilized Fab homo-oligomers of a chimeric monoclonal antibody (mAb) against carcinoembryonic antigen (CEA) enhance tumor uptake for radioimmunotherapy. T. Kamigaki and colleagues from the Kobe University School of Medicine, Japan,...

Tamoxifen - More than Just Chemotherapy.
February 22, 1999... Tamoxifen has pharmacological features with immunomodulating effects. M. Hadjikirova and colleagues from the National Oncology Center, Bulgaria, researched the immunomodulatory activity of Tamoxifen ("Immunomodulatory Effect of Tamoxifen...

Plant Interferons, A New Group of Immunomodulators against Viral Infections and Malignancies.
February 22, 1999... Cancer Immunomodulators "Plant Interferons, A New Group of Immunomodulators against Viral Infections and Malignancies." C. Mittal and O.P. Babbar. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India. ...

New Generation Anti-Carcinoembryonic Antigen (CEA) 'Designer T Cell' Therapies for Cancer.
February 22, 1999... Cancer Gene Therapy "New Generation Anti-Carcinoembryonic Antigen (CEA) 'Designer T Cell' Therapies for Cancer." E.J. Beecham, K. Nolan, C. Yon, Y. Akamatsu, G. Zheng, S. Ortiz-Pujols, J. Murphy, J. Watters, S. Leung and R.P. Junghans....

Generation of Tumor-Specific Cytotoxic T Lymphocytes against Cervical Cancer Cell Lines by In Vitro Stimulation with a Synthetic Human Papilloma Virus Type 16 E7 Epitope.
February 22, 1999... Cancer Immunotherapy "Generation of Tumor-Specific Cytotoxic T Lymphocytes against Cervical Cancer Cell Lines by In Vitro Stimulation with a Synthetic Human Papilloma Virus Type 16 E7 Epitope." W.M.J. Schoell, R. Mirhashemi, M.F. Janicek,...

Killing of Mycobacterium avium by Neutrophils and Monocytes from AIDS Patients Treated with GM-CSF.
February 22, 1999... Cytokine Therapy (MAC) "Killing of Mycobacterium avium by Neutrophils and Monocytes from AIDS Patients Treated with GM-CSF." S. Cinti, M. Coffey, A. Sullivan, W. Armstrong and P. Kazanjian. University of Michigan Medical Center, Ann Arbor,...

In Vivo Migration and Antiviral Activity of Transferred HIV-1 Specific Cytotoxic T Cells.
February 22, 1999... HIV Immunotherapy "In Vivo Migration and Antiviral Activity of Transferred HIV-1 Specific Cytotoxic T Cells." S. Brodie, D. Lewinsohn, B. Patterson, A. Ryncarz, L. Corey, P. Greenberg and S. Riddell. University of Washington, Seattle,...

Protection of Macaques Against Pathogenic SHIV-89.6PD by Passive Transfer of Neutralizing Antibodies.
February 22, 1999... HIV Vaccines "Protection of Macaques Against Pathogenic SHIV-89.6PD by Passive Transfer of Neutralizing Antibodies." J. Mascola, M. Lewis, G. Stiegler, H. Katinger, D. Harris, D. Hayes, M. Louder, T. Vancott, S. Frankel, C. Brown, C....

Lipid A Mutant Salmonella With Suppressed Virulence and TNF alpha Induction Retain Tumor-Targeting in vivo.
February 22, 1999... Bacterial Anticancer Agents Low, K.B.; Ittensohn, M.; Le, T.; Platt, J.; Sodi, S.; Amoss, M.; Ash, O.; Carmichael, E.; Chakraborty, A.; Fischer, J.; Lin, S.L.; Luo, X.; Miller, S.I.; Zheng, L.M.; King, I.; Pawelek, J.M.; Bermudes, D....

Prolonged Upregulation of the Expression of HLA Class I Antigens and Costimulatory Molecules on Melanoma Cells Treated With 5-aza-2 '-deoxycytidine (5-AZA-CdR).
February 22, 1999... Cancer Immunotherapy Coral, S.; Sigalotti, L.; Gasparollo, A.; Cattarossi, I.; Visintin, A.; Cattelan, A.; Altomonte, M.; Maio, M. "Prolonged Upregulation of the Expression of HLA Class I Antigens and Costimulatory Molecules on Melanoma...

Combined Positive/Negative Purging and Transplantation of Peripheral Blood Progenitor Cell Autografts in Breast Cancer Patients: A Pilot Study.
February 22, 1999... Cancer Therapies (Blood Products) Mapara, M.Y.; Korner, I.J.; Lentzsch, S.; Krahl, D.; Reichardt, P.; Dorken, B. "Combined Positive/Negative Purging and Transplantation of Peripheral Blood Progenitor Cell Autografts in Breast Cancer...

Combined Cytotoxic Effects of Tumor Necrosis Factor-alpha With Various Cytotoxic Agents in Tumor Cell Lines That Are Drug Resistant Due to Mutated p53.
February 22, 1999... Drug Resistance Sleijfer, S.; Le, T.K.P.; Dejong, S.; Timmerbosscha, H.; Withoff, S.; Mulder, N.H. "Combined Cytotoxic Effects of Tumor Necrosis Factor-alpha With Various Cytotoxic Agents in Tumor Cell Lines That Are Drug Resistant Due to...

IL-6 and IL-8 Levels in Plasma During Hematopoietic Progenitor Transplantation.
February 22, 1999... Hematopoietic Progenitor Transplantation Ferra, C.; Desanjose, S.; Gallardo, D.; Berlanga, J.; Rueda, F.; Marin, D.; Delabanda, E.; Ancin, I.; Peris, J.; Garcia, J.; Granena, A. "IL-6 and IL-8 Levels in Plasma During Hematopoietic...

Human Parainfluenza Virus Type 3 Up-regulates Major Histocompatibility Complex Class I and II Expression on Respiratory Epithelial Cells: Involvement of a STAT1- and CIITA-Independent Pathway.
February 22, 1999... Immunology Gao, J.; De, B.P.; Banerjee, A.K. "Human Parainfluenza Virus Type 3 Up-regulates Major Histocompatibility Complex Class I and II Expression on Respiratory Epithelial Cells: Involvement of a STAT1- and CIITA-Independent Pathway."...

Immunomodulation With Interleukin-10 and Interleukin-4 Compared With Ketorolac Tromethamine For Prevention of Postoperative Adhesions in a Murine Model.
February 22, 1999... Surgery (Postoperative Adhesions) Holschneider, C.H.; Nejad, F.; Montz, F.J. "Immunomodulation With Interleukin-10 and Interleukin-4 Compared With Ketorolac Tromethamine For Prevention of Postoperative Adhesions in a Murine Model."...

An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzae Type b-tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants.
February 22, 1999... Vaccine Safety Lee, C.Y.; Thipphawong, J.; Huang, L.M.; Lee, P.I.; Chiu, H.H.; Lin, W.; Debois, H.; Harrison, D.; Xie, F.; Barreto, L. "An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and...