Immunotherapy Weekly articles from December 2004

Immunotherapy Weekly archives from December 2004

Interferon alfa causes vitiligo and psoriasis in a patient with hepatitis B.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Interferon alfa causes vitiligo and psoriasis in a patient with hepatitis B. According to a study from Turkey, "well-known cutaneous side effects of interferon (IFN)-alfa therapy include dry skin,...

Allergic lung responses may involve interplay of diverse members of ADAM family.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Allergic lung responses seem to involve the interplay of diverse members of the ADAM family. According to recent research published in the United States, "Asthma, a complex chronic inflammatory...

Virus-induced auto-antibody responses characterized.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists have characterized virus-induced auto-antibody responses. "Here we present a comprehensive molecular mapping of virus-induced autoimmune B cell responses obtained by serological...

Epstein-Barr virus antigen elicits anti-dsDNA and anti-Sm antibodies.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. According to published research from the United States,...

Repeated boosting with E. coli bacterin needed for high antibody levels.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Repeated boosting with J5 E. coli bacterin is required to generate high levels of cross-reactive IgG[subscript]2 antibodies. According to published research from the United States,...

AIDS protection dependent on persistence of vaccine virus.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virus. According to published research from the...

Avoiding deceptive imprinting in AIDS vaccine development reviewed.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists outline methods to avoid deceptive imprinting of the immune response to HIV-1 infection in vaccine development in a recent issue of International Reviews of Immunology. According to a...

HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity. According to a study from Italy, "Tat, the trans activation...

HIV-1 Tat vaccine protects against SHIV89.6P replication in monkeys.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat vaccinated cynomolgus monkeys were protected against SHIV89.6P replication. According to a study from Italy, "Vaccination with a biologically active Tat protein or tat DNA contained...

HIV-1 gp120 and immune network reviewed.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers review HIV-1 gp120 and the immune network in a recent issue of International Reviews of Immunology. According to a study from Yugoslavia and the United Kingdom, "It has been...

Inflammatory stimuli increase neutrophil binding of HIV.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Activation by inflammatory stimuli increases neutrophil binding of human immunodeficiency virus type 1 and subsequent infection of lymphocytes. According to recent research from the United States,...

Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Oral immunization with papillomavirus pseudoviruses encoding gag induced HIV-1 gag-specific mucosal immunity. "Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV)...

Recombination property of HIV-1 gp120 gene reported.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers report the recombination properties of the HIV-1 gp120 gene in a recent issue of International Reviews of Immunology. According to a study from Yugoslavia, "Using a chimeric primer...

Retroviral vectors used to analyze SIV/HIV-specific T cell responses.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers have used retroviral vectors for the analysis of SIV/HIV-specific CD8 T cell responses. "CD8+ T cell responses and particularly cytotoxic T lymphocyte (CTL) activity are critical...

nef-deleted SHIV protects against pathogenic virus infection.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A nef-deleted simian and human immunodeficiency virus (SHIV) protected against pathogenic virus infection. According to published research from Japan, "To clarify the involvement of primitive...

High-dose melphalan and ASCT improves quality of life of AL amyloidosis patients.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- High-dose melphalan and autologous peripheral blood stem cell transplantation improves the quality of life of AL amyloidosis patients. According to a study from the United States, "Treatment of AL...

U.S. FDA approves Evoclin for treating acne.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Connetics Corp. (CNCT), a specialty-pharmaceutical company that develops and commercializes dermatology products, announced that the U.S. Food and Drug Administration (FDA) has approved Evoclin...

AML samples with FLT3/ITD mutations preferentially killed by FLT3 inhibition.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Pediatric acute myelogenous leukemia samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition. According to recent research from the United States, "Pediatric acute myelogenous...

Idarubicin and busulfan feasible for elderly AML patients undergoing ASCT.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Continuous infusion of idarubicin and oral busulfan is feasible for elderly patients with acute myeloid leukemia undergoing autologous stem cell transplantation. According to recent research from...

HealthPro Plus room air purifier chosen as Consumers Digest Best Buy.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- IQAir North America announced that their HealthPro Plus room air purifier has been chosen as a Consumers Digest Best Buy. The HealthPro Plus is featured in the December 2004 issue of Consumers...

Company gets IRB approval for phase III clinical trials for PreHistin.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Cobalis Corp. (CLSC), a pharmaceutical company specializing in the development of antiallergy medications, announced that they have received approval from institutional review board (IRB) IntegReview,...

Neurogenic mechanisms in bronchial inflammatory diseases reviewed.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The neurogenic mechanisms in bronchial inflammatory diseases have been reviewed. "Neurogenic inflammation encompasses the release of neuropeptides from airway nerves leading to inflammatory...

Beta-sheet breaker peptide prevents Alzheimer's memory impairments.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A beta-sheet breaker peptide prevents A-beta-induced spatial memory impairments with partial reduction of amyloid deposits. "Current evidence supports the notion that beta-amyloid deposits or...

Complications of Alzheimer vaccination in nonhuman primates modeled.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists have modeled hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates. "The potential of amyloid-beta (A-beta) immunization as a...

Plasmid DNA vaccine protects against aerosolized anthrax spores.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores. According to a study from the United States, "DNA vaccines provide...

Vaccine protects cheetah and black rhinoceros against anthrax.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers have developed a vaccine that protects cheetahs and rhinoceroses against anthrax. According to a study from England, Namibia, and the United States, "Institution of a policy of...

Inhaled CO has anti-inflammatory effects against ventilator-induced lung injury.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Inhaled carbon monoxide has antiinflammatory effects against ventilator-induced lung injury. "Ventilator-induced lung injury (VILI) is a major cause of morbidity and mortality in intensive care...

Company presents three posters on its antibacterial agent ECO-0501 at ICAAC.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Ecopia BioSciences, Inc., (EIA) presented data on ECO-0501 in the form of three posters at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) held in Washington, DC. ...

M4N induces growth arrest/apoptosis by inhibiting Cdc2 and survivin expression.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- M4N induces growth arrest and apoptosis by inhibiting Cdc2 and survivin expression. According to a study from the United States, "We previously reported that Sp1-dependent Cdc2 gene expression is...

New reimbursement policy increases patient access to REMICADE.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Centocor said that the new Medicare physician reimbursement policy announced by the U.S. Centers for Medicare and Medicaid Services (CMS) will facilitate increased patient access to REMICADE in a health...

Scientist claims Pfizer arthritis drug worse than Vioxx, spurs controversy.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A scientist's claim of evidence that Pfizer Inc.'s Bextra might be even riskier for people with heart disease than rival arthritis drug Vioxx sparked controversy November 10, 2004, at a medical meeting...

Aspergillosis: Emerging infection in critically ill patients without malignancy.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Invasive apergillosis is an important emerging infection in critically ill patients without malignancy. "Using criteria designed for invasive aspergillosis (IA) in patients with cancer, we aimed to...

Pharmaceutical company receives new drug approval for proprietary asthma product.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- IVAX Corporation (IVX) received approval from the U.S. Food and Drug Administration (FDA) for its New Drug Application (NDA) for its patented HFA (CFC-free) formulation of albuterol in a metered dose...

Reducing agent OTC may reduce airway inflammation, hyperresponsiveness.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Reducing agent OTC may reduce airway inflammation and hyper-responsiveness by regulating NF-kappaB activity. Researchers in South Korea report, "Oxidative stress plays an important role in the...

TGF-beta2 induces bronchial epithelial mucin expression in asthma.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The transforming growth factor (TGF)-beta family is important for tissue repair in pathological conditions including asthma. However, little is known about...

Brain inflammation found in autism.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Inflammation in the brain is clearly a feature of autism, according to a new study. The researchers found strong evidence that certain immune system components that promote inflammation are consistently...

Interferon alpha is linked to the formation of systemic sclerosis.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Interferon alpha is linked to the formation of systemic sclerosis. "In 1992 interferon alpha (IFN-alpha) was approved by the U.S. Food and Drug Administration for the treatment of chronic viral...

Indian Salmonella Typhi isolates have reduced ciprofloxacin susceptibility.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Salmonella Typhi isolates in India have reduced susceptibility to ciprofloxacin. "Typhoid fever continues to remain a health problem as the causative organism Salmonella Typhi has developed...

Basal cell carcinoma rates continuously increasing in the Netherlands since 1973.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Basal cell carcinoma rates have been continuously increasing in the Netherlands since 1973. "This study is aimed to determine the characteristics of the trends in incidence of basal cell carcinoma...

MTT/ATP/calcein assays similarly predict potency of cytotoxic anticancer agents.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- MTT, ATP and calcein assays similarly predict the potency of cytotoxic anticancer agents. "Cell viability assays are important tools in oncological research and clinical practice to assess the tumor...

Murine model developed for bone marrow failure.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A murine model was developed for bone marrow failure. According to a study from the United States, "Infusion of parental lymph node (LN) cells into sublethally irradiated hybrid F1 recipients...

Antiestrogenic DTACs inhibit estrogen receptor alpha-mediated transcription.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Antiestrogenic DTACs inhibit estrogen receptor alpha-mediated transcription. According to a study from the United States, "A novel class of pure antiestrogens,...

No correlation between B. cepacia complex wbiI RFLP genotype and species.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- There is no correlation between the Burkholderia cepacia complex wbiI RFLP genotype and species. According to recent research from the United States, "Gram-negative bacteria of the Burkholderia...

Intensive/short-term Burkitt lymphoma chemotherapy effective/manageable toxicity.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Intensive/short-term chemotherapy for Burkitt's lymphoma is effective and has manageable toxicity. "A very short, intensive pediatric chemotherapy program was tested in a consecutive...

ATryn maker reports third-quarter net loss of $7.2 million.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- GTC Biotherapeutics, Inc., (GTCB) reported its financial results for the third quarter ended October 3, 2004. The total net loss for the quarter was $7.2 million, or $0.18 per share, compared with...

Immunotherapeutics company sees Q3 revenue increase.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Corixa Corp. (CRXA), a developer of immunotherapeutics, announced financial results for the third quarter ended September 30, 2004. For the third quarter of 2004 Corixa reported total revenue of...

Pharma company reports third quarter 2004 results.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Point Therapeutics, Inc., (NASDAQ: POTP) reported results for the fiscal quarter and 9 months ended September 30, 2004. During the third quarter of 2004, Point achieved the following key...

Q3 update: Phase III trial enrollment complete; Thelin shows promise.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Encysive Pharmaceuticals (ENCY) announced financial results for the third quarter ended September 30, 2004. "Once again, we've had a productive quarter," said Bruce D. Given, MD, president and CEO...

Nonionizing and ionizing radiation inactivate Calicivirus.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Nonionizing and ionizing radiation inactivate Calicivirus. According to a study from the Netherlands, "Noroviruses (previously Norwalk-like viruses) are the most common viral agents associated with...

Immune receptors for Ganoderma lucidum polysaccharides identified.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Immune receptors for Ganoderma lucidum polysaccharides (GLPS) have been identified. Researchers in China conducted a study "to identify and characterize the immune receptors for polysaccharides"...

Negative outcome on malignant melanoma trial reported.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Maxim Pharmaceuticals (Nasdaq:MAXM) (SSE:MAXM) announced that based upon the negative outcome of it's confirmatory phase 3 clinical trial (M0104) studying Ceplene (histamine dihydrochloride) in...

Beta-lactams hold promise as anticancer chemotherapeutic drugs.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Beta-lactams hold promise as anticancer chemotherapeutic drugs. According to a study from the United States, "The discovery of natural and synthetic antibiotics is one of the most important medical...

Company achieves commercial scale of antigen for Provenge.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Dendreon Corp. (DNDN) announced that it has succeeded in reproducing the antigen used in the preparation of Provenge, the company's investigational immunotherapy for the treatment of prostate cancer, at...

Antibodies redirect cytolytic capacity of cytotoxic T lymphocytes.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alpha[subscript]vbeta[subscript]3-expressing endothelial cells. "To redirect the lytic activity of...

Cancer vaccines must break immune tolerance to malignant cells.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Cancer vaccine development involves breaking immune tolerance to malignant cells. "Exploiting a naturally occurring defense system, the immunotherapeutic approach embodies an ideal nontoxic...

IL-6 regulates dendritic cell differentiation through STAT3 activation.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. "Dendritic cells (DCs) orchestrate immune responses according to their state of maturation. In response to infection,...

Lipid-core-peptides increase adjuvant activity of T cell peptides.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Incorporation into lipid-core-peptides increased the adjuvant activity of minimal CD8 T cell peptides. "A problem facing the use of subunit peptide and protein vaccines is their inability to...

Melanoma vaccination results presented at conference.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corporation (NASDAQ:GNBT) announced the presentation by Nikoletta Kallinteris, the Antigen Express Project Leader, Ii-Key Hybrid Technology, who preformed these studies, at the...

PHB1/PHB2 identified as blood-borne tumor antigens.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Differential immunization has identified PHB1/PHB2 as blood-borne tumor antigens. "Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived...

Susceptibility of tumors to immunotherapy changes during maturation.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The susceptibility of tumors to innate and adaptive immunotherapy changes during tumor maturation. "Immunotherapy of tumors using T cells expanded in vitro has met with mixed clinical success...

DNA vaccine protects against lethal canine distemper virus challenge.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Immunization with plasmid DNA encoding the hemagglutinin and the nucleoprotein confers robust protection against a lethal canine distemper virus challenge. According to recent research from Denmark...

Cardiac troponins/NT-proBNP prognostic of amyloidosis PBSCT survival.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Cardiac troponins and N-terminal probrain natriuretic peptide are prognostic of survival for amyloidosis patients following peripheral blood stem cell transplantation. "Primary systemic amyloidosis...

Deleterious hematological effects of CBP centrifugal pumps compared.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The deleterious hematological effects of two cardiopulmonary bypass (CPB) centrifugal pumps have been compared. CPB "induces hemolysis and the activation of the inflammatory and coagulation...

Celiac disease prevalence higher in Turkish population compared to Western world.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The prevalence of celiac disease is higher in Turkish populations compared to the Western world. According to recent research published in the journal Digestive Diseases and Sciences, "Celiac...

HPV vaccine shown to "substantially" reduce cervical cancer.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- An international clinical trial has shown extremely promising results for a vaccine against the most common causes of cervical cancer. Diane Harper of the Norris Cotton Cancer Center at...

Report hails benefits of new approach to diabetes, asthma, and heart failure.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Maine Medical Center's parent company said November 8, 2004, that its coordinated approach toward managing three chronic conditions, diabetes, asthma and heart failure, has helped to keep patients...

Companies to co-develop domain antibody products to treat respiratory disease.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Domantis, Ltd., and Argenta Discovery, Ltd., a respiratory/inflammation drug development company, have entered into an agreement to co-develop fully human Domain Antibody (dAbs) therapeutics for chronic...

Low levels of cigarette smoke induce irreversible change in cell chromosomes.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Low levels of cigarette smoke induce irreversible change in cell chromosomes. "Exposure to cigarette smoke has long been linked to carcinogenesis, but the emphasis has been placed on mutational...

Results of preclinical, clinical studies of investigational antibiotic reported.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Theravance, Inc. (THRX) announced that results from a phase 2 clinical study with the investigational antibiotic telavancin (TD-6424) in patients with complicated Gram-positive skin and skin structure...

Company details clinical development plan for CG53135 and CR002.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- CuraGen Corp. (CRGN) announced progress with their pipeline of protein, antibody, and small-molecule therapeutics highlighted by the transitioning of CG53135 into phase II for the prevention of oral...

Cpe-positive Clostridium perfringens spores from feces isolated/enumerated.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Cpe-positive Clostridium perfringens spores from feces were isolated, and enumerated. According to published research from Finland, "A hydrophobic grid membrane filter-colony hybridization (HGMF-CH)...

Risk of community-associated MRSA infection is associated with several factors.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The risk of acquiring community-associated methicillin-resistant Staphylococcus aureus infection is associated with several factors. According to a study from the United States, "An outbreak of...

Crohn therapy remains stable with maintenance over 2-year period, study shows.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A new study based on nearly 30,000 Crohn disease cases, derived from a nationwide reimbursement database (2002-2003), observed that patients diagnosed with Crohn disease taking Remicade (infliximab)...

Direct smear rapid/effective for diagnosis of Cyclospora cayetanensis infection.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The direct smear method is rapid and effective for the diagnosis of Cyclospora cayetanensis infection. "Cyclospora cayetanensis oocysts in the feces of humans from Kathmandu, Nepal were identified...

Oral valganciclovir equivalent to oral ganciclovir for CMV prevention.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Oral valganciclovir is equivalent to oral ganciclovir for the prevention of CMV infection. According to investigators writing in the journal Expert Opinion on Pharmacotherapy, "Herpes virus...

Mutations in dengue virus vaccine candidate decreases virus replication.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining...

Research institute announces discovery on the virus' role in autoimmune disease.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers at the La Jolla Institute for Allergy & Immunology announced the addition of a milestone to scientific understanding of the role viruses play in the development of autoimmune diseases, such...

Data show FG-3019 improves kidney function in late-stage disease model.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced that FG-3019, the company's lead investigational antifibrotic agent, significantly improved glomerular filtration rate (a measure of kidney function) and reduced proteinuria...

LightCycler PCR assay detects/characterizes enterotoxigenic Escherichia coli.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The LightCycler PCR assay detects and characterizes enterotoxigenic Escherichia coli. According to scientists in Germany, "To facilitate the diagnosis of enterotoxigenic Escherichia coli (ETEC)...

Whole blood cytokine detection assay to quantitate T-cells developed.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists have developed a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies. According to recent research from the United States and South...

Probiotics hold promise for treating diarrhea, but more research is needed.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Probiotics hold promise for treating diarrhea, but more research is needed. According to a study from Australia, New Zealand, and Spain, "There is unequivocal evidence that administration of...

Treatment of diarrhea and dysentery in Thailand described.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Treatment of diarrhea and dysentery in Kaengkhoi district, Saraburi province, Thailand is described. "To estimate the proportion of cases missed in a passive surveillance study of diarrhea and...

Persistent itching nodules caused by diphtheria-tetanus toxoid vaccines.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers report persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminum. "Studies in Gothenburg, Sweden,...

Crystal structures of humanized anti-IFN-gamma Fab determined.
December 1, 2004... 2004 DEC 1 - (NewsRx.com & NewsRx.net) -- The crystal structures of a humanized anti-IFN-gamma antibody have been characterized. In a recent study from the United States, "[t]hree-dimensional structures were determined for two crystal...