Immunotherapy Weekly articles from December 1998

Immunotherapy Weekly archives from December 1998

"Airway Hyperreactivity Modulated by Immunotherapy with Denatured Ovalbumin in Ovalbumin-Sensitized Guinea Pigs." Journal of the Formosan Medical Association, September 1998;97(9):626-632.
December 7, 1998... Tsai, J.J.; Peng, H.J.; Han, S.H. According to the authors' abstract of an article published in Journal of the Formosan Medical Association, "Denatured immunogenic peptides have recently been used successfully to treat autoimmune diseases in...

Cell Transplantation "Expression of Human Dystrophin Following the Transplantation of Genetically Modified mdx Myoblasts." Gene Therapy, October 1998;5(10):1340-1346.
December 7, 1998... Moisset, P.A.; Gagnon, Y.; Karpati, G.; Tremblay, J.P. According to the authors' abstract of an article published in Gene Therapy, "Transplantation of genetically modified autologous myoblasts has been proposed as a possible solution to avoid...

Immunotherapy "Post-Transplant Therapy Using High-Dose Human Immunoglobulin (Intravenous Gammaglobulin) to Control Acute Humoral Rejection in Renal and Cardiac Allograft Recipients and Potential Mechanism of Action." Transplantation, September 27, 1998;66(6):800-805.
December 7, 1998... Jordan, S.C.; Quartel, A.W.; Czer, L.S.C.; Admon, D.; Chen, G.; Fishbein, M.C.; Schwieger, J.; Steiner, R.W.; Davis, C.; Tyan, D.B. According to the authors' abstract of an article published in Transplantation, "BACKGROUND: Intravenous...

Kidney Transplantation "Treatment of Peripubertal Children After Renal Transplantation (RTX) with Recombinant Human Growth Hormone: Auxological Data and Effects on Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3) During 24 Months." Journal of Pediatric Endocrinology & Metabolism, November-December 1998;11(6):713-718.
December 7, 1998... Riedl, S.; Lebl, J.; Kluge, M.; Kreisinger, J.; Simkova, E.; Kohlhauser, C.; Balzar, E.; Frisch, H. According to the authors' abstract of an article published in Journal of Pediatric Endocrinology & Metabolism, "OBJECTIVE: To evaluate growth...

Respiratory Syncytial Virus "Respiratory Syncytial Virus Immune Globulin for Prophylaxis Against Respiratory Syncytial Virus Disease in Infants and Children with Congenital Heart Disease." Journal of Pediatrics, October 1998;133(4):492-499.
December 7, 1998... Simoes, E.A.F.; Sondheimer, H.M.; Top, F.H.; Meissner, H.C.; Welliver, R.C.; Kramer, A.A.; Groothuis, J.R. According to the authors' abstract of an article published in Journal of Pediatrics, "OBJECTIVE: To examine the effectiveness of...

Therapy (HCV) "Effectiveness of Leukocyte Interferon-alpha Treatment in Patients with Chronic Hepatitis C Not Responsive to Recombinant Interferon." Digestive Diseases and Sciences, October 1998;43(10):2173-2176.
December 7, 1998... Scotto, G.; Grimaldi, M. According to the authors' abstract of an article published in Digestive Diseases and Sciences, "Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant...

Tuberculosis (Therapy) "Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages." Antimicrobial Agents and Chemotherapy, October 1998;42(10):2682-2689.
December 7, 1998... Barrow, E.L.W.; Winchester, G.A.; Staas, J.K.; Quenelle, D.C.; Barrow, W.W. According to the authors' abstract of an article published in Antimicrobial Agents and Chemotherapy, "Microsphere technology was used to develop formulations of...

Therapy Complications "Adverse Reactions to Iodinated Contrast Media in Patients Treated with Interleukin-2.".
December 7, 1998... I. Vivas, A.I. Nicolas, J.M. Lopez-Picezo, B. Elduayen, C. Delgado and L. Garcia-Del Barrio. Pamplona, Spain. According to an abstract submitted by the authors to the 84th Scientific Assembly and Annual Meeting of the Radiological Society...

Cancer Immunotherapy Intratumor IL-2 Plasmid DNA Injection Induces Immunity.
December 7, 1998... Intratumoral injection of interleukin-2 (IL-2) plasmid DNA induced CD8(+) T cell immunity in established murine tumors. IL-2 is a potent activator of natural killer (NK) cells, lymphokine-activated killer (LAK) cells and T cells and has...

Allergy Immunotherapy Immunotherapy Inhibits Airway Eosinophilia in Asthma Model.
December 7, 1998... Allergen immunotherapy inhibited airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma. A.J.M. Vanoosterhout and colleagues from the University of Utrecht, The Netherlands, investigated whether allergen...

Cancer Immunotherapy Chemo/Immunotherapy Tolerable in Renal Cancer Patients.
December 7, 1998... Combined chemo/immunotherapy has passed an initial test in renal cancer patients and gone on to controlled clinical studies as a first line therapy. D. Rohde and colleagues from the Department of Urology, Rhein Westfal Th Aachen, Germany,...

Cancer Immunotherapy Defective Maturation of Hemopoietic Progenitors Creates Complications.
December 7, 1998... The defective maturation of hemopoietic progenitor cells causes the defective function of Langerhans cells (LC) in tumor-bearing animals. T. Ishida and colleagues from the Vanderbilt University School of Medicine, Tennessee, investigated...

Immunological Parameters of TNF(alpha) Immunotherapy Identified.
December 7, 1998... Immunological responses from TNF(alpha) immunotherapy do not increase circulating lymphocytes. R. Braczkowski and colleagues from the Silesian University School of Medicine, Poland, noted that tumor necrosis factor alpha (TNF(alpha))...

Antiviral Immunity Mysterious HIV Suppression Linked to Genetic Factors.
December 7, 1998... Genetic regulation may be the key to the mysterious ability of CD8(+) T cells to suppress HIV replication. CD8(+) from healthy HIV infected individuals is able to suppress HIV in CD4(+) T-cell cultures without killing infected cells. This...

EBV Multiple TcR Clonotypes May Mediate Recognition of MHC Antigen.
December 7, 1998... Multiple T-cell receptors (TcRs) might mediate the recognition of a single major histocompatibility (MHC) complex class II restricted melanoma antigen, researchers indicated. Another possibility is that multiple MHC class II restricted...

Therapy (HBV) Combination Therapy Efficacious Against HBV.
December 7, 1998... The non-nucleoside agent robustaflavone appears to act synergistically with lamivudine and penciclovir in the treatment of hepatitis B virus. Researcher D.E. Zembower and colleagues evaluated the activity of robustaflavone in the presence...

Immunology Immune System Master Switch Cuts Off Tumors.
December 7, 1998... Scientists believe they have found a "master switch" that allows tumors to use various tricks to evade the body's immune system. It's a protein called PML. If it works, killer T cells in the body's immune system go into battle against...

HIV Immunotherapy "Hypothyroidism is Associated with IL-2 Therapy in a Randomized Controlled Trial (RCT) of IL-2 for the Treatment of HIV Infection.".
December 7, 1998... S. Sumida, K. Miller, S. Vogel, J. Kovacs, J. Falloon, R. Davey, R. Walker, H. Masur, H.C. Lane and M.A. Polis. University of California Berkeley, Berkeley, California; NIAID and Warren Grant Magnuson Clinical Center, NIH, Bethesda, Maryland....

Gene Therapy (Arthritis) "Novel Strategy for the Treatment of Rheumatoid Arthritis by Ap-r Gene Transfer.".
December 7, 1998... K. Nishioka, K. Okamoto, T. Kobayashi, T. Kato, T. Kobata and T. Hasunuma. Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St. Marianna University, Kawasah, Japan. According to an abstract submitted by the...

Gene Therapy (Lupus) "Amelioration of Lymphoid Hyperplasia and Hypergammaglobulinemia in Lupus-Prone Mice, Gld by Fas Ligand Gene Transfer.".
December 7, 1998... T. Kobatat, N. Mai Hong, K. Masuko-Hongo, H. Sasakawa, T. Kato, K. Okumura and K. Nishioka. Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Kanagawa; Department of Immunology, Juntendo University School of...

Immunology (Malaria) "Cytokine Responses During Acute Simian Malaria Infection in the Rhesus Monkey.".
December 7, 1998... A.D. Praba, F. Cogswell, S. Montenegro-James and M.A. James. Tulane Regional Primate Research Ctr., Covington, LA; Molecular Immunogenetics Laboratory, Ochsner Medical Foundation, New Orleans, LA; Tulane University Medical Ctr., New Orleans,...

Pathogenesis (HIV) "Immunopathogenesis of Primary HIV Infection.".
December 7, 1998... E. Rosenberg, J. Mukherjee, J. Billingsley, T. Gaerlan, A. Caliendo, G. Robbins, T. Flynn and B. Walker. AIDS Research Center and Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts. According to an abstract...

Lipofection Provides Immunological Advantages to DNA Vaccines.
December 14, 1998... Lipid complex-mediated gene transfer stimulates immunological advantages beyond that created from transfected gene expression. Lipid/DNA complex-mediated gene transfer is a simple and safe approach in clinical gene transfer strategies. In...

Gene Therapy Can Potentially Treat Autoimmune Disorders.
December 14, 1998... The local delivery of immunoregulatory proteins via gene therapy may have therapeutic potential against autoimmune encephalomyelitis. Autoimmune diseases are an immune attack on self tissue. Current therapies generally utilize potent and...

Fibroblast-Mediated Cytokine Gene Therapy Supports Chemotherapy.
December 14, 1998... Combined fibroblast-mediated cytokine gene therapy ameliorates hematopoietic depression after chemotherapy. Fibroblast-mediated cytokine gene therapy has developed into a promising strategy for restoring hematopoiesis after repeated...

Immunosuppressive Factors May Inhibit Immunogene Therapy.
December 14, 1998... Immunosuppressive factors expressed by tumors may inhibit cytokine immunogene therapy protocols. The immunosuppressive protein transforming growth factor beta (TGF-(beta)) inhibits the activation of various immune effectors cells including...

IL-17 Stimulates Granulopoiesis in Mice.
December 14, 1998... Interleukin-17 (IL-17) may have therapeutic potential for the treatment of AIDS-related bone marrow failure. IL-17 is a novel cytokine that is secreted primarily by CD4(+) T cells. Research has demonstrated that IL-17 supports the growth of...

IL-6 Looses Monster T-Cells.
December 14, 1998... By forcing dendritic cells into an unnatural state, the cytokine interleukin 6 (IL-6) unleashes anti-self T cells. The finding helps explain how dangerous autoimmune responses can develop after infection with a pathogen that does not itself...

Phase II Cytokine Therapy Clinical Trial Commenced. (in renal cell carcinoma).
December 14, 1998... Maxim Pharmaceuticals, San Diego, California, announced that it has initiated a Phase II clinical trial of Maxamine Therapy in the treatment of patients with advanced renal cell carcinoma (RCC). The trial is being conducted in collaboration...

"Peptide Vaccination with an Anchor-Replaced CTL Epitope Protects Against Human Papillomavirus Type 16-Induced Tumors Expressing the Wild-Type Epitope." Journal of Immunotherapy, November 1998;21(6):399-408.(Abstract)
December 14, 1998... According to the authors' abstract of an article published in Journal of Immunotherapy, "Anchor residues in cytotoxic, T-lymphocyte (CTL), epitope-bearing peptides are buried deep in the major histocompatibility complex (MHC) class I...

"Cyclosporine A in the Treatment of Early Rheumatoid Arthritis. A Prospective, Randomized 24-month Study." Clinical and Experimental Rheumatology, November-December 1998;16(6):695-702.(Abstract)
December 14, 1998... According to the authors' abstract of an article published in Clinical and Experimental Rheumatology, "OBJECTIVE: To investigate the efficacy, tolerability and safety of cyclosporine A (CSA) in early rheumatoid arthritis (RA) patients....

"T-cell Receptor Peptide Vaccination in Rheumatoid Arthritis: A Placebo-Controlled Trial Using a Combination of V(beta)3, V(beta)14, and V(beta)17 Peptides." Arthritis and Rheumatism, November 1998;41(11):1919-1929.(Abstract)
December 14, 1998... According to the authors' abstract of an article published in Arthritis and Rheumatism, "OBJECTIVE: Restricted T-cell receptor (TCR) gene usage has been demonstrated in animal models of autoimmune disease and has resulted in the successful use...

INF-(beta) Gene Therapy Caused Tumor Regression In Mice.
December 21, 1998... Interferon-(beta) (IFN-(beta)) gene therapy inhibited tumor formation and caused established tumors to regress in an immune-deficient murine model. Interferons have demonstrable antitumor effects. However, in most cancer models it has...

Immunotherapy May Reverse Drug Resistance.
December 21, 1998... Cytotoxic T lymphocyte (CTL)-mediated tumor lysis results in enhanced chemotherapy sensitivity. The increased incidence of drug resistance to chemotherapeutic agents is a major cause of treatment failure in cancer therapy. Much needed...

New Melanoma Antigens Facilitate Treatment Modalities.
December 21, 1998... Discovery of new melanoma antigens should stimulate the development of treatment modalities for HLA-diverse melanoma patients. Tyrosinase-related protein 2 (TRP2) is a melanosomal enzyme expressed in most mammalian melanocytes and...

Cisplatin Has An Immunomodulating Effect.
December 21, 1998... Cisplatin activates macrophages to a tumoricidal state that can be inhibited by a protein tyrosine kinase(s) inhibitor. Cisplatin is a potent chemoimmunotherapeutic drug. It can induce protein tyrosine phosphorylation of a number of...

Sympathetic Ophthalmia Can Occur 50 Years Later Than Anticipated.
December 21, 1998... Sympathetic ophthalmia that occurs long after the accepted norm can still be treated successfully with immunotherapy. Sympathetic ophthalmia is a rare form of autoimmune uveitis. It manifests in 90 percent of cases within the first year...

Autologous Hematopoietic Cells Treat Autoimmune Disease.
December 21, 1998... Stem cell transplantation may be beneficial in treating patients with autoimmune disease, researchers suggested. Multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis are immune-mediated diseases that respond to...

Therapy Given to Transplant Recipients Predicts TB.
December 21, 1998... The type of immunosuppressive therapy given to solid organ transplant recipients and organ rejection are predictive of post-transplant tuberculosis occurrence, according to a report from Pittsburgh, Pennsylvania's VA Medical Center. ...

Th1/Th2 Response Depends on BCG Dosage.
December 21, 1998... The mycobacterial dose used for immunization against tuberculosis determines the nature of the Th1/Th2 response independent of administration route, according to a report from Canada. It is believed that cell-mediated immunity alone can...

Allergists Swap "Immunotherapy" for "Vaccination".
December 21, 1998... Thousands of Americans are unnecessarily suffering from asthma and allergies because they don't know they can be vaccinated against the things that make them miserable. And terminology may be partly to blame, according to the American College...

Genetically Corrected Stem Cells Provide Benefit to Immune Disorder.
December 21, 1998... An important advance in the development of a gene therapy to treat chronic granulomatous disease (CGD) - a hereditary disease involving a genetic defect in the ability of certain white blood cells to kill bacteria - was presented at the Annual...

Attack on Cancer Soups Up Body's Immune Cells.
December 21, 1998... Scientists who have reprogrammed the body's immune cells said their approach was having surprising effects against cancer, sending six out of eight patients into remission. Although they stressed their findings are very preliminary, they...

Therapy Combines Radiation with Drug that Targets Tumors.
December 21, 1998... Physicians at the University of Maryland Greenebaum Cancer Center, College Park, Maryland, are participating in a U.S.-wide study to investigate a therapeutic approach for patients with non-Hodgkin's B-cell lymphoma (NHL). The treatment...

Characterization of the Col2.3deltaTK Transgenic Mouse.
December 21, 1998... "Characterization of the Col2.3deltaTK Transgenic Mouse." D. Visnjic, I. Kalajzic, A. Naprta, G. Gronowicz, S.H. Clark and D.W. Rowe. Pediatrics, Orthopedics, Medicine, University of Connecticut Health Center, Farmington, Connecticut. ...

Efficacy of Passive Local Immunotherapy in the Prevention of a Model Peritoneal Surgical Wound Infection.
December 21, 1998... "Efficacy of Passive Local Immunotherapy in the Prevention of a Model Peritoneal Surgical Wound Infection." J.B. Slunt, G. Giridhar, A.C. Felts, G.G. Anderson, I.A. Rojas, N.A. Barekzi, I.A. Holder and A.G. Gristina. Medical Sciences Research...

No Evidence of Bone Loss During the First Two Years of Corticoid Therapy in Children with Autoimmune Hepatitis Receiving Calcium Supplement and Vitamin D.
December 21, 1998... "No Evidence of Bone Loss During the First Two Years of Corticoid Therapy in Children with Autoimmune Hepatitis Receiving Calcium Supplement and Vitamin D." C. Tau, M. Ciocca, M. Cuarterolo, M. Rubinstein, S. Villafane, F. Avalos and C....

Adult Bone and Mineral Working Group: (Preregistration Required) Bone Loss After Cardiac Transplantation Due to a FKS06 (Tacrolimus) Based Immunosuppression.
December 21, 1998... "Adult Bone and Mineral Working Group: (Preregistration Required) Bone Loss After Cardiac Transplantation Due to a FKS06 (Tacrolimus) Based Immunosuppression." C. Werner, T. Assum, S. Florian, B. Meiser, C.E. Angermann, K. Theisen, R....

Role of Receptor Binding Motifs Present in Thrombospondin-Related Adhesive Proteins 1 and 2 (TRAP-C1 and TRAP-C2) in the Invasion Mechanisms of Cryptosporidium parvum.
December 21, 1998... "Role of Receptor Binding Motifs Present in Thrombospondin-Related Adhesive Proteins 1 and 2 (TRAP-C1 and TRAP-C2) in the Invasion Mechanisms of Cryptosporidium parvum." L. Camero, A.A. Lal and L. Xiao. Division of Parasitic Diseases, NCID,...

Adjuvant Treatment of Breast Cancer: A Pilot Immunochemotherapy Study with CMF, Interleukin-2 and Interferon alpha.
December 21, 1998... Tonini, G.; Nunziata, C.; Prete, S.P.; Pepponi, R.; Turriziani, M.; Masci, G.; Graziani, G.; Bonmassar, E.; Devecchis, L. "Adjuvant Treatment of Breast Cancer: A Pilot Immunochemotherapy Study with CMF, Interleukin-2 and Interferon alpha."...

Pharmacological Administration of Granulocyte/Macrophage-Colony-Stimulating Factor is of Significant Importance for the Induction of a Strong Humoral and Cellular Response in Patients Immunized with Recombinant Carcinoembryonic Antigen.
December 21, 1998... Samanci, A.; Yi, Q.; Fagerberg, J.; Strigard, K.; Smith, G.; Ruden, U.; Wahren, B.; Mellstedt, H. "Pharmacological Administration of Granulocyte/Macrophage-Colony-Stimulating Factor is of Significant Importance for the Induction of a Strong...

An Anti-CD19 Antibody Coupled to a Tetanus Toxin Peptide Induces Efficient Fas Ligand (FasL)-Mediated Cytotoxicity of a Transformed Human B-cell Line by Specific CD4(+) T cells.
December 21, 1998... Eberl, G.; Jiang, S.; Yu, Z.; Schneider, P.; Corradin, G.; Mach, J.P. "An Anti-CD19 Antibody Coupled to a Tetanus Toxin Peptide Induces Efficient Fas Ligand (FasL)-Mediated Cytotoxicity of a Transformed Human B-cell Line by Specific CD4(+) T...

Phase I Study of the Pharmacokinetics of a Radioimmunoconjugate, Y-90-T101, in Patients with CD5-expressing Leukemia and Lymphoma.
December 21, 1998... Foss, F.M.; Raubitscheck, A.; Mulshine, J.L.; Fleisher, T.A.; Reynolds, J.C.; Paik, C.H.; Neumann, R.D.; Boland, C.; Perentesis, P.; Brown, M.R.; Frincke, J.M.; Lollo, C.P.; Larson, S.M.; Carrasquillo, J.A. "Phase I Study of the...

Economic Evaluation of Ribosomal Immunotherapy in Patients with Chronic Ear, Nose and Throat and Respiratory Tract Infections: Results for Italy.
December 21, 1998... Banz, K.; Thomas, A.M.; Olivieri, D. "Economic Evaluation of Ribosomal Immunotherapy in Patients with Chronic Ear, Nose and Throat and Respiratory Tract Infections: Results for Italy." Biodrugs, November 1998;10(5):385-396. According...

Combination Tumor Vaccine is Tumoricidal In Vivo.
December 28, 1998... Vaccination with murine myeloma cells engineered to secrete interferon (IFN)-gamma and expressing enhanced major histocompatibility complex (MHC) class I antigen (Ag) resulted in protective immunity in a murine model. IFN-gamma is an important...

Antigen Based Immunotherapies Offer Hope for Autoimmune Diseases.
December 28, 1998... Autoimmune diseases may be treated in the future by antigen (Ag)-based immunotherapeutics. Studies have shown that autoantigen-based immunotherapeutics activate regulatory responses capable of inhibiting T cell-mediated autoimmune disease...

Adoptive Immunotherapy is Specific for MUC1-Specific Tumors.
December 28, 1998... Adoptive immunotherapy provides a MUC1-specific tumor immunity in vivo that is undetectable in vitro and completely nonimmunogenic in MUC1 transgenic mice. R.M. Tempero and colleagues from the University of Nebraska developed a C57BL/6...

Combination Therapy Reaches Phase III Clinical Trial.
December 28, 1998... A combination chemo-immunotherapy protocol for patients with advanced head and neck squamous-cell carcinoma (HNSCC) has reached the phase III clinical trial stage. G. Mantovani and collages from the University of Cagliari, Italy, carried...

Glycosphingolipids May Be Used for Cancer Immunotherapy.
December 28, 1998... Tumor-associated glycosphingolipids (GSLs) may be an intriguing approach to brain tumor immunotherapy. J.A. Ecsedy and colleagues from Boston College developed a procedure to analyze glycosphingolipids (GSLs) in tumor-infiltrating...

Systemic IL-2 Messes with Graft-vs-Leukemic Effect.
December 28, 1998... Systemic interleukin-2 (IL-2) interferes with an immune-mediated graft-versus-leukemic (GvL) effect and can create an undesirable graft-versus-host effect. V. Schirrmacher and colleagues from the German Cancer Research Center, Germany,...

T Cells Eliminate Hepatic NK Cells Through Fas-Dependent Mechanism.
December 28, 1998... T-cells appear to be able to actively eliminate hepatic natural killer cells through a Fas-dependent mechanism, according to a report from the U.S. National Cancer Institute. Natural killer (NK) cells have been shown to be important...

Immunostimulatory DNA Sequences Inhibit Symptoms in Animal Model.
December 28, 1998... Injections of proprietary immunostimulatory DNA sequences (ISS-DNA), under development by Dynavax Technologies Corp., can alter the nature of the immune response in allergic asthma, while also inhibiting the symptoms of that disease, the...

Cyclophosphamide Therapy Used for Previously Untreatable Autoimmune Disorders.
December 28, 1998... Researchers at the Johns Hopkins Oncology Center, Baltimore, Maryland, used high doses of the chemotherapy drug cyclophosphamide alone to control previously untreatable forms of autoimmune disorders such as rheumatoid arthritis, lupus, and...

Cancer Vaccine Data Presented at Joint FDA-NCI Workshop.
December 28, 1998... AVAX Technologies Inc., Kansas City, Missouri, announced that at the invitation of the U.S. Food and Drug Administration (FDA) it had presented an initial talk at a U.S. National Cancer Institute (NCI)-FDA sponsored workshop on the regulation...

Researchers Hope Treatment Will Jump-Start Immune System.
December 28, 1998... Two researchers at the University of Arizona have developed an HIV treatment aimed at bolstering patients' immune systems, rather than trying to kill HIV. "We're not trying to kill the virus. We're trying to reduce the immune damage it...

Fruit and Vegetable Extracts Improve Immune Function in Elderly.
December 28, 1998... People of retirement age and older, whose immune systems generally become compromised as part of the aging process, may reduce their risk of serious illness, such as cancer, heart disease, by taking newly formulated fruit and vegetable extracts...

Surgeon Lights Up Immune System To Aid Transplant Recipients.
December 28, 1998... In an article appearing in the December 10, 1998, New England Journal of Medicine, University of Southern California (USC) cardiothoracic surgeon Mark L. Barr reported that adding a novel immunomodulatory therapy, called photopheresis, to...

A New, Helicoid-Type, Oligopeptide Carrier for Peptide-Based Potent Antigens/Immunogens and Vaccines.
December 28, 1998... "A New, Helicoid-Type, Oligopeptide Carrier for Peptide-Based Potent Antigens/Immunogens and Vaccines." C. Sakarellos, V. Tsikaris, Ch. Alexopoulos, E. Panou-Pomonis, M. Sakarellos-Daitsiotis, P.G. Vlachoyiannopoulos, A.G. Tzioufas, C.J....

Bone Mineral Density and Hormone Status in Men With Systemic Lupus Erythematosus.
December 28, 1998... "Bone Mineral Density and Hormone Status in Men With Systemic Lupus Erythematosus." H.P. Bhattoa, P. Bettembuk, E. Kiss and A. Balogh. Department of Obstetrics and Gynecology, University Medical School of Debrecen, Debrecen, Hungary; 3rd...

IL-12 and IFN-gamma-Dependent Protection of Mice Against Malaria Conferred by CpG DNA.
December 28, 1998... "IL-12 and IFN-gamma-Dependent Protection of Mice Against Malaria Conferred by CpG DNA." R.A. Gramzinski, M. Sedegah, D.L. Doolan, A.M. Krieg, H.L. Davis and S.L. Hoffman. Malaria Program, Naval Medical Research Inst., Rockville, MD;...

Design of Immunogens Derived from Conformational B Cell Epitopes Within Alpha-Helical Coiled Coil Proteins.
December 28, 1998... "Design of Immunogens Derived from Conformational B Cell Epitopes Within Alpha-Helical Coiled Coil Proteins." J.A. Cooper, H. Kagawa and A. Saul. The Queensland Institute of Medical Research and CRC for Vaccine Technology, Herston, Brisbane,...

Expression of a Type II Collagen-Specific TCR Transgene Accelerates the Onset of Arthritis in Mice.
December 28, 1998... Osman, G.E.; Cheunsuk, S.; Allen, S.E.; Chi, E.M.; Liggitt, H.D.; Hood, L.E.; Ladiges, W.C. "Expression of a Type II Collagen-Specific TCR Transgene Accelerates the Onset of Arthritis in Mice." International Immunology, November...

OK-432 and 5-fluorouracil, Doxorubicin, and Mitomycin C (FAM-P) Versus FAM Chemotherapy in Patients with Curatively Resected Gastric Carcinoma: A Randomized Phase III Trial.
December 28, 1998... Kim, S.Y.; Park, H.C.; Yoon, C.; Yoon, H.J.; Choi, Y.M.; Cho, K.S. "OK-432 and 5-fluorouracil, Doxorubicin, and Mitomycin C (FAM-P) Versus FAM Chemotherapy in Patients with Curatively Resected Gastric Carcinoma: A Randomized Phase III Trial."...

Distribution of Macromolecular Dyes in Brain Using Positive Pressure Infusion: A Model for Direct Controlled Delivery of Therapeutic Agents.
December 28, 1998... Prabhu, S.S.; Broaddus, W.C.; Gillies, G.T.; Loudon, W.G.; Chen, Z.J.; Smith, B. "Distribution of Macromolecular Dyes in Brain Using Positive Pressure Infusion: A Model for Direct Controlled Delivery of Therapeutic Agents." Surgical...

Induction of Immunity to Schistosoma mansoni: Interaction of Schistosomula with Accessory Leucocytes in Murine Skin and Draining Lymph Nodes.
December 28, 1998... Riengrojpitak, S.; Anderson, S.; Wilson, R.A. "Induction of Immunity to Schistosoma mansoni: Interaction of Schistosomula with Accessory Leucocytes in Murine Skin and Draining Lymph Nodes." Parasitology, October 1998;117(Part 4):301-309. ...

Hepatitis C Virus-Associated Fibrosing Cholestatic Hepatitis After Renal Transplantation - Response to Interferon-alpha Therapy.
December 28, 1998... Toth, C.M.; Pascual, M.; Chung, R.T.; Graemecook, F.; Dienstag, J.L.; Bhan, A.K.; Cosimi, A.B. "Hepatitis C Virus-Associated Fibrosing Cholestatic Hepatitis After Renal Transplantation - Response to Interferon-alpha Therapy." Transplantation,...

A Controlled Comparison of Directly Observed Therapy vs. Self-Administered Therapy for Active Tuberculosis in the Urban United States.
December 28, 1998... Davidson, B.L. "A Controlled Comparison of Directly Observed Therapy vs. Self-Administered Therapy for Active Tuberculosis in the Urban United States." Chest, November 1998;114(5):1239-1243. According to the author's abstract of an...