Immunotherapy Weekly articles from August 2004

Immunotherapy Weekly archives from August 2004

Novel FLT3 inhibitors may be considered to treat hyperdiploid or relapsed ALL.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Novel FLT3 inhibitors may be considered for the treatment of hyperdiploid or relapsed acute lymphoblastic leukemia. "Activating mutations of the FLT3 receptor tyrosine kinase are common in acute...

Novel approach to specific allergy treatment developed.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (RSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity....

Bovine collagen peptide vaccine modulates severity of arthritis.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis. According to a study from...

Vaccination with botulinum neurotoxin fragments prevents botulism.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Vaccination with botulinum neurotoxin fragments prevents botulism. "Mice and ducks were subcutaneously immunized with recombinant whole heavy (H) chains of Clostridium botulinum type C and D...

Herbs and spices have antimicrobial and chemopreventive properties.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Herbs and spices have antimicrobial and chemopreventive properties. "Herbs and spices have been used for generations by humans as food and to treat ailments. Scientific evidence is accumulating that...

FLT3 mutations in AML adversely associate with CR with intensive chemotherapy.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- FLT3 mutations are adversely associated with complete remission in AML patients given intensive chemotherapy. "The prognostic impact of FLT3 mutations on the outcome of patients with diploid AML,...

Factors affecting good and poor CD34+ cell mobilization in AML determined.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The factors affecting good and poor CD34+ cell mobilization in AML have been determined. According to a study from Italy, "The factors possibly affecting the collection of peripheral blood stem...

Timed sequential therapy for AML patients over 60 tolerated but unsatisfactory.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Timed sequential therapy for acute myeloid leukemia patients over 60 was well tolerated but unsatisfactory. "Acute myeloid leukemia (AML) in the elderly is a serious problem characterized by poor...

Academy reacts to FDA alert on allergic reactions to pigment in permanent makeup.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- In response to the FDA's consumer alert regarding permanent makeup pigments that have been reported to cause severe allergic reactions, the American Academy of Micropigmentation wants consumers to...

Report: Dog and cat allergen present in 100% of U.S. homes.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Dog and cat allergen is found in all homes in the United States, according to a study featured in the July 2004 Journal of Allergy & Clinical Immunology (JACI). JACI is the peer-reviewed scientific...

Skin prick test for cat allergies now more accurate.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A Kaiser Permanente study published in the Annals of Allergy and Immunology shows that skin prick testing using a 6-millimeter wheal (a small swelling on the skin that may burn and/or itch indicating an...

FDA approves phase III study design for PreHistin.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- BioGentech Corp. (BGTH) has received a letter from the U.S. Food and Drug Administration (FDA) in which the FDA confirmed that two phase III study designs submitted by BioGentech for review effectively...

Heat-sensitive method tests effectiveness of allergy meds.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Summer can bring with it severe sneezing attacks and itching eyes. People who suffer from hay fever can tell you all about how sometimes a pack of tissues does not even last long enough for a short...

Tentative approval granted for Allegra-D extended-release tablets.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Barr Pharmaceuticals, Inc., (BRL) announced that Barr Laboratories, Inc., has received tentative approval from the U.S. Food and Drug Administration (FDA) for its generic version of Aventis...

Effect of citalopram on lymphocyte gene expression characterized.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The effects of citalopram on lymphocyte gene expression have been characterized in cells from Alzheimer disease patients. "Antidepressants are widely used in the treatment of mood disorders...

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers have found that a large protein, alsin, is a Rab5 and Rac1 guanine nucleotide exchange factor, and may play a role in a juvenile form of amyotrophic lateral sclerosis. "ALS2 is the gene...

Styrylquinolines do not interfere with HIV entry but act before integration.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- SQLs do not interfere with HIV entry but act before integration. According to a study from France, "We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They...

P300 regulates p53-dependent apoptosis in colorectal cancer cells.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- P300 nucleoprotein regulates p53-dependent apoptosis in colorectal cancer cells. "Activation of the tumor suppressor p53 by DNA damage induces either cell cycle arrest or apoptosis, but what...

Patients given intensive outpatient treatment have better outcomes.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Results of a U.K. study suggest that intensive monthly outpatient treatment with antirheumatic drugs and steroid injections can substantially improve patients' symptoms of rheumatoid arthritis compared...

Thymosin alpha 1 activates dendritic cells for antifungal resistance.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling. "Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of...

European approval sought for Xolair as treatment for severe allergic asthma.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Novartis Pharma AG has submitted its application for the European approval of Xolair. Xolair (omalizumab) is a novel therapy, which targets a root cause of allergic disease and offers an entirely...

Report: Singapore researchers develop gene-based asthma vaccine.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Singapore researchers have developed an asthma vaccine using a dust mite gene, a newspaper reported. Most asthma sufferers in tropical and subtropical countries are allergic to dust mites, the...

Oxidized lipids, antibodies may be markers for atherogenesis.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The oxidation hypothesis of atherogenesis has been studied and researchers report new evidence that oxidized lipids and antibodies in those lipids may play a role as markers for atherogenesis. "The...

Atomic force microscopy useful for analysis of adsorbed antibodies.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Atomic force microscopy (AFM) is useful for analysis of immobilized antibodies. "Antibody adsorption to solid surfaces creates a number of constraints that may interfere with epitope recognition and...

Vaccine targeting cancer-related antigens appears to prolong survival.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers seeking to direct cancer-killing immune cells against the deadliest brain tumors have three new targets that show promise in laboratory studies and in a Phase I patient trial, according to...

Buruli ulcer disease in Cameroon rediscovered.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers have rediscovered Buruli ulcer disease in Cameroon. According to published research from Cameroon and Belgium, "To assess the magnitude of the Buruli ulcer (BU) problem in Cameroon, we...

Licensing agreement forged for antiphospholipid therapy technology.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals (NASDAQ:PPHM) announced that it has completed a worldwide exclusive licensing agreement for intellectual property related to anti- phosphatidylserine (anti-PS) antibodies. ...

Potential of TOR pathway as cancer therapy target reviewed.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The potential of the TOR pathway as a target of cancer therapy has been reviewed. "Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine protein kinase target of...

Alloantigen presentation linked to CTL antigen response.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens. "CD8 T lymphocytes (CTL)...

Antennapedia transduction sequence promotes antitumor immunity.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The Antennapedia transduction sequence promotes antitumor immunity to epicutaneously administered CTL epitopes. According to published research from Canada, "The identification of tumor antigens...

Autologous lymphoma vaccines induce T cell responses against epitopes.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. "The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific...

DNA fusion gene vaccines against cancer reviewed.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Investigators review DNA fusion gene vaccines against cancer in a recent issue of Immunological Reviews. "Vaccination against target antigens expressed by cancer cells has now become a realistic...

NY-ESO-1-related HLA A2-restricted epitopes characterized.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers have determined the functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes. According to a study from Australia, "NY-ESO-1, a commonly expressed tumor...

Reduced L-selectin expression identifies tumor-specific type 1 T cells.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Reduced L-selectin (CD62L[superscript]Low) expression identifies tumor-specific type 1 T cells from lymph nodes draining an autologous tumor cell vaccine. "Reduced expression of CD62L can identify...

SSX-2 epitope presented by dendritic cells to CD4+ T cells identified.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Scientists have identified an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells. According to recent research from the United States, "Accumulating evidence supports...

TCR DNA vaccine induces humoral response for lymphoma beta chain.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A TCR DNA vaccine induced a humoral immunoreaction for the beta chain of T cell lymphoma. According to published research from China, "We exploited the humoral immunoreaction of mice induced by TCR...

Transfection of tumor antigens generates cytotoxic T lymphocytes.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes....

Mechanism of benzene-induced leukemia elucidated.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The mechanism of benzene-induced leukemia has been elucidated. According to published research from the United States, "Acute myeloid leukemia and chronic lymphocytic leukemia are associated with...

Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation. According to published research from Japan, "Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid...

MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity. According to recent research published in the European Journal of Cancer, "Cancer patients, especially the elderly,...

siRNA against NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- siRNA directed against the NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics. "In preclinical tumor models, inhibition of nuclear factor-kappaB (NF-kappaB) has been associated with...

Alemtuzumab effective therapy for CLL with p53 mutations and deletions.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. "The presence of p53 mutation or deletion predicts for poor response to conventional therapy...

IL-11 may improve thrombocytopenia associated with imatinib therapy in CML.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- IL-11 may improve thrombocytopenia associated with imatinib therapy in chronic myelogenous leukemia. According to published research from the United States, "During therapy with imatinib (Gleevec),...

Companies agree to discontinue codevelopment of abciximab in Japan.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Fujisawa Pharmaceutical Co., Ltd., announced that Centocor, Inc., Nippon Centocor, KK, (a Japanese subsidiary of Centocor, Inc.), and Fujisawa have reached an agreement on the withdrawal of Fujisawa...

Real-time qPCR more sensitive than COBAS Amplicor for CMV DNA detection.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A real-time quantitative PCR assay is more sensitive than the COBAS Amplicor assay for cytomegalovirus (CMV) DNA detection. According to a study from Sweden, "A duplex quantitative real-time PCR...

Microparticles act as carriers to deliver plasmid DNA in vaccines.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Cross-linked microparticles act as carriers for the delivery of plasmid DNA for vaccine development. According to a study from the United States, "Plasmid DNA was directly encapsulated into...

Recruitment complete for Phase II trial of AVAC in childhood eczema.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Genesis Research and Development Corporation (NZX/ASX:GEN) announced that recruitment is complete for the Phase II trial of its childhood eczema therapeutic candidate, AVAC. The randomized,...

Company announces patent related to transdermal delivery of amine drugs.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Dermatrends, Inc., a drug-delivery company, has received a U.S. patent that covers the method of using bases to enhance the permeation of amine drugs across the skin. The patent is the 11th granted...

Carbohydrate microarray improves fucosyltransferase inhibitor screening.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A novel carbohydrate microarray enables efficient high-throughput identification of fucosyltransferase inhibitors. In a recent study from California, a "noncovalent carbohydrate microarray was used...

Effects of naltrindole-based immunosuppressants characterized.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The immunosuppressive effects of a series of novel naltrindole (NTI)-based agents have been characterized. According to researchers in Italy, the effects of NTI "on cells of the immune system have...

Gene-based products company expands AAV patent portfolio.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corporation (TGEN) announced the issuance of a patent for its AAV (adeno-associated viral) vector technology. The company utilizes AAV vectors to deliver genes into targeted cells to...

Novel CCL3/CCR1 inhibitor identified.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A novel CCL3/CCR1 inhibitor could be used as the basis for future anti-inflammatory agents. Researchers in Connecticut described the "discovery and early fundamental structure-activity relationship...

Phase II clinical trial of interferon enhancing therapy for MS approved.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Transition Therapeutics Inc. (TTH) has received approval of its clinical trial application from Health Canada to begin a phase II human trial for its interferon enhancing therapy (I.E.T.) in patients...

Phase III trials of inhaled corticosteroid asthma treatment completed.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Phase III trials of a new version of AstraZeneca's Pulmicort (budesonide), an inhaled corticosteroid for the treatment of asthma, have been completed, SkyePharma PLC and AstraZeneca have announced. ...

Dystonia may be part of the syndrome associated with ABGA.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Dystonia may be part of the clinical spectrum of the postinfectious syndrome associated with antibasal ganglia antibodies (ABGA). "Antibasal ganglia antibodies (ABGA) have been associated with...

Delta-like 1 necessary to generate marginal zone B cells, not T cells in vivo.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. According to a study from Japan, "Notch receptors and their ligands contribute to many developmental...

Myelin peptide induces severe chronic autoimmune encephalomyelitis.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. "The use of HLA class II-transgenic (Tg) mice has...

EBV viral load increases and reaches setpoint after HIV seroconversion.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Epstein Barr virus viral load increases and reaches a setpoint after HIV seroconversion. "In contrast to the situation in the post-transplant setting, in HIV-infected individuals an elevated EBV...

Fertility preservation in females receiving cancer therapy is reviewed.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Fertility preservation in females receiving cancer therapy is reviewed. "In the Unites States alone, >650,000 women will be afflicted by cancer in 2003, and 8% of these cases will be aged "Due...

Pneumocystis jirovecii identified in lung tissue sections from SIDS victims.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Pneumocystis jirovecii was identified in lung tissue sections from sudden infant death syndrome victims. According to recent research published in the journal Microbiology - SGM, "Previous studies...

Similar P. jirovecii genotypes found in different forms of infection.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- There are similar Pneumocystis jirovecii genotypes in different forms of Pneumocystis infection. According to recent research from France, "This study describes the genotyping of P. jirovecii...

Sxi1 alpha is not required for virulence of Cryptococcus neoformans.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The alpha-specific cell identity factor Sxi1 alpha is not required for virulence of Cryptococcus neoformans. According to a study from the United States, "Cryptococcus neoformans is a human fungal...

Intestinal transplantation feasible for CIPO patients.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Intestinal transplantation (ITx) is feasible and effective for CIPO patients. According to recent research from Italy, ITx "has become a life-saving procedure for patients with irreversible...

Role of TEL-AML1 fusion gene in molecular pathogenesis of ALL elucidated.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The role of the TEL-AML1 fusion gene in the molecular pathogenesis of acute lymphoblastic leukemia is elucidated. "Balanced chromosomal translocations are frequently associated with hematopoietic...

Structure and function of chromosome 13q14 characterized.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The structure and function of chromosome 13q14 has been characterized. "Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of...

MAGE-A1-expressing tumor cell 5' region less methylated than other parts of gene.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The 5' region of MAGE-A1-expressing tumor cells are less methylated than other parts of gene. "Several male germ line-specific genes, including MAGE-A1, rely on DNA methylation for their repression...

DC stimulation of donor CD8+ T cells may be useful for prevention of GVHD.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Dendritic cell stimulation of donor CD8+ T cells may be useful for prevention of graft versus host disease. "Graft versus host disease (GVHD) is triggered by host antigen-presenting cells (APCs)...

Continued injection drug use not associated with progression to AIDS in women.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Continued injection drug use is not associated with a progression to AIDS in infected women. "Data from a prospective, multicentered study of HIV infection in women (HIV Epidemiology Research Study...

NIH cancels contract for HIV vaccine program.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- NOVAVAX, INC. (NASDAQ:NVAX) announced that the U.S. National Institute of Allergy and Infectious Diseases (NIAID) has cancelled its 5-year contract [NO1-AI-30042] for the development of human...

Kidney transplant in HIV infection plausible in era of HAART/immunosuppressives.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Kidney transplantation in HIV-infected patients is plausible in the era of HAART and immunosuppressive therapy. "Before the era of highly active antiretroviral therapy, kidney transplant recipients...

Chromatin structure affects HIV-1/ASV integration site selection opposite ways.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The chromatin structure affects the HIV-1/ASV integration site selection in opposite ways. According to recent research published in the Journal of Virology, "Integration of viral DNA into the host...

Differentially expressed genes in HIV-1-resistant cells analyzed by microarray.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Differentially expressed genes in HIV-1-resistant cells were analyzed using cDNA arrays. According to scientists at Columbia University, "We have previously isolated two matched transformed human T...

Diketo acid integrase inhibitor resistance impairs HIV-1 replication/integration.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Diketo acid integrase inhibitor resistance impairs HIV-1 replication and integration. "The diketo acids are potent inhibitors of HIV integrase (IN). Mutations in IN, T66I, S153Y and M154I, as well...

HIV-induced macrophage alterations play role in HIV encephalopathy pathogenesis.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- HIV-induced macrophage alterations play a role in the pathogenesis of HIV encephalopathy. "This study was performed to quantitate and characterize the mononuclear phagocytes (MPs) in human...

Resistance mutations sustain or enhance CTL recognition of HIV-1 Pol epitopes.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Antiretroviral resistance mutations sustain or enhance cytotoxic T lymphocyte (CTL) recognition of HIV-1 Pol epitopes. "Antiretroviral drug resistance and escape from cytotoxic T lymphocytes (CTL)...

Species-specific tropism determinants found in the HIV-1 capsid.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Species-specific tropism determinants were found in the HIV-1 capsid. According to a study from the United States, "Retroviral tropism is determined in part by cellular restriction factors that...

Tsg-101 protein has role in HIV Gag particle release.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The Tsg-101 protein has a role in HIV Gag particle release. According to recent research published in the Journal of Virology, "Human immunodeficiency virus type 1 particles form by budding at the...

$14.2 million NIH contract awarded for pathogen drug and diagnostic development.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Myriad Genetics, Inc., (NASDAQ:MYGN) announced that it has been awarded a five-year, $14.2 million contract by the U.S. National Institute of Allergy and Infectious Diseases (NIAID). The agreement...

NNRTI stereochemistry and regiochemistry profoundly affect anti-HIV activity.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The stereochemistry and regiochemistry of non-nucleoside reverse transcriptase inhibitors profoundly affect their anti-HIV activity. "Chiral derivatives of several substituted halopyridyl and...

Subcutaneous IL-2 therapy maintains CD4 cell increases in HIV-1 infection.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Subcutaneous IL-2 therapy maintains CD4 cell increases in HIV-1 infection. According to recent research from the United States, "Studies establishing that intermittent subcutaneous interleukin-2...

BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- BCL-6 mutations were seen in HIV-related pulmonary lymphoproliferative disorders. "We used a PCR and sequence procedure to analyze the Ig V-H gene and the mutations in the 5' regulatory regions of...

HAART increases survival of patients with HIV-associated Hodgkin disease.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Highly active antiretroviral therapy increases the survival of patients with HIV-associated Hodgkin disease. According to a study from Germany, "Hodgkin disease (HD) is the most common nonacquired...

Hearing loss mediated by T cells specific for inner ear peptides.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Murine autoimmune hearing loss is mediated by CD4+ T cells specific for inner ear peptides. According to published research from the United States, "Autoimmune sensorineural hearing loss (ASNHL) is...

Notch-1 signaling mediates BMS influence on hematologic malignant cell growth.
August 4, 2004... 2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Notch-1 signaling mediates bone marrow stroma influence on hematologic malignant cell growth and survival. According to a study from the United States, "The bone marrow (BM) microenvironment plays...