Immunotherapy Weekly articles from August 1999

Immunotherapy Weekly archives from August 1999

Green Fluorescent Protein Stimulates Immune Response.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Green fluorescent protein (GFP) stimulates an immune response when used in vivo for gene transfer protocols; but what may be a detriment to the gene therapy may be a boon to cancer therapy. R....

Allergoid Immunotherapy Is Safe and Effective.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Long-term Parietaria allergoid immunotherapy is safe and efficacious, clinical trial findings suggest. R. Ariano and colleagues from the University of Genoa, Italy, conducted a long-term...

Optimal Dosing Lower Than Maximum Tolerated Dose.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Bigger is not always better; the optimum dosing of specific immunotherapy (SIT) with a Dermatophagoides pteronyssinus extract is well below maximum tolerated levels. J.M. Olaguibel and...

Calreticulin Has Adoptive Immunotherapy Potential.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Calreticulin can elicit cytotoxic T lymphocyte (CTL) responses and as such has potential as a cancer immunotherapy. S. Nair and colleagues from Duke University used chemical and immunological...

IL-2 Inhalation Therapy Prolongs Survival.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Inhaled interleukin-2 combined with stop-flow thoracic perfusion and systemic chemotherapy prolongs survival in lung cancer patients. N.J. Lygidakis and colleagues from Athens, Greece, conducted...

Locoregional Administration Has Substantial Advantages.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Locoregional administration of immunopotentiating agents has significant advantages over systemic administration for tumor control. P. Boura and colleagues from Greece conducted a study to...

B Cells: New Target for Arthritis Therapy?
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Abnormal B-cell responses may be the key to new treatments for arthritis and other autoimmune diseases. Most research into arthritis immunology focuses on T lymphocytes. But B-cell abnormalities...

CD4+ T Cells: First Target For Arthritis Immunotherapy.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Harnessing T cells remains the focus of rheumatoid arthritis (RA) immunotherapy. Early efforts employed monoclonal antibodies (MAbs) directed against CD4(+) T cells. Ten years of research have...

Signal Transduction Key to New Immunotherapies.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- As much as has been learned about autoimmune disease, there is exponentially more to know. Researchers trying to develop new immunosuppressive therapies thus have encountered unexpected failure...

Immune System Assists Antitumor Photodynamic Therapy.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The immune system contributes to the antitumor effect realized from photodynamic therapy. J.A. Hendrzakhenion and colleagues from Ergo Science Corporation, Massachusetts, examined the role of the...

Paclitaxel Helps Correct Tumor-Induced Immune Dysfunction.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Paclitaxel may help correct tumor-induced immune dysfunction. D.W. Mullins and colleagues from the Virginia Polytech Institute and State University, Virginia, examined the effects of the drug...

Mouse Xenograft Model Targets Tumor Vasculature Endothelial Cells.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An immunotherapy treatment for cancer that targets both the tumor vasculature and tumor cells may prove effective in treating a broad spectrum of human solid tumors. An immunotherapy treatment...

Serine Protease Inhibitor Treats GVHD.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The use of a serine protease inhibitor may improve symptoms of post-transfusion graft-versus-host-disease by inhibiting cytotoxic T-cell-mediated killing of target cells. Cytotoxic T lymphocytes...

ISDR Doesn't Affect IFN Response in HCV-1b Patients.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Long-term response to interferon therapy is not related to differences in the so-called interferon sensitivity determining region in patients with chronic hepatitis C-1b. Contradictory data have...

CD34(+) Cells Can Be Grown, Expanded for Long Time.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- CD34(+) cord blood stem cells could be grown and expanded in vitro for very long time periods, findings indicate. An understanding of the repopulating characteristics of human hematopoietic...

M. Vaccae Immunotherapy of No Value in TB Treatment.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- It appears that a widely heralded new tuberculosis treatment option doesn't work. Immunotherapy directed toward Mycobacterium vaccae was found to have no benefit when added to standard...

1b Genotype/High HCV RNA Levels Bode Well for IFN Treatment.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Hepatitis C virus patients with genotype 1b and a high level of HCV RNA have a heightened response to prolonged interferon therapy, according to a report from Japan. The aim of this study was to...

Component in Thymus Identified that Positively Selects T Cells.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers at National Jewish Medical and Research Center, Denver, Colorado, have identified what T cells 'see' in a normal thymus that controls the development of functional or immune-system...

Stress May Increase Susceptibility to Infectious Disease.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers who have spent years studying the effects of stress on the body's immune system now believe they know enough to show that stress actually does weaken a person's health. Dozens of...

Injected Cells Boost Immune System in Humans.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A single injection of specialized immune system cells removed from the bloodstream and exposed to a foreign substance can trigger a potent immune response in humans that lasts for months, Rockefeller...

Surgery Plus Immunotherapy Extends Lives of Patients with Advanced Cancer.
August 9, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Aggressive surgery coupled with strong immunotherapy resulted in significantly increased survival times for a group of advanced kidney cancer patients for whom few other treatment options existed,...

Effect of Interleukin-2 (IL-2) Gene Therapy on Prostate Specific Antigen in Patients Undergoing Neoadjuvant or Adjuvant Gene Therapy for Prostate Cancer.
August 9, 1999... Cancer Gene Therapy "Effect of Interleukin-2 (IL-2) Gene Therapy on Prostate Specific Antigen in Patients Undergoing Neoadjuvant or Adjuvant Gene Therapy for Prostate Cancer." B. Patel, J. Naitoh, A. Stiles, C.L. Tso, R. Figlin and A....

PSA-Encoding Adenovirus Induces Potent Antitumor Immunity in a Mouse Prostate Tumor Model.
August 9, 1999... Cancer Immunotherapy "PSA-Encoding Adenovirus Induces Potent Antitumor Immunity in a Mouse Prostate Tumor Model." D.M. Lubaroff, B.D. Elzey, T.L. Ratliff, J. Schlom and J. Tartaglia. Iowa City, Iowa; Bethesda, Maryland; Albany, New York....

Treatment of Locally Advanced or Metastatic Renal Cell Cancer Patients with an Autologous Virus-Modified Tumor Cell Vaccine.
August 9, 1999... Cancer Immunotherapy "Treatment of Locally Advanced or Metastatic Renal Cell Cancer Patients with an Autologous Virus-Modified Tumor Cell Vaccine." A. Hinkel, O.C. Krup, J. Alefelder, J.H. Wieland, D. Laumann, F.W. Falkenberg, L. Hertle...

Immune Responses to Self Proteins.
August 9, 1999... Hemophilia (Immunology) "Immune Responses to Self Proteins." Jeffrey A. Frelinger and Roberta Greenwood. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599. (CW HENDERSON...

Induction of Antibody Responses to New B-Cell Epitopes Indicates Vaccination Character of Allergen Immunotherapy.
August 9, 1999... Allergy Medicine Ball, T.; Sperr, W.R.; Valent, P.; Lidholm, J.; Spitzauer, S.; Ebner, C.; Kraft, D.; Valenta, R. "Induction of Antibody Responses to New B-Cell Epitopes Indicates Vaccination Character of Allergen Immunotherapy." European...

A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-Pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen.
August 9, 1999... Cancer Immunotherapy Morse, M.A.; Deng, Y.P.; Coleman, D.; Hull, S.; Kitrellfisher, E.; Nair, S.; Schlom, J.; Ryback, M.E.; Lyerly, H.K. "A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-Pulsed,...

Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity.
August 9, 1999... Cancer Immunotherapy Melcher, A.; Todryk, S.; Bateman, A.; Chong, H.; Lemoine, N.R.; Vile, R.G. "Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity." Cancer...

Long Survival of Patients with Small Cell Lung Cancer After Adjuvant Treatment with the Anti-idiotypic Antibody BEC2 Plus Bacillus Calmette-Guerin.
August 9, 1999... Cancer Immunotherapy (SCLC) Grant, S.C.; Kris, M.G.; Houghton, A.N.; Chapman, P.B. "Long Survival of Patients with Small Cell Lung Cancer After Adjuvant Treatment with the Anti-idiotypic Antibody BEC2 Plus Bacillus Calmette-Guerin."...

Cellular Immunotherapy for Patients With Metastatic Colorectal Carcinoma Using Lymph Node Lymphocytes Localized in vivo by Radiolabeled Monoclonal Antibody.
August 9, 1999... Monoclonal Antibodies Kim, J.A.; Bresler, H.S.; Martin, E.W.; Aldrich, W.; Heffelfinger, M.; Triozzi, P.L. "Cellular Immunotherapy for Patients With Metastatic Colorectal Carcinoma Using Lymph Node Lymphocytes Localized in vivo by...

MUC1 Isoform Specific Monoclonal Antibody 6E6/2 Detects Preferential Expression of the Novel MUC1/Y Protein in Breast and Ovarian Cancer.
August 9, 1999... Monoclonal Antibodies Hartman, M.L.; Baruch, A.; Ron, I.; Aderet, Y.; Yoeli, M.; Sagiassif, O.; Greenstein, S.; Stadler, Y.; Weiss, M.; Harness, E.; Yaakubovits, M.; Keydar, I.; Smorodinsky, N.I.; Wreschner, D.H. "MUC1 Isoform Specific...

Genetically Engineered Lymphoma Cells Induce Immunity.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Genetic engineering of autologous B lymphoma cells to express idiotype and granulocyte macrophage-colony stimulating factor (GM-CSF) induced tumor immunity in three different models. M. Selmayr...

Combination Immune Therapy Kills Melanoma in Mice.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Scientists have developed a promising technique for treating the most aggressive forms of the skin cancer melanoma. The new therapy may also work for prostate cancer. The technique works by...

Self-IgG Scaffold Lets Whole Proteins Tolerize.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Inducing tolerance - arguably the least understood aspect of immunity - just got a lot easier. This is good news to researchers seeking to treat autoimmune diseases by restoring normal tolerance...

Recommendations Made for Follow-Up to Adverse Reactions.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A study of systemic adverse reactions to allergy immunotherapy results in specific follow-up recommendations. E. Toubi and colleagues from the Bnai Zion Medical Center, Israel, evaluated...

CD40 Signaling Enhances CTL Generation In Murine Model.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- CD40 signaling enhances the generation of cytotoxic T lymphocytes (CTL) in mice bearing large tumors. M. Donepudi and colleagues from the University of Illinois, examined the interactions of...

Combination Therapy Provides Synergistic Effects.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Protein A combined with interferon (IFN)-gamma has a synergistic antitumor effect in a murine model. S. Pyo and colleagues from the Sung Kyun Kwan University, South Korea, examined the potential...

New Tumor Antigen Dubbed CAMEL.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- CAMEL, a new tumor antigen, has been discovered and may be a target for anticancer immunotherapy strategies. C.A. Aarnoudse and colleagues from the University of Leiden, The Netherlands,...

Study of HLA Patterns in Ovarian Cancer.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The study of HLA class I restriction and the directed antigens of cytotoxic T lymphocytes (CTL) should facilitate a better understanding of the molecular basis of tumor-specific immunity of ovarian...

Grafts Create Their Own Marrow Space.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Pretransplant total body irradiation may provide host immunosuppression, and grafts may create their own marrow space, recent animal findings suggest. Stable mixed donor/host hematopoietic...

Vitamin D May Be Critical in TB Immunity, UK Study Finds.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Seasonal variations in tuberculosis reporting suggest that vitamin D may play a role in immunity, according to an intriguing study from the United Kingdom. Notifications of tuberculosis in...

Chemokine Interference May Prompt New Therapies.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers in Switzerland hope to develop a new class of therapeutic agents by interfering with chemokine networks. Chemokines are a large family of cytokines with a wide variety of biological...

IFN Therapy Reduces Liver Cancer in HCV Patients.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interferon therapy not only reduces liver damage in responding patients with chronic hepatitis C, it appears to lessen the risk of liver cancer as well. Previous studies examining the effect of...

Thrombopoietin Supports Expansion of Cells.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Thrombopoietin can mediate self-replication of hematopoietic stem cells in long-term bone marrow cultures, study findings show. The hematopoietic stem cell (HSC) is defined as a cell that can...

Prior Mood/Anxiety Problems Don't Preclude IFN Treatment.(interferon)
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Chronic hepatitis C virus patients with mood or anxiety disorders are good candidates for interferon therapy, according to a report from Italy. Researchers from the University of Cagliari found...

Ribavirin/IFN-(alpha) Shows Promise in Initial Nonresponders.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Combination therapy with ribavirin and alpha interferon may be useful in the treatment of patients with chronic hepatitis C virus who did not respond to initial interferon therapy. More than...

Phase I/II Study in HIV Infected Persons Initiated.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Amerimmune, Inc., Los Angeles, California, has been developing Cytolin, a revolutionary treatment for patients suffering from HIV and AIDS, announced that the U.S. Food and Drug Administration (FDA)...

Clinical Study Broadened to New Populations, Treatment Regimens.
August 16, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Idec Pharmaceuticals, San Diego, California, announced that it has entered into a Clinical Trials Agreement with the Division of Cancer Treatment and Diagnosis (DCTD) of the U.S. National Cancer...

Immunologic Approaches to HIV-1 Therapy: Minor Successes and Major Complications.
August 16, 1999... HIV Immunotherapy "Immunologic Approaches to HIV-1 Therapy: Minor Successes and Major Complications." Donald E. Mosier. Department of Immunology-IMM7, The Scripps Research Institute, La Jolla, California 92037. (CW HENDERSON PUBLISHER...

Can The Immune System Control HIV?.
August 16, 1999... Immunology (HIV) "Can The Immune System Control HIV?." Bruce D. Walker. Massachusetts General Hospital, Massachusetts. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an abstract submitted by the author to the 1999 Palm...

Natural Killer Cells Induced by Herpes Simplex Virus Thymidine Kinase Gene Transduction and Ganciclovir Therapy Are Enhanced by Interleukin-12 Gene Therapy in an Orthotopic Model of Mouse Prostate Cancer.
August 16, 1999... Cancer Gene Therapy "Natural Killer Cells Induced by Herpes Simplex Virus Thymidine Kinase Gene Transduction and Ganciclovir Therapy Are Enhanced by Interleukin-12 Gene Therapy in an Orthotopic Model of Mouse Prostate Cancer." Waleed A....

Immunologic Effects of Interleukin-2 (IL-2) Gene Therapy In Prostate Cancer (CaP).
August 16, 1999... Cancer Immunotherapy "Immunologic Effects of Interleukin-2 (IL-2) Gene Therapy In Prostate Cancer (CaP)." John Naitoh, Randhir Kaboo, Cho Lea Tso, Andreas Hinkel, Anne Stiles, Robert Figlin, and Ade Belldegrun. Los Angeles, California. ...

The Incidence of Inhibitors and the Induction of Immune Tolerance.
August 16, 1999... Hemophilia (Immune Tolerance) "The Incidence of Inhibitors and the Induction of Immune Tolerance." Ernest Bridt. Academic Medical Center, Amsterdam, The Netherlands. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

Development of Genetic Immunization with Mature CD83(+) Dendritic Cells.
August 16, 1999... Melanoma Vaccines "Development of Genetic Immunization with Mature CD83(+) Dendritic Cells." T. Tuting, H. Jonuleit, G. Miffler, J. Steitz, J. Bruck, A. Giesecke, K. Steinbrink, J. Knop and A. Erik. Department of Dermatology, University of...

Distribution of Daunorubicin and Daunorubicinol in Human Glioma Tumors After Administration of Liposomal Daunorubicin.
August 16, 1999... Glioma (Chemotherapy) Zucchetti, M.; Boiardi, A.; Silvani, A.; Parisi, I.; Piccolrovazzi, S.; Dincalci, M. "Distribution of Daunorubicin and Daunorubicinol in Human Glioma Tumors After Administration of Liposomal Daunorubicin." Cancer...

Efficacy of Interferon Treatment for Patients with Chronic Hepatitis C: Comparison of Response in Cirrhotics, Fibrotics, or Nonfibrotics.
August 16, 1999... Interferon Therapy (HCV) Everson, G.T.; Jensen, D.M.; Craig, J.R.; Vanleeuwen, D.J.; Bain, V.G.; Ehrinpreis, M.N.; Albert, D.; Joh, T.; Witt, K. "Efficacy of Interferon Treatment for Patients with Chronic Hepatitis C: Comparison of...

Expression of Interferon Receptor Genes in the Liver as a Predictor of Interferon Response in Patients with Chronic Hepatitis C.
August 16, 1999... Interferon Therapy (HCV) Morita, K.; Tanaka, K.; Saito, S.; Kitamura, T.; Kiba, T.; Fujii, T.; Numata, K.; Sekihara, H. "Expression of Interferon Receptor Genes in the Liver as a Predictor of Interferon Response in Patients with Chronic...

Mutations in the NS5A Region Do Not Predict Interferon-Responsiveness in American Patients Infected with Genotype 1b Hepatitis C Virus.
August 16, 1999... Interferon Therapy (HCV) Chung, R.T.; Monto, A.; Dienstag, J.L.; Kaplan, L.M. "Mutations in the NS5A Region Do Not Predict Interferon-Responsiveness in American Patients Infected with Genotype 1b Hepatitis C Virus." Journal of Medical...

Increased Generation of Autologous Tumor-Reactive Lymphocytes by Anti-CD3 Monoclonal Antibody and Prothymosin alpha.
August 16, 1999... Monoclonal Antibodies Baxevanis, C.N.; Spanakos, G.; Voutsas, I.F.; Gritzapis, A.D.; Tsitsilonis, O.E.; Mamalaki, A.; Papamichail, M. "Increased Generation of Autologous Tumor-Reactive Lymphocytes by Anti-CD3 Monoclonal Antibody and...

The Importance of Antibody-Specificity in Determining Successful Radioimmunotherapy of B-Cell Lymphoma.
August 16, 1999... Radioimmunotherapy Illidge, T.M.; Cragg, M.S.; Mcbride, H.M.; French, R.R.; Glennie, M.J. "The Importance of Antibody-Specificity in Determining Successful Radioimmunotherapy of B-Cell Lymphoma." Blood, July 1, 1999;94(1):233-243. (CW...

Autoimmune Diabetes Circumvented by IFN-Gamma Fusion Protein.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Intramuscular (i.m.) injection of a nonviral vector encoding an interferon (IFN)-gamma receptor/IgG1 fusion protein prevents autoimmune diabetes in a murine model. G.J. Prud'homme and Y. Chang...

Combination Cytokines Gang Up on Glioblastoma.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Tumor necrosis factor-alpha (TNF-(alpha)) enhances the effect of other cytokines in adoptive immunotherapy. Y. Suzuki and colleagues from the Sumitomo Forestry Tsukuba Research Institute, Japan,...

IL-12 May Be a Beneficial Addition To Immune Strategies.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interleukin (IL)-12 induces surface molecules on melanoma cells that might be beneficial to immunotherapy protocols. F.Y. Yue and colleagues from the University of Zurich, Switzerland,...

Phage-Display Library Catalogs Cancer Antibodies.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers from the Scripps Research Institute, California, have cataloged antibodies to the tumor-associated carbohydrate antigens Sialyl Lewis(X) and Lewis(X). "Monoclonal antibodies (mAbs)...

Tumor Pretargeting Improves Therapeutic Index.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Pretargeting tumors with avidin could improve the therapeutic index of the anticancer drug tumor necrosis factor alpha (TNF). A. Gasparri and colleagues from the San Raffaele Science Institute,...

Treatment Options Expand for Immunologic Miscarriage.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Recurrent miscarriage due to immunologic complications between a man and a woman have several different treatment options. D.A. Clark and colleagues from McMaster University, Canada, examined...

First Extensive Serial Analysis of Gene Expression Is Reported.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An extensive analysis of gene expression for human hematopoietic cells may lead to novel methods to diagnose diseases in which macrophages play key roles. Monocytes/macrophages serve as sentinels...

Progenitors Isolated Based on Aldehyde Dehydrogenase Activity.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers have developed a technique for fractionating hematopoietic stem cells that effectively isolates primitive human hematopoietic progenitors. The technique is based on aldehyde...

Self-Replicating RNA Vaccine for Cancer, Disease Therapy.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A self-replicating RNA vaccine not only protected mice against tumor challenge but also improved survival in mice with established tumors. The vaccine "self replicates" by borrowing a replicase...

Interferon Retreatment Useful in HBeAg+ Disease.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interferon retreatment is a viable therapeutic option in viremic patients with chronic hepatitis B e antigen-positive hepatitis. Treatment with interferon alpha (IFN-(alpha)) has been shown to...

FDA Designates Orphan Drug Status for CEA-Cide Therapeutic.
August 23, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunomedics, Inc., Morris Plains, New Jersey, announced that the U.S. Food and Drug Administration (FDA) has given orphan drug designation to the company's yttrium-90- radiolabeled CEA-Cide cancer...

Type I Interferon Is a Powerful Inhibitor of in vivo HIV-1 Infection and Preserves Human CD4(+) T Cells from Virus-Induced Depletion in SCID Mice Transplanted with Human Cells.
August 23, 1999... Drug Development (Antivirals) "Type I Interferon Is a Powerful Inhibitor of in vivo HIV-1 Infection and Preserves Human CD4(+) T Cells from Virus-Induced Depletion in SCID Mice Transplanted with Human Cells." C. Lapenta, S.M. Santini, E....

Advances in Conventional Treatment of Breast Cancer: The Addition of BCG and Autotumour Vaccine Immunotherapy.
August 23, 1999... Cancer Immunotherapy "Advances in Conventional Treatment of Breast Cancer: The Addition of BCG and Autotumour Vaccine Immunotherapy." R. Jiang. Monitoring Center for Cancer Therapy, Chinese Traditional Medical Hospital of Jian Ye District,...

Human HLA-A2-Specific Systemic Cytotoxic Immune Responses Induced by HIV-1 nef DNA Vaccination.
August 23, 1999... HIV Vaccines "Human HLA-A2-Specific Systemic Cytotoxic Immune Responses Induced by HIV-1 nef DNA Vaccination." J. Hinkula, J. Sandberg, C. Devito, A.-C. Leandersson, B. Kohleisen, V. Erfle, K. Karre and B. Wahren. Karolinska Institute,...

IL-12 Delivery from Recombinant Vaccinia Virus Attenuates the Vector and Enhances the Cellular Immune Response Against HIV-1 ENV in a Dose-Dependent Manner.
August 23, 1999... HIV Vaccines "IL-12 Delivery from Recombinant Vaccinia Virus Attenuates the Vector and Enhances the Cellular Immune Response Against HIV-1 ENV in a Dose-Dependent Manner." M.M. Gherardi, J.C. Ramirez, D. Rodriguez, J.R. Rodriguez, S....

A Pilot Trial of GM-CSF and MDX-H210 in Patients With erbB-2-Positive Advanced Malignancies.
August 23, 1999... Cancer Immunotherapy Posey, J.A.; Raspet, R.; Verma, U.; Deo, Y.M.; Keller, T.; Marshall, J.L.; Hodgson, J.; Mazumder, A.; Hawkins, M.J. "A Pilot Trial of GM-CSF and MDX-H210 in Patients With erbB-2-Positive Advanced Malignancies." Journal...

Generation of Human T-Cell Responses to an HLA-A2.1-Restricted Peptide Epitope Derived from alpha-Fetoprotein.
August 23, 1999... Cancer Immunotherapy Butterfield, L.H.; Koh, A.; Meng, W.; Vollmer, C.M.; Ribas, A.; Dissette, V.; Lee, E.; Glaspy, J.A.; Mcbride, W.H.; Economou, J.S. "Generation of Human T-Cell Responses to an HLA-A2.1-Restricted Peptide Epitope Derived...

Local Secretion of IFN-gamma Induces an Antitumor Response: Comparison Between T Cells Plus IL-2 and IFN-gamma Transfected Tumor Cells.
August 23, 1999... Cancer Immunotherapy Sadanaga, N.; Nagoshi, M.; Lederer, J.A.; Joo, H.G.; Eberlein, T.J.; Goedegebuure, P.S. "Local Secretion of IFN-gamma Induces an Antitumor Response: Comparison Between T Cells Plus IL-2 and IFN-gamma Transfected Tumor...

Vancomycin-Resistant Enterococci in Intensive Care Units - High Frequency of Stool Carriage During a Non-Outbreak Period.
August 23, 1999... Drug Resistance Ostrowsky, B.E.; Venkataraman, L.; Dagata, E.M.C.; Gold, H.S.; Degirolami, P.C.; Samore, M.H. "Vancomycin-Resistant Enterococci in Intensive Care Units - High Frequency of Stool Carriage During a Non-Outbreak Period."...

Therapeutic Antibodies Elicited by Immunization Against TNF-alpha.
August 23, 1999... Inflammatory Disease Dalum, I.; Butler, D.M.; Jensen, M.R.; Hindersson, P.; Steinaa, L.; Waterston, A.M.; Grell, S.N.; Feldmann, M.; Elsner, H.I.; Mouritsen, S. "Therapeutic Antibodies Elicited by Immunization Against TNF-alpha." Nature...

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993.
August 23, 1999... Melanoma Atkins, M.B.; Lotze, M.T.; Dutcher, J.P.; Fisher, R.I.; Weiss, G.; Margolin, K.; Abrams, J.; Sznol, M.; Parkinson, D.; Hawkins, M.; Paradise, C.; Kunkel, L.; Rosenberg, S.A. "High-Dose Recombinant Interleukin 2 Therapy for...

Extended Rituximab (Anti-CD20 Monoclonal Antibody) Therapy for Relapsed or Refractory Low-Grade or Follicular Non-Hodgkin's Lymphoma.
August 23, 1999... Monoclonal Antibodies Piro, L.D.; White, C.A.; Grillolopez, A.J.; Janakiraman, N.; Saven, A.; Beck, T.M.; Varns, C.; Shuey, S.; Czuczman, M.; Lynch, J.W.; Kolitz, J.E.; Jain, V. "Extended Rituximab (Anti-CD20 Monoclonal Antibody) Therapy...

Induction of Cytotoxic T Lymphocytes With Peptides in vitro: Identification of Candidate T-Cell Epitopes in Hepatitis B Virus x Antigen.
August 23, 1999... Therapy (HBV) Chung, M.K.; Yoon, H.; Min, S.S.; Lee, H.G.; Kim, Y.J.; Lee, T.G.; Lim, J.S.; Kim, C.M.; Park, S.N. "Induction of Cytotoxic T Lymphocytes With Peptides in vitro: Identification of Candidate T-Cell Epitopes in Hepatitis B...

Interferon Retreatment in Chronic Hepatitis C: Which Patients to Choose, and What Schedule to Use.
August 23, 1999... Therapy (HCV) Picciotto, A.; Campo, N.; Brizzolara, R.; Sinelli, N.; Torre, F.; Cipriani, A.G.; Ponassi, I.; Varagona, G.; Grasso, A.; Deleo, P.; Deconca, V.; Mesiti, S.; Marenco, G.; Menardo, G.; Dodero, M.; Celle, G. "Interferon...