Immunotherapy Weekly articles from April 2000

Immunotherapy Weekly archives from April 2000

Mouse Allergen Identified as an Inner-City Asthma Risk.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Researchers at the 56th Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), held in San Diego, California, presented findings that demonstrate a relationship between asthma in...

New Findings on Immune System Control of Eosinophils Presented.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Magainin Pharmaceuticals Inc., Plymouth Meeting, Pennsylvania, announced the presentation of preclinical data highlighting the important role of interleukin-9 (IL-9) in controlling eosinophils, one of the...

Anti-IGF1-R MAbs Immunoliposomes Target Pancreas Adenocarcinoma.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Immunoliposomes carrying IGF1-R and vinorelbine-tartrate molecules kill chemoresistant advanced ductal adenocarcinoma of the pancreas (DAP), reported researchers from Greece. "DAP is a very aggressive...

Co-Encapsulation of Antigen and Plasmid DNA Improves Response.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Co-encapsulation of protein antigen with plasmid DNA antigen improves the immune response of DNA vaccines, researchers from the United Kingdom reported. "The use of plasmid DNA in vaccine technology is...

Cytokine Inhibitor Findings Pave Way for Chronic Irritant Hand Dermatitis Trials.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Three preliminary studies suggest that a new investigational therapy may safely and effectively reduce symptoms of pediatric and adult eczema, including atopic dermatitis and chronic hand dermatitis. One...

Steroid-Free Medications Might Offer Alternative Treatment Option.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Clinical data have shown that patients with atopic dermatitis (more commonly known as eczema) participating in the Phase III clinical studies of tacrolimus ointment experienced significant improvement in their...

Tolerance Induced by Nondepleting Anti-CD4 Monoclonal Antibody.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Graft tolerance can be induced by the administration of nondepleting anti-CD4 monoclonal antibody (RIB 5/2) plus intravenous donor alloantigen administration, suggested a study from the United States. ...

Interleukin-12 Increases Survival after Septic Challenge.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Cytokine therapy using low-dose interleukin-12 (IL-12) in the mouse burn model increased survival and maintained IL-10 production after septic challenge, according to a report from the United States. A....

Antigen-Loaded Dendritic Cells Induce Tumor-Specific CTL in Melanoma Patient.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Gene-modified dendritic cells that transiently express tumor-associated antigens have potential use as in vivo cancer vaccines, researchers from the United States reported. "Immunization with...

MHC-Peptide Complex Is Immunomodulating.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- The expression of a class II-peptide construct effects the tumorigenicity and immunogenicity of transfected murine tumor cells, researchers from the United States reported. "The significance of CD4(+)...

Survival Influenced by Immune Response to Polymorphic Epithelial Mucin.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Survival in breast cancer patients may be linked to a natural humoral immune response to polymorphic epithelial mucin, suggested researchers from The Netherlands. "Polymorphic epithelial mucin (PEM or...

Regulatory Protein Studied.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Rigel Pharmaceuticals, Inc., San Francisco, California, announced that a team of scientists, including several company advisors, used Rigel's retroviral expression technology to further define the biologic...

Etanercept a "Dramatic Advancement" in Treatment, Say Researchers.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- A study conducted by researchers at Children's Hospital Medical Center of Cincinnati, Ohio, shows that nearly 75% of children with severe, long-standing juvenile rheumatoid arthritis (JRA) respond, often...

Treatment for Bee/Wasp Stings Provides Long-Term Results.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Venom immunotherapy provides protection for sting reactions and can cause permanent loss of venom allergy in most patients, usually after just two years of treatment, researchers announced at the American...

Task Force Publishes Consensus Document for Allergy Diagnosis and Treatment.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Improving health care and productivity for millions of Americans with allergic diseases is the goal of The Allergy Report, a compendium of diagnosis and treatment recommendations that was unveiled by the...

Macrophage Migration Inhibitory Factor Mediates Sepsis.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Macrophage migration inhibitory factor (MIF) seems to play a major role in the pathogenesis of sepsis and septic shock, according to a recent study. "Identification of new therapeutic targets for the...

Chinese Herbal Medications Have Some Therapeutic Effect.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Researchers say that traditional Chinese medicines may have some therapeutic effects on allergic asthma. Xiu-Min Li, MD, and colleagues from Mount Sinai School of Medicine, New York, and Johns Hopkins...

Proteins Reduce Allergic Asthma in Mice, May Have Application in Humans.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Researchers reported that CpG oligodeoxynucleotides (CpG-ODN) reduced allergic asthma in mice and may be useful in the treatment of allergic asthma in humans. Allergic asthma is asthma that is triggered by...

Pet Ownership During Infancy Protects Against Allergic Sensitization.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Having an indoor cat or dog during the first year of your child's life may reduce their risk of allergic disease later in childhood, researchers reported at the 56th Annual Meeting of the American Academy of...

Phase I Results for Ragweed Immunotherapy Presented.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Dynavax Technologies Corp. announced the presentation of data from a Phase I study of AIC, a proprietary conjugate of purified ragweed allergen (Amb a 1) to an immunostimulatory polynucleotide DNA sequence...

Monoclonal Antibody Reduces Frequency of Asthma Exacerbations.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Findings from two Phase III studies show that treatment with anti-IgE, a recombinant humanized monoclonal antibody to immunoglobulin E, resulted in a decrease in the frequency of asthma exacerbations and in...

IL-4 Receptor Is Effective in Persistent Asthma.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Soluble interleukin-4 receptor (IL-4R) was found to be a safe and effective way to manage moderate persistent asthma, according to a study by Larry Borish, MD, FAAAAI, of the University of Virginia, and...

Space Travel Research May Have Implications for Allergy/Immunologic Medicine on Earth.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Three new research studies presented at the 56th American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting in offer the latest information on the effects of space travel on the human immune...

Hormone Has Potential Use in Autoimmunity and Transplantation.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Researchers reported that a hormone called 1,25-dihydroxyvitamin D3 (1,25-OH2D3) has a significant immunosuppressive effect. When used with corticosteroids, this hormone also has a synergistic immunomodulatory...

Researchers Successfully Immunize Mice Against Aggressive Cancer.
April 2, 2000... 2000 APR 2 - (NewsRx.com) -- Researchers at the University of Florida have successfully immunized laboratory mice against melanoma, one of the more aggressive forms of skin cancer. So far, immunized mice have survived for as long as 150...

Rebif Study Confirms Dose-Related Effect and Need to Treat Patients Early.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Data from the largest and most comprehensive controlled long-term study in patients with relapsing-remitting multiple sclerosis (RRMS) using Rebif, an interferon beta-1a product, points to continued benefit of...

Gene Gun Generates Effector T Cells for Adoptive Therapy.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Using the gene gun for plasmid bombardment induces generation of effector T cells. "We utilized the gene gun to transfect subcutaneous D5 melanoma and MT-901 mammary carcinoma tumors in situ with a...

Interleukin-2 and Natural Killer Cells Are Well Tolerated.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Posttransplant adoptive immunotherapy with activated natural killer cells plus interleukin-2 is a treatment that may help assure successful engraftment. Relapse after high-dose chemotherapy is a primary...

Monoclonal Antibody-Based Method Assesses Environmental Exposure to Soybean Dust.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- A monoclonal antibody (MAb)-based method can be used to quantify the allergen, Gly m 1, to assess environmental exposure to soybean dust, researchers from Spain reported. "The demonstration that some...

High Interleukin-10 Production Associated with Survival.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Researchers writing in Bone Marrow Transplantation have found that high levels of the cytokine interleukin-10 (IL-10) greatly enhance the chances of surviving a bone marrow transplant. "IL-10 is a potent...

Cytokine Gene Therapy Uses Fibroblasts to Enhance Tumor Immunity.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Cytokine gene therapies can make use of fibroblasts and dendritic cells to enhance tumor immunity. "Recombinant interleukin (IL)-2 administration can mediate regression of solid tumors in patients with...

Genetic Vaccination with Self Protein Eradicates Melanoma in a Murine Model.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Genetic vaccination with a self tyrosinase-related protein 2 caused melanoma eradication but not autoimmune aggression, researchers from Italy reported. "'Self' melanocyte differentiation antigens are...

IL-2 Potentiates Immunologic Response of Dendritic-Cell-Based Tumor Vaccines.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Recombinant IL-2 potentiated the immunologic responsiveness of dendritic cell (DC)-based tumor vaccination, reported researchers from the United States. "Dendritic cells can elicit potent immune responses...

Interleukin-2 Enhances Therapeutic Anticancer Vaccines.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Interleukin (IL)-2 can enhance the therapeutic efficacy of anticancer vaccines, suggested a study from the United States. "The purpose of our efforts is to trigger the immune destruction of established...

HIV 1 and 2 Promoter Constructs Elicit More Interleukin 2.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- A study of expression vectors has shown that HIV 1 and 2 promoter constructs can produce large quantities of interleukin 2 (IL-2) in human cancer cell lines. Researchers at the University of Arizona...

Creatine Kinase, Lactate Dehydrogenase May Indicate Infectivity.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Creatin kinase and lactate dehydrogenase levels may indicate early Trypanosoma cruzi infection, according to researchers. R.C. Cano and colleagues found that the plasma of mice infected with the K-1, X-1,...

Clinical Data Suggest Remune Might Help Rebuild Immune System.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- The Immune Response Corp., Carlsbad, California, announced that recent clinical data suggest that Remune might induce HIV immunity when used as a combination therapy with other antiviral drugs or when used...

HPV-E5 Protein Targeted by Peptide Vaccine.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- The E5 protein of the human papillomavirus (HPV) is a potential target for a novel prophylactic peptide-based vaccine for cervical cancer, researchers from the United States reported. "There are active...

Complement Alternative Pathway Inhibitor Effective in Immune Complex Disease Model.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Gliatech Inc., Cleveland, Ohio, announced that company scientists have obtained data showing that an anti-properdin monoclonal antibody (MAb) is effective at reducing inflammation in a rabbit model of immune...

Phase I SBIR Grant for MHC Class II Enhanced Cancer Vaccines Announced.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Antigen Express, Inc. (AgExp), Worcester, Massachusetts, announced that it has received a $173,000 Small Business Innovative Research (SBIR) grant from the U.S. National Institutes of Health (NIH) to support...

Alliance Formed To Discover and Develop Therapeutic Monoclonal Antibodies.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Corixa Corp., Seattle, Washington, announced a collaboration with Abgenix, Inc. to discover and develop human monoclonal antibodies against selected targets from Corixa's library of proprietary autoimmune...

Chemokine Drug Discovery Alliance Extended for Inflammatory and Autoimmune Disease.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, announced that it has extended an agreement with Kyowa Hakko Kogyo Co., Ltd., of Tokyo, Japan for an additional year. This joint discovery and...

Collaboration on Interferon Delivery System Announced.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- Viragen, Inc., Plantation, Florida, and Viragen Europe Ltd. have agreed to collaborate with Biosyntech applying a protein pharmaceutical delivery system. The project will assess the potential of...

Three Zadaxin Marketing Approvals Received.
April 9, 2000... 2000 APR 9 - (NewsRx.com) -- SciClone Pharmaceuticals, San Mateo, California, announced that Zadaxin immunotherapy has been approved for marketing in Thailand, Laos, and Malta. Zadaxin now is approved for marketing in 19 countries,...

Immune-Cell Mechanism Boosts Therapeutic Antibody Potency.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Researchers at the Rockefeller University, in collaboration with Genentech, Inc., have made a surprising discovery about the mechanism by which two currently-used clinical antibodies fight tumors. The...

Gene Transfer May Engraft New Specificities onto Lymphocytes.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- A new class of chimeric receptors may be able to enhance the effectiveness of adoptive immunotherapy for treating cancer, according to researchers working in the United States. It may be possible to...

Taxol Is Useful in Mobilizing Stem Cells.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Using taxol with recombinant human granulocyte-colony stimulating factor (rhG-CSF) was effective in mobilizing stem cells and collecting CD34(+) cells, researchers working in Spain reported. J....

Combined Interleukin 12 and Indomethacin Inhibits Angiogenesis in Mice.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- According to a study from Poland, inhibition of angiogenesis in mice was enhanced through a combined treatment of interleukin 12 and the antiinflammatory drug indomethacin. "Nonsteroidal anti-inflammatory...

HIV 1 and 2 Promoter Constructs Elicit More Interleukin 2.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- A study of expression vectors has shown that HIV 1 and 2 promoter constructs can produce large quantities of interleukin 2 (IL-2) in human cancer cell lines. Researchers at the University of Arizona...

Immune System Cell Has Potent Ability to Fight HIV.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Duke University Medical Center researchers have discovered a potent ability of specific immune system cells to fight against HIV. Scientists have long known that immune system cells known as "killer CD8"...

Delta-Opioid Receptors Play Role in Post-Exercise Cytotoxicity Enhancement.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Researchers have shed new light on the role the central opioid systems play in mediating the post-exercise enhancement of in vivo natural killer (NK) cell cytotoxicity in rats I.H. Jonsdottir and...

Therapy Uses Adeno-Associated Virus Vector to Deliver Interleukin-1 Receptor Antagonist.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- A rat model of rheumatoid arthritis gene therapy demonstrated therapeutic and preventive effects, researchers from Taiwan reported. They evaluated "recombinant adenoassociated virus vector encoding...

Effects of Paternal Lymphocyte Immunization Evaluated in Patients.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- The effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR V beta and V gamma repertoire were evaluated in patients with recurrent spontaneous abortions. "The mechanism of...

Naked Gene Delivery is Safe and Results in Tumor Reduction.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Delivery of naked therapeutic genes is safe and efficacious in animal model, according to a recent report. "The use of interleukin-2 (IL-2) and p53 for immunotherapy and gene therapy for cancer has shown...

MAb Detects Cytoplasmic Protein in Melanoma Samples.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- NY-ESO-1 specific monoclonal antibodies (MAbs) were used to detect the NY-ESO-1 gene in neoplastic tissues, according to a report from Switzerland. "NY-ESO-1 gene encodes a novel member of the...

Development of Potential Preventive Vaccine Pursued.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- The Immune Response Corp. (IMNR), Carlsbad, California, announced data from preclinical animal studies of a potential new vaccine consisting of the company's HIV immunogen, Remune (whole-killed HIV depleted...

Monoclonal Antibody Appears to be Safe Treatment.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- A monoclonal antibody may be helpful for trauma patients with hemorrhagic shock, according to a recent conference report. N. Vedder and colleagues previously reported their findings in animal models which...

Repeated OvaRex Infusions Are Safe and Effective Treatment for Some.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- The monoclonal antibody (MAb) OvaRex can be safely administered to ovarian cancer patients, reported a group of researchers from Germany, Canada, and the United States. "The standard of care for newly...

E. coli Toxin to Enter Clinical Trials.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Select Therapeutics (SLPU), a Cambridge, Massachusetts-based biotechnology company developing cancer therapies, announced it has completed financial arrangements enabling it to move forward into clinical...

Therapy Combines Transduced Interleukin-12 Cells with Systemic Interleukin-18.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Researchers from Japan have evaluated a cancer therapy combining the transduction of cells with interleukin-12 given as a vaccine with systemic interleukin-18 administration. "We introduced the...

Preliminary Results from Phase I/II Immunotherapy Study in Infants Announced.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Avant Immunotherapeutics (AVAN) announced that the recently completed Phase I/II study of the TP10 inhibitor met its objectives in infants undergoing cardiac surgery. TP10 was well tolerated by the...

Gammar-P Receives Indication for Primary Immune Deficiency.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Aventis Behring L.L.C., formerly Centeon L.L.C., announced that Gammar-P I.V., Immune Globulin Intravenous (Human), is now indicated for the treatment of primary immune deficiency (PID) in adolescents and...

Patients Sought for Hepatitis C Clinical Trials.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Hepatitis C has struck at the heartland of America in the same ways it has hit major metropolitan areas: through blood transfusions and cesarean sections occurring before 1992, risky sex, and intravenous drug...

Immunodepletion of Antibodies Increases Adenovirus Efficiency.
April 16, 2000... 2000 APR 16 - (NewsRx.com) -- Passive immunization with adenovirus (Ad) antibody-depleted serum increases transduction efficiency of Ad vector in a murine model, reported researchers from the United States. "Ad vectors are capable of...

Progress Reported on HIV Therapies.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Progenics Pharmaceuticals, Inc. (PGNX) presented promising findings on two treatment strategies designed to prevent HIV from infecting healthy cells and to eliminate those cells already infected with the...

Anti-Cancer Therapy Uses Engineered Monoclonal Antibodies.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Genetically engineered monoclonal antibodies (MAbs) can be used for direct anti-neoplastic treatment as well as cancer cell specific delivery of chemotherapeutic agents. "Classical therapeutic modalities...

Phase I/II Trial of AlloMune Cancer System Initiated.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- BioTransplant Inc. (BTRN), Charlestown, Massachusetts, announced that enrollment and treatment has begun in a multi-center Phase I/II trial of the AlloMune Cancer System under an Investigative New Drug for...

Interleukin 10 Gene Transfer Prevents Colitis in Rats.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Interleukin 10 (IL-10) gene transfer prevented colitis in an experimental rat model, researchers from Canada reported. "The development of colitis in interleukin 10 (IL-10)-deficient mice, together with...

Molecular Remission Induced with Monoclonal Antibody.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Molecular remission of acute promyelocytic leukemia was induced with retinoic acid and the anti-CD33 monoclonal antibody HuM195, according to Memorial Sloan-Kettering Cancer Center workers. "Despite...

Zadaxin Plus Chemotherapy Shows Promise in Skin Cancer.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- SciClone Pharmaceuticals (SCLN), San Mateo, California, announced that a study published in Melanoma Research (April 2000;10(2)) suggests that Zadaxin increases the effectiveness of chemotherapy for metastatic...

Combination Therapy Achieves Sustained Response.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Ketoprofen combined with interferon-(alpha) 2b causes a sustained response to therapy in patients with hepatitis C virus (HCV), according to a study reported in Gut. A.E. Munoz and associates at the...

Maturation and Trafficking of Monocyte-Derived Dendritic Cells Explored.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Understanding of the maturation and trafficking of monocyte-derived dendritic cells (DC) is necessary to develop DC-based vaccines, suggested researchers from the United States. "Human dendritic cells...

Solid-State Vehicles Deliver Vectors in Murine Prostate Cancer Model.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Solid-state vehicles enhanced in vivo viral vector delivery in a mouse model of prostate cancer and improved gene expression. "Although there are increasingly more clinical trials involving gene therapy,...

Vaccine in Mouse Model Improves Relapse-Free Survival.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Avax Technologies, Inc., announced the presentation of pre-clinical data on its AC Vaccine technology, an autologous cell cancer vaccine, at the 91st Annual Meeting of the American Association for Cancer...

Vaccine May Help Prevent Associated Cancers.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Vaccination-acquired cell mediated immunity (CMI) may help prevent and treat human papillomavirus (HPV)-associated cancers, researchers from the United States reported. "Although most immunoprophylactic...

Vaccine Induces T-Cell Mediated Immune Reactions.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Avax Technologies, Inc., announced at the 91st annual meeting of the American Association for Cancer Research (AACR), that M-Vax, a cancer vaccine made from the patient's own tumor cells, induces T-cell...

Targeted Polymerized Liposomes Evaluated For Mucosal Delivery.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Targeted polymerized liposomes may be the oral vaccine delivery method of the future, suggested researchers from the United States. "A variety of micro- and nano-particulate systems have been proposed as...

Engrafting Costimulator Molecules Is Alternative to Transfection.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- The engraftment of costimulator molecules onto tumor cell surfaces with chelator lipids is an alternative to gene transfection for cancer vaccines, researchers from Australia reported. "The genetic...

Novel Antibody Reported for Vaccine Delivery.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Immunomedics, Inc. (IMMU) announced that its scientists reported progress in cancer vaccine development at the 91st Annual Meeting of the American Association for Cancer Research, held in San Francisco,...

Allograft Rejection Prevented by Blockade of Interleukin-2 Receptor.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- According to a study from the United States, cardiac allograft rejection may be circumvented by the blockade of the interleukin-2 receptor (IL-2r) by the monoclonal antibody (MAb) daclizumab. ...

Clinical Data on Cancer Vaccine Presented.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- Antigenics Inc. (AGEN), New York, New York, announced the release of data from a Phase I/II melanoma clinical trial of the company's cancer vaccine, Oncophage. Dr. Omar Eton, M.D. Anderson Cancer Center...

Anti-Mouse CD40L Single Chain Antibody/Adenovirus Vector Developed.
April 23, 2000... 2000 APR 23 - (NewsRx.com) -- A recombinant adenovirus vector encoding an anti-mouse CD40L single chain antibody has been developed. "Blockade of the interaction between CD40 and CD40 ligand (CD40L) is one of the most powerful methods...