Vaccine Weekly articles from September 1998

Vaccine Weekly archives from September 1998

First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response.
September 7, 1998... Macgregor, R.R.; Boyer, J.D.; Ugen, K.E.; Lacy, K.E.; Gluckman, S.J.; Bagarazzi, M.L.; Chattergoon, M.A.; Baine, Y.; Higgins, T.J.; Ciccarelli, R.B.; Coney, L.R.; Ginsberg, R.S.; Weiner, D.B. "First Human Trial of a DNA-Based Vaccine for...

Genetic Characterization of Incident HIV-1 Subtype B and E Strains from Injecting Drug Users (IDUs) in Bangkok, Thailand.
September 7, 1998... "Genetic Characterization of Incident HIV-1 Subtype B and E Strains from Injecting Drug Users (IDUs) in Bangkok, Thailand." S. Subbarao, S. Vanichseni, T.D. Mastro, D. Kitayaporn, S. Raktham, N.L. Young, L. Srisawanvilai, C.C. Luos, C. Hartz....

Salmonella Bacterium Used as Vaccine Delivery System.
September 7, 1998... The success of any global vaccination program depends on a vaccine that is stable, easy to administer, and effective at stimulating complex immune responses. Toward this end, researchers are experimenting with live, replicating bacteria and...

New HIV Trick: Immunization Against Antiviral Chemokines.
September 7, 1998... HIV has yet another pernicious trick: it vaccinates against antiviral defenses. New data suggest that epitopes carried in the V3 loop of the HIV-1 envelope elicit antibodies. These antibodies don't seem to hurt HIV: but they attack and...

Cervical Antibody Responses to a Herpes Simplex Virus Type 2 Glycoprotein Subunit Vaccine.
September 7, 1998... Ashley, R.L.; Crisostomo, F.M.; Doss, M.; Sekulovich, R.E.; Burke, R.L.; Shaughnessy, M.; Corey, L.; Polissar, N.L.; Langenberg, A.G.M. "Cervical Antibody Responses to a Herpes Simplex Virus Type 2 Glycoprotein Subunit Vaccine." Journal of...

Immunization Against Hepatitis B in HIV Positive Patients.
September 7, 1998... "Immunization Against Hepatitis B in HIV Positive Patients." D. Latarskal, J. Higersberger, H. Paprocka, A. Ignatowska, E. Burkacka and A. Horban. Wolska, Warszawa; Infectious Diseases Hospital, Warszawa; AIDS Diagnosis & Therapy Center...

Multicenter Phase II Clinical Studies for CeaVac Vaccine Initiated.
September 7, 1998... Titan Pharmaceuticals, Inc., South San Francisco, California, announced the initiation of multicenter Phase II human clinical trials for the CeaVac cancer vaccine in colorectal cancer, and the TriAb cancer vaccine in breast cancer. Both...

Vaccination With HIV DNA Induces Anti-HIV Chemokines.
September 7, 1998... Animals vaccinated with a candidate AIDS vaccine have increased levels of anti-HIV chemokines. In HIV infected chimpanzees, vaccination-induced increases in the chemokines correlated with decreased viral load and induction of other anti-HIV...

Uptake of Hepatitis B Vaccine Among Health Care Workers not Widespread.
September 7, 1998... Uptake of hepatitis B vaccination among health care workers falls short of recommended guidelines, according to research presented in the journal Occupational and Environmental Medicine. British Department of Health (DoH) guidelines were issued...

Antigen Loss Variants of a Murine Renal Cell Carcinoma: Implications for Tumor Vaccination.
September 7, 1998... Kerkmanntucek, A.; Banat, G.A.; Cochlovius, B.; Zoller, M. "Antigen Loss Variants of a Murine Renal Cell Carcinoma: Implications for Tumor Vaccination." International Journal of Cancer, July 3, 1998;77(1):114-122. According to the authors'...

Antitumor Memory, or Vaccination, Using Staphylococcal Enterotoxin B and Bispecific Antibody is not Mediated by V(beta)8 Specific T Cells.
September 7, 1998... "Antitumor Memory, or Vaccination, Using Staphylococcal Enterotoxin B and Bispecific Antibody is not Mediated by V(beta)8 Specific T Cells." I.E. Gecim, E.J. McConnell, L.E. Porter and H. Nelson. Mayo Clinic, Rochester, Minnesota. According to...

Prior BCG Vaccine Alters Response to hsp 65 and hsp 70.
September 7, 1998... Animal studies suggest that heat shock protein 65 is not protective against active tuberculosis. Researchers found that prior vaccination with bacillus Calmette-Guerin boosted cellular immune response to purified protein derivative and heat...

Gallo: Too Soon To Focus Solely on AIDS Vaccine.
September 7, 1998... It would be a mistake to focus all AIDS research activities on a vaccine, says HIV co-discoverer Robert Gallo. Gallo warned that even though they represent immense progress, current AIDS therapies are not good enough. He urged researchers and...

Hypertension May Limit New AIDS Therapy Approach.
September 7, 1998... New strategies to block HIV infection may have untoward side effects. Such strategies would block or down-regulate the CCR5 chemokine receptor needed for macrophage-tropic (M-tropic) HIV-1 strains to infect cells. M-tropic strains are...

Antitumor Vaccine Effect of Irradiated Murine Neuroblastoma Cells Producing Interleukin-2 or Granulocyte Macrophage-Colony Stimulating Factor.
September 7, 1998... Yoshida, H.; Enomoto, H.; Kawamura, K.; Takenaga, K.; Tanabe, M.; Ohnuma, N.; Sakiyama, S.; Tagawa, M. "Antitumor Vaccine Effect of Irradiated Murine Neuroblastoma Cells Producing Interleukin-2 or Granulocyte Macrophage-Colony Stimulating...

Reengineered Poliovirus an Effective Vector for in Murine Study.
September 7, 1998... Researchers led by scientists at University of California at San Francisco say they have made a significant breakthrough in their attempt to re-engineer the poliovirus so that it could some day be used as a transporting mechanism for inducing...

U.S. Scientists Map Out Syphilis Genes.
September 7, 1998... U.S. scientists said they had finally mapped all the genes in the bacterium that causes syphilis, helping to develop better vaccines and drugs against the disease. Syphilis has killed millions over the centuries and driven many to madness as...

Phase II Clinical Trials of Avicine in Cancer Patients Initiated.
September 7, 1998... Avi Biopharma (AVI) and ImmunoTherapy Corp. (ITC) selected Pharmaceutical Research Associates (PRA) to conduct a Phase II clinical study of the therapeutic cancer vaccine, Avicine, for the treatment of prostate cancer. The trial marks the...

Immunotherapy for HIV-1 Infection using DNA Based Vaccines.
September 7, 1998... "Immunotherapy for HIV-1 Infection using DNA Based Vaccines." D. Weiner, J. Boyer, K.E. Ugen, M. Bennett, A. Cohen, M.L. Bagarazzi, A. Jaradian and R. Ciccarelli. Philadelphia, Pennsylvania; University of Pennsylvania, Philadelphia, Pennsylvania;...

HIV-1 Dual Infections and Recombinants are an Integral Part of the HIV Epidemic in Brazil.
September 7, 1998... "HIV-1 Dual Infections and Recombinants are an Integral Part of the HIV Epidemic in Brazil." D. Pieniazak, A. Ramos, A. Tanuri, D. Hu, J. Baggs and M. Rayfeld. U.S. Centers for Disease Control, Atlanta, Georgia; UFRJ, Rio De Janeiro, Brazil....

Study of Immunization Against Anthrax with the Purified Recombinant Protective Antigen of Bacillus anthracis.
September 7, 1998... Singh, Y.; Ivins, B.E.; Leppla, S.H. "Study of Immunization Against Anthrax with the Purified Recombinant Protective Antigen of Bacillus anthracis." Infection and Immunity, July 1998;66(7):3447-3448. According to the authors' abstract of an...

Immunisation of Colorectal Cancer Patients with Autologous Tumour Cells.
September 7, 1998... Diederichsen, A.C.P.; Stenholm, A.C.O.; Kronborg, O.; Fenger, C.; Jensenius, J.C.; Zeuthen, J.; Kristensen, T.; Christensen, P.B. "Immunisation of Colorectal Cancer Patients with Autologous Tumour Cells." Oncology Reports, July-August...

Protective CD4(+) and CD8(+) T Cells Against Influenza Virus Induced by Vaccination with Nucleoprotein DNA.
September 7, 1998... Ulmer, J.B.; Fu, T.M.; Deck, R.R.; Friedman, A.; Guan, L.M.; Dewitt, C.; Liu, X.; Wang, S.; Liu, M.A.; Donnelly, J.J.; Caulfield, M.J. "Protective CD4(+) and CD8(+) T Cells Against Influenza Virus Induced by Vaccination with Nucleoprotein DNA."...

Induction of Protective Immune Responses by Immunization with Linear Multiepitope Peptides Based on Conserved Sequences from Plasmodium falciparum Antigens.
September 7, 1998... Bharadwaj, A.; Sharma, P.; Joshi, S.K.; Singh, B.; Chauhan, V.S. "Induction of Protective Immune Responses by Immunization with Linear Multiepitope Peptides Based on Conserved Sequences from Plasmodium falciparum Antigens." Infection and...

Differential Kinetics and Distribution of Antibodies in Serum and Nasal and Vaginal Secretions after Nasal and Oral Vaccination of Humans.
September 7, 1998... Rudin, A.; Johansson, E.L.; Bergquist, C.; Holmgren, J. "Differential Kinetics and Distribution of Antibodies in Serum and Nasal and Vaginal Secretions after Nasal and Oral Vaccination of Humans." Infection and Immunity, July...

Antigenic and Molecular Characterization of Wild Type 1 Poliovirus Causing Outbreaks of Poliomyelitis in Albania and Neighboring Countries in 1996.
September 7, 1998... Fiore, L.; Genovese, D.; Diamanti, E.; Catone, S.; Ridolfi, B.; Ibrahimi, B.; Konomi, R.; Vanderavoort, H.G.A.M.; Hovi, T.; Crainic, R.; Simeoni, P.; Amato, C. "Antigenic and Molecular Characterization of Wild Type 1 Poliovirus Causing Outbreaks...

Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein of Mycobacterium tuberculosis by Using Lipopeptides.
September 7, 1998... Dafonseca, D.P.A.J.; Joosten, D.; Vanderzee, R.; Jue, D.L.; Singh, M.; Vordermeier, H.M.; Snippe, H.; Verheul, A.F.M. "Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein of Mycobacterium tuberculosis by Using...

Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains of Lactococcus lactis Coexpressing Antigen and Cytokine.
September 7, 1998... eidler, L.; Robinson, K.; Chamberlain, L.; Schofield, K.M.; Remaut, E.; Lepage, R.W.F.; Wells, J.M. "Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains of Lactococcus lactis Coexpressing Antigen and Cytokine."...

HIV (beta)-Chemokine Levels Aid AIDS Vaccines.
September 7, 1998... Experimental AIDS vaccines protected only monkeys with already-high levels of beta chemokines in a Swedish study. Researchers Rigmor Thorstensson and colleagues expected to find that vaccines capable of protecting monkeys against intrarectal...

Most Cost-Effective U.S. Technology: AIDS Drugs.
September 7, 1998... AIDS drugs cost a lot. But they save society a bundle. Highly active antiretroviral therapy (HAART) - now the standard of care for the industrialized world - has greatly reduced AIDS incidence. And while HAART isn't cheap, its cost is far less...

Uninfected Sex Workers Yield Clues to AIDS Vaccine.
September 7, 1998... CDC studies of women who remain uninfected despite extremely frequent exposure to HIV at last are yielding important clues to making an AIDS vaccine. Thai sex workers who resist HIV infection have high levels of monocyte-derived factors that...

Company Developing Vaccines to Kick Nicotine, Cocaine Habits.
September 7, 1998... Trying to quit smoking? That destructive cocaine habit? A U.S. company may have a new approach to helping people overcome some of their addictions. ImmuLogic, in Waltham, Massachusetts, is developing a vaccine that counteracts the nicotine...

Failure of Postnatal Vaccine May Be Predictable.
September 7, 1998... The failure of hepatitis B virus vaccine may be predictable in infants born to hepatitis B-infected mothers. Researcher S.L. Ngui and colleagues from the United Kingdom found that nucleotide changes at certain alleles in the genome of maternal...

Conference Coverage (12th World AIDS) HIV (beta)-Chemokine Levels Aid AIDS Vaccines
September 7, 1998... Experimental AIDS vaccines protected only monkeys with already-high levels of beta chemokines in a Swedish study. Researchers Rigmor Thorstensson and colleagues expected to find that vaccines capable of protecting monkeys against intrarectal...

Conference Coverage (12th World AIDS) Gallo: Too Soon To Focus Solely on AIDS Vaccine
September 7, 1998... It would be a mistake to focus all AIDS research activities on a vaccine, says HIV co-discoverer Robert Gallo. Gallo warned that even though they represent immense progress, current AIDS therapies are not good enough. He urged researchers and...

Conference Coverage (12th World AIDS) Hypertension May Limit New AIDS Therapy Approach
September 7, 1998... New strategies to block HIV infection may have untoward side effects. Such strategies would block or down-regulate the CCR5 chemokine receptor needed for macrophage-tropic (M-tropic) HIV-1 strains to infect cells. M-tropic strains are...

Conference Coverage (12th World AIDS) Most Cost-Effective U.S. Technology: AIDS Drugs
September 7, 1998... AIDS drugs cost a lot. But they save society a bundle. Highly active antiretroviral therapy (HAART) - now the standard of care for the industrialized world - has greatly reduced AIDS incidence. And while HAART isn't cheap, its cost is far less...

Conference Coverage (12th World AIDS) New HIV Trick: Immunization Against Antiviral Chemokines
September 7, 1998... HIV has yet another pernicious trick: it vaccinates against antiviral defenses. New data suggest that epitopes carried in the V3 loop of the HIV-1 envelope elicit antibodies. These antibodies don't seem to hurt HIV: but they attack and...

Conference Coverage (12th World AIDS) Uninfected Sex Workers Yield Clues to AIDS Vaccine
September 7, 1998... CDC studies of women who remain uninfected despite extremely frequent exposure to HIV at last are yielding important clues to making an AIDS vaccine. Thai sex workers who resist HIV infection have high levels of monocyte-derived factors that...

Conference Coverage (12th World AIDS) Vaccination With HIV DNA Induces Anti-HIV Chemokines
September 7, 1998... Animals vaccinated with a candidate AIDS vaccine have increased levels of anti-HIV chemokines. In HIV infected chimpanzees, vaccination-induced increases in the chemokines correlated with decreased viral load and induction of other anti-HIV...

Addictions Company Developing Vaccines to Kick Nicotine, Cocaine Habits
September 7, 1998... Trying to quit smoking? That destructive cocaine habit? A U.S. company may have a new approach to helping people overcome some of their addictions. ImmuLogic, in Waltham, Massachusetts, is developing a vaccine that counteracts the nicotine...

Animal Models (TB) Prior BCG Vaccine Alters Response to hsp 65 and hsp 70
September 7, 1998... Animal studies suggest that heat shock protein 65 is not protective against active tuberculosis. Researchers found that prior vaccination with bacillus Calmette-Guerin boosted cellular immune response to purified protein derivative and heat...

Vaccine (HBV) Failure of Postnatal Vaccine May Be Predictable
September 7, 1998... The failure of hepatitis B virus vaccine may be predictable in infants born to hepatitis B-infected mothers. Researcher S.L. Ngui and colleagues from the United Kingdom found that nucleotide changes at certain alleles in the genome of maternal...

Vaccine Development Salmonella Bacterium Used as Vaccine Delivery System
September 7, 1998... The success of any global vaccination program depends on a vaccine that is stable, easy to administer, and effective at stimulating complex immune responses. Toward this end, researchers are experimenting with live, replicating bacteria and...

Vaccine Development Reengineered Poliovirus an Effective Vector for in Murine Study
September 7, 1998... Researchers led by scientists at University of California at San Francisco say they have made a significant breakthrough in their attempt to re-engineer the poliovirus so that it could some day be used as a transporting mechanism for inducing...

Cancer Vaccines Multicenter Phase II Clinical Studies for CeaVac Vaccine Initiated
September 7, 1998... Titan Pharmaceuticals, Inc., South San Francisco, California, announced the initiation of multicenter Phase II human clinical trials for the CeaVac cancer vaccine in colorectal cancer, and the TriAb cancer vaccine in breast cancer. Both...

Genetics U.S. Scientists Map Out Syphilis Genes
September 7, 1998... U.S. scientists said they had finally mapped all the genes in the bacterium that causes syphilis, helping to develop better vaccines and drugs against the disease. Syphilis has killed millions over the centuries and driven many to madness as...

Occupational Risk (HBV) Uptake of Hepatitis B Vaccine Among Health Care Workers not Widespread
September 7, 1998... Uptake of hepatitis B vaccination among health care workers falls short of recommended guidelines, according to research presented in the journal Occupational and Environmental Medicine. British Department of Health (DoH) guidelines were issued...

Prostate Cancer Phase II Clinical Trials of Avicine in Cancer Patients Initiated
September 7, 1998... Avi Biopharma (AVI) and ImmunoTherapy Corp. (ITC) selected Pharmaceutical Research Associates (PRA) to conduct a Phase II clinical study of the therapeutic cancer vaccine, Avicine, for the treatment of prostate cancer. The trial marks the...

HIV Immunotherapy "Immunotherapy for HIV-1 Infection using DNA Based Vaccines."
September 7, 1998... D. Weiner, J. Boyer, K.E. Ugen, M. Bennett, A. Cohen, M.L. Bagarazzi, A. Jaradian and R. Ciccarelli. Philadelphia, Pennsylvania; University of Pennsylvania, Philadelphia, Pennsylvania; University of South Florida, Tampa, Florida; Allegheny...

HIV Vaccines "Genetic Characterization of Incident HIV-1 Subtype B and E Strains from Injecting Drug Users (IDUs) in Bangkok, Thailand."
September 7, 1998... S. Subbarao, S. Vanichseni, T.D. Mastro, D. Kitayaporn, S. Raktham, N.L. Young, L. Srisawanvilai, C.C. Luos, C. Hartz. U.S. Centers for Disease Control, Atlanta, Georgia; Bangkok Metropolitan Administration, Bangkok; US CDC & HIV/AIDS...

HIV Vaccines "HIV-1 Dual Infections and Recombinants are an Integral Part of the HIV Epidemic in Brazil."
September 7, 1998... D. Pieniazak, A. Ramos, A. Tanuri, D. Hu, J. Baggs and M. Rayfeld. U.S. Centers for Disease Control, Atlanta, Georgia; UFRJ, Rio De Janeiro, Brazil. According to an abstract submitted by the authors to the 12th World AIDS Conference, held June...

Prophylaxis (HBV Vaccination) "Immunization Against Hepatitis B in HIV Positive Patients."
September 7, 1998... D. Latarskal, J. Higersberger, H. Paprocka, A. Ignatowska, E. Burkacka and A. Horban. Wolska, Warszawa; Infectious Diseases Hospital, Warszawa; AIDS Diagnosis & Therapy Center Warszawa, Poland. According to an abstract submitted by the authors...

Anthrax "Study of Immunization Against Anthrax with the Purified Recombinant Protective Antigen of Bacillus anthracis." Infection and Immunity, July 1998;66(7):3447-3448. Singh, Y.; Ivins, B.E.; Leppla, S.H.
September 7, 1998... According to the authors' abstract of an article published in Infection and Immunity, "Protective antigen (PA) of anthrax toxin is the major component of human anthrax vaccine. Currently available human vaccines in the United States and Europe...

Cancer Vaccines Implications for Tumor Vaccination." International Journal of Cancer, July 3, 1998;77(1):114-122.
September 7, 1998... Kerkmanntucek, A.; Banat, G.A.; Cochlovius, B.; Zoller, M. "Antigen Loss Variants of a Murine Renal Cell Carcinoma: According to the authors' abstract of an article published in International Journal of Cancer, "Vaccination with tumour cells...

Cancer Vaccines "Antitumor Vaccine Effect of Irradiated Murine Neuroblastoma Cells Producing Interleukin-2 or Granulocyte Macrophage-Colony Stimulating Factor."
September 7, 1998... International Journal of Oncology, July 1998;13(1):73-78. Yoshida, H.; Enomoto, H.; Kawamura, K.; Takenaga, K.; Tanabe, M.; Ohnuma, N.; Sakiyama, S.; Tagawa, M. According to the authors' abstract of an article published in International...

Cancer Vaccines "Immunisation of Colorectal Cancer Patients with Autologous Tumour Cells."
September 7, 1998... Oncology Reports, July-August 1998;5(4):823-826. Diederichsen, A.C.P.; Stenholm, A.C.O.; Kronborg, O.; Fenger, C.; Jensenius, J.C.; Zeuthen, J.; Kristensen, T.; Christensen, P.B. According to the authors' abstract of an article published in...

HIV Vaccine "First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response." Journal of Infectious Diseases, July 1998;178(1):92-100.
September 7, 1998... Macgregor, R.R.; Boyer, J.D.; Ugen, K.E.; Lacy, K.E.; Gluckman, S.J.; Bagarazzi, M.L.; Chattergoon, M.A.; Baine, Y.; Higgins, T.J.; Ciccarelli, R.B.; Coney, L.R.; Ginsberg, R.S.; Weiner, D.B. According to the authors' abstract of an article...

HSV-2 "Cervical Antibody Responses to a Herpes Simplex Virus Type 2 Glycoprotein Subunit Vaccine." Journal of Infectious Diseases, July 1998;178(1):1-7.
September 7, 1998... Ashley, R.L.; Crisostomo, F.M.; Doss, M.; Sekulovich, R.E.; Burke, R.L.; Shaughnessy, M.; Corey, L.; Polissar, N.L.; Langenberg, A.G.M. According to the authors' abstract of an article published in Journal of Infectious Diseases, "Effective...

Influenza "Protective CD4(+) and CD8(+) T Cells Against Influenza Virus Induced by Vaccination with Nucleoprotein DNA." Journal of Virology, July 1998;72(7):5648-5653.
September 7, 1998... Ulmer, J.B.; Fu, T.M.; Deck, R.R.; Friedman, A.; Guan, L.M.; Dewitt, C.; Liu, X.; Wang, S.; Liu, M.A.; Donnelly, J.J.; Caulfield, M.J. According to the authors' abstract of an article published in Journal of Virology, "DNA vaccination is an...

Malaria (Vaccines) "Induction of Protective Immune Responses by Immunization with Linear Multiepitope Peptides Based on Conserved Sequences from Plasmodium falciparum Antigens."
September 7, 1998... Infection and Immunity, July 1998;66(7):3232-3241. Bharadwaj, A.; Sharma, P.; Joshi, S.K.; Singh, B.; Chauhan, V.S. According to the authors' abstract of an article published in Infection and Immunity, "A cysteine-containing peptide motif,...

Mucosal Immunization "Differential Kinetics and Distribution of Antibodies in Serum and Nasal and Vaginal Secretions after Nasal and Oral Vaccination of Humans."
September 7, 1998... Infection and Immunity, July 1998;66(7):3390-3396. Rudin, A.; Johansson, E.L.; Bergquist, C.; Holmgren, J. According to the authors' abstract of an article published in Infection and Immunity, "Although nasal vaccination has emerged as an...

Poliomyelitis "Antigenic and Molecular Characterization of Wild Type 1 Poliovirus Causing Outbreaks of Poliomyelitis in Albania and Neighboring Countries in 1996."
September 7, 1998... Journal of Clinical Microbiology, July 1998;36(7):1912-1918. Fiore, L.; Genovese, D.; Diamanti, E.; Catone, S.; Ridolfi, B.; Ibrahimi, B.; Konomi, R.; Vanderavoort, H.G.A.M.; Hovi, T.; Crainic, R.; Simeoni, P.; Amato, C. According to the...

Tuberculosis (Immunology) "Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein of Mycobacterium tuberculosis by Using Lipopeptides."
September 7, 1998... Infection and Immunity, July 1998;66(7):3190-3197. Dafonseca, D.P.A.J.; Joosten, D.; Vanderzee, R.; Jue, D.L.; Singh, M.; Vordermeier, H.M.; Snippe, H.; Verheul, A.F.M. According to the authors' abstract of an article published in Infection...

Cancer Vaccines "Antitumor Memory, or Vaccination, Using Staphylococcal Enterotoxin B and Bispecific Antibody is not Mediated by V(beta)8 Specific T Cells."
September 7, 1998... I.E. Gecim, E.J. McConnell, L.E. Porter and H. Nelson. Mayo Clinic, Rochester, Minnesota. According to an abstract submitted by the authors to the 97th General Meeting of the American Society for Microbiology, held May 4-8, 1997, in Miami...

Vaccine Delivery "Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains of Lactococcus lactis Coexpressing Antigen and Cytokine."
September 7, 1998... Infection and Immunity, July 1998;66(7):3183-3189. Steidler, L.; Robinson, K.; Chamberlain, L.; Schofield, K.M.; Remaut, E.; Lepage, R.W.F.; Wells, J.M. According to the authors' abstract of an article published in Infection and Immunity,...

Construction and Characterization of Recombinant BCG-Vectored Vaccine against HIV-1 Clade E Strain.
September 21, 1998... HIV Vaccines "Construction and Characterization of Recombinant BCG-Vectored Vaccine against HIV-1 Clade E Strain." K. Matsuo, H. Yoshizaki, K. Someya, S. Naganawa, H. Yoshikura, S. Yamazaki and M. Honda. AIDS Research Center, Tokyo, Japan....

"Ideal" TB Vaccine Needed to Halt Global Public Health Problem, Said Expert.
September 21, 1998... There is a critical need for a new, effective vaccine to fight tuberculosis, which causes more adult deaths worldwide than any other infectious disease, a TB specialist at the University of California San Francisco (UCSF) emphasized. ...

DNA Vaccination Affords Significant Protection Against Feline Immunodeficiency Virus Infection Without Inducing Detectable Antiviral Antibodies.
September 21, 1998... DNA Vaccines Hosie, M.J.; Flynn, J.N.; Rigby, M.A.; Cannon, C.; Dunsford, T.; Mackay, N.A.; Argyle, D.; Willett, B.J.; Miyazawa, T.; Onions, D.E.; Jarrett, O.; Neil, J.C. "DNA Vaccination Affords Significant Protection Against Feline...

Temporal Analyses of Virus Replication, Immune Responses, and Efficacy in Rhesus Macaques Immunized With a Live, Attenuated Simian Immunodeficiency Virus Vaccine.
September 21, 1998... HIV Vaccines Connor, R.I.; Montefiori, D.C.; Binley, J.M.; Moore, J.P.; Bonhoeffer, S.; Gettie, A.; Fenamore, E.A.; Sheridan, K.E.; Ho, D.D.; Dailey, P.J.; Marx, P.A. "Temporal Analyses of Virus Replication, Immune Responses, and Efficacy...

Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population.
September 21, 1998... Pertussis He, Q.S.; Viljanen, M.K.; Arvilommi, H.; Aittanen, B.; Mertsola, J. "Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population." JAMA - Journal of the American Medical Association,...

Efficacy of Hepatitis B Vaccines With and Without preS2-Region Product in Sumo Wrestlers in Japan.
September 21, 1998... HBV Vaccines Yamada, K.; Kotani, M.; Eguchi, T.; Kobayashi, M.; Yamazoe, K.; Yanagi, R.; Ishikawa, S.; Tsuda, F.; Okamoto, H. "Efficacy of Hepatitis B Vaccines With and Without preS2-Region Product in Sumo Wrestlers in Japan." Hepatology...

Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain.
September 21, 1998... HIV Vaccines Farzan, M.; Choe, H.; Desjardins, E.; Sun, Y.; Kuhn, J.; Cao, J.; Archambault, D.; Kolchinsky, P.; Koch, M.; Wyatt, R.; Sodroski, J. "Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by...

Recognition of Herpes Simplex Virus Type 2 Tegument Proteins by CD4 T Cells Infiltrating Human Genital Herpes Lesions.
September 21, 1998... Herpes Simplex Virus Koelle, D.M.; Frank, J.M.; Johnson, M.L.; Kwok, W.W. "Recognition of Herpes Simplex Virus Type 2 Tegument Proteins by CD4 T Cells Infiltrating Human Genital Herpes Lesions." Journal of Virology, September...

Induction of Neonatal TH1 and CTL Responses by Live Viral Vaccines: A Role for Replication Patterns Within Antigen Presenting Cells?.
September 21, 1998... Live Viral Vaccines Siegrist, C.A.; Saddallah, F.; Tougne, C.; Martinez, X.; Kovarik, J.; Lambert, P.H. "Induction of Neonatal TH1 and CTL Responses by Live Viral Vaccines: A Role for Replication Patterns Within Antigen Presenting Cells?."...

Sustained Cytokine Delivery for Anticancer Vaccination: Liposomes as Alternative for Gene-Transfected Tumor Cells.
September 21, 1998... Cancer Vaccines Koppenhagen, F.J.; Kupcu, Z.; Wallner, G.; Crommelin, D.J.A.; Wagner, E.; Storm, G.; Kircheis, R. "Sustained Cytokine Delivery for Anticancer Vaccination: Liposomes as Alternative for Gene-Transfected Tumor Cells." Clinical...

Ulcer Vaccine Succeeds in Monkeys.
September 21, 1998... Successful vaccination of monkeys against Helicobacter pylori suggests that a human ulcer vaccine may soon be available. The monkey data suggests that the vaccine not only protects against de novo H. pylori infection but could also...

Can HAART Return CD8(+) T-Cell Subsets to Normal?
September 21, 1998... Successful anti-HIV therapy slowly permits T-cell repertoires to normalize - but new perturbations can occur. One of the earliest immune dysfunctions in HIV disease occurs early after infection, when oligoclonal expansion of CD8(+) T-cells...

Early HAART May Prevent CTL Exhaustion.
September 21, 1998... Aggressive treatment soon after HIV infection appears to prevent one of the earliest HIV-associated immune defects. Hugo Soudeyns of Beaumont Hospital, Lausanne, Switzerland, and colleagues analyzed cytotoxic T-lymphocyte (CTL) subsets in...

Mary Lou Clements-Mann and Jonathan M. Mann.
September 21, 1998... Two of the world's great lights have gone out. The loss of Drs. Mary Lou Clements-Mann and Jonathan M. Mann in the crash of Swissair Flight 111 represents a terrible blow to the international AIDS effort. The two researchers followed...

Outbreaks, Vaccine Shortage Threaten Eradication.
September 21, 1998... Measles outbreaks in Argentina, Brazil, and Bolivia have caused more than 4,000 cases and threaten the progress achieved in eradicating measles from the Americas, unless immediate measures are taken to "catch up" on vaccination programs,...

Surface Compound May Serve as Vaccine Target.
September 21, 1998... Scientists at the University of California, Irvine, and the Forschungsinstitut Borstel in Germany have taken a significant step towards the development of a vaccine against Chlamydia pneumoniae by identifying a compound on the surface of the...

TB Group Calls for Vaccine Development Plan.
September 21, 1998... A tuberculosis coalition is calling on drug manufacturers, public health groups, and funding agencies to come up with a comprehensive plan aimed at developing new tuberculosis vaccines. The Advisory Council for the Elimination of...

CDC Calls for Development of New TB Vaccine.
September 21, 1998... The following is a statement from Helene Gayle, MD, MPH, director, National Center for HIV, STD, and TB Prevention, U.S. Centers for Disease Control and Prevention (CDC): In recommendations released August 20, 1998, the federal Advisory...