Vaccine Weekly articles from October 2004

Vaccine Weekly archives from October 2004

Gene-engineered T cells are superior adjuvant therapy for cancer.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Gene-engineered T cells are a superior adjuvant therapy for metastatic cancer. According to a study from Australia, "The major limiting factor in the successful application of adjuvant therapy for...

Strategies to improve dendritic cell cancer immunotherapy outlined.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers outline strategies to improve dendritic cell-based immunotherapy against cancer in a recent issue of the Yonsei Medical Journal. "Dendritic cells (DCs) play a pivotal role in T...

HPV type 16 L1 virus-like particle vaccine may prevent infection.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A human papillomavirus (HPV) type 16 L1 virus-like particle vaccine shows promise for protection against HPV16 infection. "A post hoc analysis was performed using combined data from two Phase I...

Messenger RNA-based vaccines reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists review messenger RNA-based vaccines in a recent issue of Expert Opinion on Biological Therapy. According to a study from Germany, "RNA is the only molecule known to recapitulate all...

Influenza virosomes are efficient for adjuvanted vaccine delivery.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Influenza virosomes as an efficient system for adjuvanted vaccine delivery. "Immunopotentiating reconstituted influenza virosomes possess several characteristics defining them as vaccine adjuvants....

Gag CTL-positive vaccinees recipients do not have anti-gag p17 response.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele did not exhibit immunodominant anti-gag p17 (SL9) responses. According to recent research published in the...

HIV vaccine combination safe and immunogenic in HIV-negative adults.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- An HIV subtype B and E prime-boost vaccine combination was safe and immunogenic in HIV-negative Thai adults. "ALVAC-HIV (vCP1521) and AIDSVAX B/E were evaluated in a phase 1/2 trial of human...

Heat shock protein mediates cross-presentation of exogenous HIV antigen.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Heat shock protein mediates cross-presentation of exogenous HIV antigen on HLA class I and class II. According to a study from the United States, "Strong CD4+ and CD8+ T cell responses are...

Immune responses to hemagglutinin/SHIV-like particle vaccine reported.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists report Th cell-independent immune responses to a chimeric hemagglutinin/simian human immunodeficiency virus-like particle vaccine. "CD4+ Th cells are believed to be essential for the...

Immunization with Listeria controls virus load after FIV challenge.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Oral immunization with recombinant Listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus. "Recombinant Listeria monocytogenes has many attractive...

Methods to monitor oligomeric state of HIV vaccine antigen evaluated.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have evaluated on-line high-performance size-exclusion chromatography, differential refractometry, and multi-angle laser light scattering analysis for the monitoring of the oligomeric state...

Papillomavirus-HIV-1 gp41 virus-like particles induce HIV antibodies.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Oral immunization with bovine papillomavirus-HIV-1 gp41 chimeric virus-like particles induced mucosal and systemic neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1). ...

Plasmacytoid dendritic cell activation augments SIV-specific T cells.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques augments the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T...

Recruiting London gay men into HIV vaccine trial is feasible.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Recruiting London gay men into an HIV vaccine trial is feasible. "This paper describes a study among HIV-negative gay men in London to examine willingness to volunteer for an HIV vaccine trial....

Screening for HIV-specific T-cell responses recommended.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers recommend screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes. "The IFN-gamma enzyme-linked immunospot (ELISpot) assay is often used...

DNA vaccine reverses allergic airway inflammation and eosinophilia.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic inflammation and...

Animal models are guiding development of new immunotherapies for cancer.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Animal models are guiding the development of new immunotherapies for cancer. According to recent research published in the Journal of Leukocyte Biology, "Immunotherapy using adoptive cell transfer...

In vitro-based potency assay for anthrax vaccine developed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have developed an in vitro-based potency assay for anthrax vaccines. According to recent research published in the journal Vaccine, "The potency assay currently used to evaluate...

Anti-atherosclerosis polypeptide vaccine expressed in E. coli.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have expressed an anti-atherosclerosis polypeptide vaccine in Escherichia coli. According to recent research from China, "A chimeric polypeptide of TTP-CETPC was successfully expressed...

Thailand decides not to allow vaccine use in poultry.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Thai officials, faced with a second outbreak of bird flu, said the country's poultry would not be inoculated against the disease because vaccines offer no guarantee of safety. A panel from the...

Heat-shock proteins and host-pathogen interactions reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists review heat-shock proteins and the host-pathogen interaction during bacterial infection in a recent issue of Current Opinion in Immunology. "Heat-shock proteins (HSPs) are expressed at...

Profile of continuous antigenic regions of botulinum H-chain reported.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers present the full profile of the continuous antigenic regions of the H-chain of botulinum neurotoxin A in a recent issue of the Protein Journal. According to recent research from the...

Biologic therapy for brain cancers reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A reseracher reviews biologic therapy for brain cancers in a recent issue of the Yonsei Medical Journal. According to a study from the United States, "The overall goal of our research projects is...

Mammaglobin-A vaccine has therapeutic potential.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A mammaglobin-A vaccine has potential as a treatment for certain breast cancers, results from a study in mice suggest. The breast cancer-associated antigen mammaglobin-A has been found in 80% of...

VScan exposure increases in the Caribbean.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Medical Services International Inc. (MSITF) has begun to increase the VScan exposure in the Caribbean as a result of its early success there. The company is participating in additional regulatory...

Antibodies in tumor immunotherapy reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review antibodies in tumor immunotherapy in a recent issue of Expert Opinion on Biological Therapy. "The role of antibodies as therapeutic cancer vaccines includes two distinct...

Dendritic cell-based immunotherapy for cancer reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review dendritic cell-based immunotherapy for cancer in a recent issue of Transfusion Medicine Reviews. According to recent research from the United States, "The encouraging results...

Heat shock proteins reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review heat shock proteins in a recent issue of Immunology Letters. "The contribution of major histocompatibility complex (MHC) I and II to the adaptive immune response has been well...

Ubiquitin-fusion degradation pathway plays key role in DNA vaccination.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent...

Yeast-based immunotherapy causes mutation-selective tumor remission.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Ras-targeted, whole yeast-based immunotherapy resulted in mutation-selective tumor remission. "Activating mutations in Ras oncoproteins represent attractive targets for cancer immunotherapy, but...

Rashes from Oka vaccine are derived from single clones of virus.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of the virus. According to recent research published in the Journal of Infectious...

Efficacy of dendritic cell-induced tolerance dependent on delivery path.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The efficacy of peripheral tolerance induced by dendritic cells is dependent on the route of delivery. "Previous studies have demonstrated that the route of delivery of dendritic cells (DC) is an...

Recommendations to optimize detection of host antibodies presented.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers provide recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products. "Most biopharmaceutical therapeutics...

Microparticle encephalitis vaccine elicits mixed immmune response.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- A cationic microparticle-adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein is immunogenic in mice. "Previously, we described a plasmid pMEa, synthesizing the anchored form...

Chemokine receptor plays key role in pathogenesis of encephalomyelitis.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The CXC chemokine ligand 16/scavenger receptor that binds phosphatidylserine and oxidized lipoprotein plays a critical role in the pathogenesis of both acute and adoptive transfer experimental...

Healthcare corporation issues third quarter update.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Priority Healthcare Corporation (Nasdaq: PHCC) announced that it is adjusting its sales guidance for the third quarter ending on October 2, 2004, due to the delays in shipment and the release of...

Centrally injected GLP-1 prevents some types of gastric mucosal damage.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Centrally injected GLP-1 prevents some types of gastric mucosal damage. According to a study from Turkey, "Glucagon-like peptide-1 (GLP-1) is accepted to be a peptide involved in the central...

Dendritic cell maturation drives Th1 polarization.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Dendritic cell maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in the digestive tract, drives Th1 polarization. "Ginseng is a medicinal herb widely used in...

Biopharm company announces start of clinical trial for HIV therapy.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR), a biopharmaceutical company, announced the first patients have been enrolled at the Canadian site in its initial clinical trial investigating IR103, the company's...

WHO evaluates progress in providing AIDS drugs to victims in developing world.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- With AIDS making disastrous new inroads in the Asian-Pacific region, World Health Organization (WHO) experts are evaluating progress toward providing anti- AIDS drugs to three million people in...

High-risk groups for hepatitis B need higher vaccine rates in France.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Greater vaccination coverage of groups at high risk of hepatitis B is needed in France to eradicate hepatitis B transmission. According to recent research from France, "Both HBV plasma derived...

MAdCAM-1-expressing sacral lymph nodes provide site for immunity.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The MAdCAM-1-expressing sacral lymph nodes in lymphotoxin beta-deficient mice provide a site for immune generation following vaginal herpes simplex virus-2 infection. According to a study from the...

Hookworm aspartic proteases reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists review hookworm aspartic proteases in a recent issue of Medycyna Weterynaryjna. According to published research from Poland, "Hookworms are blood-feeding nematodes inhabiting the guts of...

HIV-1 nef down-regulates antigen-presenting molecules.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells. According to published research from Japan, "The...

HPV 16 L2E6E7 booster vaccine elicits immune response.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- An HPV 16 L2E6E7 booster vaccine elicited an immune response in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). "Heterologous...

Domestic violence threatens health of children with lower immunization rates.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Domestic violence has an obvious impact on the health and well being of the women being abused, but a new report also highlights important intergenerational effects of such violence: the children of...

Parental vaccination beliefs in inner-city population described.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Investigators describe parental beliefs about vaccination among an ethnically diverse inner-city population in a recent issue of the Journal of the National Medical Association. "To characterize...

Biotechnology company begins shipping influenza vaccine to Canadian customers.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- ID Biomedical Corporation (IDBE) has begun shipping its influenza vaccine, Fluviral S/F, to customers across Canada after receiving the required regulatory clearance from Health Canada. This...

Flu is sending more and more to hospital.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The number of people hospitalized in the United States because of the flu has climbed substantially over the past 2 decades to an average of more than 200,000 a year, in large part because of the aging...

New assay for antigenic characterization influenza B virus developed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have developed a new microneutralization assay for the antigenic characterization of influenza B virus. According to a study from Italy, "Although the hemagglutination inhibition assay...

Influenza and pneumococcal vaccination lower mortality in elderly.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Influenza and pneumococcal vaccinations lower the mortality of the elderly in Taiwan. According to a study from Taiwan, "In 1998, Taiwan became the first country in Asia to provide free influenza...

Roles of IgA and IgG in influenza control in respiratory tract studied.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the roles of IgA and IgG in the control of influenza viral infection in the murine respiratory tract. According to published research from the United States, "The...

DNA-Salmonella vaccine protects against Leishmania major.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination enhances protection against Leishmania major infection in mice. "Successful resolution of infections by intracellular...

Subdomain of Plasmodium apical membrane antigen 1 ectodomain produced.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have produced the subdomains of the Plasmodium falciparum apical membrane antigen 1 ectodomain. "The apical membrane antigen 1 of Plasmodium falciparum is one of the leading candidate...

"Intelligent" box can keep temperature stable for vaccine transport.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Vaccination supplies can be rendered useless if their temperature rises above the permitted maximum. MEDICASE has developed an intelligent transit box that ensures tight temperature control and that has...

Five dose levels of monoclonal antibody melanoma vaccine compared.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers report the results of a phase II trial comparing five dose levels of BEC2 anti-idiotypic monoclonal antibody vaccine that mimics GD3 ganglioside in a recent issue of the journal Vaccine. ...

GD3-L-KLH vaccine elicits antibody response in melanoma patients.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside elicited an antibody response that did not correlate with...

Role of CD8+ T-cell immunity in progression of melanoma reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers review the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients in a recent issue of Clinical Cancer Research. According to...

U.S. Centers for Disease Control lift limits on childhood meningitis vaccine.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Replenished supplies of a childhood meningitis vaccine has prompted health officials September 16, 2004, to lift a previous recommendation that doctors postpone some of the shots. All four shots of...

Meningococcal conjugate vaccine reduces mortality in Scotland.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The meningococcal serogroup C conjugate vaccine has reduced mortality in Scotland. According to recent research from Scotland, "The increasing number of cases of serogroup C meningococcal disease in...

Pharma company completes sale of vaccines business to ID Biomedical.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Shire Pharmaceuticals Group plc (Shire) (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) and ID Biomedical Corporation (ID Biomedical) (TSX: IDB; NASDAQ: IDBE) announced that they have closed the sale of Shire's...

Peptide-derivatized shell-cross-linked nanoparticles evaluated.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have completed a biocompatibility evaluation of peptide-derivatized shell-cross-linked nanoparticles. "The conjugation of the protein transduction domain (PTD) from the HIV-1 Tat protein...

RelB mediates TNF-induced up-regulation of polymeric Ig receptor.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. "Secretory antibodies, which operate in a principally noninflammatory fashion, constitute the first...

Transgenic tolerized T cells cannot aid B cells upon mucosal challenge.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Transgenic tolerized T cells are unable to help B cells upon mucosal challenge. "The oral delivery of soluble antigens induces unresponsiveness to systemic challenge that can be demonstrated as a...

Vaccine may be associated with increased risk of MS.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The popular hypothesis that the hepatitis B vaccine is associated with an increased risk of multiple sclerosis has been scientifically corroborated through a prospective study of patients in the United...

Vaccine failure contributes to mumps outbreak in vaccinated children.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Vaccine failure contributed to an outbreak of mumps in a vaccinated child population. According to recent research published in the journal Vaccine, "In Belgium, children are immunized against...

Genetics of variations of Yersinia pestis biovars presented.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers report the genetics of metabolic variations between Yersinia pestis biovars and propose a new biovar, microtus. "Yersinia pestis has been historically divided into three biovars:...

Anti-polysaccharide IgG linked to pneumococcal disease risk in HIV-1.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Anti-polysaccharide IgG antibodies are associated with the risk of invasive pneumococcal disease in Ugandan adults infected with HIV-1. According to a study from Malawi, "We have investigated the...

4-1BB and OX40 stimulation enhance T-cell responses to poxvirus vaccine.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. "4-1BB (CD137) is a tumor necrosis factor receptor (TNFR) family member, expressed primarily...

Companies announce revision of licensing agreement for cancer cell line vaccines.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR), a biopharmaceutical company, and NovaRx Corporation, a privately held cancer-focused company, have signed a licensing agreement to transfer all of The Immune...

Novel route to an anti-ricin vaccine reported.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Insertional mutagenesis of ricin A chain leads to a novel route toward an anti-ricin vaccine. According to recent research from England, "The insertion of a specific 25-residue internal peptide...

NIH awards grant to develop new antibodies targeting SARS.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Diversa Corp. (DVSA) announced that the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has awarded the company a grant for the discovery...

Phase I human clinical testing of SARS vaccine update offered.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Sinovac Biotech Ltd. (Sinovac) (OTCBB:SNVBF) announced that all 36 subjects of the phase I human clinical trial for its inactivated SARS vaccine have now been vaccinated with two doses of either SARS...

Glycan arrays lead to discovery of autoimmunogenic activity of SARS-CoV.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV. "Using carbohydrate microarrays, we characterized the carbohydrate binding activity of SARS-CoV neutralizing antibodies...

Severe acute respiratory syndrome in China reviewed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists review severe acute respiratory syndrome in China in a recent issue of the British Dental Journal. "The health profession faces a new challenge with the emergence of a novel viral...

Phosphoprotein binding site on Sendai virus protein mapped.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have mapped the phosphoprotein binding site on Sendai virus NP protein assembled into nucleocapsids. According to a study from the United States, "To catalyze RNA synthesis, the Sendai...

Novel immunogenic proteins of Shigella flexneri identified.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have identified novel immunogenic proteins of Shigella flexneri 2a using proteomic methodologies. "Shigella species are one of the most important etiological factors for people who are...

FDA clears IND for an attenuated smallpox vaccine candidate.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc., (VXGN.PK) announced that the U.S. Food and Drug Administration (FDA) has cleared an investigational new drug (IND) application for the company's candidate smallpox vaccine, LC16m8. ...

Agent-based analysis of smallpox preparedness performed.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have performed an agent-based analysis of smallpox preparedness and response policy. According to recent research published in the JASSS - the Journal of Artificial Societies and Social...

Major EU project shows "killer bacteria" more common than expected.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Severe infections with Group A streptococci, sometimes called "flesh-eating killer bacteria," are considerably more common than expected in many countries. In an EU project covering 11 countries,...

Cholera toxin-pneumococcal surface adhesin fusion protein characterized.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a cholera toxin B-pneumococcal surface adhesin A fusion protein expressed in Escherichia coli. "Cholera toxin B subunit (CTB) is responsible for CT holotoxin binding...

Group A streptococcal pharyngitis serotype surveillance reported.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have characterized the heterogeneity of pharyngeal group A streptococcal (GAS) genotypes in a recent issue of Clinical Infectious Diseases. According to published research from the...

Influenza vaccine protects against lethal Streptococcus superinfection.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection. "Intranasal infection with non-lethal influenza A virus (IAV)...

GRA4 or ROP2 protein partially protects against toxoplasmosis.
October 6, 2004... 2004 OCT 6 - (NewsRx.com & NewsRx.net) -- Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis. "The efficacy of vaccination with Toxoplasma gondii...