Vaccine Weekly articles from October 2000

Vaccine Weekly archives from October 2000

Clinical Trial Data for Staph. aureus Vaccine Presented.(Staph VAX)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Nabi announced preliminary results from the Phase III clinical trial for StaphVAX(TM) (Staphylococcus aureus conjugate vaccine) at the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy...

HPV16 Capsid Protein DNA Vaccine Induces Mucosal Immunity.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Researchers in Poland and the United States collaborated on the development of a DNA-adenoviral recombinant vaccine regimen for the prevention of human papillomavirus (HPV) infection. "Infection by certain...

Glycoconjugate Vaccine Formulation Enhances Immunogenicity of Tumor-Associated Antigen.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- According to a study from Italy, a new glycoconjugate vaccine formulation enhances the immunogenicity of the tumor-associated antigen CaMBr1. "Aberrant glycosylation is one of the most constant traits of...

Monoclonal Antibodies Bind Primary Isolate Virions.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Monoclonal antibodies that bind and neutralize primary isolate virions may help researchers find new targets for HIV vaccines. "Development of a broadly effective HIV-1 vaccine has been severely limited...

CDC Releases U.S. Vaccine Coverage Statistics.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- According to a report in the September 22, 2000, Morbidity and Mortality Weekly Report, immunization coverage in the U.S. was greater than or equal to 90% for three doses of poliovirus vaccine, three doses of...

Protective Immunity Induced by Engineered Avirulent Virus.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Researchers in Japan have developed an avirulent virus that successfully induced protective immunity against simian immunodeficiency virus infection in a monkey model. "In AIDS vaccine strategies, live...

Aluminium Hydroxide Up-Regulates Human Monocytes.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Aluminium hydroxide, a common vaccine adjuvant, up-regulates human monocytes by activating Th2 cells to release interleukin (IL-4), researchers in Sweden report. "Aluminium adjuvants are widely used in...

Remune Addition Announced to Treat Primary HIV Infection.(Immune Response Corp.)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The Immune Response Corp. (IMNR), Carlsbad, California, announced that Remune (HIV-1 Immunogen), an investigational therapeutic vaccine for the treatment of HIV infection, will be tested as part of a clinical...

Global Vaccine Fund To Assist 13 Developing Countries.(Global Fund for Children's Vaccines)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The Global Fund for Children's Vaccines will give more than US$150 million worth of vaccines and funding over five years to improve immunization programs in Africa, Asia, and Latin America. Thirteen...

HIV and Herpesvirus Vaccines Based on Cloning Viral Envelope Proteins.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The same principle used to develop the first successful herpes vaccine was also used to develop a preventive HIV/AIDS vaccine currently in the final stage of clinical testing. Both vaccines were produced...

WHO Issues Statement on Hypothesis that Experimental Polio Vaccine Was Origin of HIV.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The following was released by the World Health Organization on September 12, 2000: [helv] Since the beginning of the AIDS epidemic, there has been much speculation in both the scientific literature and in...

DNA-Based Vaccines Reduce Risk of Hypersensitivity in Mice.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- DNA-based vaccines reduced anaphylactic reactions in hypersensitive mice in a study from the United States. "Anaphylactic hypersensitivity is the most serious clinical concern facing allergists," stated...

Suicide Gene Therapy/Cytokine Vaccine Effective Against Brain Tumors.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Brain tumors appear to be sensitive to suicide gene therapy approaches. "The aim of our experiments is to develop new therapeutical approaches for the treatment of brain tumors," stated Drs. Szilvia...

AIDSVAX B/E Reported Safe and Highly Immunogenic in Volunteers.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The bivalent B/E rgp120 HIV vaccine (AIDSVAX B/E) was observed to be safe and highly immunogenic in volunteers, researchers from Thailand and the United States reported. The researchers assessed "safety...

First MVA Vaccine Cleared for Human Testing.(modified vaccinia Ankara-strain)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- An AIDS vaccine candidate designed specifically for Africa and manufactured in Germany has been approved for human testing. Wayne Koff, PhD, International AIDS Vaccine Initiative (IAVI), announced that the...

Immunotherapy Evaluated in SIV Infected Rhesus Macaque Model.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Th1 profiles impact viral replication in DNA vaccinated, simian immunodeficiency virus (SIV) infected Rhesus macaque monkeys, researchers in the United States reported. "A focus of antiretroviral therapy...

Scientists Reveal Possible New Target.(killer T-cell immune response)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Scientists have shown for the first time, using a non-human primate model, that HIV avoids the body's strongest immune responses during the first few weeks of infection. The finding, which appeared in the...

BioHep B Vaccine Raises Sufficient Immune Response in Infants and Children.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Scientific collaborators at two research institutions recently reported their results of the use of BioHep B vaccine on newborns and children at an immunology conference that was held in Poznan, Poland. ...

States Ready for Flu Vaccine Delay.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Health departments across the western U.S. say they will limit flu shots to high-risk people and take other steps to cope with an expected shortage of the vaccine this winter. The U.S. Centers for Disease...

New Research Facility Dedicated in Mali, West Africa.(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- A new malaria laboratory facility was recently dedicated at the University of Mali in Bamako, Mali, West Africa, to promote malaria research, especially the development of effective malaria vaccines. ...

Tiny Microchips Have Big Promise in Fighting Disease.(biological microelectromechanical devices)(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- Treatment for life-threatening diseases and relief from disease-related pain may one day be supplied by microscopic chips that could be implanted in the body, according to researchers from Ohio State...

United Nations Agency Campaign "Resounding Success".(Brief Article)
October 4, 2000... 2000 OCT 4 - (NewsRx.com) -- The U.N. health agency declared victory in the first phase of its anti-yellow fever campaign in Liberia. "The vaccination campaign is ending in Grand Cape Mount County and has been a resounding success,"...

Dendritic Cell Vaccine Stimulates Anti-Leukemic T-Cell Responses.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Researchers in Russia and the United Kingdom reported that in vitro modified leukemic cells can be used to induce tumor-specific anti-leukemic immune responses. "Dendritic cell (DC)-based vaccines which...

Vaccine is Cost-Effective in High Risk Populations.(Lyme disease)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Lyme disease (LD) vaccine is cost-effective only in high risk populations, suggest researchers in the United States. "LD is the most frequently reported tick-borne disease in the United States with an...

Vaccine is Cost-Effective in Populations at High Risk for Fungal Infection.(Coccidioides immitis vaccine)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- In highly endemic regions of the U.S., vaccination to protect against Coccidioides immitis is cost-effective, say researchers. "C. immitis is a soil-dwelling fungus that infects humans via inhalation,"...

New Direct Assay Evaluates Tumor Peptide Vaccine Response.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- A direct assay for determining immune reactivity of a cancer vaccine in melanoma patients has been developed. "Monitoring the immune response to epitope-specific vaccination in cancer patients is...

Heptavalent Pneumococcal Conjugate Vaccine Evaluated in Children.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Kaiser Permanente, California, researchers report that the Wyeth Lederle heptavalent CRM197 PCV vaccine is safe and efficacious in children. Their study aimed "to determine the efficacy, safety, and...

Vaccine Against Otitis Media and Pneumonia Found Cost-Effective in a Subset of Children.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Vaccinating children two to five years of age against pneumococcal otitis media and pneumonia appears to be a cost-effective strategy. D. Weycker and colleagues at Policy Analysts, Inc., Massachusetts,...

Conjugate Vaccines May Be More Effective than Polysaccharide Vaccines in HIV Patients.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Depending on HIV serotype, a 7-valent pneumococcal conjugate vaccine was more protective than a 23-valent polysaccharide vaccine in HIV infected adults, researchers in the United States found. "HIV...

Orphan Drug Status Awarded for O-Vax Vaccine.(Avax Technologies Inc.)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Avax Technologies, Inc. (AVXT), Kansas City, Missouri, announced that its investigational, proprietary Autologous Cell Vaccine technology (AC Vaccine) for the treatment of ovarian cancer as an adjuvant...

Therapeutic Vaccine Selected for Human Testing.(prostrate-specific membrane antigen vaccine)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Progenics Pharmaceuticals, Inc. (PGNX), Lake Tahoe, Nevada, and Cytogen Corp. (CYTO) announced a vaccine candidate that the companies will develop for the treatment of prostate cancer. The vaccine is...

Air Force Pilot Discharged for Refusing Vaccination.(Jamie C. Martin given honorable discharge for refusal to finish anthrax vaccine series)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Another active duty pilot at Dover Air Force Base in Delaware has been discharged for disobeying an order to receive an anthrax vaccination, a newspaper reported on September 26, 2000. Former 1st Lt....

HIV-1 Immunogen Stimulates HIV Specific Responses.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Treatment with an HIV-1 immunogen resulted in cell-mediated immune responses in HIV infected patients. "We hypothesized that an HIV-1 immunogen (whole-killed gp120-depleted HIV-1 in IFA, Remune), which...

Vaccine to Protect Against Two Cancer-Causing Strains of HPV Under Study.(human papillomavirus)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- A vaccine against two strains of human papillomavirus (HPV) most associated with cervical cancer is under study at the Medical College of Georgia, Augusta. Infection with the easily transmittable HPV is...

Imiquimod and R-848 are Potent Activators of B Lymphocytes.(immune response modifiers)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Corporate researchers have found that the immune response modifiers imiquimod and R-848 activated B lymphocytes. "Imiquimod and R-848 are members of a family of immune response modifiers that stimulate...

Growth Factor No Enhancer of Hepatitis B Vaccine Efficacy in Renal Patients.(granulocyte macrophage-colony stimulating growth factor)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Granulocyte macrophage-colony stimulating factor does not increase the effectiveness of hepatitis B vaccinations in individuals who must undergo hemodialysis, scientists at the University of Rochester Medical...

Public Health Genetics Crucial to Treatment, Expert Says.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- New discoveries in what is being called "Public Health Genetics" will be crucial in harnessing genetics technologies to track emerging infectious diseases and improve their diagnosis, treatment and...

Cost-Benefit of Flu Shots for Healthy Working Adults Questioned.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Giving influenza shots to healthy working adults who are less than 65 years of age can reduce rates of illness and work absenteeism, but may not be cost-beneficial overall, according to a new study published...

Experts Decide Content of 2001 "Southern Hemisphere" Vaccine.(southern hemisphere influenza season vaccine)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- The composition of the vaccine for year 2001 (southern hemisphere influenza season) has been decided and communicated to vaccine manufacturers by the World Health Organization (WHO), following agreement on...

Organizations Encourage Respiratory Disease Patients to Receive Flu Shot.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Although the flu season is still a few months away, four professional organizations are reminding the 17 million asthmatics in the U.S. that now is the time to protect against the influenza virus. The...

Biological License Application to be Filed for Stage II Melanoma Vaccine.(Corixa Corp. seeks to have approval of its Melacine melanoma vaccine)(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Corixa Corporation (CRXA), a research and development-based biotechnology company, announced its intent to file for regulatory approval of its Melacine(R) melanoma vaccine. The biological license...

Phase I/II Clinical Trial Initiated for Gene Therapy Vaccine.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- Genzyme Molecular Oncology (GZMO), Framingham, Massachusetts, announced that it has initiated a Phase I/II clinical trial to assess the safety, immunogenic efficacy, and potency of a gene therapy cancer...

Infants Immunized Against Hepatitis B at Birth Receive Most Vaccine Doses.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- U.S. government researchers at the U.S. Centers for Disease Control and Prevention report that infants who receive their first dose of hepatitis B vaccine shortly after being born are more likely to receive...

Phase I Trial of High-Dose Therapy with Y-90-Labeled Monoclonal Antibody Initiated.(Brief Article)
October 18, 2000... 2000 OCT 18 - (NewsRx.com) -- More work is needed before (90)yttrium (Y-90)-labeled monoclonal antibody (MAb) CC49 will be an effective anticancer agent, say University of California, San Francisco, cancer researchers. "A Phase I...