Vaccine Weekly articles from May 2004

Vaccine Weekly archives from May 2004

DNA vaccines encoding ras epitopes and B7.1 reduced tumor burden in rats.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- DNA vaccines encoding mutated ras epitopes and the costimulatory molecule B7.1 reduced adenocarcinoma tumor burden in rats. "1-Methyl-1-nitrosourea (MNU), a well characterized carcinogen, was used...

Dendritic cell subsets induce antigen-specific cytotoxic T cell responses.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses. "Human dendritic cells (DCs) generated in...

DNA vaccine expressing L1 protein protects against papillomavirus challenge.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A single vaccination with a vesicular stomatitis virus vector expressing high levels of L1 protein provided complete protection from papillomavirus challenge. "We generated an attenuated,...

Modified RESA protein peptide 6671 induces protection against malaria.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Modifying RESA protein peptide 6671 to fit into HLA-DRbeta[subscript]1 pockets induces protection against malaria. According to a study from Colombia, "6671 is a non-immunogenic, conserved high...

Immunoreactivity in P. gingivalis recognized by human serum.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Localizing antibody-defined immunoreactivity in Porphyromonas gingivalis HtpG is recognized by human serum utilizing selective protein expression. "Earlier studies suggested that specific...

Attenuated SIV vaccine provides early protection against viral infection.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Vaccination with attenuated simian immunodeficiency virus provided early protection against pathogenic viral infection at a mucosal challenge site. "Atraumatic application of attenuated...

Epitope mimic for human HIV-neutralizing antibody 2G12 synthesized.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have synthesized a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12. According to published research from the United States, "The...

HIV synthetic peptide-cocktail prevents SHIV transmission.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- An HIV synthetic peptide-cocktail prevented SHIV transmission in rhesus macaques. "An effective vaccine against human immunodeficiency virus (HIV) should not only protect from infection and...

Low-dose mucosal SIV challenge has same kinetics as high-dose challenge.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Repeated low-dose mucosal simian immunodeficiency virus SIVmac239 challenge results in the same viral and immunological kinetics as high-dose challenge. According to published research from the...

Nasal vaccine controls SHIV viremia and disease progression in primates.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination controlled simian/human immunodeficiency virus viremia and disease progression in nonhuman primates. According to recent research...

Current concepts and future prospects for Alzheimer disease vaccines.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers review current concepts and future prospects for Alzheimer disease vaccines in a recent issue of the journal Alzheimer Disease and Associated Disorders. "Alzheimer disease (AD) is the...

EGCG inhibits radiation-induced apoptosis by inactivating capase pathway.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Polyphenol EGCG inhibits radiation-induced apoptosis by inactivating the capase pathway in HaCaT cells. "Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a...

Pasteurella multocida contains multiple hemoglobin-binding proteins.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Pasteurella multocida contains multiple immunogenic hemin- and hemoglobin-binding proteins. According to a study from Spain, "Iron-dependent outer membrane proteins (IROMPs) play an important role...

Company reports advancements in several pipeline programs at AACR meeting.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- ImClone Systems Inc. (IMCL) presented preclinical data highlighting progress made in the development of several pipeline programs at the 95th annual meeting of the American Association for Cancer...

Phase I healthy volunteer trial of HYB2055 completed.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) has completed a phase I trial of HYB2055 in healthy volunteer subjects. In this trial, this drug candidate was safe and biologically active. HYB2055 is a second-generation...

Dendritic cell tumoristatic and tumoricidal activities are distinct.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells. According to recent research from Belgium, "Monocyte-derived dendritic cells (DC)...

P-glycoprotein-derived peptides inhibited multidrug resistance of tumors.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Immunization with synthetic P-glycoprotein-derived peptides inhibited multidrug resistance of tumors. "Overexpression of the membrane glycoprotein (P170) represents the most common multidrug...

RNA-transfected cells induce responses against viral and tumor antigens.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets. "Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms...

gONC increases conformational stability and toxicity for cancer cells.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. "Onconase (ONC) is currently in Phase III clinical trials as a cancer chemotherapeutic agent. Despite...

6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell carcinoma.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- 6-Nitro-7-hdroxycoumarin may be a novel therapeutic agent for renal cell carcinoma. "Previously, 7-hydroxycoumarin (7-OHC) and 6-nitro-7-hydroxycoumarin (6-NO2-7-OHC) have been shown to be potent...

Optimizing antibacterial therapy for respiratory infections described.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers outline the optimization of antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance. "The spread of antibacterial...

Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Polymorphic variation in thyroglobulin increases risk for non-medullary thyroid cancer. "Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation...

Epitope from Epstein-Barr virus protein elicits sustained immune response.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A novel immunodominant HLA-B*0702-associated epitope derived from an Epstein-Barr virus helicase-primase-associated protein elicited a sustained CD8+ T-cell immune response. "Generation of a...

BMP-2 modulates proliferation and differentiation of gastric cancer cells.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- BMP-2 modulates the proliferation and differentiation of gastric cancer cells. "Bone morphogenetic protein 2 (BMP-2), a member of the transforming growth factor beta super-family, has been shown to...

Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis. "Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxta-membrane...

P73 A4T14 genotype associated with cervical cancer risk.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- P73 A4T14 genotype is associated with risk of cervical cancer. A "possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms" was examined in an...

Surfactant protein D in the female genital tract described.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The action of surfactant protein D in the female genital tract is described in a recent issue of Molecular Human Reproduction. According to recent research from Denmark, "Surfactant protein D...

Analysis of Haemophilus influenzae infections after vaccination reported.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists report results of an analysis of invasive Haemophilus influenzae infections after extensive vaccination against H. influenzae type b in a recent issue of the Journal of Clinical Microbiology....

Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Eurya emarginata extracts inhibit leukemia cell growth via induction of apoptosis. The "inhibitory effect of Eurya emarginata extracts on the growth of cancer cells" was examined. "The ethylacetate...

Novel CD4+ T-helper lymphocyte epitope identified in hepatitis A virus.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have identified a novel CD4+ T-helper lymphocyte epitope in the VP3 protein of the hepatitis A virus. According to a study from Spain, "Prediction analysis of Th-cell epitopes in the...

Hepatitis B vaccine decreases hepatitis B incidence in cohort of drug users.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The incidence of hepatitis B infection has progressively decreased in a cohort of drug users followed over a period of 15 years due to anti-HBV vaccination. According to recent research from Italy,...

Functional hepatitis C virus envelope glycoproteins characterized.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have characterized functional hepatitis C virus envelope glycoproteins. According to published research from France and the United States, "Hepatitis C virus (HCV) encodes two envelope...

Protein from Ancylostoma ceylanicum shows promise as hookworm vaccine.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Recombinant Ancylostoma-secreted protein (ASP)-2 from Ancylostoma ceylanicum shows promise as a hookworm vaccine. According to recent research published in the Journal of Infectious Diseases,...

Characteristics of children who leave WIC program identified.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have identified the characteristics of children who drop out of the Women, Infants, and Children (WIC) program. According to published research from the United States, "Maintaining...

Concomitant helper response promotes action of CD8+ memory cytotoxic T cells.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivo. "This report seeks a means of maximizing memory CD8 T cell responses to peptide...

CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro. According to a study from Germany, "two distinct types of CpG oligodeoxynucleotide (ODN) have been identified that differ...

Researchers describe how cancer neutralizes T cell attack.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- It has long been recognized that the immune system is able to recognize and destroy cancer cells, but although the immunological battle might slow the progression or spread of cancer, it's usually the...

Generex reports advance in cancer immunotherapy.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced its recent report at the American Association for Cancer Research in Orlando, Florida, on a novel approach to cancer vaccination developed by scientists and...

CDC: Flu season fairly typical, despite severe start in the West.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The flu season turned out to be fairly typical, despite an alarmingly severe start that killed dozens of children and flooded emergency rooms with sick kids, primarily in the West, the U.S. government...

Lung doctors most likely to have flu vaccine on hand.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Pulmonary specialists are more likely than cardiologists or endocrinologists to make the flu vaccine available to their patients in their offices, according to a new study. Yearly flu vaccinations...

Time with patients, staff support boost flu shot rates.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Even when doctors have standing orders to give flu shots to older patients, they don't do it often enough because of lack of time or adequate staff support, a recent study has found. The...

Flu shot makers say orders for next season filling up fast.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Overwhelming demand for flu shots last season is causing this year's vaccine orders to fill up fast. So much so that there might not be as many extra doses left for sale during the upcoming season. ...

CDC says flu shots will be stockpiled for first time.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- For the first time, the government will stockpile flu shots and will target them toward children to avoid the vaccine shortages that caught health officials off-guard this past winter. "We really...

Elderly patients demonstrate blunted response to influenza vaccination.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Elderly patients demonstrate a blunted response to influenza vaccination. According to recent research from the United States, "The objective of this study was to analyze the changes in the type 1 T...

Neuraminidase-deficient influenza virus is potential vaccine vector.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a neuraminidase-deficient influenza A virus that is a potential gene delivery vector and a live vaccine. "We recently identified a packaging signal in the...

Leishmaniasis vaccine protects susceptible mice from virulent challenge.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response. According to published research from the...

ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9 fusion gene.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- ATRA and TSA are therapeutically useful in patients with acute leukemia displaying the MLL-AF9 fusion gene. In acute "leukemia patients with MLL (mixed linage leukemia), rearrangements tend to...

Americas see virtual elimination of measles.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Enormous progress has been made toward eliminating endemic measles transmission in the Region of the Americas, according to the U.S. Centers for Disease Control and Prevention. The Morbidity and...

New meningitis threat being contained by web of partnerships.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A rare strain of meningitis, which re-emerged recently in Burkina Faso, would have left health authorities helpless just 2 years ago. Now, thanks to 2 years of work orchestrated by the World Health...

Formulation reduces immunostimulatory meningococcal vaccine components.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A LTK63 mucosal adjuvant and the trimethyl chitosan delivery system allow the reduction of components that induce antibody responses to the CRM-MenC conjugate vaccine. "Previous work had shown that...

Nasal Flt3 ligand cDNA elicits dendritic cells for enhanced mucosal immunity.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity. "Nasal immunization is an effective way to induce both mucosal and systemic immune responses. In this study,...

Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage. "The activation of telomerase in phytohemagglutinin-stimulated peripheral lymphocytes is thought to play a role in...

Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Oncogenesis develops from a single base mutation in the internal ribosome entry site of Epstein-Barr nuclear antigen 1. Recently published data show that "the U leader exon located within the 5'...

Dendritic cell vaccine generates specific antipancreatic cancer T cells.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells. According to a study from the United States, "RNA-based dendritic cell immunotherapy...

Technological advances and genomics in metazoan parasites reviewed.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A scientist reviews technological advances and genomics in metazoan parasites in a recent issue of the International Journal for Parasitology. According to recent research from Scotland, "Molecular...

MLL gene rearrangement not pathogenic mechanism in de novo MDS.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Mixed lineage leukemia gene rearrangement is not a pathogenic mechanism in de novo myelodysplastic syndromes. "The mixed lineage leukemia (MLL) gene has been identified in 11q23 translocations. The...

Rahul Singhvi named VP, pharmaceutical development and manufacturing operations.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Novavax, Inc., (NVAX) announced the appointment of Rahul Singhvi, DSc, to the newly created position of vice president, pharmaceutical development and manufacturing operations. Singhvi will report...

Effectiveness of pertussis vaccine decreases from 1996-2001 in Poland.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The effectiveness of vaccination with a whole-cell pertussis vaccine decreased in Poland from 1996 to 2001. According to recent research published in the Scandinavian Journal of Infectious...

Pneumococcal vaccine not useful in HIV patients responding to HAART.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The 23-valent pneumococcal vaccine does not offer additional protection against pneumonia in HIV-infected patients who have an immunological response to highly active antiretroviral therapy (HAART). ...

Only Sabin type 3 polio vaccine strain mutation reduces viral growth.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Only the Sabin type 3 strain mutation significantly reduces viral growth in HeLa and neuroblastoma cells. "Initiation of poliovirus (PV) protein synthesis is governed by an internal ribosome entry...

PML tumor suppressor gene mutations indicate poor APL prognosis.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Promyelocytic leukemia tumor suppressor gene mutations indicate a poor acute promyelocytic leukemia prognosis. "The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia...

Metastasis-associated protein analysis indicates different metastasis roles.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Metastasis-associated protein analysis indicates different roles they may play in metastasis. "Metastasis is the most insidious and life threatening aspect of cancers. However little is known about...

World to be polio-free by next year, but losing AIDS war.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The world is likely to be polio-free next year, but the war against AIDS is being lost, the U.S. health secretary says. "We're on the precipice of accomplishing it," Tommy Thompson said of...

Region of rabies virus glycoprotein plays important pathogenic role.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A region involving amino acids 164 to 303 of the rabies virus glycoprotein plays an important role in the pathogenicity toward adult mice. According to recent research from Japan, "The authors have...

Antibody to S1 protein neutralizes SARS coronavirus.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A human monoclonal antibody to S1 protein that blocks receptor association neutralized the severe acute respiratory syndrome (SARS) coronavirus. "Effective prophylaxis and antiviral therapies are...

Response to plasmid DNAs encoding SARS-CoV spike gene fragments characterized.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have characterized the humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. "The immunological characteristics of SARS-CoV spike protein were...

Genomics of parasitic flatworms reviewed.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists review the genomics of parasitic flatworms in a recent issue of the International Journal for Parasitology. According to researchers in Australia, "Although we live in what is often...

Schistosome carbohydrates are dominant epitopes in humoral immune response.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Schistosome carbohydrate structures are dominant epitopes in the antiglycan humoral immune response of chimpanzees. According to published research from Netherlands, "The development of the humoral...

HIV-positive U.S. military personnel accidentally vaccinated against smallpox.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Ten U.S. military personnel were discovered to be HIV-positive after being vaccinated against smallpox, but did not experience any harmful effects from the vaccination, according to a new study. In...

Smallpox history reviewed.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists review the history of smallpox in a recent issue of Clinical Infectious Diseases. "Smallpox apparently arose through transfer of variola virus to humans from another animal species. By...

DNA vaccine against Streptococcus mutans characterized.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a fusion anti-caries DNA vaccine against PAc and glucosyltransferase I of Streptococcus mutans. "Glucosyltransferases (GTFs) and A cell-surface protein (PAc) are two...

Novel antigens found in Mycobacterium tuberculosis complex.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Two novel low-molecular-mass antigens were found specifically in the Mycobacterium tuberculosis complex. "New tools are urgently needed for the detection of latent tuberculosis (TB). We evaluated...

Diacylated sulfoglycolipids are novel mycobacterial antigens.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. "Mycobacterial lipids comprise a heterogeneous group...

PKC delta tumor-suppressing effects mediated by p53 transcription activation.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- PKC delta tumor-suppressing effects are mediated through p53 transcription activation. "In response to DNA damage, signal transduction pathways are activated that result in the increase of p53...

Typhoid fever vaccines cause adverse events.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Typhoid fever vaccines cause adverse events. According to a study from the United States, "Vaccines against Salmonella enterica serotype Typhi are used for prophylaxis of international travelers...

Modification of cholera toxin B subunit enhances expression in plants.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Modification of the cholera toxin B subunit coding sequence enhanced its expression in plants. "The cholera toxin B subunit (CTB) contains five identical polypeptides and targets glycosphingolipid...

Adverse events reduce public trust in safety of MMR vaccine in Brazil.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Vaccine-related adverse events reduced public trust in the safety and efficacy of the measles-mumps-rubella (MMR) vaccine in Brazil. According to recent research published in the journal Health...

Adenoviral vectors for gene transfer and therapy reviewed.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists review adenoviral vectors for gene transfer and therapy in a recent issue of the Journal of Gene Medicine. "Due to the very efficient nuclear entry mechanism of adenovirus and its low...

Antibodies and CD8+ T cells contribute to immunity to adenovirus vectors.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors. According to a study from the Netherlands and the United States, "The high...

Vaccinia virus vectors with deleted serpin genes induce immune response.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Attenuated vaccinia virus vectors with deleted serpin genes induce potent humoral and cell-mediated immune responses. According to published research from the United States, "Vaccinia virus (VV)...

Expression of viral peptide animal vaccine achieved in tobacco chloroplasts.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have produced high-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. "The 2L21 peptide, which confers protection to dogs against challenge with...

Cases of whooping cough piling up in Colorado.
May 5, 2004... 2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Larimer County health officials fighting an outbreak of whooping cough say all nine of the county's recent confirmed patients had their pertussis shots as toddlers. They got sick as teenagers. ...

Vaccine allows for infection control in macaques exposed to SHIV.
May 12, 2004... 2004 MAY 12 - (NewsRx.com & NewsRx.net) -- Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV. "The potential of vaccine-elicited anti-HIV...

Vaccination for glaucoma being developed.
May 12, 2004... 2004 MAY 12 - (NewsRx.com & NewsRx.net) -- Researchers are developing a vaccine for glaucoma. "Glaucoma is a neurodegenerative disease of the optic nerve, which continues to progress even if the primary cause of degeneration is identified...