Vaccine Weekly articles from May 2003

Vaccine Weekly archives from May 2003

First AIDS vaccine tested in Africa generates low immune response.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A preventive AIDS vaccine containing HIV-1 clade B (env and gag-pro) antigens delivered by a canarypox vector elicited a weak but detectable immune...

RANTES and CpG oligodeoxynucleotides effective adjuvants in SIV vaccine.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - RANTES and CpG oligodeoxynucleotides (ODN) functioned as adequate substitutes for the cholera toxin (CT) as potent adjuvants for a simian...

Peptide on virus-like particles protects mice against Japanese encephalitis.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A Japanese encephalitis virus peptide present on Johnson grass mosaic virus-like particles induced virus-neutralizing antibodies that protected mice against a lethal challenge. According to recent...

Amino acid residues confer temperature sensitivity to influenza virus strains.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Multiple amino acid residues conferred temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. "FluMist influenza A vaccine strains...

Dendritic cell-derived CC chemokine 1 enhances protective immunity to malaria.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhanced protective cell-mediated immunity to murine malaria. According to a study from the United States, Spain, and...

DNA vaccine protects mice against a lethal vaccinia virus challenge.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A four-gene-combination DNA vaccine protected mice against a lethal vaccinia virus challenge and elicited appropriate antibody responses in nonhuman primates. According to published research from...

Researcher reports on advances in treatment of a leading parasitic killer.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- In the developing world, 1 of every 10 children dies by his or her fifth birthday. In a new report, Dr. William Petri, professor of medicine at the University of Virginia Health System, discusses...

Soluble tumor necrosis factor receptor improves autoimmune neuritis in mice.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Exogenous soluble tumor necrosis factor receptor type I improved murine experimental autoimmune neuritis. According to a study from Sweden, "Tumor necrosis factor (TNF) and its receptor (TNFR) have...

Vaccine elicits tumor-specific antibodies in patients with breast cancer.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers have identified tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. "Thirty HLA-A2+ women with metastatic breast cancer...

CD4+ cells play critical role in tumor immunity against simian virus 40 antigen.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen. According to recent research published in the journal Cancer...

CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor model.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade enhanced the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. "p53 is overexpressed by half of all cancers, and is an...

Tumor therapy with epidermal growth factor receptor vaccine investigated.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Immunogene therapy of tumors was investigated with a vaccine based on xenogeneic epidermal growth factor receptor. "The breaking of immune tolerance against self epidermal growth factor receptor...

Transdermal gene delivery eradicates tumors expressing hepatitis C proteins.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A series of research experiments has demonstrated that hepatitis C virus (HCV) DNA vaccine can suppress tumor growth. The vaccine, developed by researchers at...

Endogenous dendritic cells required for T cell response by DC vaccines in vivo.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. According to recent research published in the Journal of Immunology,...

Mast cell-derived exosomes induce maturation of dendritic cells.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Mast cell-derived exosomes induced phenotypic and functional maturation of dendritic cells and elicited specific immune responses in vivo. "Mast cells (MCs) are considered major players in...

Rotaviruses causing diarrhea in Vietnamese children characterized.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers from England and Vietnam have characterized the rotaviruses causing diarrhea in Vietnamese children. "Fecal samples from 123 children admitted to the Centre for Tropical Diseases in Ho...

Cytokine polymorphisms modulate UVB-induced immune responses to HBV vaccine.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination. "UVB exposure can alter immune responses in experimental...

CpG enhances antibody response against hepatitis C virus core protein.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CpG immuno-stimulatory motifs enhanced the humoral, but not the cellular, immune responses against hepatitis C virus core protein after DNA-based immunization. According to published research from...

HSV vectors with vhs gene deletion offer dendritic cell immunotherapy.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Deletion of the virion host shutoff protein (vhs) from the herpes simplex virus (HSV) relieved the viral block to dendritic cell activation. According to recent research published in the Journal of...

Single chain antibody fragments neutralize infectious bursal disease virus.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers have generated chicken single chain antibody variable fragments (scFv) that differentiate and neutralize infectious bursal disease virus (IBDV). "Phage-displayed recombinant antibody...

Drug discovery, development research grant program announced.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline (GSK) will award $500,000 in grants for innovative HIV/AIDS drug research in recognition of the need to produce new alternatives and hope in the fight against the HIV/AIDS pandemic. ...

Vaccine kills mosquitoes.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers from Tulane and Case Western Reserve Universities have developed a novel method for controlling malaria transmission. They presented research suggesting the possibility of a vaccine that...

Microneme protein NcMIC3 vaccine reduces Neospora caninum infection in mice.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Vaccination with recombinant microneme protein NcMIC3 and Ribi adjuvant reduced the incidence of cerebral infection of Neospora caninum-infected mice. According to published research from...

European Phamacopoeia pertussis mouse antiserum standard established.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A European Phamacopoeia biological reference preparation for Bordetella pertussis mouse antiserum was established for serological potency testing of acellular pertussis vaccines. According to...

France's commitment to vaccines will help to save children from health risks.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- At the European Society for Paediatric Infectious Diseases, Jimmy Voisine, president of the Audrey Association, announced his support for the recent French decision to reimburse the vaccine which helps...

Afghanistan: UN joins campaign to immunize 6 million children.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- As polio continues to be the leading cause of disability in Afghanistan, two United Nations agencies have joined the national government's nationwide campaign to immunize more than 6 million children in...

Antibodies against PsaA inhibit pneumococcal adherence to nasopharyngeal cells.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Antibodies against surface adhesin A (PsaA) inhibited pneumococcal adherence to human nasopharyngeal epithelial cells. According to published research from the United States, "The role of...

Congress approves compensation for vaccine.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Congress approved a package of payments for people injured by the smallpox vaccine, a move praised by health care unions and those hoping to move the stalled inoculation program forward. Under the...

Lost genes lend new strength to TB vaccine.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Reinforcing the existing tuberculosis (TB) vaccine with new genes from the microbe that causes the disease makes the vaccine more effective, Stewart Cole and his colleagues report. There is no...

Recombinant antigenized secretory IgA recovered for use as vaccine vector.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers have developed a simplified procedure to recover recombinant antigenized secretory IgA for use as a vaccine vector. "Induced protection mechanisms at mucosal surfaces involve secretory...

HIV vaccine candidate taken by into phase I trial in U.S., Africa.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that the National Institute of Allergy and Infectious Diseases, a component of the U.S. National Institutes of Health (NIH), holds an active Investigational New Drug...

Vaccines prolong survival of colorectal cancer patients.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing autologous tumor cells and one made with the Newcastle disease virus (NDV) prolonged the survival of patients with colorectal...

Vaccination against influenza reduces elderly hospitalizations.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Elderly adults who were vaccinated against influenza had lower rates of hospitalization for heart disease, cerebrovascular disease, and pneumonia,...

HIV vaccine vectors expressing vaccinia virus IL-15 induce cellular immunity.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Co-administration of HIV vaccine vectors with vaccinia viruses expressing IL-15, but not IL-2, induced long-lasting cellular immunity. "Vaccine efficacy is determined largely by cellular and...

Human immunodeficiency virus may use transcytosis to cross genital mucosa.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- The human immunodeficiency virus may use transcytosis across a tight monolayer of polarized human endometrial cells under pro-inflammatory conditions. According to recent research from France,...

Preadolescent hepatitis B vaccination program successful in Canada.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- The universal preadolescent vaccination program against hepatitis B appears successful in providing prenatal protection in British Columbian women. "Countries with a low risk of hepatitis B (HB)...

Leucocytoclastic vasculitis reported after influenza vaccination.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Investigators have described four cases of leucocytoclastic vasculitis associated with influenza vaccination. According to a study from Scotland, "Influenza vaccination is recommended for all...

Patient dosing begins in Phase IIa trial for anticocaine addiction vaccine.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Xenova Group plc (NASDAQ: XNVA; London Stock Exchange: XEN) announced that patient dosing has begun in a Phase IIa cocaine administration trial for Xenova's therapeutic vaccine TA-CD, which is under...

TUNEL-positive labeling in mouse inner ear is not apoptosis.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- TUNEL-positive labeling caused by tubulin immunization in the mouse inner ear does not appear to be apoptosis. According to a study from the United States and Italy, "Apoptosis is involved in all...

Cancer patients experience tumor regression despite low T cell levels.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Cancer patients can experience tumor regression despite low titers of antigen-specific T cells. According to a study from Belgium, "Following vaccination with defined tumor antigens that are...

Variety of cancer vaccines available to combat malignancies.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A variety of cancer vaccines are available to combat malignancies. "There is clear evidence that certain forms of immunotherapy can be successful against certain cancers. However, it would appear...

Subtractive immunization identifies a cell surface phosphorylated glycoprotein antigen.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. According to a study from the United...

Previously unknown epitope stimulates immune response to cytomegalovirus antigen.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A previously unknown epitope stimulated an immune response to a cytomegalovirus antigen. According to recent research from the United States, "Unlike the pp65 protein of human cytomegalovirus...

Recent review of DNA vaccines published.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A review of DNA vaccines has been recently published in the Journal of Internal Medicine. According to a study from France, "The DNA vaccines are simple rings of DNA containing a gene encoding an...

Advancements in dendritic cell vaccines for cancer therapy expected.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Advancements in dendritic cell vaccine technology for the treatment of cancer are expected. According to a study from Germany and the United States, "A novel approach to vaccination against cancer...

St. Jude to manufacture investigative drugs and vaccines.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- St. Jude Children's Research Hospital has become the only pediatric cancer research center in the United States to open a Good Manufacturing Practices (GMP) facility for producing vaccines, drugs,...

Dogs vaccinated with Ancylostoma caninum exhibit antibody response.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Dogs vaccinated with Ancylostoma caninum exhibited a strong antibody response. "Infection with Ancylostoma caninum, an intestinal hookworm of dogs, can cause debilitating and potentially...

Phase II study results of vaccine combination released.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Xenova Group plc (NASDAQ: XNVA; London Stock Exchange: XEN) has announced the results of an open label, physician-sponsored Phase II "prime-boost" study, targeting the treatment of human papillomavirus...

CD25 depletion delayed growth of parasitaemia during parasite challenge.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- According to published research from Japan, CD25 depletion clearly delayed the growth of parasitaemia during parasite challenge, particularly in immunized mice. "CD4+ T cells co-expressing CD25...

Ocular and respiratory symptoms attributed to influenza vaccine in Canada.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Results from a controlled trial involving adults indicated that ocular and respiratory symptoms were associated with an inactivated split influenza vaccine. "In 2000, an influenza vaccine was...

Initiative calls for commensurate attention to leading killer of African children.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- PATH's Malaria Vaccine Initiative (MVI) marked the observance of Africa Malaria Day in April by calling for greater international attention to malaria and the urgent need for a malaria vaccine. ...

CD8+ cells essential for clearance of measles virus infection in rhesus monkeys.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- CD8+ lymphocytes are essential for the control and clearance of measles virus infection in rhesus monkeys. According to recent research published in the Journal of Virology, "The creation of an...

Clinical results reported for heat shock protein-based immunotherapy.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A presentation by Mojave Therapeutics, Inc., at The Future of Vaccines Conference in Semmering, Austria, included an update on the company's melanoma clinical trial and results from recent pre-clinical...

Meningococcal conjugate vaccine more effective than polysaccharide vaccine.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Meningococcal A/C conjugate (MACC) vaccination induced a higher antigen-specific geometric mean avidity index than did the meningococcal A/C polysaccharide vaccine in two-year-old children. ...

Toxic molecule may provide key for developing vaccine.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- University of California Irvine (UCI) researchers have discovered an important similarity in the causes of cell degeneration and death in diseases such as Alzheimer, Parkinson, Huntington, type 2...

Model provides insights into antibody dynamics in childhood diseases.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A generalized model is providing insights into the antibody dynamics in childhood diseases such as measles. "The introduction of vaccination against acute diseases such as measles induced a...

National Infant Immunization Week highlights need for parental vigilance.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Today - and every day - more than 11,000 babies will be born in the United States. Each of these youngsters will require 16-20 immunizations during the first two years of life to ensure that they...

Phase III trial for meningococcal C vaccine begins.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Chiron Corporation (CHIR) announced that it has initiated a phase III trial in the United States for Menjugate, the company's conjugated vaccine for the prevention of meningococcal C disease. The...

Phase I smallpox vaccine clinical trial completed.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Computer Sciences Corporation (CSC) announced that DynPort Vaccine Company LLC (DVC), a joint venture between CSC and Porton International, a vaccine development company focused on biodefense vaccines,...

Company receives NASDAQ panel decision.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Valentis, Inc. (NASDAQ:VLTS) received notification from the NASDAQ Listing Qualifications Panel on April 15, 2003, that its common stock will continue to be listed on The NASDAQ SmallCap Market via an...

Data suggests humoral immune responses play role in amodiaquine treatment.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Recent research in Germany suggests that humoral immune responses play a supportive role in the efficacy of amodiaquine treatment for malaria. According to the study, "The relationship between the...

Sustained release of DNA achieved with lipid microtubules and agarose hydrogel.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- The sustained release of DNA was achieved with lipid microtubules and agarose hydrogel. "Non-viral gene therapy typically results in low transfection efficiencies and transient gene expression. To...

pH-responsive polymers used for intracellular delivery of biomolecular drugs.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Bio-inspired pH-responsive polymers have been developed for the intracellular delivery of biomolecular drugs. "The biotechnology and pharmaceutical industries have developed a wide variety of...

Therapeutic vaccines firm raises UKP15 million in international funding round.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Oxxon Pharmaccines Ltd., a biotechnology company developing innovative immunotherapeutics, specifically therapeutic vaccines (pharmaccines), has raised UKP15 million pounds ($23 million) in a private...

Many young adults fear vaccine injections.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Almost a quarter of the young adult patients visiting a travel health clinic admitted being afraid of injections. "Fear of injections may interfere with receipt of vaccines. The frequency,...

Viruses of Bunya- and Togaviridae families have potential as bioterrorism agents.
May 14, 2003... 2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Viruses belonging to the Bunya- and Togaviridae families have potential as bioterrorism agents. According to recent research published in the journal Antiviral Research, "When considering viruses...

Botulism toxin could be used as biological weapon.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - French researchers warn about the potential of botulism toxin as a bioterrorist weapon in a recent issue of the French journal Presse Medicale. ...

Influenza vaccination does not worsen HIV infection.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - HIV-positive patients who received an influenza vaccination did not experience increases in the HIV viral load or decreases in CD4 T lymphocytes,...

Vaccination strategies for Alzheimer's disease reviewed.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Researchers have published a recent review of vaccine approaches to the treatment of Alzheimer disease. According to recent research published in the journal Lancet Neurology, "Recent studies in...

Novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine developed.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine has been developed and tested. "Due to the high incidence of breast cancer and associated mortality rate, the development of an...

Constrained peptide immunogens show improved binding to anti-HIV-1 antibody.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Constrained peptide immunogens showed improved binding to anti-HIV-1 antibody gp41 monoclonal antibody. "The human immunodeficiency virus type I (HIV-1) transmembrane glycoprotein gp41 mediates...

Program predicts immune response and parasite synchronization in malaria.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A computer program has been developed that can predict the immune response and parasite synchronization in malaria. "Anti-malaria vaccines and drugs could be greatly improved if we knew which...

Filoviruses could be used as biological weapons.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- The possibility exists that terrorists could use filoviruses as biological weapons. "The filoviruses, Marburg and Ebola, are classified as Category A biowarfare agents by the Centers for Disease...

Vaccines for acute lymphoblastic leukemia available.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Vaccines are available for the treatment of acute lymphoblastic leukemia. "Acute lymphoblastic leukemia (ALL) represents the most frequent malignant disease in childhood and adolescence and offers...

Plasmids encoding Japanese encephalitis virus proteins elicit immune response.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Inoculation of plasmids encoding Japanese encephalitis virus PrM-E proteins with colloidal gold elicited a protective immune response in mice. According to recent research published in the Journal...

Using CTLA-4 to target APCs could boost immunogenicity of HIV-1 vaccines.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Using CTLA-4 to target antigen-presenting cells could boost immunogenicity of HIV-1 vaccines, suggest Aaron Diamond AIDS Research Center scientists. Pointing to study results indicating weak...

Tumor-derived TGF-beta reduces efficacy of dendritic cell/tumor fusion vaccine.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Tumor-derived TGF-beta reduced the efficacy of a dendritic cell/tumor fusion vaccine. According to a study from the United States, "Dendritic cell (DC)-based antitumor vaccine is a novel cancer...

Microgel polymer beads may provide general vehicle for vaccines, gene therapy.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A simple method of shuttling proteins into cells via microscopic polymer beads shows promise as a general way of carrying vaccines or bits of DNA for gene therapy, according to chemists at the...

Cancer drug maker reports loss of $0.23 per share; SARS vaccine update.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- GenVec, Inc., (GNVC) announced financial results for the first quarter ended March 31, 2003. GenVec reported a net loss of $5.2 million or ($0.23) per share, a 19% reduction compared to a net loss...

Multivalent recombinant MVA vaccine designed for dominant HIV form in China.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A multivalent recombinant modified Vaccinia Ankara vaccine has been designed for a circulating C/B recombinant form of HIV-1 that is dominant in Yunnan, China. Z. Chen presented a poster...

T-helper cell response to HIV envelope protein has little breadth.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- T-helper cell response to a human immunodeficiency virus envelope protein Show little promise. "Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a...

Novel Ad recombinant vaccine to HIV-1 developed.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Wistar Institute scientists have developed a novel adenovirus recombinant vaccine to HIV-1. "Human recombinant adenovirus has been studied extensively as vaccine carrier for antigens from...

CIR-T cells mediate anti-HIV-1 activity, bypassing class I requirements.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Chimeric immune T-cell receptor cells "can mediate antiviral activity against HIV-1 in cells that are resistant to class I-restricted CTL-mediated activity" and also suppress the virus in several cell...

Noninfectious influenza virus induces more balanced T-lymphocyte immunodominance.
May 21, 2003... 2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A heat-aggregated noninfectious influenza virus induced a more balanced CD8+-T-lymphocyte immunodominance hierarchy than did the infectious virus. "CD8+-T-cell (T[subscript]CD8+) responses to...