Vaccine Weekly articles from May 1998

Vaccine Weekly archives from May 1998

Patient's Anti-HIV Sera Key To Cross-Clade Neutralization.
May 4, 1998... An accident of nature may provide the key to an AIDS vaccine. Serum from a person with long-term nonprogressive HIV infection is able to recognize a wide variety of HIV isolates from many different viral subtypes. These antibodies suggest...

Antibiotic Resistance: Is It Mom's Fault?
May 4, 1998... What's a mother to do? That's the question CDC researchers asked: and too often the answer was "Give antibiotics." A CDC poll of primary caregivers for children younger than four years - 88 percent of whom were mothers - found that while...

HIV/PPD Conjugate Vaccine Active in Clinical Trial.
May 4, 1998... Three HIV infected patients who received an experimental AIDS vaccine had significant and sustained decreases in viral load. The vaccine, developed at New York's Albert Einstein College of Medicine and licensed to ID Biomedical Corp., couples...

Biological Weapons Defense Gets DoD Grant.
May 4, 1998... Could a developing vaccine strategy be used to rapidly counter agents of biological warfare? Two researchers who have developed a protein-expression vector system have been asked to find out - and the U.S. Department of Defense (DoD) has...

New AIDS Vaccine Plus Booster Shot Gives Best Results.
May 4, 1998... A vaccine pairing a genetically altered, harmless, canarypox virus and a genetically engineered piece of the HIV protein coat induce immune system activity against laboratory strains of HIV better than either vaccine alone, according to a Johns...

RAP Vaccine Prevents Staphylococcus aureus Infections.
May 4, 1998... Collaborating researchers have found that treatment with one of two molecules protects mice against the ill effects of Staphylococcus aureus infection without killing the bacteria and thus without encouraging the emergence of new drug-resistant...

"Boost" in Vaccine Efficacy Seen with Hepatitis B Exposure.
May 4, 1998... A 10-year study of Alaska natives supports the view that in populations with good hepatitis B virus vaccine coverage, protection persists for a long time. The U.S. Centers for Disease Control and Prevention (CDC) report found that a...

Silent Epidemic Infects Thousands in the Philippines.
May 4, 1998... Tuberculosis (TB) is not incurable but arduous treatment all too often breeds resistance to drugs, making a cure even more difficult. "It's an epidemic but it's a silent one, because many (infected) people look normal and are walking around,"...

U.S. Measles Cases at Record Low.
May 4, 1998... U.S. health officials said there were 138 confirmed measles cases in the United States in 1997, the lowest number of cases since record keeping began in 1912. "This is the lowest number of cases ever reported in one year. It's also 55 percent...

European Marketing and New Drug Application Obtained for Zadaxin Thymosin Alpha.
May 4, 1998... SciClone Pharmaceuticals, San Mateo, California, announced the signing of an agreement with Sclavo S.p.A., providing for SciClone's acquisition of Sclavo's marketing approval for Zadaxin thymosin alpha 1 in Italy as an influenza vaccine adjuvant....

New Flu Strain To Be Included in Vaccine.
May 4, 1998... An influenza virus strain that dominated the Winter 1998 flu season has been scheduled for inclusion in the vaccine for the Winter 1999, U.S. health officials said. The U.S. Centers for Disease Control and Prevention (CDC) said two of the...

United Kingdom Doctors Identify Drug-Resistant Superbug.
May 4, 1998... British doctors have identified a "superbug" that is resistant to the most powerful antibiotics. Experts at Britain's Public Health Laboratory Service (PHLS) found a strain of the bacterium Pseudomonas aeruginosa that is resistant to "just...

U.S. Firm Starts Tests on Cocaine Vaccine.
May 4, 1998... A U.S. biotechnology company said it was starting tests on a cocaine vaccine that would stop users getting a high from the drug. Massachusetts-based ImmuLogic said it was starting Phase I safety tests of the vaccine, which it said had shown...

Lactic Acid bacteria to Live Vaccine Development: Designing Tools to Target Antigens to a Defined Cell Compartment.
May 4, 1998... "Lactic Acid bacteria to Live Vaccine Development: Designing Tools to Target Antigens to a Defined Cell Compartment." J.-C. Piard. Groupe de Genetique Appliquee, Jouy-en-Josas Cedex, France. According to an abstract submitted by the author to...

Development of Stable Formulations for Single Immunization PLGA Microsphere Vaccines.
May 4, 1998... "Development of Stable Formulations for Single Immunization PLGA Microsphere Vaccines." J.L. Cleland. Genentech, Inc., South San Francisco, California. According to an abstract submitted by the author to the conference New Trends in Vaccine R...

Experimental Mucosal Immunization Against a Widespread Bacterial Antigen: Phosphorylcholine Loaded in Microspheres Protects Mice Against Pneumococcal Pneumonia.
May 4, 1998... "Experimental Mucosal Immunization Against a Widespread Bacterial Antigen: Phosphorylcholine Loaded in Microspheres Protects Mice Against Pneumococcal Pneumonia." S. Trolle, E. Chachaty, E. Fattal, P. cowreuri, J.M. Alonso and A. Andremont....

Immune Responses to a Pneumococcal CRM[197]-Heptavalent Polysaccharide Conjugate Vaccine in Children who Responded Poorly to the 23-Valent Polysaccharide Vaccine.
May 4, 1998... "Immune Responses to a Pneumococcal CRM[197]-Heptavalent Polysaccharide Conjugate Vaccine in Children who Responded Poorly to the 23-Valent Polysaccharide Vaccine." S. Romero-Steiner, R.U. Sorensen, M.F. Schinsky, L. Leiva, P. Giangrosso, A.L....

A Two-dose Hepatitis B Vaccine Regimen: Proof of Priming and Memory Responses in Young Adults.
May 4, 1998... Marsano, L.S.; West, D.J.; Chan, I.; Hesley, T.M.; Cox, J.; Hackworth, V.; Greenberg, R.N. "A Two-dose Hepatitis B Vaccine Regimen: Proof of Priming and Memory Responses in Young Adults." Vaccine, April 1998;16(6):624-629. This study shows...

Combined Intramuscular-intradermal Protocol of Universal Neonate HB Vaccination Irrespective of Mothers' Status of HBsAg.
May 4, 1998... Yao, F.B.; Li, X.X.; Du, Y.X.; Ye, S.L. "Combined Intramuscular-intradermal Protocol of Universal Neonate HB Vaccination Irrespective of Mothers' Status of HBsAg." Vaccine, April 1998;16(6):586-589. According to the authors' abstract of an...

Evaluation of B- and T-cell Responses in Chimpanzees Immunized with Hepagene(R), a Hepatitis B Vaccine Containing pre-S1, pre-S2 and S Gene Products.
May 4, 1998... Pride, M.W.; Bailey, C.R.; Muchmore, E.; Thanavala, Y. "Evaluation of B- and T-cell Responses in Chimpanzees Immunized with Hepagene(R), a Hepatitis B Vaccine Containing pre-S1, pre-S2 and S Gene Products." Vaccine, April 1998;16(6):543-550....

Immunogenicity of Hepatitis B Vaccines Among Infant Recipients of Acellular and Whole Cell Pertussis DTP Vaccines.
May 4, 1998... Salmaso, S.; Piscitelli, A.; Rapicetta, M.; Chionne, P.; Madonna, E.; Argentini, C. "Immunogenicity of Hepatitis B Vaccines Among Infant Recipients of Acellular and Whole Cell Pertussis DTP Vaccines." Vaccine, April 1998;16(6):643-646....

Recovery of a Fully Viable Chimeric Human Parainfluenza Virus (PIV) Type 3 in Which the Hemagglutinin-neuraminidase and Fusion Glycoproteins Have Been Replaced by Those of PIV Type 1.
May 4, 1998... Tao, T.; Durbin, A.P.; Whitehead, S.S.; Davoodi, F.; Collins, P.L.; Murphy, B.R. "Recovery of a Fully Viable Chimeric Human Parainfluenza Virus (PIV) Type 3 in Which the Hemagglutinin-neuraminidase and Fusion Glycoproteins Have Been Replaced by...

Meningococcal Vaccines: Current Status and Future Possibilities.
May 4, 1998... Peltola, H. "Meningococcal Vaccines: Current Status and Future Possibilities." Drugs, March 1998;55(3):347-366. According to the author's abstract of an article published in Drugs, "Meningococcal disease causes great emotion and anxiety in the...

Reducing Missed Opportunities to Vaccinate During Child Health Visits: How Effective Are Parent Education and Case Management?
May 4, 1998... Wood, D.; Schuster, M.; Donaldsherbourne, C.; Duan, N.; Mazel, R.; Halfon, N. "Reducing Missed Opportunities to Vaccinate During Child Health Visits: How Effective Are Parent Education and Case Management?." Archives of Pediatrics & Adolescent...

The Cost of Childhood Immunisation in General Practice.
May 4, 1998... Mcleod, D.; Bowie, R.D.; Kljakovic, M. "The Cost of Childhood Immunisation in General Practice." New Zealand Medical Journal, March 13, 1998;111(1061):73-76. According to the authors' abstract of an article published in New Zealand Medical...

Vaccine-associated Liability Risk and Provider Immunization Practices.
May 4, 1998... Freed, G.L.; Kauf, T.; Freeman, V.A.; Pathman, D.E.; Konrad, T.R. "Vaccine-associated Liability Risk and Provider Immunization Practices." Archives of Pediatrics & Adolescent Medicine, March 1998;152(3):285-289. According to the authors'...

Rotavirus 2/6 Virus-like Particles Administered Intranasally With Cholera Toxin, Escherichia coli Heat-labile Toxin (LT), and LT-R192G Induce Protection From Rotavirus Challenge.
May 4, 1998... Oneal, C.M.; Clements, J.D.; Estes, M.K.; Conner, M.E. "Rotavirus 2/6 Virus-like Particles Administered Intranasally With Cholera Toxin, Escherichia coli Heat-labile Toxin (LT), and LT-R192G Induce Protection From Rotavirus Challenge." Journal of...

Tumor Vaccines: Breaking Self Tolerance Seen As Key.
May 11, 1998... A new generation of antitumor vaccines would turn the body against itself. By breaking the immune system's tolerance for specific types of cells, such vaccines would destroy tumors arising from such cells. The strategy, of course, has one...

NYVAC-SIV Protects Against Virulent SIVmac251.
May 11, 1998... Exciting results from a rigorous animal model of AIDS suggest that a recombinant vaccine can protect against HIV infection and disease. The recombinant NYVAC-SIV vaccine encodes simian immunodeficiency virus (SIV) antigens in an attenuated...

Vaccine Targets Vancomycin-Resistant Bacteria.
May 11, 1998... Antibodies to a new vaccine antigen protected mice against challenge with a clinical isolate of a vancomycin-resistant bacterium. Vancomycin is the last line of defense against organisms that have acquired resistance to antimicrobial drugs....

Ulcer Vaccine Vectored by Cholera, Typhoid Bacteria.
May 11, 1998... Attenuated vibrio and salmonella bacteria - now in early clinical trials as vaccines - are being developed as vectors capable of stimulating mucosal immunity to a wide variety of bacterial and viral pathogens. The attenuated bacteria,...

1997-8 Flu Vaccine May Have Missed Major Variant.
May 11, 1998... Last year's flu vaccine provided only limited protection, a CDC analysis shows. The major component of the trivalent 1997-98 vaccine was an A/Wuhan/359/95-like virus, an influenza A(H3N2) variant. But while influenza A(H3N2) was the major flu...

Anti-HBc Does Not Preclude Hepatitis B Vaccination.
May 11, 1998... People with antibody to hepatitis B core antigen may still benefit from vaccination against hepatitis B virus (HBV). Researchers from the U.S. National Institutes of Health Hepatitis Studies Section found that having antibody to hepatitis B...

Nasal Spray Flu Vaccine Produces Local Antibody Response.
May 11, 1998... A new nasal spray vaccine is being studied that may prove to be an effective way of vaccinating children against influenza. A report presented at the 1998 Society for Pediatric Research Annual Meeting shows that children given the new vaccine...

Rural Clinicians Refer More Children to Public Immunization Clinics.
May 11, 1998... Clinicians in rural areas refer a higher percentage of their patients to public immunization clinics than their urban counterparts, according to a study presented at the Pediatric Societies' Annual Meeting held May 1-5, 1998, in New Orleans,...

Most Pediatricians Use Combination of Poliovirus Vaccines.
May 11, 1998... Despite a continuing controversy over the most appropriate schedule for immunization against polio, a majority of pediatricians surveyed in a recent study have adopted the U.S. Centers for Disease Control Advisory Committee on Immunization...

New Tuberculosis Vaccine Candidate Developed.
May 11, 1998... Scientists at the Max Planck Institute for Infection Biology, Berlin, Germany, and at the University Clinics of Ulm have developed a putative vaccine candidate against Mycobacterium tuberculosis, the causative agent of tuberculosis. Their data...

Murine Study Finds Mucosal Vaccine Useful for STDs.
May 11, 1998... Mucosal immunization provided a high and long-lasting level of immunity from sexually transmitted viral infections of the female genital tract in murine studies from Canada. "When we compared the intranasal (inl) and intraperitoneal (ip)...

First Human Trial Shows that an Edible Vaccine Is Feasible.
May 11, 1998... Opening a new era in vaccine delivery, researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID), U.S. National Institutes of Health, have shown for the first time that an edible vaccine can trigger significant...

Two Studies Offer New Findings on Vaccination-Related Seizures in Children.
May 11, 1998... Children are at a slightly increased risk for seizures with fever (febrile seizures) following some vaccinations, but children who have these types of seizures are not at increased risk for subsequent seizures, epilepsy, or long-term psychiatric...

Bridging Study Leading To Pivotal Phase III Trial Announced.
May 11, 1998... Biomira Inc., Edmonton, Alberta, Canada, announced the start of a 23-patient study using Theratope vaccine in patients with metastatic breast cancer. Shipment of product commenced in early April to clinical trial sites in the U.S. and the...

Leaders Unite to Battle Chronic Viral Hepatitis.
May 11, 1998... Health care and biotechnology industry leaders, as well as members of the patient community, called on Congress to address a national health crisis - chronic viral hepatitis. The American Liver Foundation (ALF), the California Healthcare...

Biotech Helps Solve India's Health Problems.
May 11, 1998... By developing cheap, HIV testing kits, vaccines against leprosy and Hepatitis-B and powerful anti-fungals, India's biotechnology laboratories are helping solve some of the country's pressing public health problems. Late in April 1998, the...

Phase I Clinical Trial on Nasally-Delivered Vaccine Begins.
May 11, 1998... BioChem Pharma Inc., Laval, Quebec, Canada, and Biovector Therapeutics SA, Toulouse, France, announced the beginning of a Phase I clinical testing on an influenza vaccine designed for nasal administration. Co-developed by BioChem Vaccines, a...

Phase I DNA Vaccine Trial Yields First Data in Man.
May 11, 1998... Physicians conducting the first human trial of a DNA vaccine against malaria reported that the vaccine was well tolerated and safe, and that preliminary analysis of specimens from trial participants suggested a good cellular immune response with...

Study Shows Positive Results for Vaccine Against Tooth Decay.
May 11, 1998... Planet Biotechnology, Inc., Mountain View, California, announced findings from the first clinical trial of their plant-based immunotherapy for the prevention of tooth decay. The scientific study published in the May 1, 1998, issue of Nature...

Pivotal Clinical Trial on Anti-Staph Vaccine Begin.
May 11, 1998... The Kaiser Permanente Vaccine Study Center has launched a world evaluation of Staphvax against Staphylococcus. Staphylococcus is a bacterial infection that affects millions of hospital and treatment center patients each year and has recently...

Enterococcal Vaccine Featured at American Society for Microbiology.
May 11, 1998... Nabi, Boca Raton, Florida, announced that an abstract written by Nabi scientists describing its enterococcal vaccine and the protective effect of antibodies raised by the vaccine is to be featured at the Annual Meeting of the American Society for...

Multiclade HIV-1 Infection in Japan: Genetic and Phylogenetic Analyses of Virus Strains Among Homosexuals and Heterosexuals.
May 11, 1998... "Multiclade HIV-1 Infection in Japan: Genetic and Phylogenetic Analyses of Virus Strains Among Homosexuals and Heterosexuals." V.R. Nerurkar, S. Utsumi, Y. Nishiura, E. Mukai, W.-M. Dashwood, M.-C. Ieong and R. Yanagihara. University of Hawaii at...

Factors Determining Antibody Isotype in Measles Virus DNA Vaccination.
May 11, 1998... "Factors Determining Antibody Isotype in Measles Virus DNA Vaccination." A.I. Cardoso, N. Sixt, A. Vallier, J. Fayolle, R. Buckland and T.F. Wild. INSERM U404 'Immunite et Vaccination', Ex-Batiment Institut Pasteur de Lyon, Lyon, France....

Whole Virus Influenza Vaccine Activates Dendritic Cells and Promotes T Helper-1 Activity while Subunit Vaccines Stimulate T Cell Proliferation.
May 11, 1998... "Whole Virus Influenza Vaccine Activates Dendritic Cells and Promotes T Helper-1 Activity while Subunit Vaccines Stimulate T Cell Proliferation." M. Saurwein-Teissl, K. Zisterer, T.L. Schmitt, R. Gluck, S. Cryz and B. Grubeck-Loebenstein....

Feasibility of Gene Transfer in Different Dendritic Cell Subsets: Implications for Viral Vaccine Design.
May 11, 1998... "Feasibility of Gene Transfer in Different Dendritic Cell Subsets: Implications for Viral Vaccine Design." I Z. Berneman, V. Van Tendeloo, F. Lardon, C. Van Broeckhoven, H.W. Snoeck and D. Van Bockstaele. Laboratory of Experimental Hematology,...

Intranasal Administration of a Meningococcal Outer Membrane Vesicle Vaccine Induces Persistent Local Mucosal Antibodies and Serum Antibodies With Strong Bactericidal Activity in Humans.
May 11, 1998... Haneberg, B.; Dalseg, R.; Wedege, E.; Hoiby, E.A.; Haugen, I.L.; Oftung, F.; Andersen, S.R.; Naess, L.M.; Aase, A.; Michaelsen, T.E.; Holst, J. "Intranasal Administration of a Meningococcal Outer Membrane Vesicle Vaccine Induces Persistent Local...

Reduction of Established Spontaneous Mammary Carcinoma Metastases Following Immunotherapy With Major Histocompatibility Complex Class II and B7.1 Cell-Based Tumor Vaccines.
May 11, 1998... "Reduction of Established Spontaneous Mammary Carcinoma Metastases Following Immunotherapy With Major Histocompatibility Complex Class II and B7.1 Cell-Based Tumor Vaccines." Cancer Research, April 1, 1998;58(7):1486-1493. According to the...

Antibody Avidity as a Surrogate Marker of Successful Priming by Haemophilus influenzae Type b Conjugate Vaccines Following Infant Immunization.
May 11, 1998... Goldblatt, D.; Vaz, A.R.J.P.M.P.; Miller, E. "Antibody Avidity as a Surrogate Marker of Successful Priming by Haemophilus influenzae Type b Conjugate Vaccines Following Infant Immunization." Journal of Infectious Diseases, April...

Passive Immunization With a Human Immunodeficiency Virus Type 1-Neutralizing Monoclonal Antibody in Hu-PBL-SCID Mice: Isolation of a Neutralization Escape Variant.
May 11, 1998... Andrus, L.; Prince, A.M.; Bernal, I.; Mccormack, P.; Lee, D.H.; Gorny, M.K.; Zollapazner, S. "Passive Immunization With a Human Immunodeficiency Virus Type 1-Neutralizing Monoclonal Antibody in Hu-PBL-SCID Mice: Isolation of a Neutralization...

Effectiveness and Cost-Effectiveness of Letters, Automated Telephone Messages, or Both for Underimmunized Children in a Health Maintenance Organization.
May 11, 1998... "Effectiveness and Cost-Effectiveness of Letters, Automated Telephone Messages, or Both for Underimmunized Children in a Health Maintenance Organization." Pediatrics, April 1998;101(4):E31-E37. According to the authors' abstract of an article...

The Accuracy of Mothers' Reports of Child Vaccination: Evidence From Rural Egypt.
May 11, 1998... "The Accuracy of Mothers' Reports of Child Vaccination: Evidence From Rural Egypt." Social Science & Medicine, May 1998;46(9):1205-1212. According to the authors' abstract of an article published in Social Science & Medicine, "Estimates of...

Serological Evidence of SV40 Infections in HIV Infected and HIV Negative Adults.
May 11, 1998... Vaccine Safety (SV40) Jafar, S.; Rodriguezbarradas, M.; Graham, D.Y.; Butel, J.S. "Serological Evidence of SV40 Infections in HIV Infected and HIV Negative Adults." Journal of Medical Virology, April 1998;54(4):276-284. According to the...

Immunogenicity of Hepatitis B Vaccine in Term and Preterm Infants.
May 11, 1998... HBV Vaccines Belloni, C.; Chirico, G.; Pistorio, A.; Orsolini, P.; Tinelli, C.; Rondini, G. "Immunogenicity of Hepatitis B Vaccine in Term and Preterm Infants." Acta Paediatrica, March 1998;87(3):336-338. According to the authors' abstract of...

Prevention of Adenoviral Acute Respiratory Disease in Army Recruits: Cost-Effectiveness of a Military Vaccination Policy.
May 18, 1998... Howell, M.R.; Nang, R.N.; Gaydos, C.A.; Gaydos, J.C. "Prevention of Adenoviral Acute Respiratory Disease in Army Recruits: Cost-Effectiveness of a Military Vaccination Policy." American Journal of Preventive Medicine, April 1998;14(3):168-175....

Breakthrough in Immune Tolerance.
May 18, 1998... The discovery of a unique marker that identifies anergic T cells now makes possible the direct study of a major aspect of immunity. Induction of T-cell anergy is thought to be a major process in preventing the immune system from attacking...

OraVax To Make Candidate Vaccines against Biological Warfare.
May 18, 1998... The U.S. Department of Defense (DoD) has awarded a contract to develop and manufacture vaccines against agents of biological warfare. Chosen as Prime Systems Integration Contractor was DynPort LLC (a venture of DynCorp, Reston, Virginia and...

CEO: Biotech Breakthrough Could Shake Vaccine Industry.
May 18, 1998... A blockbuster biotech breakthrough could revolutionize the rapidly expanding vaccine industry, says Michel Greco, CEO of Pasteur Merieux MSD and president of the European Vaccine Manufacturers Association. Greco warned that such a technological...

Cancer Cell Invasion Research May Lead to Vaccine.
May 18, 1998... Using an antigen in mice, called murine epithelial glycoprotein (mEGP), that is genetically similar to the GA733 antigen in humans, scientists working in the Wistar Institute laboratory of Dorothee Herlyn, DVM, are gaining valuable information...

Evolution of Infectious Agents Discussed.
May 18, 1998... In a paper with implications for the evaluation of vaccine trials, researchers described a theoretical framework that seeks to explain how various strains of infectious agents might evolve. S. Gupta, N. Ferguson, and R. Anderson, all at the...

WHO: 170 Million Infected Worldwide With Hepatitis C and Still No Vaccine.
May 18, 1998... The current global pandemic of hepatitis C is a major public health problem. Prevalences of 0.5 percent to greater than 10 percent have been found in population samples around the world, experts heard during a meeting at World Health...

Cost-Effectiveness of Infant Immunization for Diarrhea Debatable.
May 18, 1998... A mass vaccination program to curtail rotavirus diarrhea in U.S. children could help avoid more than 34,000 hospitalizations, 95,000 emergency department visits, and be cost-effective when societal and direct medical costs are included. Costs...

Second BCG Course Unnecessary in Nonendemic Areas.
May 18, 1998... The efficacy of revaccinating against tuberculosis with bacillus Calmette-Guerin is extremely low in countries not endemic for tuberculosis, according to a report from Finland. "Revaccinating tuberculin-negative children has no scientific...

No Evidence for Link Between MMR Vaccine and Autism/Bowel Disease Syndrome.
May 18, 1998... On February 28, 1998, The Lancet published a study by Dr. Andrew Wakefield and colleagues from the Royal Free Hospital in London which suggested that there might be a link between the measles, mumps, and rubella (MMR) vaccine and a new syndrome...

UCLA Researchers Test Cancer Drug on Humans.
May 18, 1998... A potential treatment for cancer that kills tumors by starving them of their blood supply is being tested on humans by doctors at the University of California at Los Angeles (UCLA), researchers reported. The drug has been in Phase I trials on...

Cystic Fibrosis Gene Guards Against Typhoid.
May 18, 1998... Cystic fibrosis (CF) carriers of the defective gene have an enhanced natural resistance to typhoid, U.S. doctors said. The finding could explain why the gene is passed on to subsequent generations and may help in the search to develop a vaccine...

Study Findings Stress Importance of Compartmentalization.
May 18, 1998... Harvard Medical School researchers recently reported that HIV in semen and peripheral blood may arise from two distinct "compartments," or parts of the body. Their study, published in an April 1998 supplement of "AIDS Research and Human...

Firm Wants To Work with Cuba on Meningitis Vaccine.
May 18, 1998... SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania, said it had asked Washington to ease its embargo on Cuba so the company could research a Cuban vaccine that might help stamp out meningitis. SmithKline said it approached the...

Entertainment Education for Immunization Promotion: The UCLA Media Project.
May 18, 1998... "Entertainment Education for Immunization Promotion: The UCLA Media Project." D.C. Glik, E. Berkanovic, K. Stone, M. Schreibman, B. Rosen, L. Gordon, M.C. Jones and L. Ibarra. UCLA School of Public Health, UCLA Dept Film and Television,...

Antibodies can Eradicate Cancer Micrometastases.
May 18, 1998... "Antibodies can Eradicate Cancer Micrometastases." H. Zhang, S. Zhang, N.-K. Cheung, G. Ragupathi and P.O. Livingston. Memorial Sloan-Kettering Cancer Center, New York, New York. According to an abstract submitted by the authors to the 89th...

Simplified Vaccinologist's Vaccinology in the Pursuit of a Vaccine Against AIDS.
May 18, 1998... "Simplified Vaccinologist's Vaccinology in the Pursuit of a Vaccine Against AIDS." M.R. Hilleman. Merck Institute for Therapeutic Research, West Point, Pennsylvania. According to an abstract submitted by the author to the Second Annual Meeting...

New Prospect for Mucosal Immunization: Anti-Infectious and Anti-Inflammatory Vaccines.
May 18, 1998... "New Prospect for Mucosal Immunization: Anti-Infectious and Anti-Inflammatory Vaccines." J. Holmgren. University of Goteborg, Goteborg, Sweden. According to an abstract submitted by the author to the conference New Trends in Vaccine R & D:...

Apoptosis in Asymptomatic HIV-1 Seropositives Immunized With HIV-1 env Glycoprotein (gp160): Effects of Administration of Zidovudine in vivo and Interleukin-2 in vitro.
May 18, 1998... Pierdominici, M.; Mollicone, B.; Ricci, G.; Oliva, A.; Doffizi, G.; Giovannetti, A.; Aiuti, F.; Pandolfi, F. "Apoptosis in Asymptomatic HIV-1 Seropositives Immunized With HIV-1 env Glycoprotein (gp160): Effects of Administration of Zidovudine in...

Safety and Immunogenicity of a Hepatitis B Vaccine Formulated With a Novel Adjuvant System.
May 18, 1998... Thoelen, S.; Vandamme, P.; Mathei, C.; Lerouxroels, G.; Desombere, I.; Safary, A.; Vandepapeliere, P.; Slaoui, M.; Meheus, A. "Safety and Immunogenicity of a Hepatitis B Vaccine Formulated With a Novel Adjuvant System." Vaccine, April...

Whole-Killed gp120-Depleted HIV-1 Antigen in a Murine Model for Prophylactic Vaccination.
May 18, 1998... Lanza, P.; Moss, R.B.; Giermakowska, W.; Hancock, R.B.; Richieri, S.P.; Theofa, G.; Jensen, F.C.; Salk, P.L.; Carlo, D.J. "Whole-Killed gp120-Depleted HIV-1 Antigen in a Murine Model for Prophylactic Vaccination." Vaccine, April...

Enhancement of Immune Response to Intranasal Influenza HA Vaccine by Microparticle Resin.
May 18, 1998... Higaki, M.; Takase, T.; Igarashi, R.; Suzuki, Y.; Aizawa, C.; Mizushima, Y. "Enhancement of Immune Response to Intranasal Influenza HA Vaccine by Microparticle Resin." Vaccine, April 1998;16(7):741-745. According to the authors' abstract of an...

Enhanced Immunogenicity for CD8(+) T-Cell Induction and Complete Protective Efficacy of Malaria DNA Vaccination by Boosting With Modified Vaccinia Virus Ankara.
May 18, 1998... Schneider, J.; Gilbert, S.C.; Blanchard, T.J.; Hanke, T.; Robson, K.J.; Hannan, C.M.; Becker, M.; Sinden, R.; Smith, G.L.; Hill, A.V.S. "Enhanced Immunogenicity for CD8(+) T-Cell Induction and Complete Protective Efficacy of Malaria DNA...

Evaluation of SPf66 Malaria Vaccine Efficacy in Brazil.
May 18, 1998... Urdaneta, M.; Prata, A.; Struchiner, C.J.; Tosta, C.E.; Tauil, P.; Boulos, M. "Evaluation of SPf66 Malaria Vaccine Efficacy in Brazil." American Journal of Tropical Medicine and Hygiene, March 1998;58(3):378-385. According to the authors'...