Vaccine Weekly articles from March 2004

Vaccine Weekly archives from March 2004

Adenovirus expressing papillomavirus E2 protein eliminates infection.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection. "Cervical cancer arises from lesions caused by infection...

Defective M. tuberculosis provides greater TB immunity than BCG vaccine.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than does the existing bacille Calmette-Guerin (BCG) vaccine....

Measles virus expressing HIV proteins induces antibodies to HIV.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses...

Malaria vaccine developments reviewed.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers review recent developments in malaria vaccines in the journal Lancet. "Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades....

Tumor RNA-pulsed dendritic cells treat pancreatic tumors in mice.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model. "Pancreatic tumors lack adequate recruitment of...

Immune response to telomerase tumor antigen studied as possible vaccine.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers at the Abramson Cancer Center of the University of Pennsylvania have begun a Phase I clinical trial to evaluate the effectiveness of a telomerase peptide as a possible vaccine against breast...

Cancer vaccines use high molecular weight stress proteins.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Scientists are developing cancer vaccines using autologous and recombinant high molecular weight stress proteins. According to published research from the United States, "High molecular weight heat...

Companies ink agreement to develop MicroPyramid-based vaccine delivery.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- NanoPass Technologies, Ltd., has signed an agreement with GlaxoSmithKline's Biopharmaceutical Centre of Excellence for Drug Discovery (GSK) to develop NanoPass' MicroPyramid technology for the delivery...

CAP nanotechnology product developments reported.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- BioSante Pharmaceuticals, Inc., (BPA) announced an update on recent developments of its calcium phosphate-based nanotechnology (CAP). "To date we have made significant progress in development of...

DNA vaccines made from polymer time-bombs more potent.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Chun Wang and colleagues have incorporated DNA in a new formulation of biocompatible poly(ortho ester) micro-particles, the opening of which can be timed to occur with a specific delay, and only inside...

Gates Foundation commits $82.9 million to develop new tuberculosis vaccines.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The Bill & Melinda Gates Foundation has announced an $82.9 million grant to the Aeras Global TB Vaccine Foundation to support development of new vaccines to prevent tuberculosis (TB), a disease that...

SECEBT receives nearly $1 million for bioterror studies.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- A new 1-year federal grant of nearly $1 million will help the Southeastern Center for Emerging Biologic Threats (SECEBT) fulfill its mission of combating emerging infectious diseases and potential...

Monoclonal antibodies show promise for AIDS vaccines.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Monoclonal antibodies show promise for AIDS vaccines. According to a study from the United States, "Human immunodeficiency virus type 1 (HIV-1) is phylogenetically classified into groups and clades...

Haemophilus influenzae vaccine does not elicit helper T cells.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The Haemophilus influenzae type b conjugate vaccine does not elicit antigen-specific helper T cells. "A small number of fully vaccinated children in the U.K. have experienced invasive Haemophilus...

Phase I study to begin for therapeutic vaccine for hepatitis.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Genencor International, Inc., (GCOR) will begin phase I safety and immunogenicity testing for its DNA-based therapeutic vaccine to treat hepatitis B. Trials are scheduled to begin under an...

Cucumber mosaic virus as carrier of a hepatitis C virus-derived epitope.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The cucumber mosaic virus can be used as a carrier of a hepatitis C virus-derived epitope. "Cucumber mosaic virus (CMV) is a three component isodiametric plant virus which is common worldwide and...

IL-23 induces strong immune responses in hepatitis C DNA immunization.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- IL-23 induces stronger sustained CTL and Th1 immune responses than does IL-12 after hepatitis C virus envelope protein 2 DNA immunization. "IL-23 is a heterodimeric cytokine consisting of p19 and...

Prevention of cervical cancer through HPV vaccination reviewed.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- A researcher has reviewed the prevention of cervical cancer through human papillomavirus (HPV) vaccination in a recent issue of Nature Reviews Immunology. According to recent research from...

Iowa Senator wants ban on vaccines containing thimerosal.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Iowa Senator Ken Veenstra, R-Orange City, said he'll propose a bill that would ban the use of a mercury-based preservative used in some childhood vaccines. Veenstra, chairman of the Senate Human...

New Mexico moves toward immunization registry to aid tracking of vaccine rates.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- While New Mexico already has emerged from the bottom of national immunization-rate rankings, state health officials say their efforts would be bolstered by a proposal that moved closer to legislative...

Soldier who refused anthrax vaccine off to Iraq.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The United States Army dropped one charge against an Ohio National Guard member convicted once and charged again with disobeying a lawful order after he refused to take the anthrax vaccine, then...

Apical membrane antigen 1 mediates merozoite attachment to host cells.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells. "Apical membrane antigen 1 (AMA-1) of Plasmodium...

Explosive growth to push cancer vaccine market past $1B.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The worldwide market for cancer vaccines will experience explosive growth in the next few years, according to a new study released from Kalorama Information. Triple-digit growth will propel the market...

Thousands of babies need to retake hepatitis B vaccine.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- About 4,300 babies born at University Hospital in Denver, Colorado, in the past 2 years need to get the hepatitis B vaccine again because their first shot may have been defective. The vaccine may...

Antibody to neisserial antigen 2132 protects against bacteremia.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. ...

Conjugate vaccines may prevent otitis media.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Conjugate vaccines may be able to prevent otitis media. According to a study from England, "The relative abilities of pneumococcal serotypes and strains (clones) to cause acute otitis media (AOM)...

Epidemiology of otitis media caused by S. pneumoniae reported.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Scientists report the epidemiology of acute otitis media caused by Streptococcus pneumoniae before and after licensure of the 7-valent pneumococcal protein conjugate vaccine. "We studied, by...

Patent granted for EradicAide technology to diagnose, prevent, treat AIDS.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Adventrx Pharmaceuticals (AVRX) announced that its collaborators at the University of Texas M.D. Anderson Cancer Center have been issued United States Patent number 6,656,471 entitled "HIV-specific...

Nigerian team seeks reassurance that polio vaccine is safe.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- With its polio outbreak spreading, Nigeria recently sent a team of scientists, officials and Muslim leaders abroad to bring back proof that the vaccine is neither contaminated nor a Western plot to...

Company restructures to support commercialization programs.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- GTC Biotherapeutics, Inc., (GTCB) is restructuring its organization to support its focus on clinical development and commercialization of its internal pipeline of proprietary products and its portfolio...

SARS vaccine phase I clinical testing commences.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Sinovac Biotech Ltd. (SNVBF) announced that the Chinese State Drug Administration (SFDA) has authorized its operating subsidiary in Beijing, Sinovac Biotech Co., Ltd., to select 30 volunteers for the...

Potential vaccine antigens of Streptococcus pyogenes identified.
March 3, 2004... 2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers have characterized 16 putative extracellular lipoproteins made by Streptococcus pyogenes, which are new candidate vaccine antigens. "Putative extracellular lipoproteins made by group A...

Hepatitis E virus-like particles protect monkeys against HEV infection.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Oral administration of recombinant hepatitis E virus-like particles protected cynomolgus monkeys against HEV infection. According to recent research published in the journal Vaccine, "Hepatitis E...

Lentiviral vector encoding NY-ESO-1 induces effective CTL response.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective cytotoxic T lymphocyte (CTL) response. "Lentiviral vectors can efficiently transduce a variety of nondividing...

Altering conditions of DNA immunization allows control of immune response.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Altering the cellular localization of expressed protein and the immunization route in DNA immunization allows manipulation of the immune response. According to published research from the United...

Peptide vaccine helpful for HLA-A2-positive patients with prostate cancer.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Peptide vaccination is helpful in HLA-A2-positive patients with metastatic hormone-refractory prostate cancer. "To evaluate the safety and toxicity of peptide vaccination for patients with...

HIV-1 Tat peptide-rotavirus enterotoxin protein stimulates immune response.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Co-immunization with an HIV-1 Tat transduction peptide-rotavirus enterotoxin fusion protein stimulates a Th1 mucosal immune response in mice. According to published research from the United States,...

IL-12 enhances immunity of Schistosoma mansoni fatty acid-binding protein.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14-kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway. ...

Vaccine shows promise in animal model.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- A new vaccine for Alzheimer disease created by researchers at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia has shown promise in initial testing in primates. ...

FDA-licensed anthrax vaccine supplied to Taiwan.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- BioPort Corporation announced the sale of U.S. Food & Drug Administration (FDA)-licensed anthrax vaccine, BioThrax, to the Taiwanese government, marking the company's entry into the commercial market...

IL-2-activated NK cells enhance effect of tumor vaccine in brain cancer.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model. "Combined...

Drug development company announces reduced loan principal.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- VaekstFonden has informed Pharmexa that the principal of a loan taken out by Pharmexa in 1997 will be written down from DKK 21 million to DKK 9 million. The DKK 12 million was used in the...

CG motifs in virus-like particles induce cytotoxic T cell responses.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. According to a study from Switzerland, "DNA rich in...

Progress made in vaccines against gastrointestinal helminth parasites.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Scientists are making progress in developing vaccines against most important gastrointestinal helminth parasites of humans and animals. According to a study from Poland, "Among many vaccine...

HIV-1 Nef delivery to dendritic cells may stimulate immune response.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Delivery of HIV-1 Nef to dendritic cells using an adenoviral vector shows promise as a method to induce an immune response against HIV-1. "The Net gene is a major determinant of HIV-1...

HIV-neutralizing antibody fragment isolated from lupus library.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- An HIV-neutralizing lupus antibody fragment has been identified. According to published research from the United States, a "single-chain fragment containing antibody V domains (scFv) isolated from...

Hepatitis B surface antigenemia occurs after hepatitis A and B vaccination.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Hepatitis B surface antigenemia may occur following vaccination with a combined vaccine against hepatitis A and B. "We report a case of transient hepatitis B surface antigenemia (HBsAg) following...

Targeted treatment could contain pandemic influenza.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- In a future outbreak of pandemic influenza, such as the three pandemics that sickened and killed millions of people during the 20th century, supplies of flu vaccine might not be available quickly...

Children with nephrotic syndrome have adequate response to influenza vaccine.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Children with nephrotic syndrome have an adequate antibody response to influenza A vaccination. "The aim of this study was to determine the antibody response to influenza vaccination in children...

Parainfluenza type 3 vaccine safe and effective in children.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Parainfluenza type 3 cold passage mutant 45 live attenuated vaccine was safe and effective in healthy children 6 to 18 months old. "A phase 2 evaluation of live attenuated parainfluenza type 3...

Fibroblast cell lines susceptible to TSE agents.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Common fibroblast cell lines are susceptible to transmissible spongiform encephalopathy (TSE) agents. "The risk of contamination of tissue culture cells with transmissible spongiform...

New inoculations show promise.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Tests of an experimental smallpox vaccine have produced encouraging results in monkeys and mice. The discovery may lead to an alternative for humans unable to receive current smallpox vaccines. ...

Recommendations issued on development of drugs for vaccine side effects.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration has issued draft guidance for the development of drugs to treat the side effects of vaccination against smallpox with vaccinia virus. The need for drugs to...

Altastaph receives FDA fast track designation.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NABI) announced that the U.S. Food and Drug Administration (FDA) has determined the company's investigational product, Altastaph [Staphylococcus aureus Immune Globulin (Human)]...

Prospects for new tuberculosis vaccines reviewed.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Researchers review prospects for new tuberculosis vaccines in a recent issue of the International Journal of Tuberculosis and Lung Disease. According to recent research from Switzerland, "Research...

Acetyl and phosphate groups quantified in vaccine polysaccharides.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Scientists have quantified O-acetyl, N-acetyl and phosphate groups in bacterial vaccine polysaccharides by high-performance anion-exchange chromatography with conductivity detection (HPAEC-CD). ...

Diphtheria-tetanus-pertussis vaccine booster effective in adults.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- A diphtheria-tetanus-acellular pertussis vaccine booster was effective at increasing immunity in adults. According to recent research published in the journal Vaccine, "Two clinical studies were...

Expression of exogenous genes in Trypanosoma cruzi improved.
March 31, 2004... 2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Investigators have improved the expression of exogenous genes in Trypanosoma cruzi. "To improve transfection efficiency in Trypanosoma cruzi, we developed a new electroporation protocol and...