Vaccine Weekly articles from March 1999

Vaccine Weekly archives from March 1999

AIDS Vaccine From Mutant-Fingered HIV?
March 1, 1999... Could DNA encoding HIV with mutant zinc fingers work as an AIDS vaccine? Yes, according to monkey studies conducted at the U.S. National Cancer Institute (NCI). Three of four animals that received the prototype vaccine remain AIDS...

AIDS Vaccine From Tied-Up HIV?
March 1, 1999... Can tying up HIV's two fingers make it a safe vaccine? If so, it might provide the most complete inactivated whole-virus retroviral vaccine yet created. The major question, of course, is whether such a vaccine could be safe. "We've...

CTL Defect Gives HIV A Toehold.
March 1, 1999... Soon after it enters the body, HIV appears to hammer a chink in immune defenses. Taking advantage of this early defect in lymphoid cytotoxic lymphocytes (CTLs), new findings suggest, HIV establishes the permanent vantage point from which...

CTL Epitope Effort Moves Toward AIDS Vaccine.
March 1, 1999... Bit by bit, a group of research teams are piecing together the parts of an HIV vaccine. It is widely believed that the most effective AIDS vaccine should capable of eliciting HIV specific cytotoxic lymphocyte (CTL) responses....

Infected People Who Test Negative Carry Normal Virus.
March 1, 1999... They test negative for HIV but the virus they carry appears normal, although fully infectious. AIDS surveillance by the U.S. Centers for Disease Control and Prevention (CDC) has turned up several people who test negative on most...

Live Vaccine Protects Against Heterologous Challenge.
March 1, 1999... A live, nef-deleted simian immunodeficiency virus (SIV) offered monkeys long-term protection against infection with many different SIV strains. It seems doubtful, however, whether live virus with attenuated replicative capacity can ever be...

When Can HAART Patients Stop OI Prophylaxis?
March 1, 1999... "Can I stop taking some of these pills?" Clinicians face this question for each patient responding to highly active antiretroviral therapy (HAART). When can such a patient cease taking medicines that prevent opportunistic infections (OIs)?...

MAbs May be Used for Immunotherapy.
March 1, 1999... Human monoclonal antibodies with potent neutralizing activity against human parvovirus B19 might be used for immunotherapy of B19 virus infected individuals, findings suggest. Andreas Gigler of Germany's Universitat Regensburg and...

Protein Associated with Erythrocyte Membrane Induces Protective Response.
March 1, 1999... Researchers report the characterization of a protective antigen of Plasmodium yoelii that is associated with the red cell membrane. James M. Burns, Jr., and colleagues of Tennessee's Meharry Medical College previously used the P. yoelii...

Work Provides Novel Insights into Immunity to Antigenic Variants.
March 1, 1999... Researchers have identified a novel Plasmodium falciparum gene that is switched on during antigenic variation. A primary infection by the Plasmodium falciparum Palo Alto O and R antigenic variants induces a variant-specific immunity in the...

Structural Proteins vp4 and 2a Influence Hepatitis A.
March 1, 1999... The structural proteins vp4 and 2a are critical in the capsid assembly of hepatitis A virus particles, according to a report from Germany's University of Lubeck. Capsid assembly is the final event of virus replication, and its...

Taiwan Experience Shows Universal Immunization is Best.
March 1, 1999... Universal infant immunization has been more effective than selective vaccination in reducing overall hepatitis B carriage in Taiwan. In 1984, a hepatitis B mass immunization program was launched in the country, beginning with newborns of...

Combined HBV/Flu Vaccine is Cost Effective.
March 1, 1999... A combination vaccine protecting against hepatitis B virus and influenza would be cost effective as part of a routine childhood immunization schedule, according to a report from the University of Michigan. Compliance with hepatitis B virus...

Long-Term Follow-Up of HAV Immunizations Reported.
March 1, 1999... Inactivated hepatitis A vaccine is safe and immunogenic in children, and the duration of protection against HAV infection is longer than five years. Researcher C.Y. Chan and colleagues conducted a long-term follow-up of hepatitis A...

Response to pre-S/S Vaccine Influenced by Genotype.
March 1, 1999... It appears that immune response to a pre-S/S hepatitis B vaccine is influenced by the HLA genotype of the person being vaccinated. In this study, A.B. McDermott and colleagues investigated the effects of single pre-S/S (Hepagene)...

Protestors Up in Arms Over Experiments that Give Chimps HIV.
March 1, 1999... Does the prospect of developing an effective HIV vaccine justify condemning chimpanzees to death? That's the stark question dividing biomedical researchers in the U.S., now that virologists know that some strains of HIV cause the same...

Collaborations Signed To Develop Solid Tumor Treatments.
March 1, 1999... Idec Pharmaceuticals, San Diego, California, announced the signing of three research collaborations that expand the company's product development efforts in the field of cancer. The collaborations focus on the use of both immunotherapeutic...

Multicomponent Vaccine Shows Promise in Laboratory Tests.
March 1, 1999... A team of researchers, including grantees of the U.S. National Institute of Allergy and Infectious Diseases (NIAID), reported positive results of research on a broad-based malaria vaccine. A paper describing their findings was published in...

Possible Vaccine Fights Disease Throughout Its Life Cycle.
March 1, 1999... Researchers have discovered a possible way to vaccinate against malaria, which kills up to 3 million people a year and sickens an additional 300 million. Creating a vaccine is crucial because the parasite has begun developing resistance to...

Mass Immunization Plan Announced To Fight Meningitis.
March 1, 1999... North Dakota state officials announced plans to vaccinate nearly 5,000 young people in Williston to try to prevent the spread of a bacterial infection that killed a two-year-old boy. "We're recommending that children in Williston between 18...

CDC Panel Urges Mandatory Hepatitis Shots for Children.
March 1, 1999... A U.S. health group urged Arizona, Utah, and nine other states with a high incidence of hepatitis A to require the children be vaccinated. Children are one of the highest risk groups for hepatitis A, the U.S. Centers for Disease Control and...

South African Health Minister Slams AIDS Researchers.
March 1, 1999... Medical researchers seeking an AIDS vaccine were lambasted by South African Health Minister Nkosazana Zuma for ignoring the region where the disease is most prevalent. "About 70 percent of the cases of AIDS in the world are in sub-Saharan...

Neonatal Testosterone and Sexual Development.
March 1, 1999... Hormones (Sexual Development) "Neonatal Testosterone and Sexual Development." D.R. Mann. Morehouse School of Medicine, Atlanta, Georgia. NIH GRANT NUMBER: 5ROIHD26423-09. GRANT EXPIRES: March 31, 1999. PRINCIPLE INVESTIGATOR: David R....

Gene Gun-Mediated Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)/Interleukin-12 (IL-12) cDNA Tumor Cell Vaccine is Effective Against Multi-Drug Resistant Murine Myeloma.
March 1, 1999... Cancer Immunotherapy "Gene Gun-Mediated Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)/Interleukin-12 (IL-12) cDNA Tumor Cell Vaccine is Effective Against Multi-Drug Resistant Murine Myeloma." J.G. Turner, A. Stihl, W.S. Dalton...

An Ethical Dilemma: HTLV False Positives, Flu Vaccine, and Donor Retention.
March 1, 1999... Donor Deferral "An Ethical Dilemma: HTLV False Positives, Flu Vaccine, and Donor Retention." C.A. Litty, J. Lugo and C. McDevitt. American Red Cross, Philadelphia, Pennsylvania. According to an abstract submitted by the authors to the...

Lymphoepithelial Interaction During Chlamydial Infection.
March 1, 1999... STDs (Chlamydia) "Lymphoepithelial Interaction During Chlamydial Infection." J.U. Igietseme. Morehouse School of Medicine, Atlanta, Georgia. NIH GRANT NUMBER: 5ROIAI41231-03. GRANT EXPIRES: August 31, 2001. PRINCIPLE INVESTIGATOR:...

Methods for Evaluating Vaccine Efficacy.
March 1, 1999... Vaccine Efficacy "Methods for Evaluating Vaccine Efficacy." Mary E. Halloran. Emory University, Atlanta, Georgia. NIH GRANT NUMBER: 5ROIA132042-07. GRANT EXPIRES: March 31, 1999. PRINCIPLE INVESTIGATOR: Mary E. Halloran. PERFORMING...

Current Status of a Mucosal Vaccine Against Dental Caries.
March 1, 1999... Dental Caries Hajishengallis, G.; Michalek, S.M. "Current Status of a Mucosal Vaccine Against Dental Caries." Oral Microbiology and Immunology, February 1999;14(1):1-20. According to the authors' abstract of an article published in...

The Effect of Random Vaccine Response on the Vaccination Coverage Required To Prevent Epidemics.
March 1, 1999... Epidemiologic Models Becker, N.G.; Starczak, D.N. "The Effect of Random Vaccine Response on the Vaccination Coverage Required To Prevent Epidemics." Mathematical Biosciences, December 15, 1998;154(2):117-135. According to the authors'...

Effect of Transplacentally Acquired Tetanus Antibodies on the Antibody Responses to Haemophilus influenzae Type b-Tetanus Toxoid Conjugate and Tetanus Toxoid Vaccines in Filipino Infants.
March 1, 1999... Haemophilus influenzae Nohynek, H.; Gustafsson, L.; Capeding, M.R.Z.; Kayhty, H.; Olander, R.M.; Pascualk, L.; Ruutu, P. "Effect of Transplacentally Acquired Tetanus Antibodies on the Antibody Responses to Haemophilus influenzae Type...

Histologic and Immunologic Associations of an HPV16 Variant in LoSIL Smears.
March 1, 1999... Human Papillomavirus Etherington, I.J.; Ellis, J.R.; Luesley, D.M.; Moffitt, D.D.; Young, L.S. "Histologic and Immunologic Associations of an HPV16 Variant in LoSIL Smears." Gynecologic Oncology, January 1999;72(1):56-59. According to...

Protection Against Influenza After Annually Repeated Vaccination - A Meta-analysis of Serologic and Field Studies.
March 1, 1999... Influenza Beyer, W.E.P.; Debruijn, I.A.; Palache, A.M.; Westendorp, R.G.J.; Osterhaus, A.D.M.E. "Protection Against Influenza After Annually Repeated Vaccination - A Meta-analysis of Serologic and Field Studies." Archives of Internal...

Poor Serologic Responses Five to Seven Years After Immunization With High and Standard Titer Measles Vaccines.
March 1, 1999... Measles Vaccines (Persistence) Whittle, H.; Aaby, P.; Samb, B.; Cisse, B.; Kanteh, F.; Soumare, M.; Jensen, H.; Bennett, J.; Simondon, F. "Poor Serologic Responses Five to Seven Years After Immunization With High and Standard Titer Measles...

Direct Detection of Sabin Poliovirus Vaccine Strains in Stool Specimens of First-Dose Vaccinees by a Sensitive Reverse Transcription PCR Method.
March 1, 1999... Poliovirus Vaccine Buonagurio, D.A.; Coleman, J.W.; Patibandla, S.A.; Prabhakar, B.S.; Tatem, J.M. "Direct Detection of Sabin Poliovirus Vaccine Strains in Stool Specimens of First-Dose Vaccinees by a Sensitive Reverse Transcription PCR...

Recombinant Caccinia-PSA [PROSTVAC] Can Induce a Prostate-Specific Immune Response in Androgen-Modulated Human Prostate Cancer.
March 1, 1999... Prostate Cancer Sanda, M.G.; Smith, D.C.; Charles, L.G.; Hwang, C.; Pienta, K.J.; Schlom, J.; Milenic, D.; Panicali, D.; Montie, J.E. "Recombinant Caccinia-PSA [PROSTVAC] Can Induce a Prostate-Specific Immune Response in Androgen-Modulated...

ALVAC As Postexposure AIDS Vaccine For Newborns.
March 8, 1999... Newborn babies of HIV infected women are getting an experimental AIDS vaccine in a daring clinical trial. The trial, ACTG 326, hopes to show that the Virogenetics Corp./Pasteur-Merieux-Connaught ALVAC vaccine can help protect against...

Another Mysterious Anti-HIV Factor.
March 8, 1999... A new, naturally occurring factor may protect some people against HIV. Immunologic studies of sex workers who remain uninfected despite heavy HIV exposure suggested to U.S. Centers for Disease Control and Prevention (CDC) researcher T....

Canarypox Has Odd Impact on Dendritic Cells.
March 8, 1999... Canarypox-based AIDS vaccines have an unusual effect on dendritic cells (DC). DCs are the antigen-presenting cells (APCs) that take up and transport exogenous antigen to the lymph nodes, initiating a cascade of immune responses. Canarypox...

HIV Neutralizing Antibodies Restricted To V2 Loop?
March 8, 1999... Studies with DNA vectors may have located HIV epitopes that elicit neutralizing antibodies. Researchers L. Stamatatos and C. Cheng-Mayer at the Aaron Diamond AIDS Research Center (ADARC) have built DNA constructs that express two soluble...

PBMC From Some ALVAC Vaccinees Resist Heterologous HIV.
March 8, 1999... Blood cells from some recipients of an experimental AIDS vaccine strongly resist in vitro HIV infection. This resistance is dependent on CD8(+) T lymphocytes - currently considered the most important immune response for AIDS vaccines to...

The Dam Begins to Break.
March 8, 1999... Remember David Ho's gentle image of a kitchen sink filling with T cells as HIV drained them away? Forget about it. The new symbol for AIDS is a dam about to give way. The image comes from hard-working AIDS writer Laurie Garrett. Her...

CDC Says Vaccinate Hemodialysis Patients.
March 8, 1999... Efforts to vaccinate hemodialysis patients against hepatitis B are inadequate, says the U.S. Centers for Disease Control and Prevention. Hepatitis B virus (HBV) infection is a well-recognized risk in chronic hemodialysis patients. Although...

Multistage, Multicomponent Vaccine Produces Antiparasitic Activity.
March 8, 1999... A multistage and multicomponent recombinant malaria vaccine inhibited parasite development. "Compared with a single-stage antigen-based vaccine, a multistage and multivalent Plasmodium falciparum vaccine would be more efficacious by...

Interleukin-2 Boosts Vaccine Effectiveness in Mice.
March 8, 1999... In a study published in the March 2, 1999, issue of the Proceedings of the National Academy of Sciences, University of Michigan researchers presented the results of experiments testing the effectiveness of the vaccine/Interleukin-2 (IL-2)...

Hypothesis Says Germs Behind Heart Disease and Cancer.
March 8, 1999... A shot to prevent cancer? Vaccination against heart disease? Immunization against multiple sclerosis? All might be possible if a theory in medicine holds true. The idea that many of the most serious illnesses may be caused sometimes by...

Hepatitis A May Become Part of Routine Immunization Some States.
March 8, 1999... Children in Idaho and Washington, USA, may get one more shot in the arm when they go the doctor's office or health district. A U.S. federal health panel voted to add hepatitis A to the list of recommended childhood vaccinations in states...

Two States Plan To Continue Targetted Vaccinations.
March 8, 1999... New Mexico, USA, has planned to stick with its current program of targeting hepatitis A vaccinations at children who live in communities that are hot spots for the disease, rather than implementing statewide requirements, a health official...

Association Urges Universal Hepatitis Vaccinations for Gay Men.
March 8, 1999... The Gay and Lesbian Medical Association (GLMA) called for universal hepatitis A and B vaccinations for men who have sex with men. These guidelines note that gay men are at increased risk for both hepatitis A and B, both of which are...

Hepatitis B Vaccination Requirement New to New Hampshire.
March 8, 1999... In Fall 1999, student athletes will be required to get vaccinations against the hepatitis B virus. The policy is a first in the state of New Hampshire and perhaps in the northeastern U.S. The state recommends hepatitis B vaccinations for...

Senegal Meningitis Outbreak Kills 200.
March 8, 1999... Two hundred people have died from meningitis in Senegal so far in 1999 and more than 1,900 cases have been reported, medical sources said. Senegal and other countries in the Sahel region on the fringes of the Sahara desert experience...

WHO Says Polio Almost Eradicated.
March 8, 1999... The world can eradicate poliomyelitis within two years, Dr. Gro Harlem Brundtland, World Health Organization (WHO), said. "Thanks to steady progress in vaccination, we are on the brink of eradicating this crippling disease - with an...

Scientist Denies that Polio Vaccine-Cancer Link Is Proven.
March 8, 1999... A Baylor College of Medicine, Louisiana, scientist said a London, United Kingdom, newspaper misinterpreted her study about a possible link between an early polio vaccine and cancer. Dr. Janet S. Butel has not proved that a monkey virus that...

Automated Single Donor Hepatitis C Virus PCR.
March 8, 1999... Diagnostics (HCV) "Automated Single Donor Hepatitis C Virus PCR." T.J. Legle, Q. Wolf, J. Riggert, R. Thomssen, K.H. Heermann, Q. Simson and M. Kohler. Dept. of Transfusion Medicine; Dept. of Medical Microbiology, University of Goettingen,...

Basic Principles of Transfection Initiated Immunizations.
March 8, 1999... DNA Vaccines "Basic Principles of Transfection Initiated Immunizations." Harriet L. Robinson. Emory University, Atlanta, Georgia. NIH GRANT NUMBER: 5ROIA134946-06. GRANT EXPIRES: June 30, 2002. PRINCIPLE INVESTIGATOR: Harriet L....

T-Cell Responses to Mycobacterial Infection.
March 8, 1999... Diagnostics (TB) "T-Cell Responses to Mycobacterial Infection." Harry K. Ziegler. Emory University, Atlanta, Georgia. NIH GRANT NUMBER: 5ROIA135285-05. GRANT EXPIRES: June 30, 1999. PRINCIPLE INVESTIGATOR: Harry K. Ziegler. PERFORMING...

CD8(+) T Cells and Trypanosoma cruzi Infections.
March 8, 1999... Immunology (T. cruzi) "CD8(+) T Cells and Trypanosoma cruzi Infections." Rick L. Tarleton. University of Georgia, Athens, Georgia. NIH GRANT NUMBER: 2ROIA133106-05. GRANT EXPIRES: May 31, 2003. PRINCIPLE INVESTIGATOR: Rick L. Tarleton....

Hepatitis B Surface Antigenemia in Adult Hemodialysis Patients Following Vaccination. Is it Associated to Vaccine Non-Responders?
March 8, 1999... Transient Antigenemia "Hepatitis B Surface Antigenemia in Adult Hemodialysis Patients Following Vaccination. Is it Associated to Vaccine Non-Responders?" N. Esparza, A. Moreno, A. Toledo, S. Suria, P. Rossique, C. Ciarcia-Canton, R....

Changes in the Fine Specificity of gp100((209-217))-Reactive T Cells in Patients Following Vaccination With a Peptide Modified at an HLA-A2.1 Anchor Residue.
March 8, 1999... Cancer Vaccines Clay, T.M.; Custer, M.C.; Mckee, M.D.; Parkhurst, M.; Robbins, P.F.; Kerstann, K.; Wunderlich, J.; Rosenberg, S.A.; Nishimura, M.I. "Changes in the Fine Specificity of gp100((209-217))-Reactive T Cells in Patients Following...

Isolation of MHC Class I-Restricted Tumor Antigen Peptide and its Precursors Associated With Heat Shock Proteins hsp70, hsp90, and gp96.
March 8, 1999... Cancer Vaccines Ishii, T.; Udono, H.; Yamano, T.; Ohta, H.; Uenaka, A.; Ono, T.; Hizuta, A.; Tanaka, N.; Srivastava, P.K.; Nakayama, E. "Isolation of MHC Class I-Restricted Tumor Antigen Peptide and its Precursors Associated With Heat...

Effectiveness of a Vaccine Composed of Heat-Killed Candida albicans and a Novel Mucosal Adjuvant, LT(R192G), Against Systemic Candidiasis.
March 8, 1999... Candidiasis Cardenasfreytag, L.; Cheng, E.; Mayeux, P.; Domer, J.E.; Clements, J.D. "Effectiveness of a Vaccine Composed of Heat-Killed Candida albicans and a Novel Mucosal Adjuvant, LT(R192G), Against Systemic Candidiasis." Infection and...

Genetic Vaccination Against Coccidioides immitis: Comparison of Vaccine Efficacy of Recombinant Antigen 2 and Antigen 2 cDNA.
March 8, 1999... DNA Vaccines Jiang, C.; Magee, D.M.; Quitugua, T.N.; Cox, R.A. "Genetic Vaccination Against Coccidioides immitis: Comparison of Vaccine Efficacy of Recombinant Antigen 2 and Antigen 2 cDNA." Infection and Immunity, February...

IL-6 Induces Long-Term Protective Immunity Against a Lethal Challenge of Influenza Virus.
March 8, 1999... Influenza DNA Vaccines Lee, S.W.; Youn, J.W.; Seong, B.L.; Sung, Y.C. "IL-6 Induces Long-Term Protective Immunity Against a Lethal Challenge of Influenza Virus." Vaccine, February 5, 1999;17(5):490-496. According to the authors'...

Accuracy of ICD-9-CM Codes in Detecting Community-Acquired Pneumococcal Pneumonia for Incidence and Vaccine Efficacy Studies.
March 8, 1999... Pneumonia Guevara, R.E.; Butler, J.C.; Marston, B.J.; Plouffe, J.F.; File, T.M.; Breiman, R.F. "Accuracy of ICD-9-CM Codes in Detecting Community-Acquired Pneumococcal Pneumonia for Incidence and Vaccine Efficacy Studies." American Journal...

Nucleocapsid Protein Zinc-Finger Mutants of Simian Immunodeficiency Virus Strain Mne Produce Virions that are Replication Defective in vitro and in vivo.
March 8, 1999... Simian Immunodeficiency Virus Gorelick, R.J.; Benveniste, R.E.; Gagliardi, T.D.; Wiltrout, T.A.; Busch, L.K.; Bosche, W.J.; Coren, L.V.; Lifson, J.D.; Bradley, P.J.; Henderson, L.E.; Arthur, L.O. "Nucleocapsid Protein Zinc-Finger Mutants...

The Effect of Smoking on Influenza, Influenza Vaccination Efficacy and on the Antibody Response to Influenza Vaccination.
March 8, 1999... Smoking (Influenza) Cruijff, M.; Thijs, C.; Govaert, T.; Aretz, K.; Dinant, G.J.; Knottnerus, A. "The Effect of Smoking on Influenza, Influenza Vaccination Efficacy and on the Antibody Response to Influenza Vaccination." Vaccine, February...

VEE Replicons Moving Forward As AIDS Vaccine.
March 15, 1999... A recombinant encephalitis virus protects monkeys against AIDS and is moving steadily toward human trials. University of North Carolina, Chapel Hill researchers have developed recombinant proviral genomes - known to virologists as...

AIDS Mystery Solved.
March 15, 1999... AIDS occurs when HIV learns to infect naive T cells, a new study confirms. A central mystery to AIDS is why CD4(+) T cells drop precipitously after a long period in which they remain low but relatively stable. Virology studies show that a...

Ex-Vivo-Expanded CTL Home In On Lymph-Node HIV.
March 15, 1999... It's one step back, two steps forward for a promising AIDS immunotherapy. The idea seems simple: since HIV specific cytotoxic lymphocytes (CTLs) appear to be important in fighting the virus, why not expand a patient's CTL ex vivo and...

Vaccinia Comes Back As An AIDS Vaccine.
March 15, 1999... Can vaccinia virus do for AIDS what it did for smallpox? Researchers at the U.S. National Institute of Allergy and Infectious Diseases (NIAID) think it can. Live, attenuated vaccinia is the basis of the hugely successful smallpox...

Routine Vaccination is Needed in U.S.
March 15, 1999... Routine universal childhood vaccination against hepatitis A is the only way to eradicate related illness in the United States, according to a noted researcher. In a recent editorial, Raymond S. Koff of Massachusetts' MetroWest Medical...

Combined HAV/HBV Vaccine Shown Effective.
March 15, 1999... A combined hepatitis A and B vaccine designed for children and adolescents was shown to be highly effective in a Canadian cohort. Pediatric monocomponent formulations of vaccines against hepatitis A and B have proven to be safe and...

Intervention Programs Increase HBV Immunizations.
March 15, 1999... Community intervention and doctor education programs can dramatically increase infant immunizations against hepatitis B, according to a California study. The study compared the hepatitis B vaccination incidence in San Francisco, where an...

Patent Issued for Use of PSA in Prostate Cancer Vaccine.
March 15, 1999... Jenner Biotherapies, San Ramon, California, announced the allowance of claims in the United States covering the use of recombinant prostate specific antigen (PSA) in the immunotherapy of patients with prostate cancer. The allowed claims...

Middle-Aged Women with Chronic Conditions at Higher Risk During Flu Season.
March 15, 1999... Morbidity and mortality associated with the flu is higher among women with chronic medical conditions, concluded University of Washington, Seattle, researchers. Kathleen Maletic Neuzil, MD, MPH, and colleagues studied women aged 15 to 64...

Vaccine Reduces Flu Incidence in Health Care Workers.
March 15, 1999... Annual flu shots are effective in preventing infection, onset of respiratory illness, and may reduce work absences, according to an article in the March 10, 1999, issue of The Journal of the American Medical Association (JAMA). James A....

Results of Novel HIV Test Published.
March 15, 1999... IGEN International, Inc., Gaithersburg, Maryland, announced that Amsterdam Medical Centre (AMC) in The Netherlands published data in the January 1999 issue of the Journal of Clinical Microbiology on a novel HIV test developed in collaboration...

Construction of a Vaccinia Virus Vectored Multiepitope Live Vaccine for Plasmodium falciparum and the Assessment of Immunological Character.
March 15, 1999... Malaria Vaccines "Construction of a Vaccinia Virus Vectored Multiepitope Live Vaccine for Plasmodium falciparum and the Assessment of Immunological Character." D. Wenqi, L. Ming, B. Huixtang and L. Yingjie. Institute of Tropical Medicine,...

GPI-Anchored Molecules as Therapeutic Vaccines.
March 15, 1999... Cancer Vaccines "GPI-Anchored Molecules as Therapeutic Vaccines." Periasamy Selvaraj. Emory University, Atlanta, Georgia. NIH GRANT NUMBER: 5ROICA70833-03. PRINCIPLE INVESTIGATOR: Periasamy Selvaraj. PERFORMING ORGANIZATION: Emory...

Tentative Vaccination of Mice with a Poliovirus cDNA Carrying Tumor Rejection Antigens from the Murine P815 Mastocytoma.
March 15, 1999... Cancer Vaccines "Tentative Vaccination of Mice with a Poliovirus cDNA Carrying Tumor Rejection Antigens from the Murine P815 Mastocytoma." G. Duncan, R. Mouawadi, D. Khayati, C. Soubrane and F. Colbere-Garapin. Genetique Virale-NRSN,...

Liposome-Based Vaccine Adjuvant System for HIV Immunization.
March 15, 1999... HIV Vaccines "Liposome-Based Vaccine Adjuvant System for HIV Immunization." Gary Fujii. Molecular Express, Inc., 13310 S. Figueroa St., Los Angeles, California 9061. NIH GRANT NUMBER: 1R43AI43807-01. GRANT EXPIRES: February 14, 2000....

Development of a Malaria Transmission Blocking Vaccine.
March 15, 1999... Malaria Vaccine "Development of a Malaria Transmission Blocking Vaccine." Nirbhay Kumar. Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218. NIH GRANT NUMBER: 1R21AI38403-01A2. GRANT EXPIRES: September 29, 1999....

IL-2 Gene-Modified Tumour Vaccines: Monitoring of IL-2 Levels in Serum and Peritoneal Cavity of Vaccinated Mice.
March 15, 1999... Cancer Vaccines Indrova, M.; Pajtaszpiasecka, E.; Jandlova, T.; Simova, J.; Bubenik, J.; Radzikowski, C. "IL-2 Gene-Modified Tumour Vaccines: Monitoring of IL-2 Levels in Serum and Peritoneal Cavity of Vaccinated Mice." Folia Biologica,...

T-Cell-Epitope Mapping of the Idiotypic Monoclonal IgG Heavy and Light Chains in Multiple Myeloma.
March 15, 1999... Cancer Vaccines Fagerberg, J.; Yi, Q.; Gigliotti, D.; Harmenberg, U.; Ruden, U.; Persson, B.; Osterborg, A.; Mellstedt, H. "T-Cell-Epitope Mapping of the Idiotypic Monoclonal IgG Heavy and Light Chains in Multiple Myeloma." International...

The Immunogenicity and Safety of a New Combined Diphtheria, Tetanus, and Poliomyelitis Booster Vaccine (Td-eIPV).
March 15, 1999... Combined Vaccines Laroche, P.; Barrand, M.; Wood, S.C.; Vanhasbrouck, K.; Lang, J.; Harzer, E.; Hessel, L. "The Immunogenicity and Safety of a New Combined Diphtheria, Tetanus, and Poliomyelitis Booster Vaccine (Td-eIPV)." Infection,...