Vaccine Weekly articles from June 2004

Vaccine Weekly archives from June 2004

Role of therapeutic vaccines for the control of HIV-1 reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review the role of therapeutic vaccines for the control of HIV-1 in a recent issue of the Journal of Antimicrobial Chemotherapy. According to recent research from England, "The recent...

Hepatitis vaccination in patients with chronic liver disease reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review hepatitis vaccination in patients with chronic liver disease in a recent issue of Alimentary Pharmacology and Therapeutics. According to a study from the United States, "Evidence...

Intranasal influenza vaccine causes facial paralysis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The intranasal influenza vaccine caused facial paralysis in a working population in Switzerland. According to recent research from Switzerland, "In the present study, we assessed the incidence of...

Aerosol better than subcutaneous delivery for measles booster.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have performed immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine. ...

Prevalence of dermatologic reactions to smallpox vaccine reported.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers report the prevalence of benign dermatologic reactions to smallpox vaccination in adults in a recent issue of Clinical Infectious Diseases. "A phase 1 smallpox vaccine trial involving...

CTL ontogeny and viral escape have implications for HIV vaccine design.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Cytotoxic T lymphocyte (CTL) ontogeny and viral escape have implications for HIV vaccine design. According to recent research published in the journal Trends in Immunology, "The protective role of...

Components of HIV vaccine are recognized by T-helper cells.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells. "HIV has thus far evaded control by vaccines, in part due to the high diversity among viral...

IL-15 may be beneficial for AIDS immunotherapy.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Interleukin-15 (IL-15) may be beneficial for AIDS immunotherapy. According to recent research published in the journal Trends in Immunology, "The current antiretroviral therapy has improved the...

Neutralizing antibodies against HIV-1 tat antigen characterized.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have characterized neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 tat antigen. According to a study from France, "The human immunodeficiency virus...

Hamster model for Chlamydia pneumoniae infection developed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a hamster model for Chlamydia pneumoniae infection. "We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes...

Membranal polypeptides of Bacillus anthracis identified.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have identified chromosomally encoded membranal polypeptides of Bacillus anthracis through a proteomic analysis. "Bacillus anthracis is the causative agent of anthrax disease....

Hedgehog-interacting protein prevents basal cell carcinoma.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant hedgehog-interacting protein provides immunoprevention of basal cell carcinomas. "Basal cell carcinomas (BCCs) are driven by abnormal hedgehog signaling and highly overexpress several...

Sentinel node biopsy in locally advanced breast cancer reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers review sentinel node biopsy in the era of neoadjuvant therapy and locally advanced breast cancer in a recent issue of Surgical Oncology - Oxford. According to published research from the...

Novel systemic therapies for breast cancer reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers review novel systemic therapies for breast cancer in a recent issue of Surgical Oncology - Oxford. According to published research from England, "The rapid expansion in our knowledge of...

Flea-borne transmission model evaluates vaccines against bubonic plague.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A flea-borne transmission model is useful for evaluating vaccine efficacy against naturally acquired bubonic plague. "A flea-to-mouse transmission model was developed for use in testing new...

Complement function in antibody-mediated cancer immunotherapy described.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers describe complement function in monoclonal-antibody-mediated cancer immunotherapy in a recent issue of Trends in Immunology. "Complement activation by monoclonal antibodies can cause...

Current developments of immunotherapy in the clinic reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers review current developments of immunotherapy in the clinic According to published research from the United States, "The clinical application of immunotherapy for cancer is rapidly moving...

Heat shock protein 70-pulsed dendritic cells elicit tumor immunity.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. "Vaccination with autologous tumor-derived heat shock proteins...

Plasmids costimulate DNA vaccine against carcinoembryonic antigen.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA). "Vaccination with plasmids encoding an antigen of interest (DNA...

Tumor-specific antigens are encoded by gene MAGE-C2.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers report two new tumor-specific antigenic peptides that are encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. According to a study from Belgium, "We have...

Vaccination against cervical cancer reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review vaccines against cervical cancer in a recent issue of Hospital Medicine. According to recent research from Wales, "The link between human papillomavirus (HPV) and cervical cancer...

C-terminal antibody binding domain of C. albicans mp58 is protective.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The C-terminal antibody binding domain of Candida albicans mp58 represents a protective epitope during candidiasis. "The 58-kDa surface mannoprotein of Candida albicans (mp58) elicits strong...

Cytomegalovirus glycoprotein elicits antibody response in macaques.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Rhesus cytomegalovirus glycoprotein B elicits an antibody response in naturally infected rhesus macaques. "Rhesus cytomegalovirus (RhCMV) exhibits strong parallels with human CMV (HCMV) in terms of...

DNA dry powder for non-viral gene delivery prepared by freeze-drying.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA dry powder for non-viral gene delivery can be prepared by spray-freeze drying. According to a study from Taiwan, "This study investigates the feasibility of using the process of spray-freeze...

Artificial antigen presentation reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review artificial antigen presentation in a recent issue of Nature Biotechnology. "Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity....

Dendritic cell vaccine efficacy quantified using flow cytometry.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model was quantified using flow cytometry. According to recent research published in the...

Pediatric dengue vaccine is cost-effective.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A pediatric dengue vaccine is cost-effective in Southeast Asia. According to published research from the United States, "To ascertain the economic feasibility of a pediatric tetravalent dengue...

Oral diphtheria vaccine with microparticle adjuvant is immunogenic.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant elicited a strong immune response. "Oral vaccination offers the advantage of eliciting both a mucosal and a...

FDA approves Vitrase for use as a spreading agent.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- ISTA Pharmaceuticals, Inc., (ISTA) announced that the U.S. Food and Drug Administration (FDA) has approved ISTA's new drug application (NDA) for Vitrase (hyaluronidase for injection; lyophilized, ovine)...

Vaccine-derived poliovirus isolated from stream waters in Hispaniola.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Circulating type 1 vaccine-derived poliovirus was isolated from sewage and stream waters in Hispaniola. "Twenty-one cases of acute flaccid paralysis (AFP) were reported on the island of Hispaniola...

Systemic treatment of esophageal cancer reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review systemic treatment of esophageal cancer in a recent issue of the European Journal of Gastroenterology and Hepatology. "Most patients with esophageal cancer present with locally...

Biopharmaceutical company announces first quarter 2004 financial results.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Vical Incorporated (VICL) reported revenues of $0.9 million for the first quarter which ended March 31, 2004, compared with revenues of $0.9 million for the first quarter of the prior year. Grant...

Netherlands holding company reports increase in first quarter net sales.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Qiagen N.V. (QGENF) announced the results of operations for its first quarter and three-month period ended March 31, 2004. The company reported that consolidated net sales for its first quarter...

Vaccine maker reports 170% increase in total revenues during first quarter.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Novavax, Inc., (NVAX) announced its financial results for the first quarter ended March 31, 2004. Total revenues for the first quarter ended March 31, 2004, rose 170% to $3.2 million compared to...

Botulinum toxin structure offers clues for vaccines/treatments.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- By deciphering the near-atomic-level structure of the catalytic domain of botulinum toxin type E - one of seven neurotoxins that cause botulism, a disease that paralyzes victims by blocking nerve cells'...

P6 protein intranasal vaccine protects against Haemophilus influenzae.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against otitis media and lung infection by nontypeable Haemophilus...

Site provides information about hepatitis infection and therapy.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have developed an Internet site (Hep-Net) to provide information about hepatitis infection and therapy. "In Germany almost 1 million people are affected by chronic viral hepatitis....

Hepatitis A/B vaccine cost-effective substitute for hepatitis B vaccine.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Substituting the bivalent hepatitis A/B vaccine for the hepatitis B in prisons in the United States would be cost-effective. According to a study from the United States, "Hepatitis B immunization...

Vaccinia virus encoding T-cell chemoattractant is attenuated in vivo.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo. According to recent research from Australia, "Murine interferon-inducible T-cell...

DNA vaccine offers protection against infectious bursal disease virus.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes provided partial protection against infectious bursal disease virus. "Several DNA vaccination experiments were performed...

Pandemic influenza can be contained with antiviral agents.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Pandemic influenza can be contained with antiviral agents. According to recent research published in the American Journal of Epidemiology, "For the first wave of pandemic influenza or a...

Guillain-Barre coexists with pericarditis after influenza vaccination.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Guillain-Barre syndrome can coexist with pericarditis or nephrotic syndrome after influenza vaccination. According to a study from Taiwan, "A 68-year-old woman and a 72-year-old man presented with...

Trivalent inactivated influenza vaccine in young children reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers review the safety and efficacy of trivalent inactivated influenza vaccine in young children in a recent issue of the Pediatric Infectious Disease Journal. "Increasing use of influenza...

Leishmania amazonensis vaccine not effective against leishmaniasis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- An autoclaved Leishmania amazonensis vaccine plus BCG adjuvant was not effective against New World cutaneous leishmaniasis. According to a study from the United States, "The safety, immunogenicity,...

DNA vaccine induces protection against intracellular bacterial pathogen.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA vaccination with gp96-peptide fusion proteins induces protection against an intracellular bacterial pathogen. "Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP),...

Structure allows autoantigenic epitopes to induce autoimmune response.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. "A subset of lupus patients with severe nephritis and anti-nRNP...

Circumsporozoite antigens quantified in Plasmodium-infected mosquitoes.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have quantified sporozoites and circumsporozoite antigen in mosquitoes infected with Plasmodium falciparum or P. vivax. According to published research from Brazil and the United States,...

Genotypes of malaria-infected patients in Papua New Guinea reported.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have determined the distribution of msp2 genotypes among symptomatic and asymptomatic individuals infected with Plasmodium falciparum from the Wosera region of Papua New Guinea. ...

Plasmodium falciparum peptides bind to human hepatocytes.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes. According to recent research from Colombia, "Sporozoite and Liver Stage Antigen (SALSA)...

Plasmodium gametocyte stages neglected in vaccine development.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Plasmodium vivax and Plasmodium falciparum gametocyte stages are neglected in malaria vaccine development. "Plasmodium gametocytes are responsible for transmission from the vertebrate host to the...

Apical membrane antigens lead to evasion of immune system in malaria.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum. "Apical membrane antigen-1 (AMA-1) is a target of antibodies...

Displacement in 6725 SERA peptide analogue protects against malaria.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Induction and displacement of an alpha helix in the 6725 SERA peptide analogue confers protection against Plasmodium falciparum malaria. "The protein called serine repeat antigen (SERA) is a P....

Malaria vaccine results indicate protection related to antibody levels.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. "The...

Response to conserved epitope linked to protection from malaria.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease. According to a study from...

Vaccine genes of P. falciparum during hepatic phase identified.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have determined the transcription status of vaccine candidate genes of Plasmodium falciparum during the hepatic phase of its life cycle. "The CSP, EMP2/MESA, MSP2, MSP3, MSP5, RAP1,...

X-ray analysis conducted on protein vaccine candidate for malaria.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have conducted a preliminary X-ray analysis of the Plasmodium vivax sexual stage 25-kDa protein Pvs25, a transmission-blocking vaccine candidate for malaria. According to a study from...

Neisseria meningitidis 2086 lipoprotein shows vaccine potential.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The Neisseria meningitidis 2086 lipoprotein shows potential for effective vaccine use. According to recent research published in the journal Infection and Immunity, "A novel antigen that induces...

Assay to quantify antibodies to Neisseria meningitidis developed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a tetraplex flow cytometric assay for quantitation of serum antibodies to Neisseria meningitidis serogroups A, C, Y, and W-135. According to a study from England, "A rapid...

Cyclic peptides that bind to meningococcal LPS antibody characterized.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have characterized cyclic peptides that bind to a monoclonal antibody against meningococcal L3,7,9 lipopolysaccharides. According to a study from Norway, "There is still no general...

Group B meningococcal vaccine safe but not effective in men.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A group B meningococcal N-propionylated polysaccharide conjugate vaccine was safe in adult, male volunteers, but did not appear to be efficacious. According to recent research published in the...

Norovirus virus-like particles induce specific immune responses.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant virus-like particles of a norovirus (Genogroup II strain) administered intranasally and orally with mucosal adjuvants LT and LT(R192G) in BALB/c mice induce specific humoral and cellular...

Onchocerca secreted larval acidic proteins are protective.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The secreted larval acidic proteins (SLAPs) of Onchocerca species are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential. "Onchocerca volvilus is a...

Bovine parainfluenza virus type 3 vaccine shows promise in monkeys.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Bovine parainfluenza virus type 3 (PIV-3) vaccine shows promise in studies in rhesus monkeys. According to recent research published in the Journal of General Virology, "Restricted replication in...

Components of acellular pertussis vaccines in Japan verified.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have verified components of acellular pertussis vaccines that have been distributed solely, been in routine use for the last two decades and contributed greatly to control of pertussis in...

Vaccine reduces racial disparity in incidence of childhood pneumonia, meningitis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A vaccine that was distributed beginning in 2000 has reduced the incidence of childhood pneumonia and meningitis and has helped to decrease the excess incidence among black Americans, according to a new...

Conjugate pneumococcal vaccines effective against pneumococcal diseases.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Conjugate pneumococcal vaccines are effective against pediatric pneumococcal diseases. "Children younger than age 2 years have the highest rates of invasive pneumococcal disease and play an...

Pneumococcal vaccine is immunogenic in ataxia-telangiectasia patients.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The seven-valent pneumococcal conjugate vaccine elicited an immune response in patients with ataxia-telangiectasia. According to recent research from Germany, "Immune responses to a 7-valent...

Two pneumococcal vaccines safe and effective in American Indian infants.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Results from a pilot study indicated that two octavalent pneumococcal conjugate vaccines are safe and effective in American Indian infants. "We evaluated the safety and immunogenicity of two...

Antigens of abnormal isoform of prion protein characterized.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers characterized the antigens of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies. "We established a panel of monoclonal antibodies (mAbs) against...

Peptide-based vaccine effective for prostate cancer.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A synthetic luteinizing hormone releasing hormone (LHRH) vaccine was effective for the treatment of prostate cancer. "We have designed a peptide-based immunotherapeutic vaccine for treatment of...

Fc-dependent antibodies protect mice against Rickettsia conorii.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. "An emphasis on...

Rubella in developing countries still causing blindness and deafness.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Rubella in developing countries continues to cause blindness and deafness. According to a study from England, "Maternal rubella is now rare in many developed countries that have rubella vaccination...

DNA vaccine induces SARS coronavirus protective immunity in mice.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. "Public health measures have successfully identified and contained outbreaks of the severe acute respiratory...

Passive transfer of antibody prevents SARS replication.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. According to a study from the...

Muscarinic M3 receptor antibodies mimic autoantibodies in Sjogren's.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Antibodies raised against the second extracellular loop of the human muscarinic M3 receptor mimic functional autoantibodies in Sjogren's syndrome. "Functional antimuscarinic M3 receptor (M3R)...

Company receives development funding for smallpox vaccine.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- INCELL Corp., LLC, has been awarded a U.S. Air Force (USAF) contract to further develop its oral smallpox vaccine product and oral vaccine platform technology. INCELL began developing its oral...

Imvamune smallpox vaccine clinical study to include eczema patients.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Bavarian Nordic A/S announced that the U.S. Food and Drug Administration (FDA) has approved the company's Investigational New Drug application (IND) for its third-generation smallpox vaccine candidate...

Third-generation vaccine against smallpox tested.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Not everybody can safely be vaccinated against smallpox using the current U.S. Food and Drug Administration-approved vaccine. Scientists hope another study vaccine, now undergoing its first testing...

Method developed to monitor immune response against vaccinia virus.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a high-throughput method to monitor the humoral immune response against vaccinia virus. According to published research from Germany and Sweden, "Vaccination against...

World experts unite in urgent effort to fight deadly disease.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Leaders in the fight against disease emphasized the importance of preventing unnecessary child deaths from Streptococcus pneumoniae - a disease currently responsible for killing between 800,000 and 1...

CpG is not effective adjuvant to Toxoplasma gondii vaccination.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- CpG is not an effective adjuvant to Toxoplasma gondii vaccination. "Unmethylated CpG dinucleotides have been found to stimulate general immune responses in mammals. CpG motifs have further been...

Attenuated Listeria harboring plasmids protect against tuberculosis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant attenuated self-destructing Listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPB/MPT51 induce protective cellular immunity against...

Cell envelope protein contributes to M. tuberculosis immunogenicity.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. "The protective efficacy of...

E. coli strain Nissle 1917 prevents intestinal inflammation.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Escherichia coli strain Nissle 1917 exerts preventive effects on acute and chronic intestinal inflammation in two different murine models of colitis. According to a study from Germany, "Escherichia...