Vaccine Weekly articles from June 2000

Vaccine Weekly archives from June 2000

Cytokine Gene Injection Stimulates Anti-Asthmatic Response.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Injection of plasmid DNA containing an interleukin-12 (IL-12) gene stimulated immune responses in asthmatic mice, researchers report. M.L. Kuo et al., Chang Gung Memorial Hospital, Korea, presented data...

Mixed Chimerism May Induce Tolerance.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Mixed chimerism may help induce tolerance to allograft transplants, researchers report. "The induction of tolerance to transplanted organs could make transplantation safer and more uniformly successful,"...

ErbB2 Potentiates Breast Tumor Proliferation.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- "Overexpression of the ErbB2 receptor, a major component of the ErbB receptor signaling network, contributes to the development of a number of human cancers, ErbB2 presents itself therefore, as a target for...

Antisense Enhances Immunogenicity of Tumor Cell Vaccine.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules can enhance the immunogenicity of tumor cell vaccines. "Insulin-like growth factor-1 (IGF-1) is expressed in...

Vector Combines IL-4 and HSV-tk for Glioma Tumor Vaccine.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in the United States constructed a retroviral vector that combined interleukin-4 (IL-4) with the herpes simplex virus thymidine kinase (HSV-tk) gene into a glioma tumor cell vaccine. ...

DNA-Based Vaccine Boosted by Nonviral Cytokine Gene Transfer.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Nonviral cytokine gene transfer has an adjuvant effect when added to a DNA-based anticancer vaccine. "Intramuscular (i.m.) injections of a plasmid encoding human carcinoembryonic antigen (CEA) elicited...

Tumor-Associated Glycoprotein 72 is Expressed in Salivary Gland Neoplasias.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in Greece conducted an immunohistochemical study using the monoclonal antibody (MAb) CC49 to determine tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasias. "The...

Trial Participants Try Intradermal Immunization.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- According to a Canadian study, higher-dose intradermal administration of the hepatitis B virus (HBV) vaccine may be a cost-effective, viable method for inoculating vaccine recipients. Currently, the...

Protective Antibody Responses Induced by Novel Vaccine Delivery System.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Type two herpes simplex virus (HSV-2) antigens formulated in novel vaccine delivery systems induced protective antibody responses in mice. "The immunogenicity of a HSV-2 antigen preparation following its...

Vaccine Evaluated in Non-Immune Volunteers.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in Australia evaluated a Plasmodium falciparum vaccine in non-immune volunteers. "A placebo-controlled, randomized, double-blind trial was conducted in human volunteers to test a mixture of...

Major Chemokine Receptor for HIV Type 1 is Modulated by CD28.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- CD28 has a major influence on the expression of surface CXC chemokine receptor 4 (CXCR4), which is known to be a major cell receptor targeted by the human immunodeficiency virus. In this study, published...

Conjugate Vaccines Immunogenic in Young Children.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Conjugate pneumococcal vaccines induced immunological responses in children, researchers in Finland reported. "Prevention of pneumococcal infections is a public health priority because of the high impact...

Dendritic Cells a Potential Adjuvant for CD8(+) T-Cell Clearance.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers at Atlanta, Georgia's Emory University School of Medicine suggest that dendritic cells may prove to be important adjuvants for influencing the clearance of polyomavirus by CD8(+) T cells. ...

Liver Target Needed for Effective Antiviral Response.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- New evidence from a study conducted by researchers at the University of Ulm in Germany finds that the microenvironment of the liver needs to be primed in order to be more effectively targeted by hepatitis B...

Virulence a Hurdle to Overcome for HIV Type 1 Vaccine.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- One of the major factors that researchers must address when determining the best way to design a vaccine against the human immunodeficiency virus type 1 (HIV-1) is viral virulence. Scientists at the...

Nitric Oxide Study Demonstrates Importance for Interferon Efficacy.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Additional evidence from a study conducted at the Scripps Clinic and Research Foundation in La Jolla, California, shows that nitric oxide plays an important role in the effectiveness of therapy against...

Monoclonal Antibodies Used to Explore Pollen-Related Food Allergies.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in Korea and Germany have discovered that three monoclonal antibodies (MAbs) against the major apple allergen Mal d1 have different binding characteristics. "Mal d1, the major apple antigen,...

Monoclonal Antibody-Based Assay Quantifies Major Plant Allergen.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in Spain used a monoclonal antibody (MAb)-based enzyme-linked immunosorbent assay (ELISA) to quantify a major plant allergen. "Plantago lanceolata (English plantain or ribwort) is a...

T-Cell Epitope Encoding DNA Suggested for Allergy Gene Therapy.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- DNA vaccination using T-cell epitopes may be a viable gene therapy for allergies, researchers in the United States and Korea suggested. "Genetic vaccination with naked plasmid DNA provided longstanding...

Listeria Infection Prevented by Anti-Toxin Monoclonal Antibody.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- The course of Listeria monocytogenes infection was prevented in a murine model by the use of an anti-toxin monoclonal antibody (MAb), researchers in the United States and France reported. "Listeriolysin O...

DNA Vaccines Under Development for Lassa Fever Virus.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Researchers in the United States are exploring vaccines for emerging arenaviruses. "Lassa fever virus is a rodent-borne arenavirus endemic to West Africa," explained M.J. Buchmeier and colleagues from...

Clinical Trials of New Vaccine Slated for Fall 2000.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- National clinical trials for a colon cancer vaccine developed by two Cincinnati, Ohio, researchers are expected begin this fall, doctors announced May 20, 2000, at the American Society of Clinical Oncology...

B/T-Cell Interactions Important for Inducing Immune Responses.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Major histocompatibility complex (MHC) class II-antigen (Ag)/TCR, B7/CD28, and CD40/CD40L interactions are responsible for stimulating immune responses to glycoconjugate vaccines, researchers in the United...

Investigators See Immune Response in Cancer Vaccine Trial.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Genzyme Molecular Oncology (GZMO), Framingham, Massachusetts, announced that investigators of its Phase I/II melanoma cancer vaccine trial have observed immune responses in several patients. Of nine...

Cancer Vaccine Extends Five-Year Overall Survival.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Avax Technologies, Inc., announced the presentation of data at the 36th Annual Meeting of the American Society of Clinical Oncology on May 23, 2000, in New Orleans, Louisiana, on the company's autologous cell...

Bexxar Highly Effective as First-Line Treatment.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- A radioactive antibody compound known as Bexxar produced tumor shrinkage in 97% of 76 previously untreated patients with advanced-stage, low-grade non-Hodgkin's lymphoma (NHL) in a new study at the University...

Vaccine Induces Positive Immunological and Clinical Outcomes.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Avax Technologies, Inc. announced the presentation of data at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO), May 22, 2000 in New Orleans, Louisiana, on the company's autologous...

Positive Results in Initial GVAX Vaccine Trial Reported.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Cell Genesys, Inc. (CEGE), Foster City, California, reported prolongation of disease-free survival in a Phase I trial of a pancreatic cancer vaccine in patients who received the vaccine following surgery and...

Chlamydia pneumoniae Found in Atherosclerotic Coronary Arteries.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Chlamydia pneumoniae has been discovered in the adventitia of atherosclerotic coronary arteries, researchers in The Netherlands reported. "A role for Chlamydia pneumoniae (Cp) in the atherosclerotic...

Viral Infection Reduces Natural Killer T Cells in Liver.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Results of a murine study of viral infection on natural killer T cells in the liver were presented at the 56(th) Annual Meeting of the American Academy of Allergy, Asthma, and Immunology, recently held in San...

Agreements Set Vaccine on Fast Track to Developing Countries.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- The development of an innovative, orally-administered AIDS vaccine by the Institute of Human Virology (IHV) will be funded by the International AIDS Vaccine Initiative (IAVI) under terms of a new multi-year,...

Treatment of Malignant Gliomas Tested in Animal Model.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- Improving microglia response might boost efficacy of herpes simplex virus thymidine kinase (HSV-tk) gene transfer and ganciclovir administration in treatment of gliomas, researchers suggest. A.M. Sandmair...

Misperceptions About Value of Vaccines May Lead Parents to Question their Use.(Brief Article)(Statistical Data Included)
June 7, 2000... 2000 JUN 7 - (NewsRx.com) -- An alarmingly high percentage of parents hold misperceptions about the value and safety of vaccines, which may lead them to refuse some or all immunizations for their children, says Bruce G. Gellin, MD, MPH,...

IL-9 Blocking Antibody Reduces Allergy Induced Inflammation.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Interleukin-9 (IL-9) blocking antibody delivered to the lung inhibited allergic inflammatory responses in a murine model of asthma,according to a recent study. "We have shown previously that IL-9 is an...

BCG Vaccine Dangerous for Children with Primary Immunodeficiency.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Bacillus Calmette-Guerin (BCG) vaccine is contraindicated in children with primary immunodeficiency (PID), researchers in Brazil reported. "Immunization schedule for children in Brazil includes BCG and...

Vinblastine and VEGF Receptor-2 Antibody Cause Tumor Regression.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- According to a study from Canada, a low dose combination therapy with vinblastine and vascular endothelial growth factor (VEGF) receptor-2 antibody induced tumor regression in an animal model. "Various...

Two Neutralizing Single-Chain Antibodies Compared.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Mechanisms of virus neutralization were compared between two single-chain antibodies that neutralized canine parvovirus. "We cloned the heavy- and light-chain variable domains of two monoclonal antibodies...

Mouse Study Shows Repair Effected by Enhanced Immune System.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- In a major scientific discovery, Mayo Clinic scientists conducting research in mice with central nervous system damage have found a way to enhance the immune system that resulted in nervous system repair in...

Dual-Monoclonal Sandwich Assay Detects Prostate-Specific Membrane Antigen.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- A dual-monoclonal sandwich assay accurately detects prostate-specific membrane antigen (PSMA) in tissues, seminal fluid, and urine. "PSMA is a 750-residue integral membrane glycoprotein and the target of...

Cost-Effectiveness of Varicella Vaccine Evaluated in U.S. Army Recruits.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- A analysis of screening and vaccinating for varicella in new recruits in the U.S. Army indicates the current preventive programs are not cost-effective. "Varicella outbreaks in the U.S. Army disrupt...

New Vaccine Results in Good Antibody Response.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Meningococcal C conjugate vaccine is safe and results in immunologic memory (immune system "remembers" characteristics of meningococcal C and reacts to it), according to an article appearing in the June 7...

PSA-Based Vaccine Generates Reactive Effector Cells.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- A prostate-specific antigen (PSA)-based vaccine generates PSA-reactive effector cells in prostate cancer patients. "JET 1001 is a vaccine used for therapy of prostate cancer (CA), which consists of...

Effects of Two Human Monoclonal IgG Antiphospholipid Antibodies Analyzed.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Researchers in Germany analyzed the prothrombotic effects of two human monoclonal immunoglobulin G (IgG) antiphospholipid antibodies that had similar specificity. "Two human monoclonal antiphospholipid...

Adverse Reactions Evaluated in Israel Defense Force.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- The smallpox vaccine was deemed "relatively safe" in a study of Israel Defense Force recruits. "The aim of the present study was to assess the post-smallpox vaccination complication rate in a cohort of...

Interleukin-2 Plasmids Augment Response to HIV and SIV Vaccines in Monkeys.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Harvard University School of Medicine researchers reported in a major scientific publication that interleukin-2 (IL-2) plasmids enhance the immune response to HIV and simian immunodeficiency virus (SIV)...

Assay Designed to Test in vitro Potency of Vaccines.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Researchers in France have developed an assay to help determine the in vitro potency of yellow fever vaccines before they go to market. "Quality control of yellow fever vaccines performed by Control...

Humanized Gene Construct Increases in vivo Efficiency.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- The efficiency of allergen-specific immunotherapy using a DNA vaccine was increased by the addition of a humanized Amb aI gene construct, researchers in the United States reported. "Immunization with...

Reverse ELISA Measures Specific Immunoglobulin E to Major Allergens.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Researchers in Brazil and the United States have developed a very sensitive reverse enzyme-linked immunosorbent assay (ELISA) that measures specific immunoglobulin E (IgE) to major allergens. "We...

Uncontrolled Asthma May Cause Recurrent Pneumonia.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Uncontrolled asthma may be the cause of recurrent pneumonia in patients vaccinated against the disease, researchers in Brazil and the United States report. "We evaluated the response to 23-valent...

Antigen Stimulation Needed to Maintain T-Cell Memory.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Continuous antigen stimulation is needed to maintain T-cell memory against Toxoplasma gondii infection, researchers in the United States reported. "Immunization of mice with vaccine (ts-4) strain of...

Researchers Want to Know How Vaccines Work.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Vaccines work simply by producing antibodies, right? Well, probably not. And this misconception coupled with basic ignorance of how they do work is stalling the urgent quest for an AIDS vaccine, claim...

Monoclonal Antibody Treatment Results in Improved Outcomes.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- New data from the ADMIRAL study released at the Paris Course on Revascularization suggest significantly better clinical outcomes for patients undergoing primary stenting in acute myocardial infarction (AMI)...

Microbial Lipoproteins Induce Dendritic Cell Maturation.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Bacterial lipoproteins stimulate the maturation of dendritic cells (DCs), researchers say. "The maturation of DCs allows them to become potent antigen presenting cells (APCs)," said Cheryl J. Hertz and...

Trans-Phage Technology Enables High Throughput Genomic Medicine.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Biosite Diagnostics Inc. (BSTE), San Diego, California, and Medarex Inc. (MEDX), Princeton, New Jersey, announced the launch of an alliance aimed at accelerating drug research via Trans-Phage Technology. ...

AIDS Vaccine Patent Disputes Settled.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- VaxGen Inc. (VXGN), Brisbane, California, announced that it has prevailed in two separate European patent disputes, confirming its exclusive rights to vaccines containing key proteins for preventing AIDS. ...

NIAID Creates Global Network to Advance Development of Vaccines.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- The worldwide search for an HIV vaccine received a boost as the U.S. National Institute of Allergy and Infectious Diseases (NIAID) announced funding of nine U.S. clinical units of the new HIV Vaccine Trials...

Company Says Unplanned Analysis Didn't Allow Time for Vaccine to Realize Full Potential.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Progenics Pharmaceuticals, Inc. (PGNX), Tarrytown, New York, announced that the Eastern Cooperative Oncology Group (ECOG) will conclude its participation in the company's Phase III clinical trial for the GMK...

Vaccine Development Agreement Initiated.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- Chiron Corp. (CHIR), Emeryville, California, and the National Institute of Public Health of Norway (NIPH or FOLKEHELSA) in Oslo announced a signing ceremony formalizing previous agreements to collaborate on...

'Injuries' Cost U.S. Government $1 Billion.(Brief Article)(Statistical Data Included)
June 14, 2000... 2000 JUN 14 - (NewsRx.com) -- The U.S. government has paid more than $1 billion to compensate patients of vaccination injuries and continues to compile a huge database of all reported "adverse events" from vaccine administration,...

Live Vaccine May Be Possible.(Brief Article)(Statistical Data Included)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- A live HIV vaccine that can't infect the people it's supposed to protect may be possible after all. A team based in California has created a hybrid of HIV and another virus that can enter cells, but can't...

Allogeneic Tumor Cell-Based Vaccine Produces Antitumor Response.(Brief Article)(Statistical Data Included)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Potent antitumor responses were realized from a granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic tumor cell-based vaccine, according to a recent study. GM-CSF-transduced...

Accelerating Development and Future Availability.(Brief Article)(Statistical Data Included)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- An HIV-1 vaccine offers the best long-term hope to control the AIDS pandemic, especially in less-developed countries, according to research presented in the June 10 issue of The Lancet. To ensure its...

Multi-Epitope Vaccines Increase Levels of Antibodies in Animal Model.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Researchers in China reported that multiepitope vaccines increased the levels of antibodies that recognize neutralizing epitopes on HIV-1 envelope protein. "A few neutralizing antibodies against HIV-1...

Researchers Identify Possible Drug Target.(Brief Article)(Statistical Data Included)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- University of Minnesota researchers have identified the molecule on human cells that binds to the bacterium responsible for human granulocytic ehrlichiosis (HGE), a recently discovered tick-borne disease. ...

Scientists Discover New Way the Body Distinguishes Self From Foreign.(Brief Article)(Statistical Data Included)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Challenging an important dogma, immunologists have discovered a new way the body distinguishes its cells from foreign cells so it can destroy microbes without harming itself. The findings suggest a new...

Antibody May Play Diagnostic Role in Malignant Disease.(anti-MAGE 57B antibody)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- The anti-MAGE antibody 57B may have diagnostic usefulness for determining the malignant potential of a melanocytic tumor. "The melanoma-associated antigen (MAGE) family consists of a number of antigens...

Soluble CD4 Activates HIV-1 Env-Mediated Membrane Fusion.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Soluble CD4 (sCD4) can activate HIV-1 Env-mediated membrane fusion with CD4-negative/coreceptor-positive target cells, researchers in the United States reported. "The push for an effective AIDS vaccine...

Genetic Approach Targets Breast and Ovarian Cancers.(HER-2/neu protein)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- University of Washington, Seattle, researchers in collaboration with the Seattle-based Corixa Corp., have determined that the HER-2/neu protein, which is overproduced, or expressed, by some breast and ovarian...

(beta) Cell Autoimmunity Suppressed by Plasmid DNA Vaccination.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Antigen-specific suppression of (beta) cell autoimmunity mediated by plasmid DNA vaccination may be an effective strategy to prevent and treat insulin dependent diabetes mellitus (IDDM), according to...

Elecsys Analyser Effectively Detects Anti-Hepatitis A Virus Antibodies.(developed by Roche Diagnostics GmbH)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- The Elecsys analyser is a sensitive and specific diagnostic tool for detecting anti-hepatitis A virus (HAV) antibodies in human serum, according to a study presented at the 10th International Symposium on...

Lethal Syndrome Prevented by Early Injections of Anti-Interleukin-4 Monoclonal Antibody.(graft-vs-host syndrome)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Lethal host-vs-graft (HVG) syndrome can be prevented with early injections of anti-interleukin-4 (anti-IL-4) monoclonal antibody (MAb), researchers in the United States reported. "Lethal HVG syndrome is...

Hepatitis A Vaccine Schedule Determined for Infants.(Israel Center for Disease Control sets schedule)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Initial hepatitis A vaccines should be administered at 18 months and the second at 24 months, recommend researchers in Israel. M.S. Green and colleagues with the Israel Center for Disease Control in Tel...

Hepatitis B Vaccination Prevents Infection in Thousands of Children Annually.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Thousands of U.S. children would be infected with hepatitis B virus (HBV) each year if they did not receive vaccination for the illness as infants, a recent study concludes. To determine the prevalence of...

Whole-Killed Virus Vaccine Candidates Inactivated by Aldrithiol-2.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Aldrithiol-2 can be used to inactivate whole virus for vaccine development, researchers say. "We have previously shown that a variety of disulfide compounds can inactivate whole virus causing complete...

Mississippi Receives $2 Million to Combat Public Safety Threats.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- The estimated $2 million the state of Mississippi will receive in the next five years to prepare for biological warfare will be spent on education and detection, say health officials. The U.S. Centers for...

Researchers Developing Vaccines with the Aid of Tobacco.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Federal research funding is flowing to U.S. scientists trying to use genetically altered tobacco as a tool to fight cervical cancer. Researchers at North Carolina State University and Georgetown...

Alliance Formed to Discover and Develop Therapeutic Monoclonal Antibodies.(Medarex Inc. and Corixa Corp. sign development pact)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Medarex, Inc., Princeton, New Jersey, and Corixa Corp., Seattle, Washington, announced a collaboration to discover and develop fully human monoclonal antibodies against selected targets from Corixa's library...

Scientists Conclude HIV Began in 1930s Africa.(evolved from benign simian infection)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- HIV evolved from a benign simian infection into a human virus in the early 1930s, long before it was recognized as a disease, but it stayed in remote Africa until jet travel, urban environments, and the...

Investigational New Drug Application Submitted to FDA for Humanized Monoclonal Antibody.(Millennium Pharmaceuticals Inc. to develop LDP-02 monoclonal antibody)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Millennium Pharmaceuticals, Inc. (MLNM), Cambridge, Massachusetts, announced that it has submitted an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) to initiate U.S....

Vaccine May Not Be Best Bet for Everyone.(Lyme disease vaccine)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Minnesotans considering the Lyme disease vaccine probably shouldn't be influenced by a high-profile ad campaign targeting Minneapolis and St. Paul (the Twin Cities), and Duluth by the vaccine's manufacturer,...

Company Says Herceptin Infringes on Monoclonal Antibody Patent.(Chiron Corp. files patent suit against Genentech)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Chiron Corp., Emeryville, California, filed a patent infringement lawsuit against Genentech alleging that the manufacture and sale of Herceptin (trastuzumab), an anti-HER-2 monoclonal antibody, infringes...

AAP Recommends Pneumococcal Vaccine for Children Under Age Two.(American Academy of Pediatrics)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- In a new policy statement, the American Academy of Pediatrics (AAP) announced childhood immunization recommendations for use of the newest form of the pneumococcal vaccine. The pneumococcal vaccine helps...

Agreement Signed to Develop Pulmonary Delivery System for Monoclonal Antibody.(MedImmune Inc. and Alkermes Inc. sign development pact)(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- MedImmune, Inc. (MEDI), Gaithersburg, Maryland, and Alkermes, Inc. (ALKS), Cambridge, Massachusetts, announced that they have signed an agreement to develop an inhalable formulation of a monoclonal antibody...

Transient Immunosuppression Allows Repeated Adenoviral Vector Delivery.(Brief Article)
June 28, 2000... 2000 JUN 28 - (NewsRx.com) -- Antibody blockade of T cells allows re-administration of adenoviral gene therapy vectors, researchers in France and The Netherlands reported. "In many instances, repeated administrations of adenoviral...