Vaccine Weekly articles from June 1999

Vaccine Weekly archives from June 1999

Only Mature RSV Envelope Elicits Neutralizing Abs.(respiratory syncytial virus, antibodies)
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Subunit vaccines for respiratory syncytial virus (RSV) must use the mature form of the immunodominant protein in the viral envelope, new studies show. RSV is the leading viral cause of major...

Florida Chickenpox Deaths Were Preventable.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Despite the ready availability of a vaccine, six Florida residents died of chickenpox (varicella) in 1998. The six patients included two children and four adults. All but one (a child with acute...

Peptide-Pulsed PBMC is an Effective Melanoma Vaccine.(peripheral blood mononuclear cells)
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunization with Mage3 or Melan-A peptide-pulsed autologous peripheral blood mononuclear cells (PBMC) plus recombinant human interleukin-12 (RhIL-12) makes an effective vaccination. Thomas F....

AIDS-Ravaged Lymphoid Tissues Regenerate with HAART.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immune reconstitution is possible even in AIDS patients with advanced disease, new data indicate. Follicular dendritic cells (FDCs) in lymphoid tissues trap and retain antigens, allowing the...

RAP1 IgG Response Is Short-Lived.(Rhoptry-associated protein of Plasmodium falciparum)
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The short-lived antibody response to a malaria parasite antigen may have important implications, in terms of drug treatment where transmission is unstable. Rhoptry-associated protein 1 (RAP1) of...

Experimental Staph Vaccine Protective in Animal Studies.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers supported by the U.S. National Institute of Allergy and Infectious Diseases (NIAID) have developed a vaccine that protects mice against multiple strains of Staphylococcus aureus. The...

Type 1 Diabetes Prevention by Single Immunization with Cloned BCG.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Diabetes was prevented by a single vaccination with a cloned bovine Mycobacterium (BCG) in a mouse model. Dr. Yong-Soo Bae, Hannam University, Korea, and his colleagues cloned a BCG (bacille...

Vaccine Study Seeks Volunteers in Gay Bars.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers who have come up with a genetically-engineered vaccine to treat HIV are now hitting gay bars to recruit volunteers to test it. Since March 1999, Albany Medical Center in New York has...

Immunized Girl Contracts Meningitis.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A six-year-old Palatka, Florida, girl has contracted a case of bacterial meningitis of the same strain that killed a high school senior and infected nine other people in December 1998. The girl...

Nasal Vaccine Shows Promise Against Gonorrhea.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Nasal administration to mice of an experimental vaccine reduces vaginal colonization by Neisseria gonorrhoeae. Gonorrhea remains a leading cause of sexually transmitted disease in both...

Lost Genes May Be Causing TB Vaccine's Failure.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Nearly 80-years-old, the tuberculosis vaccine is showing its age. This stalwart of the global campaign against TB may no longer work, and Stanford University researchers in California have...

Anti-Idiotypic Antibody Vaccination in Conjunction with Intensive Therapy (IT) and Autologous Stem Cell Transplantation (ASCT) for Patients (PTS) with Metastatic Breast Cancer (MBC).
June 14, 1999... Cancer Vaccines "Anti-Idiotypic Antibody Vaccination in Conjunction with Intensive Therapy (IT) and Autologous Stem Cell Transplantation (ASCT) for Patients (PTS) with Metastatic Breast Cancer (MBC)." D. Reece, K. Foon, R. Ceriani, M....

Systemic Immunotherapy of Advanced Prostate Cancer (CaP): Preliminary Results of a Phase I Clinical Trial Using Recombinant Vaccina Virus Encoding Human MUC-1 and Interleukin-2 (IL-2) Genes.
June 14, 1999... Cancer Vaccines "Systemic Immunotherapy of Advanced Prostate Cancer (CaP): Preliminary Results of a Phase I Clinical Trial Using Recombinant Vaccina Virus Encoding Human MUC-1 and Interleukin-2 (IL-2) Genes." Arndt van Ophoven, Cho-Lea...

Vaccination of High Risk Breast Cancer Patients (pts) Lacking Identifiable Disease with GN12-Keyhole Limpet Hemocyanin (KLH) Conjugate Plus QS21.
June 14, 1999... Cancer Vaccines "Vaccination of High Risk Breast Cancer Patients (pts) Lacking Identifiable Disease with GN12-Keyhole Limpet Hemocyanin (KLH) Conjugate Plus QS21." T. Gilewski, L. Norton, A. Houghton and R. Israel. Memorial...

Low Passage Associated Proteins From B. burgdorferi.(Lyme disease)
June 14, 1999... Lyme Disease "Low Passage Associated Proteins Form B. burgdorferi." Frank C. Gberardim. University of Georgia, Athens, Georgia 30602. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 5R29AI33501-05. GRANT EXPIRES: July...

Enhancement of Mucosal Immune Responses to HIV Gp160.
June 14, 1999... Vaccine Development (HIV) "Enhancement of Mucosal Immune Responses to HIV Gp160." R.M. Buller. St. Louis University, 221 N. Grand Blvd., St. Louis, Missouri 63103. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Molecular Basis of NALT-Induced Mucosal Immunity to SIV.
June 14, 1999... Vaccine Development (HIV) "Molecular Basis of NALT-Induced Mucosal Immunity to SIV." Jerry R. McGhee. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

M. tuberculosis PHOP-Like Gene in Macrophages.
June 14, 1999... Vaccine Development (TB) "M. tuberculosis PHOP-Like Gene in Macrophages." Nancy A. Buchmeier. University of California, Gilman and La Jolla Village Drive, San Diego, California 92093. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH...

Protection Against Mammary Tumor Growth by Vaccination With Full-Length, Modified Human ErbB-2 DNA.
June 14, 1999... Cancer Vaccines Wei, W.Z.; Shi, W.P.; Galy, A.; Lichlyter, D.; Hernandez, S.; Groner, B.; Heilbrun, L.; Jones, R.F. "Protection Against Mammary Tumor Growth by Vaccination With Full-Length, Modified Human ErbB-2 DNA." International Journal...

Recombinant Influenza A Virus Vaccines for the Pathogenic Human A Hong Kong 97 (H5N1) Viruses.
June 14, 1999... Influenza Li, S.Q.; Liu, C.G.; Klimov, A.; Subbarao, K.; Perdue, M.L.; Mo, D.; Ji, Y.Y.; Woods, L.; Hietala, S.; Bryant, M. "Recombinant Influenza A Virus Vaccines for the Pathogenic Human A Hong Kong 97 (H5N1) Viruses." Journal of...

Early Two-Dose Measles Vaccination Schedule in Guinea-Bissau: Good Protection and Coverage in Infancy.
June 14, 1999... Measles Garly, M.L.; Martins, C.L.; Bale, C.; Dacosta, F.; Dias, F.; Whittle, H.; Aaby, P. "Early Two-Dose Measles Vaccination Schedule in Guinea-Bissau: Good Protection and Coverage in Infancy." International Journal of Epidemiology,...

Mucosal Vaccination Strategies for Women.
June 14, 1999... Mucosal Immunization Kozlowski, P.A.; Cuuvin, S.; Neutra, M.R.; Flanigan, T.P. "Mucosal Vaccination Strategies for Women." Journal of Infectious Diseases, May 1999;179(Suppl. 3):S493-S498. (CW HENDERSON PUBLISHER www.newsfile.com) --...

The Effect of Route of Immunization on Mucosal Immunity and Protection.
June 14, 1999... Mucosal Immunization Lehner, T.; Wang, Y.F.; Ping, L.; Bergmeier, L.; Mitchell, E.; Cranage, M.; Hall, G.; Dennis, M.; Cook, N.; Doyle, C.; Jones, I. "The Effect of Route of Immunization on Mucosal Immunity and Protection." Journal of...

Safety and Immunogenicity of Haemophilus influenzae-Tetanus Toxoid Conjugate Vaccine Given Separately or in Combination With a Three-Component Acellular Pertussis Vaccine Combined With Diphtheria and Tetanus Toxoids and Inactivated Poliovirus Vaccine.
June 14, 1999... Pediatrics Halperin, S.A.; King, J.; Law, B.; Mills, E.; Willems, P. "Safety and Immunogenicity of Haemophilus influenzae-Tetanus Toxoid Conjugate Vaccine Given Separately or in Combination With a Three-Component Acellular Pertussis...

The Effect of Human Immunodeficiency Virus-1 Infection and Stunting on Measles Immunoglobulin-G Levels in Children Vaccinated Against Measles in Uganda.
June 14, 1999... Pediatrics Waibale, P.; Bowlin, S.J.; Mortimer, E.A.; Whalen, C. "The Effect of Human Immunodeficiency Virus-1 Infection and Stunting on Measles Immunoglobulin-G Levels in Children Vaccinated Against Measles in Uganda." International...

Safety and Immunogenicity of an Acellular Pertussis Vaccine in Premature Infants.
June 14, 1999... Pertussis Schloesser, R.L.; Fischer, D.; Otto, W.; Rettwitzvolk, W.; Herden, P.; Zielen, S. "Safety and Immunogenicity of an Acellular Pertussis Vaccine in Premature Infants." Pediatrics, May 1999;103(5):E601-E604. (CW HENDERSON...

Antibody Response After a Four-Site Intradermal Booster Vaccination With Cell-Culture Rabies Vaccine.
June 14, 1999... Rabies Tantawichien, T.; Benjavongkulchai, M.; Limsuwan, K.; Khawplod, P.; Kaewchompoo, W.; Chomchey, P.; Sitprija, V. "Antibody Response After a Four-Site Intradermal Booster Vaccination With Cell-Culture Rabies Vaccine." Clinical...

Variable Efficacy Linked to BCG Evolution.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A Canadian/U.S. research team may at last be close to solving one of vaccinology's great mysteries. The mystery is why the bacillus Calmette-Guerin (BCG) tuberculosis vaccine has in some...

Excitement, Fear Over Continued "Berlin Patient" Success.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Even as they thrill over his success, clinicians worry that the "Berlin patient" will inspire other HIV infected patients to copy his dangerous experiment. Against his doctor's advice, the...

Bacterial CpG Motif Enhances T-Cell Response to Peptides.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Oligonucleotides (ODNs) containing a bacterial motif allow peptide vaccines to stimulate protective T-cell responses. CpG dinucleotides are far more common in bacterial genomes than in...

Sweet New Antigen for Staph Vaccines.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A sugar produced by Staphylococcus aureus is sweet news to vaccine researchers. The sugar is the surface polysaccharide poly-N-succinyl (beta)-1-6 glucosamine or PNSG. It is produced only during...

CDC's 21st Century Plan: Repair, Prepare.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Repair public-health potholes while paving and planning new highways to speed responses to emerging diseases. That's the best way to keep the public health moving forward despite the many...

Analysis of Unique Cohort Gives Insight into Role of Nef.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- An analysis of a cohort composed of an HIV-1 infected blood donor and transfusion recipients in Australia provides insight into the natural history of infection. Jennifer C. Learmont, Australian...

T-Cell Epitope Identification May Further Vaccine Search.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- T-cell epitope mapping of the three most prevalent extracellular proteins of Mycobacterium tuberculosis suggest they may be useful in epitope-based TB vaccines. In this study, Bai Yu Lee and...

Vaccine Study Yields Positive Findings.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A vaccine to treat brain cancer has shown promising results in preliminary studies at the University of California Los Angeles (UCLA) Jonsson Cancer Center. A cover-story article published in the...

CDC Recommends Vaccine for Schoolchildren.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- U.S. health officials recommended that all states require chickenpox vaccinations for all children entering daycare or elementary school. The requirements are recommended because the highly...

Health Officials Report Fewer People Contracting HAV.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Utah health officials reported that hepatitis A is on a rapid retreat only three years after an outbreak of the virus swept across the state. In 1995, Utah had an incidence nearly five times the...

Study Casts Doubt on Use of Weak HIV as Vaccine.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Three people infected with a weak form of HIV more than 14 years ago have begun to show signs of immunological damage, reducing hope that such HIV strains could be used to develop AIDS vaccines, a...

Anti-Fungal Technology May Promote Vaccine Development Against Candida albicans.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Inhibitex, Inc., Alpharetta, Georgia, has signed an exclusive licensing agreement with the University of Minnesota for proprietary MSCRAMM surface proteins from Candida albicans that may be useful in...

HIV-VAC To Investigate IMNR's Vaccine Setback.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- HIV-VAC, Inc, Toronto, Ontario, Canada, announced that Dr. Gordon Skinner, MD, DSc, FRCOG, FRCPath, the developer of HIV-VAC's HIV vaccine has expressed interest in Immune Response Corp's Remune HIV...

In Lyme, No Rush for Vaccine.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A Lyme Disease vaccine is getting the cold shoulder in the wooded enclave that gave the disease its name. Experts say that if the LYMErix vaccine (SmithKline Beecham Pharmaceuticals) is going to...

CDC Finds Increased Risk Among Freshmen in Dorms.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- College freshmen, especially those who live in dormitories, face a higher risk of potentially fatal meningococcal meningitis than others in their age group, a study by the U.S. Centers for Disease...

Concomitant Use of Autologous Tumor Vaccine and Autologous Stimulated Immune Serum from Co-Culture To Treat Refractory Solid Tumor.
June 28, 1999... Cancer Immunotherapy "Concomitant Use of Autologous Tumor Vaccine and Autologous Stimulated Immune Serum from Co-Culture To Treat Refractory Solid Tumor." K. Alonso, R. Page, G. Kindness and J. McLaren. Institute Advanced Studies in...

Preliminary Results of ALVAC-CEA-B7 Phase I Vaccine Trial in Patients with Metastatic CEA-Expressing Tumors.
June 28, 1999... Cancer Vaccines "Preliminary Results of ALVAC-CEA-B7 Phase I Vaccine Trial in Patients with Metastatic CEA-Expressing Tumors." David S. Lee, William Conkright, Heidi E. Horig, Henry Hasson, David S. Park, Vickie Stockdale and Howard L....

Treatment of Ovarian Cancer with Autologous, Hapten-Modified Tumor Cell Vaccine.
June 28, 1999... Cancer Vaccines (Ovarian) "Treatment of Ovarian Cancer with Autologous, Hapten-Modified Tumor Cell Vaccine." David Berd, John Carlson, Ellen Bloome and Charles Dunton. Thomas Jefferson University, Philadelphia, Pennsylvania. (CW...

Standardization of an ELISA for Pneumococcal Polysaccharide Antibodies.
June 28, 1999... Diagnostics (Pneumococcus) "Standardization of an ELISA for Pneumococcal Polysaccharide Antibodies." C.E. Frasch. Current affiliation unavailable. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 1ZO01J02014-05. PRINCIPLE...

Nonreplicating Modified Virus-Like Particles Vaccine for HIV.
June 28, 1999... HIV Vaccines "Nonreplicating Modified Virus-Like Particles Vaccine for HIV." Polly Roy. University of Alabama at Birmingham, Birmingham, Alabama. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 1R21AI44346-01. GRANT...

Comparative Ontogenetic Approach to Vaccine Strategy.
June 28, 1999... Vaccine Development "Comparative Ontogenetic Approach to Vaccine Strategy." Max D. Cooper. University of Alabama at Birmingham, Birmingham, Alabama. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 5R01AI39816-04. GRANT...

Liposome S Mutans Delivery System for Caries Immunity.
June 28, 1999... Vaccine Development "Liposome S Mutans Delivery System for Caries Immunity." Noel K. Childers. University of Alabama at Birmingham, Birmingham, Alabama. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 5R01DE09846-07....

Active Specific Immunotherapy for Metastatic Colorectal Carcinoma: Phase I Study of an Allogeneic Cell Vaccine Plus Low-Dose Interleukin-1 alpha.
June 28, 1999... Colorectal Cancer Vaccine Woodlock, T.J.; Sahasrabudhe, D.M.; Marquis, D.M.; Greene, D.; Pandya, K.J.; Mccune, C.S. "Active Specific Immunotherapy for Metastatic Colorectal Carcinoma: Phase I Study of an Allogeneic Cell Vaccine Plus...

Immunoglobulin G (IgG) Subclass Distribution and IgG1 Avidity of Antibodies in Human Immunodeficiency Virus-Infected Individuals After Revaccination With Tetanus Toxoid.
June 28, 1999... Immunology Kroon, F.P.; Vantol, M.J.D.; Jolvanderzijde, C.M.; Vanfurth, R.; Vandissel, J.T. "Immunoglobulin G (IgG) Subclass Distribution and IgG1 Avidity of Antibodies in Human Immunodeficiency Virus-Infected Individuals After...

Baculovirus-Derived Hemagglutinin Vaccines Protect Against Lethal Influenza Infections by Avian H5 and H7 Subtypes.
June 28, 1999... Influenza Vaccine Crawford, J.; Wilkinson, B.; Vosnesensky, A.; Smith, G.; Garcia, M.; Stone, H.; Perdue, M.L. "Baculovirus-Derived Hemagglutinin Vaccines Protect Against Lethal Influenza Infections by Avian H5 and H7 Subtypes." Vaccine,...

Paradoxical Response to a Novel Influenza Virus Vaccine Strain: The Effect of Prior Immunization.
June 28, 1999... Influenza Vaccine Gross, P.A.; Sperber, S.J.; Donabedian, A.; Dran, S.; Morchel, G.; Cataruozolo, P.; Munk, G. "Paradoxical Response to a Novel Influenza Virus Vaccine Strain: The Effect of Prior Immunization." Vaccine, May 4,...

Active Specific Immunotherapy With Polyvalent Melanoma Cell Vaccine for Patients With In-Transit Melanoma Metastases.
June 28, 1999... Melanoma Vaccine Hsueh, E.C.; Nathanson, L.; Foshag, L.J.; Essner, R.; Nizze, J.A.; Stern, S.L.; Morton, D.L. "Active Specific Immunotherapy With Polyvalent Melanoma Cell Vaccine for Patients With In-Transit Melanoma Metastases." Cancer,...

Impact of Community Volunteers on Immunization Rates of Children Younger Than 2 Years.
June 28, 1999... Pediatrics Barnes, K.; Friedman, S.M.; Namerow, P.B.; Honig, J. "Impact of Community Volunteers on Immunization Rates of Children Younger Than 2 Years." Archives of Pediatrics & Adolescent Medicine, May 1999;153(5):518-524. (CW...

Selection of the Most Efficacious of Twenty-Two Inactivated Sendai Virus Nasal Vaccines by Determination of the Protection Index in Mice.
June 28, 1999... Sendai Virus Nasal Vaccines Miyamae, T. "Selection of the Most Efficacious of Twenty-Two Inactivated Sendai Virus Nasal Vaccines by Determination of the Protection Index in Mice." Laboratory Animal Science, April 1999;49(2):149-152. ...