Vaccine Weekly articles from June 1998

Vaccine Weekly archives from June 1998

Tug-of-War Over Thailand in AIDS Squabble.
June 1, 1998... A Japanese deal to develop and possibly test an AIDS vaccine in Thailand has been blasted as unethical. The accusation, by an unnamed "leading Japanese researcher" cited in a news article in the journal Nature Medicine (1998;4(5):540),...

CDC's Vaccine Advisory To Focus on Combinations.(U.S. Centers for Disease Control and Prevention)
June 1, 1998... New U.S. vaccination guidelines will recommend the use of combination vaccines whenever possible. The guidelines, developed by the independent Advisory Committee of Immunization Practice (ACIP) for the U.S. Centers for Disease Control and...

Tips on Vaccine Licensing from Wyeth-Lederle.
June 1, 1998... Not everything comes from the R&D department. Modern pharmaceutical firms are constantly on the lookout for sources of technology that they can acquire or license. The trick, of course, is to spot relevant technologies before one's competitors:...

Hantavirus Epidemic Latest Spawn of El Nino.
June 1, 1998... An epidemic of the lethal hantavirus among deer mice raises the specter of a human outbreak, the journal Science reports. Particularly disturbing is the finding that record numbers of mice are carrying the Sin Nombre ("No Name") strain of the...

M. tuberculosis Peptide May Be Vaccine Vehicle.
June 1, 1998... A small peptide from Mycobacterium tuberculosis, labelled inv3, may be a useful tool for the delivery of macromolecules into mammalian cells, according to a report from the University of California at Berkeley. "This product of a human...

Vaginally Delivered Bacteria May Be Vehicle for STD Vaccines.
June 1, 1998... Vaginal administration of benign bacteria may be useful to deliver vaccines for sexual diseases. Researchers from Italy's University of Siena found that non-pathogenic commensal bacteria may be appropriate vectors for theses vaginal vaccines....

RNA Vaccine Revs Up Immune System To Vanquish Cancer.
June 1, 1998... An unusual form of gene therapy to treat several forms of cancer is entering the second phase of human testing at Duke University in North Carolina. The ultimate goal of the concoction is to help a person's immune system become its own best...

BEC2 Enters Phase III Small Cell Lung Carcinoma Clinical Trials.
June 1, 1998... ImClone Systems Inc., New York, New York, announced the commencement of a Phase III international trial of the cancer vaccine, BEC2. Merck KGaA, Darmstadt, Germany, is ImClone's corporate partner in the development of BEC2. The Phase III trial...

Immunology AIDS Free Babies May Not Have Been Infected.
June 1, 1998... Mistakes, and not some miracle of the immune system, might be behind tests that doctors thought showed some babies were somehow able to fight off HIV infection, researchers said. The cases of the babies had intrigued and excited doctors, who...

World AIDS Meeting May Produce Some Bad News.
June 1, 1998... The World AIDS conference may be in for some grim news as problems emerge with the "cocktail" therapy of protease inhibitor drugs, Robert Gallo, AIDS researcher said. The 12th World AIDS Conference, to be held in Geneva, Switzerland, June 28 -...

Campaign Promoting Hepatitis B Vaccine a Success in Kenya.
June 1, 1998... The hepatitis B vaccine promotion ongoing in Kenya is such a success, hospital stocks have to be replenished frequently. According to an article in The Nation newspaper ("Hepatitis B Vaccine Is in High Demand in Kenya," May 15, 1998), one...

CDC: Children Should Be Vaccinated To Prevent Chickenpox and its Complications.(U.S. Centers for Disease Control and Prevention)
June 1, 1998... Chickenpox, though a common and usually mild disease of childhood, can result in death in previously healthy children. A study in the May 15, 1998, Weekly Morbidity and Mortality Report highlighted three deaths (a 21-month-old boy, a...

Synergy Between Radiation and Cytokine-Producing Tumor Vaccines in Immunotherapy for Murine Renal Cell Carcinoma.
June 1, 1998... "Synergy Between Radiation and Cytokine-Producing Tumor Vaccines in Immunotherapy for Murine Renal Cell Carcinoma." N. Nishisaka, A. Maini, R.F. Jones, C.Y. Wang and G.P. Haas. Department of Urology, SUNY Health Science Center and VA Medical...

Immunogenicity of Murine Renal Carcinoma (RENCA) Cells Infected with a Disabled Infectious Single Cycle (DISC) Herpes Simplex Vector Carrying the mGMCSF Gene.
June 1, 1998... "Immnogenicity of Murine Renal Carcinoma (RENCA) Cells Infected with a Disabled Infectious Single Cycle (DISC) Herpes Simplex Vector Carrying the mGMCSF Gene." R.C. Rees, S.A. Ali, C.S. McLean, M.E.G. Boursnell, S. Reeder, S.D. Sivasubramaniam,...

National Adenovirus Surveillance and Typing among High Risk Military Populations.
June 1, 1998... "National Adenovirus Surveillance and Typing among High Risk Military Populations." G.C. Gray, P.R. Goswami, A.W. Hawksworth, J.D. Callahan, R.L. Greenup, R.M. Hendrix, R.J. O'Mara and M. Ryan. Naval Health Research Center, San Diego, CA; Walter...

Estimated Persistence of Anti-HAV Antibodies After Single Dose and Booster Hepatitis A Vaccination (0-6 Schedule).
June 1, 1998... Wiedermann, G.; Kundi, M.; Ambrosch, F. "Estimated Persistence of Anti-HAV Antibodies After Single Dose and Booster Hepatitis A Vaccination (0-6 Schedule)." Acta Tropica, May 1998;69(2):121-125. The persistence of antibodies after a single dose...

Improved Humoral and Cellular Immune Responses Against the gp120 V3 Loop of HIV-1 Following Genetic Immunization With a Chimeric DNA Vaccine Encoding the V3 Inserted Into the Hepatitis B Surface Antigen.
June 1, 1998... Fomsgaard, A.; Nielsen, H.V.; Bryder, K.; Nielsen, C.; Machuca, R.; Bruun, L.; Hansen, J.; Buus, S. "Improved Humoral and Cellular Immune Responses Against the gp120 V3 Loop of HIV-1 Following Genetic Immunization With a Chimeric DNA Vaccine...

Opsonophagocytic and Bactericidal Activity Mediated by Purified IgG Subclass Antibodies After Vaccination With the Norwegian Group B Meningococcal Vaccine.
June 1, 1998... Aase, A.; Hoiby, E.A.; Michaelsen, T.E. "Opsonophagocytic and Bactericidal Activity Mediated by Purified IgG Subclass Antibodies After Vaccination With the Norwegian Group B Meningococcal Vaccine." Scandinavian Journal of Immunology, April...

Loss of Maternally Derived Measles Immunity in Argentinian Infants.
June 1, 1998... Nates, S.V.; Giordano, M.O.; Medeot, S.I.; Martinez, L.C.; Baudagna, A.M.; Naretto, E.; Garrido, P.; Dewolff, C.D. "Loss of Maternally Derived Measles Immunity in Argentinian Infants." Pediatric Infectious Disease Journal, April...

Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide Presentation on Dendritic Cells.
June 1, 1998... Toes, R.E.M.; Vandervoort, E.I.H.; Schoenberger, S.P.; Drijfhout, J.W.; Vanbloois, L.; Storm, G.; Kast, W.M.; Offringa, R.; Melief, C.J.M. "Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide...

Effectiveness of Prenatal Tetanus Toxoid Immunization Against Neonatal Tetanus in a Rural Area in India.
June 1, 1998... Gupta, S.D.; Keyl, P.M. "Effectiveness of Prenatal Tetanus Toxoid Immunization Against Neonatal Tetanus in a Rural Area in India." Pediatric Infectious Disease Journal, April 1998;17(4):316-321. According to the authors' abstract of an...

Irradiated IL-2 Gene-Modified Plasmacytoma Vaccines Are More Efficient Than Live Vaccines.
June 1, 1998... Simova, J.; Bubenik, J.; Jandlova, T.; Indrova, M. "Irradiated IL-2 Gene-Modified Plasmacytoma Vaccines Are More Efficient Than Live Vaccines." International Journal of Oncology, May 1998;12(5):1195-1198. According to the authors' abstract of...

Transient HIV Infection a Myth.
June 1, 1998... Intensive evaluation has failed to corroborate transient HIV infection. There have been several reports of infants apparently infected with HIV who were later found to be uninfected. Because these studies used highly accurate tests for the...

AIDS Immunity Transient HIV Infection a Myth
June 1, 1998... Intensive evaluation has failed to corroborate transient HIV infection. There have been several reports of infants apparently infected with HIV who were later found to be uninfected. Because these studies used highly accurate tests for the...

AIDS Vaccines Tug-of-War Over Thailand in AIDS Squabble
June 1, 1998... A Japanese deal to develop and possibly test an AIDS vaccine in Thailand has been blasted as unethical. The accusation, by an unnamed "leading Japanese researcher" cited in a news article in the journal Nature Medicine (1998;4(5):540),...

Conference Coverage (ECPI Combination Vaccines) CDC's Vaccine Advisory To Focus on Combinations
June 1, 1998... New U.S. vaccination guidelines will recommend the use of combination vaccines whenever possible. The guidelines, developed by the independent Advisory Committee of Immunization Practice (ACIP) for the U.S. Centers for Disease Control and...

Conference Coverage (ECPI Combination Vaccines) Tips on Vaccine Licensing from Wyeth-Lederle
June 1, 1998... Not everything comes from the R&D department. Modern pharmaceutical firms are constantly on the lookout for sources of technology that they can acquire or license. The trick, of course, is to spot relevant technologies before one's competitors:...

Epidemics Hantavirus Epidemic Latest Spawn of El Nino
June 1, 1998... An epidemic of the lethal hantavirus among deer mice raises the specter of a human outbreak, the journal Science reports. Particularly disturbing is the finding that record numbers of mice are carrying the Sin Nombre ("No Name") strain of the...

Conference Coverage (ASM) M. tuberculosis Peptide May Be Vaccine Vehicle
June 1, 1998... A small peptide from Mycobacterium tuberculosis, labelled inv3, may be a useful tool for the delivery of macromolecules into mammalian cells, according to a report from the University of California at Berkeley. "This product of a human...

Conference Coverage (ASM) Vaginally Delivered Bacteria May Be Vehicle for STD Vaccines
June 1, 1998... Vaginal administration of benign bacteria may be useful to deliver vaccines for sexual diseases. Researchers from Italy's University of Siena found that non-pathogenic commensal bacteria may be appropriate vectors for theses vaginal vaccines....

Cancer Gene Therapy (Vaccine) RNA Vaccine Revs Up Immune System To Vanquish Cancer
June 1, 1998... An unusual form of gene therapy to treat several forms of cancer is entering the second phase of human testing at Duke University in North Carolina. The ultimate goal of the concoction is to help a person's immune system become its own best...

Cancer Vaccines BEC2 Enters Phase III Small Cell Lung Carcinoma Clinical Trials
June 1, 1998... ImClone Systems Inc., New York, New York, announced the commencement of a Phase III international trial of the cancer vaccine, BEC2. Merck KGaA, Darmstadt, Germany, is ImClone's corporate partner in the development of BEC2. The Phase III trial...

Immunology AIDS Free Babies May Not Have Been Infected
June 1, 1998... Mistakes, and not some miracle of the immune system, might be behind tests that doctors thought showed some babies were somehow able to fight off HIV infection, researchers said. The cases of the babies had intrigued and excited doctors, who...

Protease Inhibitors World AIDS Meeting May Produce Some Bad News
June 1, 1998... The World AIDS conference may be in for some grim news as problems emerge with the "cocktail" therapy of protease inhibitor drugs, Robert Gallo, AIDS researcher said. The 12th World AIDS Conference, to be held in Geneva, Switzerland, June 28 -...

Public Health (HBV) Campaign Promoting Hepatitis B Vaccine a Success in Kenya
June 1, 1998... The hepatitis B vaccine promotion ongoing in Kenya is such a success, hospital stocks have to be replenished frequently. According to an article in The Nation newspaper ("Hepatitis B Vaccine Is in High Demand in Kenya," May 15, 1998), one...

Varicella CDC: Children Should Be Vaccinated To Prevent Chickenpox and its Complications
June 1, 1998... Chickenpox, though a common and usually mild disease of childhood, can result in death in previously healthy children. A study in the May 15, 1998, Weekly Morbidity and Mortality Report highlighted three deaths (a 21-month-old boy, a...

Conference News . . . June 1, 1998 Information About Research Worldwide . . . Compiled by Michelle Marble
June 1, 1998... Cancer Vaccines "Synergy Between Radiation and Cytokine-Producing Tumor Vaccines in Immunotherapy for Murine Renal Cell Carcinoma." N. Nishisaka, A. Maini, R.F. Jones, C.Y. Wang and G.P. Haas. Department of Urology, SUNY Health Science Center and...

Cancer Vaccines "Immunogenicity of Murine Renal Carcinoma (RENCA) Cells Infected with a Disabled Infectious Single Cycle (DISC) Herpes Simplex Vector Carrying the mGMCSF Gene."
June 1, 1998... R.C. Rees, S.A. Ali, C.S. McLean, M.E.G. Boursnell, S. Reeder, S.D. Sivasubramaniam, C. Entwisle, D.M. Blakeley and J.G. Shields. Nottingham Trent University, Nottingham, United Kingdom; Cantab Pharmaceuticals Research Ltd., Cambridge, United...

Epidemiology (Pulmonary Infections) "National Adenovirus Surveillance and Typing among High Risk Military Populations."
June 1, 1998... G.C. Gray, P.R. Goswami, A.W. Hawksworth, J.D. Callahan, R.L. Greenup, R.M. Hendrix, R.J. O'Mara and M. Ryan. Naval Health Research Center, San Diego, CA; Walter Reed Army Institute of Research, Washington, DC; Leonard Wood Army Hospital, Ft....

Journal News . . . June 1, 1998 Reviews and Information From Periodicals and Journals Worldwide . . . Compiled by Alan D. Henderson
June 1, 1998... HAV Vaccines Wiedermann, G.; Kundi, M.; Ambrosch, F. "Estimated Persistence of Anti-HAV Antibodies After Single Dose and Booster Hepatitis A Vaccination (0-6 Schedule)." Acta Tropica, May 1998;69(2):121-125. According to the authors' abstract...

HIV Vaccines Fomsgaard, A.; Nielsen, H.V.; Bryder, K.; Nielsen, C.; Machuca, R.; Bruun, L.; Hansen, J.; Buus, S.
June 1, 1998... "Improved Humoral and Cellular Immune Responses Against the gp120 V3 Loop of HIV-1 Following Genetic Immunization With a Chimeric DNA Vaccine Encoding the V3 Inserted Into the Hepatitis B Surface Antigen." Scandinavian Journal of Immunology,...

Meningococcal Disease Aase, A.; Hoiby, E.A.; Michaelsen, T.E. "Opsonophagocytic and Bactericidal Activity Mediated by Purified IgG Subclass Antibodies After Vaccination With the Norwegian Group B Meningococcal Vaccine." Scandinavian Journal of Immunology, April 1998;47(4):388-396.
June 1, 1998... According to the authors' abstract of an article published in Scandinavian Journal of Immunology, "To study how the different immunoglobulin (Ig)G subclass antibodies may confer protection against systemic meningococcal disease, we isolated IgG1,...

Pediatrics (Measles) Nates, S.V.; Giordano, M.O.; Medeot, S.I.; Martinez, L.C.; Baudagna, A.M.; Naretto, E.; Garrido, P.; Dewolff, C.D. "Loss of Maternally Derived Measles Immunity in Argentinian Infants." Pediatric Infectious Disease Journal, April 1998;17(4):313-316.
June 1, 1998... According to the authors' abstract of an article published in Pediatric Infectious Disease Journal, "BACKGROUND: Measles immunization of children at 1 year of age with a single dose of the current vaccine has successfully reduced measles...

Peptide Vaccines Toes, R.E.M.; Vandervoort, E.I.H.; Schoenberger, S.P.; Drijfhout, J.W.; Vanbloois, L.; Storm, G.; Kast, W.M.; Offringa, R.; Melief, C.J.M.
June 1, 1998... "Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide Presentation on Dendritic Cells." Journal of Immunology, May 1, 1998;160(9):4449-4456. According to the authors' abstract of an article...

Tetanus Gupta, S.D.; Keyl, P.M. "Effectiveness of Prenatal Tetanus Toxoid Immunization Against Neonatal Tetanus in a Rural Area in India." Pediatric Infectious Disease Journal, April 1998;17(4):316-321.
June 1, 1998... According to the authors' abstract of an article published in Pediatric Infectious Disease Journal, "BACKGROUND: Neonatal tetanus is the cause of 23 to 73% of neonatal deaths in developing countries and continues to be am important killer in many...

Vaccine Development Simova, J.; Bubenik, J.; Jandlova, T.; Indrova, M. "Irradiated IL-2 Gene-Modified Plasmacytoma Vaccines Are More Efficient Than Live Vaccines." International Journal of Oncology, May 1998;12(5):1195-1198.
June 1, 1998... According to the authors' abstract of an article published in International Journal of Oncology, "The effect of irradiation on the therapeutic efficacy of IL-2 gene-modified plasmacytoma cells used as a vaccine in the immunotherapy of parental...

Vaccinated Mice Reject Established Tumors.
June 8, 1998... A fusion-cell vaccine could cause the body to reject tumors, animal studies suggest. The vaccine is made up of fusion cells (FC) created by combining the nuclei of carcinoma cells and dendritic cells. Dendritic cells (DC) are the body's chief...

Memory Cells May Promote Their Own Infection by HIV.
June 8, 1998... A normal cell-surface enzyme may pave the way for HIV to destroy immunologic memory. The finding provides an explanation for the selective loss of memory T cells during HIV infection. It may also provide clues to the development of an AIDS...

Advocacy Group Blasts Clinton, NIH, SmithKline Beecham.
June 8, 1998... It's not like the space race. That's the opinion of the independent AIDS Vaccine Advocacy Coalition (AVAC) on the first anniversary of President Bill Clinton's avowed 10-year, all-out effort to develop an AIDS vaccine. The organization says...

Many Hurdles for Successful Combination Vaccines.
June 8, 1998... It's more than just mixing. Combinations of existing vaccines are more than the sum of their parts: they are complex new vaccine entities. Developers wishing to take advantage of the trend toward combination vaccines must make similarly...

Less Than 1000 Days Left, More Than $1 Billion Needed.
June 8, 1998... Fewer than 1000 days remain to reach the goal of global polio eradication by the year 2000. U.S. Centers for Disease Control and Prevention (CDC) statistics for 1997 demonstrate great progress in the past year. This has been due mainly to the...

Persistent Antibodies Detected Years after Brief Exposure.
June 8, 1998... Anti-malarial antibodies persisted in a group of people exposed to Plasmodium vivax malaria seven years previously. "Whether the persistent anti-malarial antibodies in such subjects will be sufficient to protect them in the case of a new...

Three Children Die of Chickenpox Related Complications.
June 8, 1998... Three recently described cases of fatal chickenpox indicate that children continue to die from varicella-related complications. During the first quarter of 1998, the Texas Department of Health and the Iowa Department of Health notified the U.S....

Research Grant Announced for Herpes Simplex Vaccine.
June 8, 1998... Cel-Sci Corp., Alexandria, Virginia, announced the receipt of a phase I $100,000 research grant to fund further animal studies with its herpes simplex vaccine. The grant was given pursuant to the Small Business Innovation Research Program...

Collaboration Extended To Develop Vaccine for Gonorrhea.
June 8, 1998... ImClone Systems Inc., New York, New York, announced the extension of an agreement with American Home Product Corp.'s Wyeth-Lederle Vaccine Division to develop a vaccine against gonorrhea. Under an agreement previously signed in 1993 with...

Australian Firm Sneezes At Common Cold.
June 8, 1998... A small Australian company has hoped to peddle a "cure" for the common cold. But unlike history's promoters of boldly named potions and vile elixirs, Biota Holdings Ltd. is being taken seriously. Biota, in partnership with Glaxo Wellcome,...

First Vaccine Receives Approval from Expert.
June 8, 1998... A U.S. Food and Drug Administration (FDA) advisory panel has recommended approval of the first vaccine against tick-borne Lyme disease. SmithKline Beecham Plc's vaccine would be used to protect hikers, campers and other people who are outdoors...

Lyme Disease LYMErix Found Safe and Effective for Disease Prevention.
June 8, 1998... LYMErix [Lyme Disease Vaccine (Recombinant OspA)] was found safe and effective for the prevention of Lyme disease by the Vaccine and Related Biological Products Advisory Committee of the U.S. Food and Drug Administration (FDA), SmithKline Beecham...

Trial Results Reported in Infants of Group C Meningococcal Conjugate Vaccine.
June 8, 1998... North American Vaccine, Beltsville, Maryland, announced positive results from two clinical trials for the company's polysaccharide conjugate vaccine against group C meningococcal infection. The data was reported at the meeting of the European...

North Carolina Is Getting Its Money's Worth on Vaccines.
June 8, 1998... North Carolina's practice of buying almost all vaccines distributed to doctors' offices and public health clinics across the state has been a wise investment, a new University of North Carolina at Chapel Hill study concluded. Comparable...

New Vaccine Developed for Common Childhood Diarrhea.
June 8, 1998... Rotavirus is responsible for one of every three hospitalizations worldwide and 873,000 deaths each year - mostly among young children. But a new vaccine proven effective by a Johns Hopkins University scientist may change that. When Mathuram...

Accelerated Repair of Acetic Acid Induced Gastric Ulcers Using Antiviral and Antibacterial Vaccines Stimulating Angiogenesis and Fibrogenesis in Rats.
June 8, 1998... "Accelerated Repair of Acetic Acid Induced Gastric Ulcers Using Antiviral and Antibacterial Vaccines Stimulating Angiogenesis and Fibrogenesis in Rats." O.A. Bedini, O.M. Laudanno, A. Naves, G. Guastalli, P. San Miguel and J.A. Cesolari. Cat. de...

Cost-Effective Analysis of Different Strategies of Hepatitis A Vaccination in Adults: A Markov Model Analysis.
June 8, 1998... "Cost-Effective Analysis of Different Strategies of Hepatitis A Vaccination in Adults: A Markov Model Analysis." A. Das. Division of Gastroenterology, University Hospitals of Cleveland, Cleveland, Ohio. According to an abstract submitted by the...

Selective Down-Regulation of T-Cell Receptor V(beta)6 Gene Expression in Tuberculin Skin Test-Reactive Individuals.
June 8, 1998... "Selective Down-Regulation of T-Cell Receptor V(beta)6 Gene Expression in Tuberculin Skin Test-Reactive Individuals." C. Yin, V.R. Nerurkar, L. Kimura, W. Dashwood and R. Yanagihara. University of Hawaii at Manoa, and Tripler Army Medical Center,...

The Development of Natural Immunity to the Plasmodium falciparum Malaria Merozoite Surface Protein in Infants: Implications in their Continued Susceptibility to Malaria and Possible Vaccine Strategies.
June 8, 1998... "The Development of Natural Immunity to the Plasmodium falciparum Malaria Merozoite Surface Protein in Infants: Implications in their Continued Susceptibility to Malaria and Possible Vaccine Strategies." O.H. Branch, A.J. Oloo, B.L. Nahlen, D....

Irradiated IL-2 Gene-Modified Plasmacytoma Vaccines Are More Efficient Than Live Vaccines.
June 8, 1998... Simova, J.; Bubenik, J.; Jandlova, T.; Indrova, M. "Irradiated IL-2 Gene-Modified Plasmacytoma Vaccines Are More Efficient Than Live Vaccines." International Journal of Oncology, May 1998;12(5):1195-1198. According to the authors' abstract of...

Vaccination With Multiple Antigen Peptide as Rejection Antigen Peptide in Murine Leukemia.
June 8, 1998... Manki, A.; Ono, T.; Uenaka, A.; Seino, Y.; Nakayama, E. "Vaccination With Multiple Antigen Peptide as Rejection Antigen Peptide in Murine Leukemia." Cancer Research, May 1, 1998;58(9):1960-1964. According to the authors' abstract of an article...

Plasmid DNA: A New Era in Vaccinology.
June 8, 1998... Mor, G. "Plasmid DNA: A New Era in Vaccinology." Biochemical Pharmacology, April 15, 1998;55(8):1151-1153. According to the author's abstract of an article published in Biochemical Pharmacology, "DNA vaccination is a novel approach for...

Overview of Melanoma Vaccines: Active Specific Immunotherapy for Melanoma Patients.
June 8, 1998... Ollila, D.W.; Kelley, M.C.; Gammon, G.; Morton, D.L. "Overview of Melanoma Vaccines: Active Specific Immunotherapy for Melanoma Patients." Seminars in Surgical Oncology, June 1998;14(4):328-336. According to the authors' abstract of an article...

Clinical Acceptability and Immunogenicity of a Pentavalent Parenteral Combination Vaccine Containing Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliomyelitis and Haemophilus influenzae Type b Conjugate Antigens ...
June 8, 1998... Lagos, R.; Kotloff, K.; Hoffenbach, A.; Sanmartin, O.; Abrego, P.; Ureta, A.M.; Pines, E.; Blondeau, C.; Bailleux, F.; Levine, M.M. "Clinical Acceptability and Immunogenicity of a Pentavalent Parenteral Combination Vaccine Containing Diphtheria,...

Routine and Influenza Vaccination Rates in Children With Asthma.
June 8, 1998... Chung, E.K.; Casey, R.; Pintomartin, J.A.; Pawlowski, N.A.; Bell, L.M. "Routine and Influenza Vaccination Rates in Children With Asthma." Annals of Allergy Asthma & Immunology, April 1998;80(4):318-322. According to the authors' abstract of an...

T-Cell Vaccination Induces T-Cell Receptor V beta-Specific Qa-1-Restricted Regulatory CD8(+) T Cells.
June 8, 1998... Jiang, H.; Kashleva, H.; Xu, L.X.; Forman, J.; Flaherty, L.; Pernis, B.; Braunstein, N.S.; Chess, L. "T-Cell Vaccination Induces T-Cell Receptor V beta-Specific Qa-1-Restricted Regulatory CD8(+) T Cells." Proceedings of the National Academy of...

Trypanosoma cruzi: IgG1 and IgG2b Are the Main Immunoglobulins Produced by Vaccinated Mice.
June 8, 1998... Pyrrho, A.S.; Moraes, J.L.C.; Pecanha, L.M.T.; Gattass, C.R. "Trypanosoma cruzi: IgG1 and IgG2b Are the Main Immunoglobulins Produced by Vaccinated Mice." Parasitology Research, April 1998;84(4):333-337. According to the authors' abstract of...

New Strategies for the Microencapsulation of Tetanus Vaccine.
June 8, 1998... Schwendeman, S.P.; Tobio, M.; Joworowicz, M.; Alonso, M.J.; Langer, R. "New Strategies for the Microencapsulation of Tetanus Vaccine." Journal of Microencapsulation, May-June 1998;15(3):299-318. According to the authors' abstract of an article...

Cancer Vaccines Vaccinated Mice Reject Established Tumors
June 8, 1998... A fusion-cell vaccine could cause the body to reject tumors, animal studies suggest. The vaccine is made up of fusion cells (FC) created by combining the nuclei of carcinoma cells and dendritic cells. Dendritic cells (DC) are the body's chief...

AIDS Pathogenesis Memory Cells May Promote Their Own Infection by HIV
June 8, 1998... A normal cell-surface enzyme may pave the way for HIV to destroy immunologic memory. The finding provides an explanation for the selective loss of memory T cells during HIV infection. It may also provide clues to the development of an AIDS...

AIDS Vaccines Advocacy Group Blasts Clinton, NIH, SmithKline Beecham
June 8, 1998... It's not like the space race. That's the opinion of the independent AIDS Vaccine Advocacy Coalition (AVAC) on the first anniversary of President Bill Clinton's avowed 10-year, all-out effort to develop an AIDS vaccine. The organization says...

Conference Coverage (ECPI Combination Vaccines) Many Hurdles for Successful Combination Vaccines
June 8, 1998... It's more than just mixing. Combinations of existing vaccines are more than the sum of their parts: they are complex new vaccine entities. Developers wishing to take advantage of the trend toward combination vaccines must make similarly...

Polio Eradication Less Than 1000 Days Left, More Than $1 Billion Needed
June 8, 1998... Fewer than 1000 days remain to reach the goal of global polio eradication by the year 2000. U.S. Centers for Disease Control and Prevention (CDC) statistics for 1997 demonstrate great progress in the past year. This has been due mainly to the...

Malaria Persistent Antibodies Detected Years after Brief Exposure
June 8, 1998... Anti-malarial antibodies persisted in a group of people exposed to Plasmodium vivax malaria seven years previously. "Whether the persistent anti-malarial antibodies in such subjects will be sufficient to protect them in the case of a new...

Varicella Three Children Die of Chickenpox Related Complications
June 8, 1998... Three recently described cases of fatal chickenpox indicate that children continue to die from varicella-related complications. During the first quarter of 1998, the Texas Department of Health and the Iowa Department of Health notified the U.S....

Funding Research Grant Announced for Herpes Simplex Vaccine
June 8, 1998... Cel-Sci Corp., Alexandria, Virginia, announced the receipt of a phase I $100,000 research grant to fund further animal studies with its herpes simplex vaccine. The grant was given pursuant to the Small Business Innovation Research Program...

Industry News (Joint Venture) Collaboration Extended To Develop Vaccine for Gonorrhea
June 8, 1998... ImClone Systems Inc., New York, New York, announced the extension of an agreement with American Home Product Corp.'s Wyeth-Lederle Vaccine Division to develop a vaccine against gonorrhea. Under an agreement previously signed in 1993 with...

Influenza Australian Firm Sneezes At Common Cold
June 8, 1998... A small Australian company has hoped to peddle a "cure" for the common cold. But unlike history's promoters of boldly named potions and vile elixirs, Biota Holdings Ltd. is being taken seriously. Biota, in partnership with Glaxo Wellcome,...