Vaccine Weekly articles from July 2004

Vaccine Weekly archives from July 2004

T cells primed by DCs pulsed with hepatoma acid-eluted substances.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Natural killer T cells can be primed in vivo by dendritic cells (DCs) pulsed with hepatoma-derived acid-eluted substances. "Many murine tumor cells express not only individual haplotype-matched...

CTL precursor-oriented peptide vaccine promising for colorectal cancer.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Results from a phase I trial indicate some benefit from cytotoxic T-lymphocyte (CTL) precursor-oriented peptide vaccines for colorectal carcinoma patients. According to recent research from Japan,...

Surface-accessible proteins protect mice against pneumococcal disease.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Immunization with conserved surface-accessible proteins protected mice against pneumococcal disease. "The development of a vaccine against Streptococcus pneumoniae has been complicated by the...

SARS coronavirus spike protein protectively immunizes mice.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice. "The spike protein (S), a membrane component of severe acute...

Flagellin fusion proteins induce specific immune responses.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. "Vaccination is the most efficient prophylaxis against a variety of infectious diseases. New vaccination...

Molecular analysis of adenovirus isolates from young adults reported.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers have performed a molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults. "Infections of adenovirus type 4 (Ad4) and Ad7 were discovered among previously...

Stem cells not necessarily magic bullet for brain-wasting diseases.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Despite the high profile that Nancy Reagan and others have given the idea of using embryonic stem cells to treat Alzheimer disease, advances are likely to come faster from other approaches. Experts...

Anthrax antibody profiled in medical journal.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals' (AVN) anti-anthrax monoclonal antibodies protected rats from lethal anthrax toxins, according to a study published in the peer-reviewed Journal of Immune Based Therapies and...

UVB-irradiated dendritic cells fail to tolerize murine CD8+ T cells.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- UVB-irradiated dendritic cells fail to tolerize murine CD8+ naive or effector T cells. "UVB radiation has been shown to induce T cell tolerance most likely via modulation of the function of...

Significant survival advantage reported in phase III trial of Theratope.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) of Edmonton, Alberta, Canada, announced that an exploratory analysis showed a statistically significant survival advantage for women in the hormonal therapy subset of patients...

FDA grants fast track designation for MedPulser Electroporation Therapy System.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB) has been granted a fast track designation by the U.S. Food and Drug Administration for its MedPulser Electroporation System clinical development program for patients...

NSABP protocol C-06: Oral chemotherapy equally effective and tolerated.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Five-year results of NSABP (National Surgical Adjuvant Breast and Bowel Project) Protocol C-06 that compared oral chemotherapy (UFT/leucovorin) with intravenous chemotherapy (5-FU/leucovorin)...

Study: Oral Xeloda is equivalent IV chemo in adjuvant colon cancer.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Xeloda, an oral tablet, could replace the most widely-used intravenous (IV) chemotherapy for colon cancer, according to new results from a large international phase III study presented at the 40th...

Folate-mediated targeting of T cells to tumors reviewed.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists review folate-mediated targeting of T cells to tumors in a recent issue of Advanced Drug Delivery Reviews. According to recent research from the United States, "Recently various...

Immunological therapies in lymphoproliferative disorders reviewed.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- A scientist reviews the accomplishments and perspectives of immunological interventions in lymphoproliferative disorders in a recent issue of the Journal of Experimental and Clinical Cancer Research....

Toll-like receptor signals needed to reverse regulatory CD8 tolerance.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. According to a study from the United States, "One chief barrier to cancer immunotherapy...

Tumor suppressor candidate protein in PTEN turnover identified.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have identified a tumor suppressor candidate protein in phosphatase and tensin homologue deleted on chromosome 10 (PTEN) turnover. According to published research from Japan, "The turnout...

New findings on drug composition may allow better preservation in heat.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- A spoonful of sugar may help the medicine go down, but it may take only a thin coating of freeze-dried sugar to keep insulin, vaccines and other heat-sensitive, protein-based drugs working reliably even...

Rabies has potential use in vaccines for other infectious diseases.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists at Jefferson Medical College have literally "fused" a part of a rabies virus protein to another foreign protein, resulting in a more robust immune response in animals than with the protein...

Novel gene therapy approach suppresses autoimmune encephalomyelitis.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have developed a novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP. ...

Advocacy group applauds G8 inclusion of AIDS vaccine as agenda item.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- The International AIDS Vaccine Initiative (IAVI) applauded the Group of Eight Industrialized Nations (G8) for including HIV/AIDS - and specifically a preventive vaccine - on the agenda for this year's...

rAAV technology highlighted for its potential utility in AIDS prevention.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corporation (TGEN) announced that its recombinant adeno-associated viral (rAAV) vector technology was highlighted for its potential utility in the prevention of AIDS at the 7th Annual...

Epitope for antibodies inhibiting H. pylori urease characterized.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have characterized the epitope for monoclonal antibodies inhibiting enzymatic activity of Helicobacter pylori urease. "Two characteristic monoclonal antibodies (HpU-2 and -18) out of 26...

Normalizing hemoglobin aids hemodialysis patients.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Normalizing the hemoglobin concentration in hemodialysis patients who receive recombinant human erythropoietin. "Partial correction of anemia by erythropoietin improves hemodialysis (HD)-associated...

iTopia Epitope Discovery System launched for immune response prediction.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Beckman Coulter, Inc., (BEC) announced the commercial availability of its new iTopia Epitope Discovery System, which incorporates a proprietary technology announced last year at the World Vaccine...

Mucosal immune responses reviewed.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists review mucosal immune responses in a recent issue of Best Practice & Research in Clinical Gastroenterology. "The host gastrointestinal tract is exposed to countless numbers of foreign...

OX40L needed for alloantibody production after alloimmunizations.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- OX40L plays an essential role on B cells in persistent alloantibody production following repeated alloimmunizations. "OX40/OX40 ligand (OX40L) interactions are implicated in costimulation for both...

Positive results reported for telomerase cancer vaccine clinical trial.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Geron Corp. (GERN) announced the presentation of new positive results from a phase I/II clinical trial of its telomerase therapeutic vaccine in metastatic prostate cancer. The presentation was...

Trial launched for new kidney-cancer vaccine.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Merix Bioscience, a company pioneering therapeutic cancer vaccines, announced its first corporate-sponsored clinical trial, a trial with potential significant impact on the future treatment of kidney...

Leishmania amastigotes induce transcription factor in macrophages.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages. "Invasion of a host by pathogens is frequently associated with activation of nuclear factor kappa...

Immunity and immunosuppression in visceral leishmaniasis reviewed.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists review immunity and immunosuppression in experimental visceral leishmaniasis in a recent issue of the Brazilian Journal of Medical and Biological Research. "Leishmaniasis is a disease...

Data from trial of EP-2101 released at ASCO.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) provided preliminary data from ongoing phase I/II clinical trials of its EP-2101 therapeutic vaccine in non-small cell lung (NSCL) cancer and colorectal cancer patients in a...

Stability indicating method for SPf66 antimalarial peptide in solution.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method for indicating the stability of SPf66 antimalarial peptide in solution. According to published research from Spain, "Stability studies on the SPf66 antimalarial...

Leukocyte antigen alleles affect antibodies to Plasmodium antigen.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface...

Lessons from measles surveillance in the U.S. outlined.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Investigators outline the lessons learned from establishing and evaluating indicators of the quality of measles surveillance in the United States in a recent issue of the Journal of Infectious Diseases....

Overall population immunity to measles in U.S. is 93%.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Overall population immunity to measles in the United States is 93%. According to recent research published in the Journal of Infectious Diseases, "To estimate population immunity, we examined...

MDX-010 receives orphan drug designation.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) announced that under the U.S. Orphan Drug Act, the U.S Food and Drug Administration (FDA) has granted orphan drug designation to Medarex's fully human anti-CTLA-4 antibody,...

N. meningitidis membrane vesicles elicited antibody responses in mice.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Intranasal immunization with native and detergent-extracted outer membrane vesicles from Neisseria meningitidis elicited local and systemic antibody responses in mice. "The mouse humoral immune...

Lipopolysaccharide of Neisseria meningitidis examined.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers distinguish the structural determinants of 'toxicity' and 'adjuvanticity' in the lipopolysacchracide of Neisseria meningitidis in a recent issue of the Journal of Endotoxin Research. ...

Phycocyanin plus antigen-entrapped microparticles enhance IgA response.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles. According to a study from...

Mutants of lactic acid bacteria enhance mucosal delivery of antigen.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Cell wall mutants of lactic acid bacteria enhance the mucosal delivery of antigen. According to recent research from France, "The potential of recombinant lactic acid bacteria (LAB) to deliver...

Therapeutic vaccine approach for PD discovered.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists at the University of Nebraska Medical Center (UNMC) in Omaha and Columbia University Medical Center in New York have discovered a new vaccine approach that successfully prevents the death of...

Tumor-associated antigens show promise for prostate cancer vaccines.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have identified potential tumor-associated antigens for the development of prostate cancer vaccines. According to published research from Norway, "Serological cloning of tumor-associated...

Vaccine benefits some prostate cancer patients in biochemical relapse.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Vaccination with autologous dendritic cells pulsed with recombinant human PSA benefits some prostatectomized prostate cancer patients in biochemical relapse. "This study was conducted in prostate...

Nucleonics licenses key promoter technology for use in RNAi applications.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Nucleonics, Inc., a biotechnology company focused on the development of novel RNA interference-based (RNAi) therapeutics, has acquired an exclusive license from the University of California to...

Colloidal bacterial extract elicits specific immune responses.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Intranasal immunization with a colloid-formulated bacterial extract induces an acute inflammatory response in the lungs and elicits specific immune responses. "Nonspecific stimulation of lung...

Factors affecting immune responses to Salmonella vaccine reported.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists outline the host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains in a recent issue of Infection and Immunity. ...

Schistosoma dismutase cross-reacts with host superoxide dismutase.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Schistosoma mansoni cytosolic superoxide dismutase, a protective vaccine candidate, cross-reacts with host superoxide dismutase. "Schistosoma mansoni, an intravascular parasite, has evolved a...

Heterozygosity of field and laboratory Schistosoma mansoni compared.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers provide a comparison of microsatellite polymorphism and heterozygosity among field and laboratory populations of Schistosoma mansoni in a recent issue of the International Journal for...

Shigella flexneri mutant shows no attenuation of virulence.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- A DNA adenine methylase mutant of Shigella flexneri shows no significant attenuation of virulence. "Mutants of Salmonella defective in DNA adenine methylase (dam) have been reported to be...

IMC-BEC2 cancer vaccine trial did not meet primary endpoint.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- ImClone Systems, Inc., (IMCL) and Merck, KGaA, of Darmstadt, Germany (MRK), announced that the international, randomized, phase III, clinical trial of the companies' IMC-BEC2 cancer vaccine did not meet...

Multivalent streptococcal vaccine protects mice against infection.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections. "We have previously shown that a hexavalent group A streptococcal M...

Tetanus vaccine impairs tetanus-specific responses in filariasis.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Tetanus vaccination impairs tetanus-specific cellular and humoral responses in human lymphatic filariasis. "To investigate the consequences of the impaired parasite-specific immune response in...

Methoxymycolic acid loss by M. bovis does not affect BCG virulence.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Loss of methoxymycolic acid production by Mycobacterium bovis does not affect the virulence of BCG vaccine strains. "BCG vaccines are a family of closely related daughter strains of an attenuated...

Novel M. tuberculosis gene products to detect TB identified.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have identified novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for the specific detection of human tuberculosis infection. According to a study from England, "The...

Tuberculin-boosted antibodies correlate with immunity in cattle.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Tuberculin-boosted antibody responses correlate with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis. According to published...

Clostridium difficile toxin peptide acts as mucosal adjuvant.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant. "The receptor binding domains of the most potent mucosal adjuvants,...

Epicutaneous CpG oligodeoxynucleotides with antigen promotes CTL.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Epicutaneous application of CpG oligodeoxynucleotides with peptide or protein antigen promotes the generation of cytotoxic T lymphocytes (CTL). According to recent research published in the Journal...

Inadequate vaccines can help breed more vicious malaria strains.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Vaccination programs could create conditions that promote the evolution of virulent strains of the disease, according to a laboratory-based study of the malarial parasite Plasmodium in mice. The...

Merck, KGaA, returns Theratope rights.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM) and Merck, KGaA, of Darmstadt, Germany, announced that development and commercialization rights to the therapeutic cancer vaccine, Theratope, will be returned to Biomira. The...

pH-sensitive toxins find application in vaccines and drug delivery.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- pH-sensitive toxins are finding application in vaccines and drug delivery. "pH-sensitive toxins are secreted by bacteria and reach the cytosol of eukaryotic target cells by complex mechanisms...

Community Health Care Centers in Utah pays fine for vaccine fraud.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Utah's largest community-based health care provider has agreed to pay $267,000 to state and federal agencies for improperly using vaccines intended for needy children, officials said June 15, 2004. ...

Empirical data on varicella situation in Germany released.
July 7, 2004... 2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Investigators have released empirical data on the varicella situation in Germany in a recent issue of Clinical Microbiology and Infection to help make vaccination decisions. "As epidemiological...

Tobacco cells produce antibodies to hepatitis B virus surface antigen.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Transgenic tobacco cells can produce human monoclonal antibodies to hepatitis B virus surface antigen. "The recombinant human monoclonal antibody (MAb) against hepatitis B virus (HBV) surface...

Dendritic cells loaded with microspheres used for immunotherapy.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Human monocyte-derived dendritic cells loaded with biodegradable poly(Lactide-co-glycolide) microspheres can be used for immunotherapy. According to published research from Switzerland, "Dendritic...

DNA vaccine induces SARS-nucleoprotein-specific immune response.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- A DNA vaccine induced SARS-nucleoprotein-specific immune response. According to recent research published in the journal Immunology Letters, "Induction of effective cytotoxic T lymphocyte (CTL)...

Nanoparticles enhance immunogenicity of tuberculosis DNA vaccine.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis. "In this study, we used...

Minimalistic expression constructs are vectors for DNA vaccines.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Minimalistic expression constructs show promise as vectors for DNA vaccines. According to published research from Spain, "The low efficacy obtained in large animals makes plasmid-based DNA vaccines...

Genetic immunization effective against anthrax.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Genetic immunization is effective against anthrax. According to recent research from the United States, "The objective of this study was to determine whether a DNA prime-protein boost immunization...

Dendritic cell vaccines show promise for breast cancer therapy.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines show promise for breast cancer therapy. According to published research from Australia, "The long-held belief that breast cancer is a weakly immunogenic tumor and a poor...

Henry Schein named exclusive distributor of FluMist.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) and Henry Schein (HSIC) announced that Henry Schein has been selected as the exclusive U.S. distributor of MedImmune's FluMist (Influenza Virus Vaccine Live, Intranasal) for the...

Irish pharmaceutical company enters oral drug-delivery market.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Merrion Pharmaceuticals, Inc., has entered the $25 billion oral drug-delivery market. The company will develop its own products and seek collaboration and licensing opportunities with...

Novel cancer compound targets EGFR pathway; demonstrates positive trial results.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- CancerVax Corp. (CNVX) announced data from phase I/II clinical trials of an investigational specific active immunotherapeutic product candidate (SAI-EGF) that targets the epidermal growth factor...

Adenovirus encoding HCA661 targets hepatoma cells.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells. According to recent research from China,...

CTLA-4 blockade plus DNA vaccine enhances tumor immunity.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity, and autoimmunity to self-antigens in animal and cellular model systems. According to recent...

Gene transfer of OX40 ligand to tumor cells enhances antitumor immunity.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. According to recent research published in the journal Cancer...

Peptides immunogenic for HLA-A2+ cancer patients identified.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Scientists have identified epidermal growth factor receptor-derived peptides immunogenic for HLA-A2+ cancer patients. According to published research from Japan, "Epidermal growth factor receptor...

Alliance to advance development of botulinum toxin vaccines.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- DOR BioPharma, Inc., (DOR) announced that they, and their academic development partner, Thomas Jefferson University (Jefferson), Philadelphia, Pennsylvania, have entered into a Cooperative Research and...

Immune responses to self-antigen after DNA immunization reported.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Scientists compare the immune response to a self-antigen after DNA immunization of HLA*A201/H-2Kb and HHD transgenic mice in a recent issue of Vaccine. "HHD mice which express human HLA-A2 but no...

Mannosylated cationic liposomes enhance immune response of DNA vaccine.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Mannosylated cationic liposomes enhance the immune responses elicited by DNA vaccination. "The present study investigated the potency of the mannosylated cationic liposomes (Man liposomes) that we...

Antigen loading of dendritic cells with antigen reviewed.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Researchers review antigen loading of dendritic cells (DCs) with antigen in a recent issue of Cytotherapy. According to published research from Australia, "Understanding the biology of the...

Current issues in delivering dendritic cells for immunotherapy reviewed.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Researchers review current issues in delivering dendritic cells for immunotherapy in a recent issue of Cytotherapy. "Dendritic cell (DC)-based immunotherapy has shown early promise in clinical...

Dendritic cell immunotherapy reviewed.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Scientists review dendritic cell immunotherapy in a recent issue of Nature Medicine. "Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system, with the potential to...

Dendritic cells are attractive targets for vaccine design.
July 14, 2004... 2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Dendritic cells are attractive targets for vaccine design. According to published research from Australia, "The increasingly stringent requirements laid down by regulatory authorities have brought...