Vaccine Weekly articles from July 2003

Vaccine Weekly archives from July 2003

MnSOD expression after pancreatic cancer vaccination may be suppressive.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Animal and human experiments show promise for vaccination with manganese superoxide dismutase gene to suppress pancreatic cancer progression. "Cells contain a large number of antioxidants to prevent...

Interleukins-2 and -4, but not interferon-gamma, exhibit adjuvant activity.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Interleukin-2 and interleukin-4 act provide adjuvant activity for herpes simplex virus vaccines, in contrast to interferon-gamma, which does not...

Needle-free delivery of DNA vaccine increases immune responses.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Needle-free intradermal injection of plasmid DNA-coated nanoparticles enhanced humoral and cellular immune responses in mice, according to a report in...

Antitumor immunity induced by electrofusion of tumor and dendritic cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Specific antitumor immunity was induced in mice with the electrofusion product of tumor cells and dendritic cells. According to a study from the United States, "Dendritic cells (DCs) are potent...

Cytomegalovirus-specific T cells stimulated using modified dendritic cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Ex vivo stimulation of cytomegalovirus (CMV)-specific T cells was accomplished using CMV pp65-modified dendritic cells as stimulators. "Cytomegalovirus (CMV) infection is a dangerous complication...

Lipid core peptides provide novel self-adjuvanting vaccine delivery system.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Lipid core peptide technology shows promise as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens. "This study demonstrates the effectiveness of a...

Company presents preclinical results from AIDS vaccine program.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corporation (NASDAQ:TGEN) announced that it presented positive data in support of its AIDS vaccine program at the 6th Annual Meeting of the American Society of Gene Therapy in...

FDA clears IND for anthrax vaccine candidate.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc., (VXGN) announced that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for its candidate anthrax vaccine. The effective IND...

New investigational vaccine set to be tried in humans.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Researchers at Saint Louis University's Center for Vaccine Development and its clinical research organization, SoLUtions, are preparing to conduct a human study of a new investigational vaccine to...

Study will evaluate recombinant canarypox HIV-1 vaccine in IV drug users.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A Harvard School of Public Health researcher will be conducting a study to evaluate the efficacy of a recombinant canarypox HIV-1 vaccine in IV drug users. S. Dhalla announced the clinical trial at...

Biodefense R&D agreement signed with U.S. Army.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- BioSante Pharmaceuticals, Inc., (BISP) announced that it has signed a Cooperative Research and Development Agreement (CRADA) with the U.S. Army's Medical Research Institute of Infectious Diseases...

Apoptosis plus CD80 costimulation promote immune response by melanoma cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Apoptotic cell death in conjunction with CD80 costimulation conferred uveal melanoma cells with the ability to induce immune responses. "Uveal melanoma is a rare malignancy with a poor prognosis...

Systemic priming with mucosal boosting shows promise in animals.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Vaccine researchers in the United States say that a mixture of systemic and mucosal immunization may offer improved protection against HIV infection. ...

Guidelines for hepatitis A vaccination suggested.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Suggestions for the type of people who make the best candidates for hepatitis A vaccination have been published in a recent issue of the Journal of Viral Hepatitis. According to recent research from...

DNA immunization effective against MRSA.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A novel DNA vaccine may provide protection against methicillin-resistant Staphylococcus aureus (MRSA), researchers in Brazil report. MRSA is "a major pathogen responsible for serious hospital...

Company announces follow on finance to undertake vaccination initiative.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Adjuvantix Limited, a Sheffield, U.K., based vaccine adjuvant company, announced the completion of a further investment from the White Rose Technology Seedcorn Fund (WRTSF), bringing its total funding...

Epidemiologic data for 2002-03 flu season reported.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, reported that, overall, the 2002-03 U.S. influenza season was mild, though various regions of the country...

Influenza surveillance in Europe and its future reviewed.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A report on the evolution of influenza surveillance in Europe and prospects for the next 10 years has been published in the journal Vaccine. "This report traces the evolution of surveillance...

Novel generations of influenza vaccines reviewed.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A review of the new generations of influenza vaccines has been published in the journal Vaccine. According to recent research from the United States, "Several strategies are being pursued to...

Recommendations for influenza vaccine use in 50 countries released.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Pandemic influenza vaccine may be difficult to obtain in countries that use the vaccine but do not produce it. "Influenza vaccination is becoming an increasingly important aspect of public health...

Attenuation of Leishmania parasites accomplished.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Attenuation of Leishmania parasites was accomplished and attenuated lines were tested for efficacy in mice. According to a study from Scotland, "A method for attenuation of Leishmania species by...

Campaign targets more than 5 million children.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A measles vaccination and vitamin A campaign, targeting more than five million children aged between six months and 15 years, was launched in Ethiopia on June 6, 2003, by the United Nations Children's...

Eradication of measles in the Western Pacific Region close to reality.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Accelerated measles control in the Western Pacific Region has brought eradication of the disease in the area close to realization. According to a study from Philippines, "By the 1990s, an...

Measles antibodies interfere with immune response in revaccinated adults.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Measles-specific antibodies interfere with the humoral immune response in adults re-immunized with measles vaccine. According to published research from Mexico, "The objective of this study was to...

Measles eradicated in Haiti after outbreak in 2000.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Measles was eradicated in Haiti after an outbreak occurred in 2000. "On 8 March 2000 a case of laboratory-confirmed measles was detected in Haiti. Over the ensuing months, an explosive epidemic...

Smallpox vaccination recommended for those exposed to virus.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The U.S. Centers for Disease Control and Prevention (CDC) has issued interim guidance advising states that persons investigating monkeypox outbreaks and involved in caring for infected individuals or...

Initial clinical data reported from phase I/II trial of GVAX vaccine.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported initial clinical data from a phase I/II trial of GVAX cancer vaccine for multiple myeloma, a type of bone marrow cancer, as well as positive interim results on a...

Low efficacy of Rubini mumps vaccine strain leads to outbreak in Singapore.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Hemagglutinin-neuraminidase sequence and phylogenetic analyses were conducted on mumps virus isolates from a vaccinated population in Singapore. According to recent research published in the...

Eradication efforts should continue in southern Africa, report says.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Although wild poliovirus circulation appears to have been interrupted in the Southern part of Africa polio eradication activities should be sustained until global eradication is certified, officials...

RSV attachment glycoprotein mediates pulmonary eosinophilia.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediated pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. ...

J8-and diphtheria toxoid antibodies help protect against group A strep.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- J8-and diphtheria toxoid-specific antibodies contribute to protection against group A streptococcus. "A conformationally constrained, minimally conserved peptide from the M protein of group A...

Patent granted for herpes vaccine; peptide may be used as adjuvant for vaccines.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Cel-Sci Corp. (CVM) has been issued a new U.S. patent, no. 6,572,860, which further expands the proprietary protection for Cel-Sci's herpes simplex-based therapeutic and preventive vaccines. The...

Toxoplasma gondii tachyzoite antigens elicit immune response in mice.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Toxoplasma gondii tachyzoite antigens elicited protective immune responses in mice. According to a study from Iran, "excretory secretory antigens (ESA) of Toxoplasma gondii were evaluated in...

Adjuvant activity of monophosphoryl lipid A investigated.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The adjuvant activity of monophosphoryl lipid A was investigated by a team at the University of Alabama-Birmingham. "Monophosphoryl lipid A (MPL) is a nontoxic derivative of lipopolysaccharide...

Feasibility of edible vaccine development demonstrated.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Researchers have demonstrated the feasibility of edible vaccine development. According to recent research published in the journal Molecular Breeding, "Mannheimia haemolytica is the principal...

Human vaccine strain of lamb rotavirus (Chinese) NSP4 gene sequenced.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A human vaccine strain of lamb rotavirus (Chinese) NSP4 gene has been sequenced. According to recent research published in the journal Virus Genes, "A lamb strain of rotavirus has recently been...

Interleukins-2 and -4, but not interferon-gamma, exhibit adjuvant activity.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Cell wall components of Bacillus anthracis Sterne did not adversely affect the immune response generated by protective antigen, the main bacterial...

DNA vaccine prevents diabetic phenotype in Huntington disease murine model.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A DNA vaccine against the toxic intracellular proteins involved in Huntington disease prevented the development of diabetes in the HDR6/2 mouse model...

Dendritic cell vaccine elicits clinical responses in renal cancer patients.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A tumor RNA-transfected dendritic cell vaccine elicited clinical responses in renal cancer patients. According to recent research from the United States, "Autologous dendritic cells transfected...

DNA vaccine and microparticle boost produce potent anti-HIV immune response.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Broad and potent anti-human immunodeficiency virus immune responses were obtained in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide...

Adjuvants interleukin-12 and cholera toxin enhance immunity to HIV-1.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Interleukin-12 and cholera toxin subunit B act as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins. According to recent research published in...

Reverse vaccinology allows development of novel vaccines.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- The concept of reverse vaccinology is discussed in a recent issue of Drug Discovery Today. "Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology...

Intradermal injection enhances immunogenicity and suppresses tumorigenicity.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Intradermal injection, as opposed to subcutaneous injection, enhanced immunogenicity and suppressed tumorigenicity of tumor cells. "Tumor cell immunogenicity depends heavily upon the...

Lipid-protamine-DNA-mediated antigen delivery enhances immune responses.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Lipid-protamine-DNA-mediated antigen delivery to antigen-presenting cells resulted in enhanced antitumor immune responses. According to a study from the United States, "Vaccination with antigenic...

Gamma-inulin/liposomes/vitamin E adjuvant used in contraceptive vaccines.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A combination adjuvant composed of gamma-inulin, liposomes, and vitamin E promoted the formation of antibodies against sperm. "The adjuvanticity of two gamma inulin/liposomes/vitamin E combinations...

Nature Technology Corp. announces RapidVACC DNA vaccine technology.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Nature Technology Corp. (NTC) announced the launch of an improved technology for DNA vaccine delivery. Unlike traditional vaccines, DNA vaccines do not expose patients to pathogens, but rather...

Epitopes of Borna disease virus p10 protein identified.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein have been identified by cytotoxic T lymphocytes induced by DNA-based immunization. According...

Dengue virus NS1, NS2A, NS3, and NS5 mutant proteins restrict replication.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Temperature-sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restricted replication in the brains of mice. "Using reverse...

Meridian announces manufacturing agreement with Hawaii Biotech.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Meridian Bioscience, Inc., (VIVO) announced the signing of its second biopharmaceutical manufacturing agreement for the company's life-science production facility located at Viral Antigens, Inc.,...

Misdirected immune response causes more severe illness second time around.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- While some diseases leave the patient with immunity against future attacks, people with dengue fever get sicker the second time around. Scientists now believe they know why, and their finding may...

Immunodominant epitopes found in tat-vaccinated volunteers.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Immunodominant epitopes have been identified in inactivated tat-vaccinated healthy and HIV-1-infected volunteers. According to a study from Italy and France, "We analyzed the epitopes and the...

Status and emerging concepts of HPV vaccination reviewed.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- The status and emerging concepts of HPV vaccination have been reviewed in the journal Gynakologe. According to published research from Germany, "A recent editorial in the prestigious New England...

FDA approves first nasal mist flu vaccine.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Most people who avoid flu shots because they fear needles will not have that excuse this season. The U.S. Food and Drug Administration (FDA) has approved a flu vaccine that is delivered by a squirt...

Strong immunogenicity data reported from phase II trials of FluINsure.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- ID Biomedical announced that the analysis of immunogenicity data from its various phase II clinical trials of FluINsure intranasal, nonlive, influenza vaccine shows continuing strong immunogenicity...

Peptide-pulsed dendritic cells produce little clinical effect.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A therapeutic leukemia vaccine prototype based on peptide-pulsed dendritic cells (DCs) has little if any clinical effect, researchers in Japan say. ...

Modified merozoite surface protein immunogenic.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A modified plasmodial peptide could be the basis for a malaria vaccine. "The conserved, nonantigenic, nonimmunogenic malaria merozoite surface protein-2 peptide 1, having high affinity for red blood...

Belgium gives $2 million for vaccine campaign.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- The Belgian aid agency, Cooperation Belge, has donated US $2 million toward a measles vaccination campaign being run by the U.N. Children's Fund (UNICEF), in Equateur Province, Democratic Republic of...

Economic evaluation of measles vaccination options reviewed.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- An economic evaluation of options for measles vaccination strategies in a hypothetical Western European country has been published recently. "In this study, an analysis was made of economic costs...

Smallpox vaccine to prevent infection draws few.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Some people eligible for smallpox vaccinations offered by the state of Wisconsin declined to roll up their sleeves after learning of potential side effects, a state health official said. Herb...

Immunization policy in the U.K. moving from compliance to concordance.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Immunization policy in the U.K. may be moving from compliance to concordance, according to a report in the British Journal of General Practice. "Immunization has proved a highly effective public...

Lowering age for preventive vaccine could save lives, money, study says.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Vaccinating everyone 50 or older against a bug that can cause pneumonia, meningitis, or a blood infection would save lives and money, a new study suggests. Current guidelines call for vaccinating...

Phase III D9902B trial will serve as basis for Provenge approval.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Dendreon Corporation (DNDN) announced that the company has received a Special Protocol Assessment (SPA) from the U.S. Food and Drug Administration (FDA) indicating that its pivotal phase III trial,...

WHO urges investment in SARS vaccine.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- As severe acute respiratory syndrome (SARS) subsides, governments need to pour more money into finding a vaccine to prevent the virus from striking again in a mutated form, the World Health Organization...

Prevention and treatment of sexually transmitted diseases updated.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Guidelines for the prevention and treatment of sexually transmitted diseases have been updated. According to a study from the United States, "The Centers for Disease Control and Prevention (CDC)...

Ocular complications of smallpox and smallpox immunization outlined.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- The ocular complications of smallpox and smallpox immunization have been outlined in a recent issue of Archives of Ophthalmology. "Although smallpox was eradicated worldwide, concerns have been...

Bacille Calmette-Guerin vaccine may improve immunity against other infections.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The bacille Calmette-Guerin (BCG) tuberculosis vaccine may improve immunity against other infections as well, researchers say. Results from other studies...

Casein phosphopeptide enhances mucosal IgA response to Salmonella LPS.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A dietary casein phosphopeptide preparation stimulated the mucosal IgA response of mice to an orally ingested lipopolysaccharide from Salmonella typhimurium. "The effect on immunoglobulin production...

Peptide vaccine immunogenicity predicted by molecular dynamics simulation.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- The immunogenicity of peptide vaccine candidates could be predicted by molecular dynamics simulations. According to a study from the Netherlands, "We present an in silico, structure-based approach...

Panel warns against danger of smallpox vaccine.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A U.S. federal health advisory committee recommended that the Bush administration shouldn't follow through on plans to offer smallpox vaccinations to 10 million emergency workers because of previously...

Mucosal and systemic vaccination with vaccinia virus Ankara immunogenic.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Both mucosal and systemic vaccination with the Ankara strain of vaccinia virus (MVA) stimulated strong immune responses in mice. According to a study from Spain and Switzerland, "MVA is a candidate...

Young women generally positive about human papillomavirus vaccine.
July 9, 2003... 2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Young women in general possessed positive attitudes toward receiving the human papillomavirus vaccine. According to recent research from the United States, "Human papillomavirus (HPV) vaccines are...

Vaccine against carcinoembryonic antigen does not induce autoimmunity.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine directed against human carcinoembryonic antigen (CEA), which is naturally expressed by some tissues in adults and is overexpressed by some...

Efficacy results of the current generation of AIDS vaccines due this year.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Strategies for AIDS vaccines now undergoing clinical testing involve the optimization of antibody and cellular immune responses, according to a...

Contraceptive potential of plasmid pCMV4-rZPC' DNA vaccine evaluated.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- The contraceptive potential of a plasmid pCMV4-rZPC' DNA vaccine has been evaluated. "Zona pellucida C (ZPC) is a major glycoprotein of the zona pellucida that possesses the sperm receptor...

Cytokines stimulated by DNA vaccine against glutamic acid decarboxylase 65.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Regulatory cytokine production was stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in mice. According to a study from Canada, "Nonobese diabetic (NOD) mice...

Listeria HIV gag immunization induces antigen-specific T cell response.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Immunization with recombinant Listeria monocytogenes HIV gag induced HIV gag-specific CD8+ T cells in the spleen and gut-associated lymphoid tissue. According to recent research published in the...

H. pylori outer membrane antigens protective in guinea pigs.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori outer membrane antigens were protective in guinea pigs. According to recent research published in the journal FEMS Immunology and Medical Microbiology, "Mice and guinea Pigs...

Anti-A-beta antibodies reduce beta-amyloid deposition.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Intracranially administered anti-A-beta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. According to recent research...

R&D agreement initiated with U.S. Army for oral anthrax vaccine.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Emisphere Technologies, Inc., (EMIS) announced that it has signed a cooperative research and development agreement (CRADA) with the U.S. Army Medical Research Institute of Infectious Diseases...

Hot proteins may sharpen DNA tests; help bioprocessing.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Unique heat shock proteins that protect bacteria in undersea hot vents could be used to improve the sensitivity of polymerase chain reaction (PCR), the common technique used to amplify bits of DNA for...

Phase III Theratope vaccine trial does not meet primary endpoints.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM) (BRA) and Merck KGaA of Darmstadt, Germany, announced that the results from a large pivotal phase III trial of Theratope vaccine for women with metastatic breast cancer did not...

T-cell response against breast adenocarcinoma focused on single epitope.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous...

Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers. According to a study from the United States, "With the clinical use of purified,...

New CholeraGarde manufacturer announced.
July 16, 2003... 2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Avant Immunotherapeutics, Inc., (AVAN) announced the termination of its manufacturing contract with Bio Sidus, S.A., of Buenos Aires, Argentina, for the manufacture of its CholeraGarde vaccine. ...