Vaccine Weekly articles from July 1999

Vaccine Weekly archives from July 1999

New Tool ID's CD4(+) T-Cell Antigens.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A new, broadly applicable technique identifies antigens recognized by CD4(+) T cells. As these so-called T-helper cells are the basis of cell-mediated immunity, the technique promises to...

Attenuated HIV: Immune Damage After Prolonged Infection.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- If it were a vaccine, the risk would be unacceptably high. But the accidental infection of a group of blood recipients with a naturally attenuated strain of HIV shows that the virus is far less...

Globo H Safe in Phase I Prostate Cancer Trial.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A synthetic sugar molecule is a safe and immunogenic vaccine in prostate cancer patients, data from a Phase I trial show. The safety trial offered some evidence of efficacy, but also showed that...

Active Specific Immunotherapy Mediates Tumor Regression.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Active specific immunotherapy with an autologous tumor vaccine, combined with recombinant granulocyte macrophage-colony stimulating factor (GM-CSF), either with or without interferon alfa-2B (IFN...

Hepatitis Vaccine Guidelines Aren't Being Followed.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A report from North Carolina that shows that the government's recommended hepatitis vaccination policies are not being routinely followed for infants in that state may have implications across the...

Annual Vaccination Schedule is Efficacious.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A one-, 12-, and 24-month hepatitis B virus immunization schedule is highly effective in children who have a low risk of exposure. Hepatitis B vaccines are usually administered on a schedule of...

T-Cell Response May Control Viremia During Vaccine Therapy.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Induction of CD4(+) T-cell responses could be important in controlling viremia during vaccine therapy of chronic hepatitis B virus carriers, according to a study from France's Institut Pasteur. ...

Clinton Breaks Ground on AIDS Research Center.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- U.S. President Bill Clinton dedicated a research center devoted to developing a vaccine against HIV, but AIDS groups said the U.S. government was not spending enough on AIDS research. The Dale...

Group Seeks Volunteers for HIV Vaccine Testing.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Volunteers are being sought for a clinical trial of a genetically engineered vaccine aimed at stemming the spread of HIV. The U.S., three-year testing program, being conducted on 5,000 people at...

Marking System Gives Scientists Real View of Immune Memory Cells.(Statistical Data Included)
July 12, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A method of permanently marking T cells has allowed Emory University immunologists and colleagues in Atlanta, Georgia, to overcome one of the most challenging barriers to understanding just how the...

Active Specific Immunization with a hybrid Cell Vaccine is Effective in Patients with Advanced Renal Cell Carcinoma.(Statistical Data Included)
July 12, 1999... Cancer Immunotherapy "Active Specific Immunization with a hybrid Cell Vaccine is Effective in Patients with Advanced Renal Cell Carcinoma." Alexander Kugler, Gerd A. Muller, Florian Seseke, Manfred Kallerhoff, Rolf-Hermann Ringert, Peter...

Mature Dendritic Cells Induce T Helper Type 1-Dominant Immune Responses in Patients With Metastatic Renal Cell Carcinoma.(Statistical Data Included)
July 12, 1999... Cancer Immunotherapy "Mature Dendritic Cells Induce T Helper Type 1-Dominant Immune Responses in Patients With Metastatic Renal Cell Carcinoma." C. Rieser, R. Ramoner, L. Holtl, H. Rogatsch, C. Papesh, A. Stenzi, G. Barsch and M. Thurnher....

Epidemiology and Diagnosis of Pertussis.(Statistical Data Included)
July 12, 1999... Epidemiology (Pertussis) "Epidemiology and Diagnosis of Pertussis." B.D. Meade. Current affiliation unavailable. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1Z01BJ03010-06. PRINCIPLE INVESTIGATOR: B.D. Meade....

Response to HBV Vaccine in Cirrhotic Patients on Liver Transplant Waiting List.(Statistical Data Included)
July 12, 1999... HBV Vaccines "Response to HBV Vaccine in Cirrhotic Patients on Liver Transplant Waiting List." M. Dominguez, R. Barcena, A. Lopez-Sanroman, R. Fernandez-Braso, R. Nash, S. Del Campo, J. Urman, J. Nuflo and A. Candela. Gastroenterology,...

Impaired Antibody Response Following Vaccination With T-Cell Dependent Antigens in Patients With Type-1 Diabetes.(Statistical Data Included)
July 12, 1999... Immunology (Diabetes Patients) "Impaired Antibody Response Following Vaccination With T-Cell Dependent Antigens in Patients With Type-1 Diabetes." N.L. Eibl, H. Wolf, S. Hink, G. Schemthaner and M.M. Eibl. Department of Medicine 1,...

Immunologic Memory to Preerythrocytic P. falciparum.(Statistical Data Included)
July 12, 1999... Immunology (Malaria) "Immunologic Memory to Preerythrocytic P. falciparum." James W. Kazura. Case Western Reserve University, University Circle, Cleveland, Ohio 44106. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Cross-Subtype Neutralizing Antibodies Induced in Baboons by a Subtype E gp120 Immunogen Based on an R5 Primary Human Immunodeficiency Virus Type 1 Envelope.(Statistical Data Included)
July 12, 1999... HIV Vaccines Vancott, T.C.; Mascola, J.R.; Loomisprice, L.D.; Sinangil, F.; Zitomersky, N.; Mcneil, J.; Robb, M.L.; Birx, D.L.; Barnett, S. "Cross-Subtype Neutralizing Antibodies Induced in Baboons by a Subtype E gp120 Immunogen Based on...

Association Between Type 1 Diabetes and Haemophilus influenzae Type b Vaccination: Birth Cohort Study.(Statistical Data Included)
July 12, 1999... Haemophilus influenzae Karvonen, M.; Cepaitis, Z.; Tuomilehto, J. "Association Between Type 1 Diabetes and Haemophilus influenzae Type b Vaccination: Birth Cohort Study." British Medical Journal, May 1, 1999;318(7192):1169-1172. (CW...

Highly Attenuated Vaccine Strains of Simian Immunodeficiency Virus Protect Against Vaginal Challenge: Inverse Relationship of Degree of Protection With Level of Attenuation.(Statistical Data Included)
July 12, 1999... Mucosal Immunization Johnson, R.P.; Lifson, J.D.; Czajak, S.C.; Cole, K.S.; Manson, K.H.; Glickman, R.; Yang, J.; Montefiori, D.C.; Montelaro, R.; Wyand, M.S.; Desrosiers, R.C. "Highly Attenuated Vaccine Strains of Simian Immunodeficiency...

IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered With Protein Immunogens.(Statistical Data Included)
July 12, 1999... Mucosal Immunization Staats, H.F.; Ennis, F.A. "IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered With Protein Immunogens." Journal of Immunology, May 15, 1999;162(10):6141-6147. (CW HENDERSON...

Pertussis Vaccination and Wheezing Illnesses in Young Children: Prospective Cohort Study.(Statistical Data Included)
July 12, 1999... Pertussis Henderson, J.; North, K.; Griffiths, M.; Harvey, I.; Golding, J. "Pertussis Vaccination and Wheezing Illnesses in Young Children: Prospective Cohort Study." British Medical Journal, May 1, 1999;318(7192):1173-1176. (CW...

Influenza and Pneumococcal Vaccine Receipt in Older Persons With Chronic Disease - A Population-Based Study.(Statistical Data Included)
July 12, 1999... Pneumococcal/Influenza Vaccines Petersen, R.L.; Saag, K.; Wallace, R.B.; Doebbeling, B.N. "Influenza and Pneumococcal Vaccine Receipt in Older Persons With Chronic Disease - A Population-Based Study." Medical Care, May 1999;37(5):502-509....

Heterotypic Protection and Induction of a Broad Heterotypic Neutralization Response by Rotavirus-Like Particles.(Statistical Data Included)
July 12, 1999... Rotavirus Crawford, S.E.; Estes, M.K.; Ciarlet, M.; Barone, C.; Oneal, C.M.; Cohen, J.; Conner, M.E. "Heterotypic Protection and Induction of a Broad Heterotypic Neutralization Response by Rotavirus-Like Particles." Journal of Virology,...

Tolerance As Arthritis Therapy.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers are hoping to find a way to treat arthritis by inducing mucosal tolerance. Tolerance is the paradoxical phenomenon of reduced immune reactivity to an antigen by mucosal exposure to...

HIV Sails into Cells on Gb3 "Raft".(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The AIDS virus boards a lipid raft that keeps it afloat as it searches for a way into a cell, a French research team suggests. According to their hypothesis, the raft is made up of...

HPV Vaccine Enters Clinical Trial Stage.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Preliminary results from a clinical trial of a human papillomavirus (HPV) vaccine for the treatment of cervical cancer show the vaccine is well tolerated. Margaret Wojtowicz, representing...

Nasal Immunization Elicits Ab in Lung, Urogenital Tract.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Human volunteers developed IgA and IgG antibodies in the lung and urogenital tract after intranasal vaccination with cholera toxin B subunit (CTB). Intranasal immunization is considered the most...

Wars Threaten Polio Eradication Plan.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- War is disrupting the World Health Organization (WHO) plan to eradicate polio by the year 2000, according to a report by the WHO and the U.S. Centers for Disease Control and Prevention (CDC). ...

Rational Development of New TB Vaccine.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Targeted genetic manipulations permit the rational attenuation of Mycobacterium tuberculosis and may lead to new live tuberculosis vaccines. Pasteur Institute researchers Mary Jackson and...

HBV Vaccine Inactivity Assessed in Pregnant Women.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Obesity, maternal age, and smoking have a negative impact on hepatitis B virus vaccination efficacy in pregnant women. In this study, C.J. Ingardia and colleagues of Connecticut's Hartford...

Rational Attenuation May be Key to Better TB Vaccines.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Rational attenuation of Mycobacterium tuberculosis may lead to new candidate live vaccines against tuberculosis. Over the past few years much tuberculosis research has been aimed at the...

Liver Disease Patients Need Early Hepatitis A Vaccine.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Patients with chronic liver disease should receive hepatitis A vaccine as early as possible in the disease process, according to a report from Ohio's Cleveland Clinic Foundation. Researcher J.A....

Immunostimulatory DNA Sequences Exert Systemic Effects.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunostimulatory DNA sequences may have promise as vaccine adjuvants and potential therapeutic agents in prevention and treatment of leishmaniasis. Resistance to murine leishmaniasis correlates...

Booster Immunization Not Needed During Childhood.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Booster immunization within 10 years of infant vaccination against hepatitis B virus is unnecessary, even in those who are at high-risk for infection. A study from the University of Texas-Houston...

Parents Debate Whether Vaccine is Warranted.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- One woman hopes her eight-year-old son catches chickenpox from his five-year-old brother. "That way we won't have to deal with it anymore," the Pocatello, Idaho, mother said. The five-year-old...

Vaccine Progress Updated.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- HIV VAC, Inc., Toronto, Ontario, Canada, announced that Kevin Murray, HIVC, was interviewed by Wall Street Interview to update the progress of the company's AIDS vaccine, developed by Dr. Gordon...

Strep Vaccine To Be Tested in Humans.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A vaccine to prevent strep throat and rheumatic fever is scheduled to be tested for the first time in humans during Summer 1999. Researchers recently received clearance from the U.S. Food and...

Study Shows No Link Between MMR Vaccine and Autism.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A study finds no evidence that the controversial combined measles-mumps-rubella (MMR) vaccine, given to millions of children across the world, causes autism. Parents have been concerned about the...

Clinical Activity and Broken Immunologic Tolerance from ex vivo GM-CSF Gene Transduced Prostate Cancer Vaccines.(Statistical Data Included)
July 26, 1999... Cancer Vaccines "Clinical Activity and Broken Immunologic Tolerance from ex vivo GM-CSF Gene Transduced Prostate Cancer Vaccines." J.W. Simons, B. Mikhak, J.F. Chang, A. DeMarzo, M. Lim, M.A. Carducci, M. Goemann, F. Marshall, C. Weber, S....

MHC Class I Restricted Tumor Cell Lysis in Renal Cell Carcinoma.(Statistical Data Included)
July 26, 1999... Cancer Vaccines "MHC Class I Restricted Tumor Cell Lysis in Renal Cell Carcinoma." R. Oberneder, P. Jantzer, E. Noner, A. Hofstetter and D.J. Schendel. Munich, Germany. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

Polynucleotide Vaccines for Colon Cancer and Melanoma.(Statistical Data Included)
July 26, 1999... Cancer Vaccines "Polynucleotide Vaccines for Colon Cancer and Melanoma." Robert M. Conry. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 5R01CA68256-04. GRANT...

The Role of Heat Shock Proteins for Vaccination Models in Renal Cell Carcinoma.(Statistical Data Included)
July 26, 1999... Cancer Vaccines "The Role of Heat Shock Proteins for Vaccination Models in Renal Cell Carcinoma." J. Roigas, E.S. Wallen, S.A. Loening and P.L. Moseley. Berlin, Germany. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

Using Live, Recombinant Bakers Yeast as an HIV Vaccine.(Statistical Data Included)
July 26, 1999... HIV Vaccine "Using Live, Recombinant Bakers Yeast as an HIV Vaccine." Richard C. Duke. Ceres Pharmaceuticals, 1899 Gaylord Street, Denver, Colorado 80206. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1R43AI43143-01....

Molecular Basis of NALT-Induced Mucosal Immunity to SIV.(Statistical Data Included)
July 26, 1999... HIV Vaccines "Molecular Basis of NALT-Induced Mucosal Immunity to SIV." Jerry R. McGhee. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1R21RR13149-01A1. GRANT...

GM-CSF as a Systemic Adjuvant in a Phase II Prostate Cancer Vaccine Trial.(Statistical Data Included)
July 26, 1999... Cancer Vaccines Simmons, S.J.; Tjoa, B.A.; Rogers, M.; Elgamal, A.; Kenny, G.M.; Ragde, H.; Troychak, M.J.; Boynton, A.L.; Murphy, G.P. "GM-CSF as a Systemic Adjuvant in a Phase II Prostate Cancer Vaccine Trial." Prostate, June 1,...

Engineering of Noninfectious HIV-1-Like Particles Containing Mutant gp41 Glycoproteins as Vaccine Candidates That Allow Vaccinees to be Distinguished from HIV-1 Infectees.(Statistical Data Included)
July 26, 1999... HIV Vaccines Rovinski, B.; Dekaban, G.A.; Cao, S.X.; Yao, F.L.; Persson, R.; Matthews, T.J.; Klein, M.H. "Engineering of Noninfectious HIV-1-Like Particles Containing Mutant gp41 Glycoproteins as Vaccine Candidates That Allow Vaccinees to...

Treatment of Intracranial Gliomas With Bone Marrow-Derived Dendritic Cells Pulsed With Tumor Antigens.(Statistical Data Included)
July 26, 1999... Intracranial Gliomas Liau, L.M.; Black, K.L.; Prins, R.M.; Sykes, S.N.; Dipatre, P.L.; Cloughesy, T.F.; Becker, D.P.; Bronstein, J.M. "Treatment of Intracranial Gliomas With Bone Marrow-Derived Dendritic Cells Pulsed With Tumor Antigens."...

Immunogenicity, Genetic Stability, and Protective Efficacy of a Recombinant, Chimeric Yellow Fever-Japanese Encephalitis Virus (ChimeriVax-JE) as a Live, Attenuated Vaccine Candidate Against Japanese Encephalitis.(Statistical Data Included)
July 26, 1999... Japanese Encephalitis Guirakhoo, F.; Zhang, Z.X.; Chambers, T.J.; Delagrave, S.; Arroyo, J.; Barrett, A.D.T.; Monath, T.P. "Immunogenicity, Genetic Stability, and Protective Efficacy of a Recombinant, Chimeric Yellow Fever-Japanese...

A Novel System Based on a Poloxamer PLGA Blend as a Tetanus Toxoid Delivery Vehicle.(Statistical Data Included)
July 26, 1999... Microencapsulation Tobio, M.; Nolley, J.; Guo, Y.Y.; Mciver, J.; Alonso, M.J. "A Novel System Based on a Poloxamer PLGA Blend as a Tetanus Toxoid Delivery Vehicle." Pharmaceutical Research, May 1999;16(5):682-688. (CW HENDERSON...

Helminth- and Bacillus Calmette-Guerin-Induced Immunity in Children Sensitized in utero to Filariasis and Schistosomiasis.(Statistical Data Included)
July 26, 1999... Pediatrics Malhotra, I.; Mungai, P.; Wamachi, A.; Kioko, J.; Ouma, J.H.; Kazura, J.W.; King, C.L. "Helminth- and Bacillus Calmette-Guerin-Induced Immunity in Children Sensitized in utero to Filariasis and Schistosomiasis." Journal of...

Human Calicivirus-Associated Sporadic Gastroenteritis in Finnish Children Less Than Two Years of Age Followed Prospectively During a Rotavirus Vaccine Trial.(Statistical Data Included)
July 26, 1999... Rotavirus Pang, X.L.; Joensuu, J.; Vesikari, T. "Human Calicivirus-Associated Sporadic Gastroenteritis in Finnish Children Less Than Two Years of Age Followed Prospectively During a Rotavirus Vaccine Trial." Pediatric Infectious Disease...

Human T-Cell Recognition of the Mycobacterium leprae LSR Antigen: Epitopes and HLA Restriction.(Statistical Data Included)
July 26, 1999... Vaccine Development Oftung, F.; Lundin, K.E.A.; Meloen, R.; Mustafa, A.S. "Human T-Cell Recognition of the Mycobacterium leprae LSR Antigen: Epitopes and HLA Restriction." Fems Immunology and Medical Microbiology, June 1999;24(2):151-159....

NIAID Launches Major Step in Trial of Experimental Shingles Vaccine.(Statistical Data Included)
July 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- On June 17, 1999, researchers at NIAID launched an important next step in a study of an experimental vaccine to prevent shingles (also known as herpes zoster, or just "zoster"). In the Phase III...