Vaccine Weekly articles from July 1998

Vaccine Weekly archives from July 1998

NIH Advised To Hand Over AIDS Vaccine Leadership.
July 13, 1998... The National Institutes of Health fails to grasp the urgency of developing an AIDS vaccine, a leading AIDS researcher asserts. Only an empirical approach and decisive leadership can produce an effective HIV vaccine, argued Mary Lou...

CDC Shows Allergic Reactions Linked to Vaccine Gelatin.
July 13, 1998... The U.S. Centers for Disease Control and Prevention (CDC) has confirmed a suspected link between gelatin-containing vaccines and allergic reactions. Isolated case reports suggested a link between gelatin, used to stabilize some vaccines, and...

Thymus Transplants May Aid AIDS Kids.
July 13, 1998... Children with rapidly progressive HIV disease may benefit from thymus transplants. The thymus is an important immune organ in children, who need the organ to generate CD4(+) T cells. Early attempts to provide thymus transplants to HIV(+)...

Unsafe Sex Common In Republic of Georgia Teens.
July 13, 1998... The Republic of Georgia is ripe for the spread of AIDS. A survey of high-school students reveals an alarming frequency of unsafe sex, misconceptions about HIV and AIDS, and the kind of blame-the-victim attitudes that have preceded AIDS...

Vaginal Immunization Protects against High-Dose Wild-Type Virus Challenge.
July 13, 1998... Vaginal immunization may be more effective than parenteral immunization against herpes simplex virus type 2 (HSV-2). Previously, the vaginal immunization of adult mice with attenuated HSV-2 induced strong immunity against vaginal challenge...

Therapeutic Monoclonal Antibody Approved for Respiratory Syncytial Virus Disease.
July 13, 1998... The U.S. Food and Drug Administration (FDA) has approved a monoclonal antibody to protect high-risk infants against the worst effects of respiratory syncytial virus (RSV) disease, the most common cause of lower respiratory infections in children....

Human Trials of Two-Step Vaccine Planned for 1999.
July 13, 1998... A malaria vaccine effective in mice is planned for clinical trials in humans next year. The vaccine is delivered in two stages, explained Paul Redfern, correspondent for The Nation newspaper ("Vaccine Against Malaria Developed," The Nation,...

Measles-Mumps-Rubella Immunization Rates Drop in U.K.
July 13, 1998... A recent assessment of the effect of recent publicity about measles-mumps-rubella (MMR) immunization revealed a substantial drop in the uptake of vaccination in Wales. In a Research Letter in the June 27, 1998, issue of the Lancet, Dr. D.Rh....

Increased Immune Response at Vaginal Mucosa Does Not Inhibit HSV Infection.
July 13, 1998... A herpes simplex virus (HSV) recombinant vaccine administered to mice was unable to prevent infection at the vaginal mucosal surface, although it did boost immune response. "Despite the induction of both [immunoglobulin A] IgA and IgG vaginal...

Japanese Patent Received Covering Core Technology for Vaccines.
July 13, 1998... Jenner Biotherapies Inc., San Ramon, California, announced it has been issued a Japan patent which covers vectors, compounds and methods for expression of a human adenocarcinoma antigen known as KSA (GA733-2). Jenner is using this core...

Australian Patent Received Covering Cancer Vaccine.
July 13, 1998... Jenner Biotherapies, Inc., San Ramon, California, announced that it has been issued an Australian patent entitled, "Prostatic Cancer Vaccine." The patent covers the use of PSA, PSMA, and PAP, inclusive of derivatives, peptides, anti-idiotypic...

Phase II Trial with HGP-30W AIDS Vaccine Begins.
July 13, 1998... Cel-Sci Corp., Vienna, Virginia, announced that the Institute for Clinical Pharmacology, Pharma BioResearch, The Netherlands, began inoculating the first volunteers with the HGP-30W AIDS vaccine in the only ongoing European Phase II AIDS vaccine...

Study Said Elderly Should Get Pneumonia Vaccine.
July 13, 1998... It is easy, inexpensive and can save lives, but a vaccine that prevents pneumonia is rarely given to the elderly, according to a report in the June 25, 1998, issue of the New England Journal of Medicine (NEJM). Researchers reported that an...

Chronology of Development and Spread of HIV/AIDS.
July 13, 1998... Nearly 12 million people have died since the AIDS epidemic began two decades ago. Although the illness is on the decline in the developed world, it is spreading rapidly in developing countries. Following are some of the key events in the...

AIDS Drug Makers Seek Simpler Regimes in Geneva.
July 13, 1998... Two years ago in Vancouver, British Columbia, the 11th World AIDS Conference was electrified by evidence of a breakthrough in treatment that seemed to herald the end of the illness as a death sentence. Since then thousands of lives have been...

Protection against Mycobacterium ulcerans Infection of C57BL/6 Mice by Tuberculosis DNA Vaccination.
July 13, 1998... "Protection against Mycobacterium ulcerans Infection of C57BL/6 Mice by Tuberculosis DNA Vaccination." A. Tanghe, A. Van Aerde, F. Jurion, K. Palfliet, J. Content, F. Portsels and K. Huygen. Pasteur Institute of Brussels, Belgium; Institute of...

Tuberculin Reactivity in a Group of Filipino Children With or Without BCG Vaccination Exposed to AFB Smear Positive TB Families - A Case Control Study.
July 13, 1998... "Tuberculin Reactivity in a Group of Filipino Children With or Without BCG Vaccination Exposed to AFB Smear Positive TB Families - A Case Control Study." L.Y. Lao, A.M. Arreza and C.J. Carbon. Quezon City, Philippines. According to an abstract...

Therapeutic Uses of Immunization.
July 13, 1998... "Therapeutic Uses of Immunization." M.G. Peters. Washington University School of Medicine, St. Louis, Missouri. According to an abstract submitted by the author to the American Liver Foundation, Hepatitis B Transplant Symposium, held June...

Mapping of T Cell Epitopes in Recombinant PFR Proteins of Trypanosoma cruzi.
July 13, 1998... "Mapping of T Cell Epitopes in Recombinant PFR Proteins of Trypanosoma cruzi." J.E. Manning, K. Luhrs and R.A. Wrightsman. Department of Molecular Biology and Biochemistry University of California at Irvine, Irvine, California. According to an...

Development and Characterization of a Cytokine-Secreting Pancreatic Adenocarcinoma Vaccine From Primary Tumors for Use in Clinical Trials.
July 13, 1998... Jaffee, E.M.; Schutte, M.; Gossett, J.; Morsberger, L.A.; Adler, A.J.; Thomas, M.; Greten, T.F.; Hruban, R.H.; Yeo, C.J.; Griffin, C.A. "Development and Characterization of a Cytokine-Secreting Pancreatic Adenocarcinoma Vaccine From Primary...

Evaluation of the Protective Efficacy of a Recombinant Dengue Envelope B Domain Fusion Protein Against Dengue 2 Virus Infection in Mice.
July 13, 1998... Evaluation of the Protective Efficacy of a Recombinant Dengue Envelope B Domain Fusion Protein Against Dengue 2 Virus Infection in Mice." American Journal of Tropical Medicine and Hygiene, May 1998;58(5):655-662. According to the authors'...

Economisation of Vaccination Against Haemophilus influenzae Type b: A Randomised Trial of Immunoaffinity of Fractional-Dose and Two-Dose Regimens.
July 13, 1998... Lagos, R.; Valenzuela, M.T.; Levine, O.S.; Losonsky, G.A.; Erazo, A.; Wasserman, S.S.; Levine, M.M. "Economisation of Vaccination Against Haemophilus influenzae Type b: A Randomised Trial of Immunoaffinity of Fractional-Dose and Two-Dose...

Influenza Immunization: Improving Compliance of Healthcare Workers.
July 13, 1998... "Influenza Immunization: Improving Compliance of Healthcare Workers." Infection Control and Hospital Epidemiology, May 1998;19(5):337-342. According to the authors' abstract of an article published in Infection Control and Hospital...

Shedding of Rotavirus After Administration of the Tetravalent Rhesus Rotavirus Vaccine.
July 13, 1998... Ward, R.L.; Dinsmore, A.M.; Goldberg, G.; Sander, D.S.; Rappaport, R.S.; Zito, E.T. "Shedding of Rotavirus After Administration of the Tetravalent Rhesus Rotavirus Vaccine." Pediatric Infectious Disease Journal, May 1998;17(5):386-390....

Report of the Council on Scientific Affairs, American Medical Association: Immunization of Healthcare Workers With Varicella Vaccine.
July 13, 1998... "Report of the Council on Scientific Affairs, American Medical Association: Immunization of Healthcare Workers With Varicella Vaccine." Infection Control and Hospital Epidemiology, May 1998;19(5):348-353. According to the authors' abstract of...

Conference Coverage (1st Annual Vaccine Research) NIH Advised To Hand Over AIDS Vaccine Leadership
July 13, 1998... The National Institutes of Health fails to grasp the urgency of developing an AIDS vaccine, a leading AIDS researcher asserts. Only an empirical approach and decisive leadership can produce an effective HIV vaccine, argued Mary Lou...

Conference Coverage CDC Shows Allergic Reactions Linked to Vaccine Gelatin
July 13, 1998... The U.S. Centers for Disease Control and Prevention (CDC) has confirmed a suspected link between gelatin-containing vaccines and allergic reactions. Isolated case reports suggested a link between gelatin, used to stabilize some vaccines, and...

Conference Coverage (12th World AIDS) Thymus Transplants May Aid AIDS Kids
July 13, 1998... Children with rapidly progressive HIV disease may benefit from thymus transplants. The thymus is an important immune organ in children, who need the organ to generate CD4(+) T cells. Early attempts to provide thymus transplants to HIV(+)...

Conference Coverage (12th World AIDS) Unsafe Sex Common In Republic of Georgia Teens
July 13, 1998... The Republic of Georgia is ripe for the spread of AIDS. A survey of high-school students reveals an alarming frequency of unsafe sex, misconceptions about HIV and AIDS, and the kind of blame-the-victim attitudes that have preceded AIDS...

HSV-2 Vaginal Immunization Protects against High-Dose Wild-Type Virus Challenge
July 13, 1998... Vaginal immunization may be more effective than parenteral immunization against herpes simplex virus type 2 (HSV-2). Previously, the vaginal immunization of adult mice with attenuated HSV-2 induced strong immunity against vaginal challenge...

Industry News (RSV) Therapeutic Monoclonal Antibody Approved for Respiratory Syncytial Virus Disease
July 13, 1998... The U.S. Food and Drug Administration (FDA) has approved a monoclonal antibody to protect high-risk infants against the worst effects of respiratory syncytial virus (RSV) disease, the most common cause of lower respiratory infections in children....

Malaria (Vaccine) Human Trials of Two-Step Vaccine Planned for 1999
July 13, 1998... A malaria vaccine effective in mice is planned for clinical trials in humans next year. The vaccine is delivered in two stages, explained Paul Redfern, correspondent for The Nation newspaper ("Vaccine Against Malaria Developed," The Nation,...

Pediatrics (Vaccines) Measles-Mumps-Rubella Immunization Rates Drop in U.K.
July 13, 1998... A recent assessment of the effect of recent publicity about measles-mumps-rubella (MMR) immunization revealed a substantial drop in the uptake of vaccination in Wales. In a Research Letter in the June 27, 1998, issue of the Lancet, Dr. D.Rh....

Vaccine Development (HSV) Increased Immune Response at Vaginal Mucosa Does Not Inhibit HSV Infection
July 13, 1998... A herpes simplex virus (HSV) recombinant vaccine administered to mice was unable to prevent infection at the vaginal mucosal surface, although it did boost immune response. "Despite the induction of both [immunoglobulin A] IgA and IgG vaginal...

Cancer Vaccines Japanese Patent Received Covering Core Technology for Vaccines
July 13, 1998... Jenner Biotherapies Inc., San Ramon, California, announced it has been issued a Japan patent which covers vectors, compounds and methods for expression of a human adenocarcinoma antigen known as KSA (GA733-2). Jenner is using this core...

Cancer Vaccines (Prostate Cancer) Australian Patent Received Covering Cancer Vaccine
July 13, 1998... Jenner Biotherapies, Inc., San Ramon, California, announced that it has been issued an Australian patent entitled, "Prostatic Cancer Vaccine." The patent covers the use of PSA, PSMA, and PAP, inclusive of derivatives, peptides, anti-idiotypic...

HIV Vaccines Phase II Trial with HGP-30W AIDS Vaccine Begins
July 13, 1998... Cel-Sci Corp., Vienna, Virginia, announced that the Institute for Clinical Pharmacology, Pharma BioResearch, The Netherlands, began inoculating the first volunteers with the HGP-30W AIDS vaccine in the only ongoing European Phase II AIDS vaccine...

Immunizations Study Said Elderly Should Get Pneumonia Vaccine
July 13, 1998... It is easy, inexpensive and can save lives, but a vaccine that prevents pneumonia is rarely given to the elderly, according to a report in the June 25, 1998, issue of the New England Journal of Medicine (NEJM). Researchers reported that an...

Pathogenesis Chronology of Development and Spread of HIV/AIDS
July 13, 1998... Nearly 12 million people have died since the AIDS epidemic began two decades ago. Although the illness is on the decline in the developed world, it is spreading rapidly in developing countries. Following are some of the key events in the...

Protease Inhibitors AIDS Drug Makers Seek Simpler Regimes in Geneva
July 13, 1998... Two years ago in Vancouver, British Columbia, the 11th World AIDS Conference was electrified by evidence of a breakthrough in treatment that seemed to herald the end of the illness as a death sentence. Since then thousands of lives have been...

Conference News . . . July 13 & 20, 1998 Information About Research Worldwide . . . Compiled by Michelle Marble
July 13, 1998... DNA Vaccines "Protection against Mycobacterium ulcerans Infection of C57BL/6 Mice by Tuberculosis DNA Vaccination." A. Tanghe, A. Van Aerde, F. Jurion, K. Palfliet, J. Content, F. Portsels and K. Huygen. Pasteur Institute of Brussels, Belgium;...

TB Exposure "Tuberculin Reactivity in a Group of Filipino Children With or Without BCG Vaccination Exposed to AFB Smear Positive TB Families - A Case Control Study."
July 13, 1998... L.Y. Lao, A.M. Arreza and C.J. Carbon. Quezon City, Philippines. According to an abstract submitted by the authors to the American Thoracic Society, 1998 International Conference, held April 25-29, 1998, in Chicago, Illinois, "PPD skin testing...

Vaccination (Transplantation) "Therapeutic Uses of Immunization." M.G. Peters. Washington University School of Medicine, St. Louis, Missouri.
July 13, 1998... According to an abstract submitted by the author to the American Liver Foundation, Hepatitis B Transplant Symposium, held June 12-14, 1998, "Universal immunization of all neonates is now standard of care in the United States and many other...

Vaccine Development (T. cruzi) "Mapping of T Cell Epitopes in Recombinant PFR Proteins of Trypanosoma cruzi."
July 13, 1998... J.E. Manning, K. Luhrs and R.A. Wrightsman. Department of Molecular Biology and Biochemistry University of California at Irvine, Irvine, California. According to an abstract submitted by the authors to the 2nd Congress of Molecular Medicine,...

Journal News . . . July 13 & 20, 1998 Reviews and Information From Periodicals and Journals Worldwide . . . Compiled by Alan D. Henderson
July 13, 1998... Cancer Vaccines Jaffee, E.M.; Schutte, M.; Gossett, J.; Morsberger, L.A.; Adler, A.J.; Thomas, M.; Greten, T.F.; Hruban, R.H.; Yeo, C.J.; Griffin, C.A. "Development and Characterization of a Cytokine-Secreting Pancreatic Adenocarcinoma Vaccine...

Dengue Virus Simmons, M.; Nelson, W.M.; Wu, S.J.L.; Hayes, C.G.
July 13, 1998... "Evaluation of the Protective Efficacy of a Recombinant Dengue Envelope B Domain Fusion Protein Against Dengue 2 Virus Infection in Mice." American Journal of Tropical Medicine and Hygiene, May 1998;58(5):655-662. According to the authors'...

Haemophilus influenzae Lagos, R.; Valenzuela, M.T.; Levine, O.S.; Losonsky, G.A.; Erazo, A.; Wasserman, S.S.; Levine, M.M.
July 13, 1998... "Economisation of Vaccination Against Haemophilus influenzae Type b: A Randomised Trial of Immunoaffinity of Fractional-Dose and Two-Dose Regimens." Lancet, May 16, 1998;351(9114):1472-1476. According to the authors' abstract of an article...

Influenza Harbarth, S.; Siegrist, C.A.; Schira, J.C.; Wunderli, W.; Pittet, D. "Influenza Immunization:
July 13, 1998... Improving Compliance of Healthcare Workers." Infection Control and Hospital Epidemiology, May 1998;19(5):337-342. According to the authors' abstract of an article published in Infection Control and Hospital Epidemiology, "OBJECTIVE: In spite...

Rotavirus Ward, R.L.; Dinsmore, A.M.; Goldberg, G.; Sander, D.S.; Rappaport, R.S.; Zito, E.T.
July 13, 1998... "Shedding of Rotavirus After Administration of the Tetravalent Rhesus Rotavirus Vaccine." Pediatric Infectious Disease Journal, May 1998;17(5):386-390. According to the authors' abstract of an article published in Pediatric Infectious Disease...

Varicella-Zoster Virus Lyznicki, J.M.; Bezman, R.J.; Genel, M.
July 13, 1998... "Report of the Council on Scientific Affairs, American Medical Association: Immunization of Healthcare Workers With Varicella Vaccine." Infection Control and Hospital Epidemiology, May 1998;19(5):348-353. According to the authors' abstract of...

Vaccination Might Improve HAART.
July 27, 1998... The only thing missing is the main thing. People with HIV disease who receive highly active antiretroviral therapy (HAART) regain immune function: except for immunity to the AIDS virus. "Successful HAART does not seem to induce a recovery of...

HIV Exposed Health-Care Workers Won't Take AIDS Drugs.
July 27, 1998... Most health-care workers would rather risk HIV infection than take commonly-prescribed antiretroviral drugs. A U.S. Centers for Disease Control and Prevention (CDC) study shows that most health-care workers accidentally exposed to HIV don't...

SF Health Department Defends Controversial Plan.
July 27, 1998... They say it's a counseling plan, not a drug plan. San Francisco health authorities say they will forge ahead with a controversial study that provides antiretroviral drugs to people who think they may have been exposed to HIV. The trial...

Adoptive Immunotherapy Slowed Some Tumor Growth.
July 27, 1998... A new treatment that activates a person's immune system appears to lead to remission in some patients with a common form of aggressive brain cancer, according to a Cleveland Clinic, Cleveland, Ohio, study published in the July 1998 issue of the...

Intranasal Vaccine Protects Against HSV-1 Eye Infection in Mice.
July 27, 1998... Mice treated with an intranasal herpes simplex virus type 1 (HSV-1) vaccine demonstrated mucosal immunity and protection from eye disease upon viral challenge, researchers from the United Kingdom reported. A vaccine composed of HSV-1...

New Vaccines Could Cut Childhood Mortality Dramatically.
July 27, 1998... New vaccines already in use and in the pipeline for the Americas could have a huge impact in reducing childhood deaths, said the top vaccine expert at the Pan American Health Organization (PAHO). In a presentation to PAHO's Executive Committee...

Nasal Route Better Than Muscular Route for HIV-1 DNA Vaccine.
July 27, 1998... The route of immunization may be critical in the effectiveness of a DNA vaccination against HIV-1. A Japanese study suggests that the intranasal route of vaccine administration may offer superior efficacy in such a vaccine ("Induction of...

University To Participate In Human Trial for AIDS Vaccine.
July 27, 1998... Saint Louis University, Saint Louis, Missouri, will participate in the nation's first large-scale human trial of an AIDS vaccine. University researchers got the go-ahead on June 30, 1998. The study will involve about 200 people, said Robert...

HIV Still Eludes Even Most Potent Drugs.
July 27, 1998... Leading AIDS experts held out hope for a vaccine within a decade and warned that even the most potent triple drug combinations are not eliminating HIV in infected patients. Drug cocktails including the latest protease inhibitors can reduce HIV...

NCI Funds Ovarian Cancer Trial with Avax Immunotherapy.
July 27, 1998... Avax Technologies, Inc., Kansas City, Missouri, announced that the Gynecologic Oncology Group (GOG), funded by the U.S. National Cancer Institute (NCI), has voted to conduct a Phase I/II clinical study of the O-Vax vaccine in Stage 3 ovarian...

Product License Application Submission for FluMist Announced.
July 27, 1998... Aviron, Mountain View, California, announced the company has submitted its first Product License Application/Establishment License Application (PLA/ELA) to the U.S. Food and Drug Administration (FDA) for FluMist. FluMist is an intranasal...

Evaluation of Gene Expression and Gold Bead Distribution in Guinea Pigs Vaccinated with an Ebola Glycoprotein Naked DNA/Gene Gun Vaccine.
July 27, 1998... "Evaluation of Gene Expression and Gold Bead Distribution in Guinea Pigs Vaccinated with an Ebola Glycoprotein Naked DNA/Gene Gun Vaccine." L. Vanderzanden, D. Custer, C. Schmaljohn and K. Steele. U.S. Army Medical Research Institute of...

The Efficiency of B7-1 Modified Breast Cancer Vaccines is Impaired by Prostaglandin E[2] and Other Immunosuppressive Factors Produced by Tumor Cells.
July 27, 1998... "The Efficiency of B7-1 Modified Breast Cancer Vaccines is Impaired by Prostaglandin E[2] and Other Immunosuppressive Factors Produced by Tumor Cells." H.K.E. Boxhorn, R. Gutzmer, J.G. Smith, D. Guerry IV and S.L. Eck. Department of Medicine,...

Persistent Measles Virus (MV) Infection and Immunodeficiency in Children with Autism, Ileo-Colonic Lymphonodular Hyperplasia and Non-Specific Colitis.
July 27, 1998... "Persistent Measles Virus (MV) Infection and Immunodeficiency in Children with Autism, Ileo-Colonic Lymphonodular Hyperplasia and Non-Specific Colitis." A.J. Wakefield, A. Anthony, S. Schepelmann, H. Kawashima, R. Sim, K. Khan, S.H. Murch, A.P....

Antigenic Differences between Circulating Influenza A Viruses and Vaccine Strains in Argentina.
July 27, 1998... "Antigenic Differences between Circulating Influenza A Viruses and Vaccine Strains in Argentina." V. Savy, E. Baumeister and A. Pontoriero. INEI-ANLIS 'Carlos G. Malbran', Buenos Aires, Argentina. According to an abstract submitted by the...

Transfection of Interleukin-12 cDNAs Into Tumor Cells Induces Cytotoxic Immune Responses Against Native Tumor: Implications for Tumor Vaccination.
July 27, 1998... Hoshino, T.; Jiang, Y.Z.; Dunn, D.; Paul, D.; Qazilbash, M.; Cowan, K.; Wang, J.X.; Barrett, J.; Liu, J. "Transfection of Interleukin-12 cDNAs Into Tumor Cells Induces Cytotoxic Immune Responses Against Native Tumor: Implications for Tumor...

Rectal and Intranasal Immunizations With Recombinant Urease Induce Distinct Local and Serum Immune Responses in Mice and Protect Against Helicobacter pylori Infection.
July 27, 1998... Kleanthous, H.; Myers, G.A.; Georgakopoulos, K.M.; Tibbitts, T.J.; Ingrassia, J.W.; Gray, H.L.; Ding, R.; Zhang, Z.Z.; Lei, W.D.; Nichols, R.; Lee, C.K.; Ermak, T.H.; Monath, T.P. "Rectal and Intranasal Immunizations With Recombinant Urease...

Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria.
July 27, 1998... Ockenhouse, C.F.; Sun, P.F.; Lanar, D.E.; Wellde, B.T.; Hall, B.T.; Kester, K.; Stoute, J.A.; Magill, A.; Krzych, U.; Farley, L.; Wirtz, R.A.; Sadoff, J.C.; Kaslow, D.C.; Kumar, S.; Church, L.W.P.; Crutcher, J.M.; Wizel, B.; Hoffman, S.; et al....

Age-Dependent Neisseria meningitidis Serogroup C Class-Specific Antibody Concentrations and Bactericidal Titers in Sera From Young Children From Montana Immunized With a Licensed Polysaccharide Vaccine.
July 27, 1998... Maslanka, S.E.; Tappero, J.W.; Plikaytis, B.D.; Brumberg, R.S.; Dykes, J.K.; Gheesling, L.L.; Donaldson, K.B.J.; Schuchat, A.; Pullman, J.; Jones, M.; Bushmaker, J.; Carlone, G.M. "Age-Dependent Neisseria meningitidis Serogroup C Class-Specific...

Streptococcus pneumoniae Type 14 Polysaccharide-Conjugate Vaccines: Length Stabilization of Opsonophagocytic Conformational Polysaccharide Epitopes.
July 27, 1998... Laferriere, C.A.; Sood, R.K.; Demuys, J.M.; Michon, F.; Jennings, H.J. "Streptococcus pneumoniae Type 14 Polysaccharide-Conjugate Vaccines: Length Stabilization of Opsonophagocytic Conformational Polysaccharide Epitopes." Infection and Immunity,...

Isotypes and Opsonophagocytosis of Pneumococcus Type 6B Antibodies Elicited in Infants and Adults by an Experimental Pneumococcus Type 6B-Tetanus Toxoid Vaccine.
July 27, 1998... Vidarsson, G.; Sigurdardottir, S.T.; Gudnason, T.; Kjartansson, S.; Kristinsson, K.G.; Ingolfsdottir, G.; Jonsson, S.; Valdimarsson, H.; Schiffman, G.; Schneerson, R.; Jonsdottir, I. "Isotypes and Opsonophagocytosis of Pneumococcus Type 6B...

Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis.
July 27, 1998... Baldwin, S.L.; Dsouza, C.; Roberts, A.D.; Kelly, B.P.; Frank, A.A.; Lui, M.A.; Ulmer, J.B.; Huygen, K.; Mcmurray, D.M.; Orme, I.M. "Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis." Infection and Immunity, June...

Analysis of the Persistence of Humoral and Cellular Immunity in Children and Adults Immunized With Varicella Vaccine.
July 27, 1998... "Analysis of the Persistence of Humoral and Cellular Immunity in Children and Adults Immunized With Varicella Vaccine." Journal of Infectious Diseases, June 1998;177(6):1701-1704. According to the authors' abstract of an article published in...

Vaccination Might Improve HAART
July 27, 1998... The only thing missing is the main thing. People with HIV disease who receive highly active antiretroviral therapy (HAART) regain immune function: except for immunity to the AIDS virus. "Successful HAART does not seem to induce a recovery of...

HIV Exposed Health-Care Workers Won't Take AIDS Drugs
July 27, 1998... Most health-care workers would rather risk HIV infection than take commonly-prescribed antiretroviral drugs. A U.S. Centers for Disease Control and Prevention (CDC) study shows that most health-care workers accidentally exposed to HIV don't...

SF Health Department Defends Controversial Plan
July 27, 1998... They say it's a counseling plan, not a drug plan. San Francisco health authorities say they will forge ahead with a controversial study that provides antiretroviral drugs to people who think they may have been exposed to HIV. The trial...

Brain Cancer (Treatment) Adoptive Immunotherapy Slowed Some Tumor Growth
July 27, 1998... A new treatment that activates a person's immune system appears to lead to remission in some patients with a common form of aggressive brain cancer, according to a Cleveland Clinic, Cleveland, Ohio, study published in the July 1998 issue of the...

Herpes Vaccines (HSV-1) Intranasal Vaccine Protects Against HSV-1 Eye Infection in Mice
July 27, 1998... Mice treated with an intranasal herpes simplex virus type 1 (HSV-1) vaccine demonstrated mucosal immunity and protection from eye disease upon viral challenge, researchers from the United Kingdom reported. A vaccine composed of HSV-1...

Pediatrics New Vaccines Could Cut Childhood Mortality Dramatically
July 27, 1998... New vaccines already in use and in the pipeline for the Americas could have a huge impact in reducing childhood deaths, said the top vaccine expert at the Pan American Health Organization (PAHO). In a presentation to PAHO's Executive Committee...

Vaccine Development Nasal Route Better Than Muscular Route for HIV-1 DNA Vaccine
July 27, 1998... The route of immunization may be critical in the effectiveness of a DNA vaccination against HIV-1. A Japanese study suggests that the intranasal route of vaccine administration may offer superior efficacy in such a vaccine ("Induction of...

Clinical Trials University To Participate In Human Trial for AIDS Vaccine
July 27, 1998... Saint Louis University, Saint Louis, Missouri, will participate in the nation's first large-scale human trial of an AIDS vaccine. University researchers got the go-ahead on June 30, 1998. The study will involve about 200 people, said Robert...

Drug Resistance HIV Still Eludes Even Most Potent Drugs
July 27, 1998... Leading AIDS experts held out hope for a vaccine within a decade and warned that even the most potent triple drug combinations are not eliminating HIV in infected patients. Drug cocktails including the latest protease inhibitors can reduce HIV...

Funding NCI Funds Ovarian Cancer Trial with Avax Immunotherapy
July 27, 1998... Avax Technologies, Inc., Kansas City, Missouri, announced that the Gynecologic Oncology Group (GOG), funded by the U.S. National Cancer Institute (NCI), has voted to conduct a Phase I/II clinical study of the O-Vax vaccine in Stage 3 ovarian...

Influenza Vaccines Product License Application Submission for FluMist Announced
July 27, 1998... Aviron, Mountain View, California, announced the company has submitted its first Product License Application/Establishment License Application (PLA/ELA) to the U.S. Food and Drug Administration (FDA) for FluMist. FluMist is an intranasal...