Vaccine Weekly articles from January 2003

Vaccine Weekly archives from January 2003

Heat shock protein complex successfully treats subset of malignant melanoma patients.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A small but significant percentage of patients with malignant melanoma experienced complete remission or stabilization of the disease after...

Multiantigenic carbohydrate vaccines stimulate strong humoral response in mice.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Cancer vaccines containing multiple tumor-associated antigens elicited immune responses on several fronts in mice, according to a report in the...

G17DT safe in phase II clinical trials and increases survival of pancreatic cancer patients.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Phase II clinical trial results indicate that a vaccine containing the compound, G17DT, which causes the production of anti-gastrin antibodies,...

Vaccinia melanoma cell lysates do not extend survival of melanoma patients.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Phase II clinical trial results indicated that treatment of malignant melanoma with a vaccine containing vaccinia melanoma cell lysates (VMCL) did not...

Adenovirus encapsulation curbs immune response problems of gene therapy.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Enclosing adenovirus-based recombinant gene therapies in alginate microspheres could be one way to eliminate undesirable immune response, according to a study...

Large trial underway in Brazil to test efficacy of BCG revaccination in preventing TB.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A large randomized, controlled clinical trial, the Brazilian BCG-REVAC trial, has been designed to test whether revaccination with bacillus Calmette...

Trivalent influenza vaccine safe in young children.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The trivalent, cold-adapted influenza vaccine (CAIV-T) was safe in children from 15 months to 6 years old, causing only mild transient symptoms with...

Nasal administration of CTB-insulin induces active tolerance in murine model.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Nasal administration of beta cell-derived auto-antigens has been reported to suppress the development of autoimmune diabetes. We investigated the tolerogenic effects of insulin conjugated to the B...

Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype studied.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "B-cell lymphomas express tumor-specific immunoglobulin, the variable regions of which idiotype (Id) can serve as a target for active immunotherapy....

Intratumoral injection of dendritic and irradiated glioma cells studied.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Malignant astrocytoma is the most common primary brain tumor in adults. The median survival of patients with malignant astrocytomas (high-grade astrocytomas) is about 1-2 years, despite aggressive...

Antibody deficiency isn't common causal factor after 40.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- According to a study from Scotland, "Bronchiectasis is a common complication of primary antibody deficiency but the incidence of antibody deficiency as an underlying cause of bronchiectasis is largely...

New approach helps identify peptide-based immunotherapeutics.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Researchers in Germany are trying "to identify as many candidates as possible for tumor-associated T-cell epitopes in individual patients." According to T. Weinschenk and colleagues, University of...

Mercury in vaccines is at safe levels.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- The first detailed analysis of blood mercury levels in infants who received vaccines containing the preservative thimerosal indicates that blood levels of mercury in children are comfortably below...

Intranasal immunization with sperm-specific antigen has vaccine potential.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that an intranasal vaccine they developed elicited immunoglobulin A (IgA) and IgG antibodies in the sera and vaginal secretions of mice. "The common mucosal immune system...

Infection by closely related HIV strains possible.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- A report of an individual infected with a second strain of HIV despite effective drug treatment following the first infection has researchers concerned. "For the first time, we've shown it is...

Mamu-A*01 allele has protective effect in animals.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have identified a genetic factor that protects primates against AIDS. Zhi-Qiang Zhang and colleagues working at Merck...

HPV vaccine offers hope.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "News of a vaccine that can combat the type of human papillomavirus (HPV) that causes most cervical cancer is very hopeful, but also points out how prevalent and dangerous this sexually transmitted...

Mathematical models assess impact of prophylactic vaccine.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- The ongoing development of a vaccine against human papillomavirus (HPV) raises important questions about the impact of various vaccination strategies," University of Washington biostatisticians say. ...

Tumor model established in HLA-A*0201 transgenic mice to test vaccines.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully...

OHSU researchers make key immune system discover.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- A key discovery about the immune system's skill in fighting off harmful disease-causing germs may lead to the ability to boost the immune systems of the elderly and otherwise susceptible, and offer more...

FluINsure vaccine challenge trial started.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- ID Biomedical announced that it has begun a human influenza challenge trial of its intranasally delivered FluINsure vaccine. The clinical trial site began intranasal immunization of study subjects...

Retro-inverso peptide technology used to develop vaccine against influenza.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - An intranasal vaccine developed with an retro-inverso analogue of the influenza virus hemagglutinin B-cell epitope protected mice against serious...

Adjuvant immunotherapy using vaccinia viral lysates found ineffective.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Phase III study results show immunotherapy with vaccinia viral lysates doesn't benefit patients with high-risk melanoma. The "prospective, randomized, multicenter trial [aimed] to determine whether...

Antibiotic-resistant Streptococcus pneumoniae emerges in Vietnam.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "Surveillance for Streptococcus pneumoniae resistant to penicillin and other antimicrobial agents is necessary to define the optimal empirical antibiotic therapy for meningitis in resource-poor...

Mycobacterium tuberculosis H37Rv transposon library created.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Researchers at pharmaceutical giant GlaxoSmithKline have created a library of Mycobacterium tuberculosis insertional mutants generated with the transposon Tn5370." "The junction sequence between...

New vaccine approach described in animal models.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "The capsular polysaccharide of Neisseria meningitidis group B is an autoantigen, whereas noncapsular antigens are highly variable. These factors present formidable challenges for development of a...

Genitope initiates clinical trial to evaluate GTOP-99 following use of Rituxan.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Genitope Corp. announced the initiation of a clinical trial to evaluate the use of GTOP-99, a personalized vaccine-like immunotherapy, following treatment with Rituxan (rituximab) for patients...

Personalized vaccine for NHL being tested at New York Weill Cornell.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- New York Weill Cornell Medical Center of Presbyterian-Presbyterian Hospital is currently seeking patients for a nationwide, multicenter clinical research trial to explore the benefits of a vaccine to...

Adenovirus-mediated transfer of viral IL-10 gene has potential to treat uveitis.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Gene therapy to promote systemic and local expression of viral interleukin 10 could have potential against uveitis, researchers say. "Pathological ocular manifestations result from a dysregulation...

Antigastrin immunogen induces immune response in phase II study.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Patients participating in a phase II clinical trial of the antigastrin immunogen G17DT as treatment for advanced pancreatic cancer were able to mount what researchers said was an "adequate antibody...

$2.1M clinical consulting contracts announced.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- Covalent Group, Inc., (CVGR) announced the signing of $2.1 million of clinical consulting contracts with several leading pharmaceutical companies. These contracts cover a wide range of therapeutic...

C5a peptidase enhances clearance of group B Strep from lungs of infected mice.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Group B streptococci (GBS) are among the most common causes of life-threatening neonatal infections. Vaccine development since the late 1970s has focused...

Antitumor reactivity of peptide-induced CTLs important for epitope selection.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "The development of immunotherapy for cancer, such as synthetic peptide-based vaccines, relies heavily on the identification of appropriate epitopes capable of eliciting antitumor T-cell responses,"...

Intranasal dLOS-CRM vaccine against Moraxella catarrhalis studied.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- U.S. National Institutes of Health researchers investigated the effect of intranasal immunization with a detoxified-lipooligosaccharide-cross-reactive mutant of diphtheria toxin (dLOS-CRM) vaccine...

ER workers ready for vaccine.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- In a town known for high-stakes gambling, Suzanne Lau is ready to risk a small chance of injury and even death to be vaccinated against smallpox. A nurse at one of the city's busiest emergency rooms,...

Healthcare workers union eyes vaccination protections.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- The nation's largest union representing health care workers has announced that various protections are needed for nurses and others set to receive smallpox vaccinations three decades after the United...

Protective abilities of live avirulent strains of M. tb complex vary widely.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- According to researchers in New Zealand, "A better tuberculosis vaccine is urgently required to control the continuing epidemic. Molecular techniques are now available to produce a better live vaccine...

Adjuvant protects against bacterial exotoxin and influenza virus infection.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- "A novel nontoxic form of chimeric mucosal adjuvant that combines the A subunit of mutant cholera toxin E112K with the pentameric B subunit of heat-labile enterotoxin from enterotoxigenic Escherichia...

TETRAMUNE/PnCV combination is safe, immunogenic.
January 1, 2003... 2003 JAN 1 - (NewsRx.com & NewsRx.net) -- A recent study reports that the combination of a 9-valent pneumococcal polysaccharide/protein conjugate vaccine and TETRAMUNE - the diphtheria, tetanus toxoid, cell pertussis and Haemophilus influenzae...

DNA vaccine elicits humoral and cellular immune responses in lymphoma patients.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing DNA encoding tumor immunoglobulin from patients with follicular B-cell lymphoma was shown to be safe and immunogenic in phase...

Intranasal vaccine delays onset of autoimmune diabetes in mice.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The development of autoimmune diabetes was delayed in mice immunized with insulin conjugated to the B subunit of cholera toxin (CTB) in comparison to...

Pancreatic cancer research should focus on antigen presentation, targeted drug delivery.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The most promising avenues of research into T cell targeting immunotherapy for pancreatic cancer are dendritic cell vaccines, methods of enhancing...

Modified rabies virus vectors safe, effective.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Novel rabies virus (RV)-based vaccines can safely protect animals against HIV infection, researchers in the United States report. RV-based vectors "show...

Bacterial meningitis vaccine elicits protective antibody production.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A novel vaccine against Neisseria meningitidis elicits a protective humoral response in human infants, researchers in the United States report. Kenneth T....

Pancreatic cancer research should focus on antigen presentation, targeted drug delivery.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Mistletoe lectins were adjuvants as powerful as the cholera toxin when administered with herpes simplex virus glycoprotein D2 (gD2) nasotracheally,...

Complete DNA sequences of Oka varicella vaccine and its parental virus compared.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Osaka University microbiologists have compared the DNA sequences of the Oka varicella vaccine virus (V-Oka) and its parental virus (P-Oka). They found "42 base substitutions, which led to 20 amino...

No link found between MMR vaccine and autism.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A large Danish study detected no increase in the risk of developing autism in children who received the measles-mumps-rubella (MMR) vaccine, according...

Chiron extends collaboration to explore delivery of HIV vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Genetronics, Inc., (GEB) has extended a collaborative agreement with Chiron Corp. (CHIR) to conduct additional experiments using electroporation, Genetronics' proprietary technology, to test an HIV DNA...

Antibiotics combined with antigen-based vaccine protects guinea pigs against anthrax.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Almost all of the guinea pigs treated with a regimen of antibiotics and a protective-antigen vaccine survived a challenge with a lethal dose of...

In vitro diagnostic test developer completes agreement with American distributor.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- MedMira, Inc., (MIR) announced that it has reached a strategic investment agreement with its American distributor, American Health Diagnostics, LLC, (AHD). This agreement contemplates the issuance...

Positive results announced from phase II testing of FluINsure vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- ID Biomedical announced positive results on its two phase II clinical trials of FluINsure, the company's intranasally delivered influenza vaccine. Results of these ongoing, randomized, double-blind,...

Vaccine generates strong immune response in women with advanced disease.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Dendreon Corp. (DNDN) has announced that results of a phase I study indicate that APC8024, the company's investigational therapeutic vaccine for breast, ovarian and colon cancer appears to be safe and...

Recombinant E. coli vaccine promotes MHC class I-dependent antigen presentation.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Cancer researchers in England "have examined the potential of recombinant Escherichia coli expressing listeriolysin 0 (LL0) to deliver tumor antigens to dendritic cells (DCs) for cancer immunotherapy."...

IND application filed for lung and colorectal cancer vaccine candidate.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that it has filed an investigational new drug application, or IND, with the United States Food and Drug Administration (FDA), for a multiepitope vaccine for the...

Tumor cell lysate-pulsed DC effective for T-cell lymphoma immunotherapy.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemical adjuvant (QS-21) induces a protective, Id-specific...

Study: Two vaccines work best.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- A chickenpox outbreak at a day care center two years ago found vaccinations surprisingly ineffective and may suggest that children should get two shots instead of one, researchers say. Dr. Karin...

Cultural Olympiad to donate $7 million to vaccinate 1.4 million children.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Greece's Cultural Olympiad, which is organizing cultural events leading up to the 2004 Olympic Games, will donate U.S. $7 million to UNICEF to vaccinate 1.4 million children around the world, a Greek...

Self-adjuvanting peptide vaccines mediate antibody responses.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Immunologists at the University of Melbourne, Australia, have synthesized "various lipopeptides based on the sequence of luteinizing hormone-releasing hormone (LHRH)... and [reported] on their...

Oligonucleotide-based topical immunotherapy against HSV-2 has promise.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Vaccinologists at the University of Texas say immunostimulatory sequence-containing oligonucleotides may have application as treatment for genital herpes. "Synthetic oligonucleotides containing CpG...

No more medical roulette: Publisher says internet will change in 2003.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- NewsRx is celebrating its twentieth year as a publisher by adding 20 new weeklies. The company's CEO is predicting major changes in the publishing industry and Internet in 2003. The Atlanta-based...

Soybeans could offer edible alternative to injected vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - For years, scientists have strived to develop vaccines that could be eaten in vegetables. One of the latest studies indicates soybeans could some day be...

Vaccine manufacturer announces plans to meet U.S. demand for flu vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Aventis Pasteur has announced the company is committed to meeting U.S. demand for Fluzone influenza virus vaccine following Wyeth's recent announcement to discontinue production of its influenza...

Cryptococcus neoformans protein triggers murine anticandidal activity.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Italy and the United States have identified a novel method for inducing anticandidal immune activity. "We previously demonstrated that...

Production ends on FluShield, Pnu-Imune vaccines.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Wyeth (WYE) announced that it is ceasing production of two of its vaccine products - FluShield, an injectable influenza virus vaccine and Pnu-Imune, an injectable polysaccharide pneumococcal vaccine for...

PRIMABioMed announces DCtag antigen collaboration with Institute Pasteur.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- PRIMABioMed, Ltd., the cancer and immunotherapy research and therapeutic development company, announced that its Panvax, Ltd., subsidiary has entered into a research collaboration with the Paris-based...

Plasmodium yoelii merozoite antigen protects mice against parasitemia.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing a recombinant form of the surface protein of the merozoite stage of the malaria parasite protected mice against malaria...

Trial evaluates dosing and scheduling of adjuvant administered with personalized immunotherapy.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Genitope Corp. has announced promising results of a phase II clinical trial to evaluate dosage and scheduling of an adjuvant which is administered with the company's personalized vaccine-like...

Centegra Health System participates in smallpox vaccination program.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Selected healthcare personnel at Centegra Health System will receive smallpox vaccinations as part of the Illinois Department of Public Health's smallpox vaccination program. The first phase of the...

Macaque model used to assess safety of nonreplicating candidate RSV vaccines.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- A study in macaques showed that "formalin-inactivated respiratory syncytial virus (RSV) [induced] interleukin-13-associated hypersensitivity to subsequent RSV infection." R.L. Deswart and...

Pharma company to build vaccine research center on its Laval, Canada site.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Shire Pharmaceuticals Group, plc, (SHPGY) announced that it will invest approximately US$18.5 million in the construction of a new global vaccine research center in Canada. This center will support...

Analysis: U.S. vulnerable to smallpox's return.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- It was one of history's greatest triumphs: eliminating a disease that killed hundreds of millions of people and was feared across the globe. Yet in a new world of terrorist threats, smallpox is...

Bush to offer Americans vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- After agonizing for months, President Bush has decided to make a risky but effective smallpox vaccine available to all Americans, beginning with the military and health workers who would be front-line...

Colorado readies plan to vaccinate health workers.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Colorado hasn't seen a case of smallpox since 1949, but 53 years later, the state is preparing a plan to vaccinate hundreds of health care workers who could vaccinate the public in the event of a...

MedMira enters collaboration for smallpox vaccine antibody detection test.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- MedMira, Inc., (MIR) announced that it has reached a collaboration venture with a Canadian biopharmaceutical company, Cangene Corp. (CNJ), which will facilitate MedMira in reaching the global market for...

New Jersey health officials hold first public test of tracking system.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Public health officials from around New Jersey participated in the state's first public field trial of an innovative vaccination tracking system at the Hunterdon County Administration Building in...

Poll: More in U.S. want vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Two in three Americans are willing to be vaccinated against smallpox, despite the risk of serious side effects, a poll released December 11, 2002 has found. The survey also found an increasing...

Report: New York City to order 15,000 doses of vaccine.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- New York City is requesting 15,000 doses of vaccine for health and emergency workers in the event of a smallpox outbreak, health officials said. The vaccine would be distributed to those in the city...

Vaccine test subjects suffer side effects.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- A week after she was given an experimental dose of smallpox vaccine, Elizabeth Forrester's arm became swollen, her head throbbed and she felt tired and feverish. "At one point I was like 'cut it...

Systemic administration of IL-15 augments T cell-directed vaccine responses.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- A study by researchers in the U.S. shows for the first time that interleukin-15 (IL-15) is capable of augmenting the primary CD8+ T-cell response to vaccination. "The systemic administration of...

Mechanisms of CD8+ T-cell memory persistence studied in lung airways.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Researchers at Trudeau Institute Inc., New York, have studied "the mechanisms underlying the persistence of memory CD8+ T cells in the lung airway lumina following recovery from a respiratory virus...

Production and characterization of clinical grade exosomes described.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Anosys Inc., California, scientists have described "methods for the production, purification, and characterization of clinical grade (cGMP) exosomes derived from antigen presenting cells (APCs)." ...

Transmissible gastroenteritis coronavirus genome-derived vector developed.
January 8, 2003... 2003 JAN 8 - (NewsRx.com & NewsRx.net) -- Researchers in Spain report that "[r]eplication-competent propagation-deficient virus vectors based on the transmissible gastroenteritis coronavirus (TGEV) genome that are deficient in the essential E...

Enterotoxin and recombinant H. pylori urease safe in humans.(Brief Article)
January 15, 2003... 2003 JAN 15 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Healthy adults who received E. coli heat labile enterotoxin (LT) and a recombinant form of Helicobacter pylori urease experienced only mild side...

Neisseria meningitidis vesicles generate highly bactericidal antibodies.(Brief Article)
January 15, 2003... 2003 JAN 15 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Antisera from mice and guinea pigs vaccinated with vesicles from strains of Neisseria meningitidis protected infant rats against meningococcal group...