Vaccine Weekly articles from February 1999

Vaccine Weekly archives from February 1999

Tobacco Twist: Plants Grow Cancer Cure.
February 1, 1999... In an ironic twist, tobacco plants may be used to grow therapeutic cancer vaccines. By engineering a tobacco virus, researchers at Biosource Technologies Inc. and Stanford University have found a way to cause tobacco plants to quickly...

More Bad News For Live Attenuated HIV Vaccine.
February 1, 1999... The bad news continues for proponents of live attenuated HIV vaccines. A steady decline in his CD4 T-cell count has forced a U.S. man naturally infected with nef-deleted HIV - the same deletion used in a prototype AIDS vaccine - to begin...

CDC Changes Recommended Childhood Immunization Schedule.
February 1, 1999... New childhood vaccination guidelines narrow options for polio vaccines, add rotavirus vaccines, and clarify hepatitis B vaccine recommendations. The guidelines are the latest version of recommendations for U.S. health-care practitioners...

Measles Epidemics Provide Vaccine Boost.
February 1, 1999... Measles provide natural boosting of vaccinated children, a study in West Africa demonstrates. The findings have important implications for the worldwide campaign to eradicate measles, suggested Hilton C. Whittle of MRC Laboratories,...

Vaccination Best Way to Prevent HBV in IVDUs.
February 1, 1999... Vaccination against hepatitis B is the best way to prevent the virus among intravenous drug users, according to a report from the United Kingdom. Researcher K.H. Lamden and colleagues sought to identify the risk factors for hepatitis B...

Gene Discovery through EST.
February 1, 1999... Gene discovery through expressed sequence tag sequencing may be a cost-efficient way to eradicate Chagas disease, researchers suggest. The analysis of expressed sequence tags (ESTs) establishes a useful approach for gene identification....

BCG Only Moderately Effective in Indian Children.
February 1, 1999... Bacillus Calmette-Guerin vaccination is only moderately effective in preventing childhood tuberculosis in Central India. A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in...

Study in Mice Suggests Approach for Vaccine.
February 1, 1999... University of Montana (UM) researchers have developed a vaccine that attacks HIV at a vulnerable moment of the virus' infection cycle, and may someday lead to a human vaccine that could help stop the spread of HIV. A report on the study...

Epitope-Based Vaccine Promising for HIV Treatment and Prevention.
February 1, 1999... Epimmune Inc. announced presentations by its scientists and collaborators of initial data suggesting that epitope-based vaccines hold promise for the control of HIV infection. Data from two HIV related model studies were presented at the...

Researchers Say Second Vaccine Worth Sore Arms.
February 1, 1999... Sore arms, redness, and other reactions to a second pneumonia vaccine are harmless and should not prevent the elderly and other susceptible groups from getting revaccinated after five years, according to a study. Researchers said some...

"Comparing the Structure, Expression and Immunogenicity of two Groups of Chimeric P. falciparum DNA Vaccine.".
February 1, 1999... J. Yanfang, L. Chengtao, Y. Bin, H. Xiangyun, X. Pei, L. Baofeng and W. Heng. Peking Union Medical College, Department of Etiology, Beijing. According to an abstract submitted by the authors to the 4th International Meeting of Tropical...

"Studies on the DNA Vaccine (pCD-Sj32) and Its Efficacy of Protective Immunity.".
February 1, 1999... Y.E. Shi, L.P. Xie, C.M. Li and J.J. Han. Department of Parasitology, Tongji Medical University, Wuhan, China; Department of Immunology, University of Alabama, Birmingham, Alabama. According to an abstract submitted by the authors to the...

"Hepatitis A Enhanced Surveillance in British Columbia, 1996.".
February 1, 1999... S. Yeung, A. King and M. Fyfe. British Columbia. According to an abstract submitted by the authors to the 3rd Canadian National Immunization Conference entitled Partnerships for Health Through Immunization, held December 6-9, 1998, in...

"Cost and Efficacy Comparisons of Hepatitis B Vaccination Within and Outside the School Environment.".
February 1, 1999... M. Guay, M. Blackburn, G. Baron, A.M. Clouatre, P. De Wals, C. Roy, J. Desrochers and F. Milord. Quebec, Canada. According to an abstract submitted by the authors to the 3rd Canadian National Immunization Conference entitled Partnerships...

"Vaccine Development Against Malaria Tropica: Analysis of MSP-1 of P. falciparum - A New Approach.".
February 1, 1999... W. Pan, R. Tolle, E. Ravot, I. Turbachova, S. Herrera, G. Sutter, D. Soldati and H. Bujard. Second Military Medical University, Shanghai, China; Universidad del Valle, Cali, Colcmbia; Institut fur Molekularvirologie, Oberschleibheim, Germany....

"Sulfolipo-cyclodextrin in Squalane-in-water as a Novel and Safe Vaccine Adjuvant." Vaccine, January 21, 1999;17(3):219-228.
February 1, 1999... Hilgers, L.A.T.; Lejeune, G.; Nicolas, I.; Fochesato, M.; Boon, B. According to the authors' abstract of an article published in Vaccine, "Previously, we described synergistic adjuvanticity of combinations of synthetic...

"IgG2a Induced by Interleukin (IL) 12-producing Tumor Cell Vaccines But not IgG1 Induced by IL-4 Vaccine is Associated With the Eradication of Experimental Metastases." Cancer Research, December 15, 1998;58(24):5812-5817.
February 1, 1999... Rodolfo, M.; Melani, C.; Zilocchi, C.; Cappetti, B.; Luison, E.; Arioli, I.; Parenza, M.; Canevari, S.; Colombo, M.P. According to the authors' abstract of an article published in Cancer Research, "We evaluated whether antibody response...

"Modulating the Immune Response to Genetic Immunization." Faseb Journal, December 1998;12(15):1611-1626.
February 1, 1999... Cohen, A.D.; Boyer, J.D.; Weiner, D.B. According to the authors' abstract of an article published in Faseb Journal, "Genetic immunization, also known as DNA or polynucleotide immunization, is a novel strategy for vaccine development in...

"Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-infected Seroconverters in India, With Evidence of Intersubtype Recombination." Journal of Virology, January 1999;73(1):152-160.
February 1, 1999... Lole, K.S.; Bollinger, R.C.; Paranjape, R.S.; Gadkari, D.; Kulkarni, S.S.; Novak, N.G.; Ingersoll, R.; Sheppard, H.W.; Ray, S.C. According to the authors' abstract of an article published in Journal of Virology, "The development of an...

"Microparticles and Polymers for the Mucosal Delivery of Vaccines." Advanced Drug Delivery Reviews, December 1, 1998;34(2-3):305-320.
February 1, 1999... Ohagan, D.T. According to the author's abstract of an article published in Advanced Drug Delivery Reviews, "Because microparticles are taken up across the gastrointestinal tract following oral administration, they may be exploited for the...

Mucosal Immunisation With Papillomavirus Virus-like Particles Elicits Systemic and Mucosal Immunity in Mice.
February 1, 1999... Liu, X.S.; Abduljabbar, I.; Qi, Y.M.; Frazer, I.H.; Zhou, J. According to the authors' abstract of an article published in Virology, "It has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus can induce...

In vivo Immune Responses to Idiotypic VH Complementarity-determining Region 3 Peptide Vaccination in B-cell Non-Hodgkin's Lymphoma.
February 1, 1999... Wen, Y.J.; Lim, S.H. According to the authors' abstract of an article published in British Journal of Haematology, "Idiotypic IgM expressed by B-cell non-Hodgkin's lymphoma (NHL) is clone specific and an ideal tumour antigen for immune...

The Preparation and Characterization of Polymeric Antigen Delivery Systems for Oral Administration.
February 1, 1999... Singh, M.; Ohagan, D. According to the authors' abstract of an article published in Advanced Drug Delivery Reviews, "Although polymeric delivery systems are well established for the oral administration of conventional drugs, they have not...

Infusion of Dendritic Cells Pulsed with HLA-A2-specific Prostate-specific Membrane Antigen Peptides: A Phase II Prostate Cancer Vaccine Trial Involving Patients With Hormone-refractory Metastatic Disease.
February 1, 1999... Murphy, G.P.; Tjoa, B.A.; Simmons, S.J.; Jarisch, J.; Bowes, V.A.; Ragde, H.; Rogers, M.; Elgamal, A.; Kenny, G.M.; Cobb, O.E.; Ireton, R.C.; Troychak, M.J.; Salgaller, M.L.; Boynton, A.L. According to the authors' abstract of an article...

Synthetic and Immunological Studies on Clustered Modes of Mucin-related Tn and TF O-linked Antigens: The Preparation of a Glycopeptide-based Vaccine for Clinical Trials Against Prostate Cancer..
February 1, 1999... Kuduk, S.D.; Schwarz, J.B.; Chen, X.T.; Glunz, P.W.; Sames, D.; Ragupathi, G.; Livingston, P.O.; Danishefsky, S.J. According to the authors' abstract of an article published in Journal of the American Chemical Society, "The syntheses of two...

Limited Breadth of the Protective Immunity Elicited by Simian Immunodeficiency Virus SIVmne gp160 Vaccines in a Combination Immunization Regimen.
February 1, 1999... Polacino, P.; Stallard, V.; Klaniecki, J.E.; Montefiori, D.C.; Langlois, A.J.; Richardson, B.A.; Overbaugh, J.; Morton, W.R.; Benveniste, R.E.; Hu, S.L. According to the authors' abstract of an article published in Journal of Virology, "We...

Improved Efficacy of Dendritic Cell Vaccines and Successful Immunization With Tumor Antigen Peptide-pulsed Peripheral Blood Mononuclear Cells by Coadministration of Recombinant Murine Interleukin-12.(International Journal of Cancer, January 18, 1999;80(2):324-333)
February 1, 1999... Fallarino, F.; Uyttenhove, C.; Boon, T.; Gajewski, T.F. According to the authors' abstract of an article published in International Journal of Cancer, "The well-characterized P815 tumor model was used to optimize anti-tumor immunization...

Priming of CD8(+) CTL Effector Cells in Mice by Immunization With a Stress Protein Influenza Virus Nucleoprotein Fusion Molecule.
February 1, 1999... Anthony, L.S.D.; Wu, H.C.; Sweet, H.; Turnnir, C.; Boux, L.J.; Mizzen, L.A. According to the authors' abstract of an article published in Vaccine, "Literature is accumulating which suggests the potential for stress proteins to form the...

Homing Potentials of Circulating Antibody-Secreting Cells After Administration of Oral or Parenteral Protein or Polysaccharide Vaccine in Humans.
February 1, 1999... Kantele, A.; Westerholm, M.; Kantele, J.M.; Makela, P.H.; Savilahti, E. According to the authors' abstract of an article published in Vaccine, "The site of antigen encounter influences the Ig-distribution and homing potentials of...

Influence of Maternal Antibodies on Vaccine Responses: Inhibition of Antibody But Not T-cell Responses Allows Successful Early Prime-Boost Strategies in Mice.
February 1, 1999... Siegrist, C.A.; Barrios, C.; Martinez, X.; Brandt, C.; Berney, M.; Cordova, M.; Kovarik, J.; Lambert, P.H. According to the authors' abstract of an article published in European Journal of Immunology, "The transfer of maternal antibodies...

The Guillain-Barre Syndrome and the 1993 and 1993-1994 Influenza Vaccines.
February 1, 1999... Lasky, T.; Terracciano, G.J.; Magder, L.; Koski, C.L.; Ballesteros, M.; Nash, D.; Clark, S.; Haber, P.; Stolley, P.D.; Schonberger, L.B.; Chen, R.T. According to the authors' abstract of an article published in New England Journal of...

Single-Strain Vaccines Could Do More Harm than Good.
February 8, 1999... Single-strain vaccines - such as some currently being tested for HIV - could increase the risk of disease, a new infection-dynamics model suggests. A study of the transmission dynamics of dengue virus populations shows that epidemics of...

AIDS Immunology--Correlate of HIV Immunity Found.
February 8, 1999... What it is remains unknown, but it seems to protect against HIV infection. Jay A. Levy and colleagues at the University of California, San Francisco, have shown that a soluble factor produced by the CD8(+) T cells can inhibit HIV infection...

Conference Coverage (Retrovirus)--Seronegative HIV Infection: Good News or Bad?
February 8, 1999... Some people with HIV infection remain negative on HIV antibody tests, a two-year study proves. T. Zhu and colleagues at the University of Washington have found HIV lurking in the resting T cells of some people who remain HIV seronegative...

Conference Coverage (Retrovirus)--Viral Dynamics Predict Disease Course.
February 8, 1999... How soon a person gets AIDS depends not only on the amount of virus, but also its rate of increase. Soon after HIV infection, the virus and a person's immune system reach an equilibrium - called the viral setpoint - at which viral load...

At-Risk Populations (HBV)--Vaccine Efforts Should Target Gay Men in College Towns.
February 8, 1999... Hepatitis B vaccination efforts should target gay men living in college towns, according to a report from the University of Michigan. Researcher K. Neighbors and colleagues conducted a preliminary assessment of hepatitis B vaccination rates...

PstS-3 Protein is Candidate for TB Prevention.
February 8, 1999... The PstS-3 protein is a promising new subunit vaccine candidate for the prevention of tuberculosis, according to a report from Belgium's Pasteur Institute of Brussels. Using culture filtrate Ag-specific monoclonal antibodies generated from...

Epidemiology (HAV)--Washington State Hepatitis A Outbreak Has Run Its Course.
February 8, 1999... An aggressive, controversial vaccination program has defeated a Spokane County, Washington, hepatitis A outbreak that reached epidemic levels in 1998, a health official said. Since September 1997, 531 cases of disease have been reported to...

Hemophilia--HIV Lends Hand To Hemophilia Gene Therapy.
February 8, 1999... Researchers said they had found a possible way to use HIV as an effective delivery system for gene therapy. Their tests in mice show a crippled version of the virus - one in which only a single gene is intact - might be used to deliver new...

Influenza (Epidemiology) -- Flu Season Mild So Far, But Cases Increasing.
February 8, 1999... The flu has been relatively mild in the United States for Winter 1999, with New York the only state reporting a widespread outbreak, U.S. health officials said. Since October 1998, 40 other states have reported some flu cases, but no...

Otitis Media--Study for Prevention of Pediatric Ear Infections Initiated.
February 8, 1999... Neose Technologies Inc., Horsham, Pennsylvania, announced that it has initiated a Phase II clinical trial of NE-1530 for the prevention of pediatric middle ear infections, or otitis media. The Finnish National Public Health Institute in...

Vaccine Safety (Anthrax)--Families of Marines Protest Imposed Anthrax Vaccinations.
February 8, 1999... The families of two upstate New York Marines said the U.S. government should do more testing on a vaccination for anthrax before administering it to 2.4 million military personnel. The parents of two friends who grew up together in a town...

Vaccine Safety (HBV)--Hepatitis B Vaccination Controversy Rages On.
February 8, 1999... The following was released by the Institute for Health Freedom (IHF): According to ABC television's 20/20 special titled "Who's Calling the Shots?," the hepatitis B vaccination controversy rages on. Sylvia Chase moderated a segment on...

Vaccine Safety (HBV)--Hepatitis B Vaccine Is Life-Saving.
February 8, 1999... "The hepatitis B vaccine protects children and adults from serious illness and it's a safe vaccine parents can trust," said acting health officer Dr. Maxine Hayes, Washington state Department of Health. Stories in local and national...

Paediatric Hospital Based Surveillance for Chickenpox in Canada: 1991-1996.
February 8, 1999... Paediatric Hospital Based Surveillance for Chickenpox in Canada: 1991 - 1996." B. Law et al. The CPS/LCDC Immunization Monitoring Program. According to an abstract submitted by the authors to the 3rd Canadian National Immunization...

Study on Plasmodium falciparum DNA Vaccines Containing Merozoite Surface Antigen-2 Gene.
February 8, 1999... "Study on Plasmodium falciparum DNA Vaccines Containing Merozoite Surface Antigen-2 Gene." Z. Chen, W. Guan, W. Miao, S. Wu and B. Jiao. The Second Military Medical University, Shanghai; Shenzhen Sanitary and Epidemic Disease Prevention...

Chickenpox in Manitoba: A Population-Based Assessment Using the Manitoba Health Services Commission Database.
February 8, 1999... "Chickenpox in Manitoba: A Population-Based Assessment Using the Manitoba Health Services Commission Database." B. Law, M. Brownell, R. Walid and L. Roos. Canada. According to an abstract submitted by the authors to the 3rd Canadian...

The Cost of Care of Chickenpox in Canada.
February 8, 1999... "The Cost of Care of Chickenpox in Canada." B. Law, C. Fitzsimon, J. McCormick, A. Michaliszyn and E. Ford-Fones. Members of the Canadian Pediatric Society/Laboratory Center for Disease Control, Immunization Monitoring Program Active...

Study on Inhibition Effect of P195 Protein and Its Antibodies on the Invasion of Merozoites of P. Falciparum Into Human Erythrocytes.
February 8, 1999... "Study on Inhibition Effect of P195 Protein and Its Antibodies on the Invasion of Merozoites of P. Falciparum Into Human Erythrocytes." F. Jun and G. Weibin. Department of Parasitology, The Second Military University of Medical Sciences,...

Changes in the Serum Aluminum Levels After Hepatitis B Vaccination in Patients on Hemodialysis.
February 8, 1999... "Changes in the Serum Aluminum Levels After Hepatitis B Vaccination in Patients on Hemodialysis." A. Moreno, N. Esparza, A. Toledo, S. Suria, P. Rossique, C. Garcia-Canton, R. Palomar and M.D. Checa. Department of Nephrology, Hospital Insular...

An Effective Tumor Vaccine Against Malignant Melanoma: Irradiated Autologous Tumor Cells Admixed with MVE-2.
February 8, 1999... Novakovic, S.; Ihan, A.; Wraber, B.; Jezersek, B. "An Effective Tumor Vaccine Against Malignant Melanoma: Irradiated Autologous Tumor Cells Admixed with MVE-2." International Journal of Molecular Medicine, January 1999;3(1):95-102. ...

Reemergence of Invasive Haemophilus influenzae Type b Disease in a Well-Vaccinated Population in Remote Alaska.
February 8, 1999... Galil, K.; Singleton, R.; Levine, O.S.; Fitzgerald, M.A.; Bulkow, L.; Getty, M.; Perkins, B.A.; Parkinson, A. "Reemergence of Invasive Haemophilus influenzae Type b Disease in a Well-Vaccinated Population in Remote Alaska." Journal of...

Immunization of Mice With Urease Vaccine Affords Protection Against Helicobacter pylori Infection in the Absence of Antibodies and Is Mediated by MHC class II-Restricted Responses.
February 8, 1999... Ermak, T.H.; Giannasca, P.J.; Nichols, R.; Myers, G.A.; Nedrud, J.; Weltzin, R.; Lee, C.K.; Kleanthous, H.; Monath, T.P. "Immunization of Mice With Urease Vaccine Affords Protection Against Helicobacter pylori Infection in the Absence of...

High-Level Expression of Plasmodium vivax Apical Membrane Antigen 1 (AMA-1) in Pichia pastoris: Strong Immunogenicity in Macaca mulatta Immunized With P. vivax AMA-1 and Adjuvant SBAS2.
February 8, 1999... Kocken, C.H.M.; Dubbeld, M.A.; Vanderwel, A.; Pronk, J.T.; Waters, A.P.; Langermans, J.A.M.; Thomas, A.W. "High-Level Expression of Plasmodium vivax Apical Membrane Antigen 1 (AMA-1) in Pichia pastoris: Strong Immunogenicity in Macaca mulatta...

Mutations of the beta(2)-microglobulin Gene Result in a Lack of HLA Class I Molecules on Melanoma Cells of Two Patients Immunized with MAGE Peptides.
February 8, 1999... Benitez, R.; Godelaine, D.; Lopeznevot, M.A.; Brasseur, F.; Jimenez, P.; Marchand, M.; Oliva, M.R.; Vanbaren, N.; Cabrera, T.; Andry, G.; Landry, C.; Ruizcabello, F.; Boon, T.; Garrido, F. "Mutations of the beta(2)-microglobulin Gene Result in...

Intranasal Immunization With Plasmid DNA-Lipid Complexes Elicits Mucosal Immunity in the Female Genital and Rectal Tracts.
February 8, 1999... Klavinskis, L.S.; Barnfield, C.; Gao, L.Q.; Parker, S. "Intranasal Immunization With Plasmid DNA-Lipid Complexes Elicits Mucosal Immunity in the Female Genital and Rectal Tracts." Journal of Immunology, January 1, 1999;162(1):254-262. ...

Immunogenicity of Intranasally Administered Meningococcal Native Outer Membrane Vesicles in Mice.
February 8, 1999... Saunders, N.B.; Shoemaker, D.R.; Brandt, B.L.; Moran, E.E.; Larsen, T.; Zollinger, W.D. "Immunogenicity of Intranasally Administered Meningococcal Native Outer Membrane Vesicles in Mice." Infection and Immunity, January 1999;67(1):113-119....

Respiratory Syncytial Virus Pneumonia Among the Elderly: An Assessment of Disease Burden.
February 8, 1999... Han, L.L.; Alexander, J.P.; Anderson, L.J. "Respiratory Syncytial Virus Pneumonia Among the Elderly: An Assessment of Disease Burden." Journal of Infectious Diseases, January 1999;179(1):25-30. According to the authors' abstract of an...

Antibody-Inducing Vaccine Could Prevent AIDS.
February 15, 1999... Maybe antibodies can do the trick after all. The most difficult problem facing AIDS vaccine researchers is that they don't know what protective immunity to HIV looks like. Studies of highly exposed, uninfected individuals and of people who...

Monkey-Meat Trade Could Unleash New AIDS Viruses.
February 15, 1999... The next AIDS virus may already have jumped from monkeys to humans. This harrowing suggestion comes from French researchers F. Simon and colleagues, who have discovered four new strains of simian immunodeficiency virus (SIV) among three...

Persistent Antigen Presentation with rAAV.
February 15, 1999... What do you call a virus that has no genes? Some researchers are hoping to call it an AIDS vaccine. Recombinant adeno-associated virus (rAAV) is already known by gene-therapy researchers, who are exploring the use of its unique...

AtDocs Not Complying with CDC Recommendations.
February 15, 1999... Physicians vaccinated against hepatitis B are not complying with postvaccination guidelines recommended by the U.S. Centers for Disease Control and Prevention (CDC). R. Goldberg and colleagues determined antibody titers to hepatitis B...

P. vivax AMA-1 and Adjuvant SBAS2 Induces Immunity.
February 15, 1999... Using methylotrophic yeast, researchers achieved high-level secreted expression of the Plasmodium vivax apical membrane antigen 1 ectodomain. The apical membrane antigen 1 (AMA-1) family is a promising family of malaria blood-stage vaccine...

gamma-delta T Cells Respond to Heat Shock Proteins.
February 15, 1999... T cells generated during malaria infection responded to Plasmodium heat shock proteins in a murine study. In both murine and human malarias, gammadelta cells accumulate during Plasmodium infections. Recent findings suggest that gammadelta...

Study Finds Universal Vaccination to be Effective and Cost-Effective.
February 15, 1999... Mass vaccination against hepatitis A is an important and cost-effective disease-prevention strategy and should be incorporated into current childhood immunization programs, according to a new study published in the February issue of Hepatology....

Studies Offer Clues to Vaccine Design and Safety.
February 15, 1999... Studies by U.S. National Institute of Allergy and Infectious Diseases (NIAID) scientists and grantees are helping to fill in pieces of the AIDS vaccine research puzzle. In three separate reports published in the February 1999 issue of...

Herpes Vaccine Effective in Animals.
February 15, 1999... In a study published in the journal Vaccine, researchers demonstrated increased survival in mice after challenge with the herpes simplex virus. The immunizations allowed the animals to fight the infection much more quickly and effectively,...

European Marketing Clearance Granted for DTaP Vaccine.
February 15, 1999... Chiron Corp., Emeryville, California, announced that it has received approval from the European Medicines Evaluation Agency (EMEA) to market Triacelluvax, its diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) for infants and...

"Antibody Responses to Single and Multiple Brugia malayi Antigens After DNA Vaccination by I.M. Injection or Gene Gun in Mice.".
February 15, 1999... B.W. Li, S.R. Zhang, A. Hofer, K.C. Curtis and G.J. Weil. Washington University, St. Louis, Missouri. According to an abstract submitted by the authors to the 4th International Meeting of Tropical Medicine and Parasitology, held October...

"Effects of a Supplementary Hepatitis B Vaccine Dose in Children Aged 8 to 10 Years Unprotected after Primary Vaccination.".
February 15, 1999... N. Laflamme, B. Duval, N. Boulianne, G. De Serres, P. De Wals, R. Masse, G. Trudeau, G. Delage and L. DesJardins. Affiliation not provided. According to an abstract submitted by the authors to the 3rd Canadian National Immunization...

"Immunization Against Hepatitis A During an Outbreak in a Jewish Orthodox Community - Montreal Region, 1997-1998.".
February 15, 1999... D. Deshaies, R. Dion and N. Auger. Affiliation not provided. According to an abstract submitted by the authors to the 3rd Canadian National Immunization Conference entitled Partnerships for Health Through Immunization, held December 6-9,...

"Hepatitis A Immunization Program for Intravenous Drug Users (IDU) and Persons with Hepatitis C in British Columbia.".
February 15, 1999... A. King, M. Fyfe and K. Piela et al. Hepatitis A Immunization Working Group. According to an abstract submitted by the authors to the 3rd Canadian National Immunization Conference entitled Partnerships for Health Through Immunization,...

"Immunization in a First Nations Community During a Hepatitis A Outbreak.".
February 15, 1999... D. Kostluk and M. Mercredi. Affiliation not provided. According to an abstract submitted by the authors to the 3rd Canadian National Immunization Conference entitled Partnerships for Health Through Immunization, held December 6-9, 1998, in...

"Phase I Study in Cancer Patients of a Replication-Defective Avipox Recombinant Vaccine that Expresses Human Carcinoembryonic Antigen." Journal of Clinical Oncology, January 1999;17(1):332-337.
February 15, 1999... Marshall, J.L.; Hawkins, M.J.; Tsang, K.Y.; Richmond, E.; Pedicano, J.E.; Zhu, M.Z.; Schlom, J. According to the authors' abstract of an article published in Journal of Clinical Oncology, "PURPOSE: A Phase I clinical trial in patients...

"Development and Standardization of Methods To Evaluate the Antibody Response to an HIV-1 Candidate Vaccine in Secretions and Sera of Seronegative Vaccine Recipients." Journal of Immunological Methods, January 1, 1999;222(1-2):111-124.
February 15, 1999... Raux, M.; Finkielsztejn, L.; Salmonceron, D.; Bouchez, H.; Excler, J.L.; Dulioust, E.; Grouin, J.M.; Sicard, D.; Blondeau, C. According to the authors' abstract of an article published in Journal of Immunological Methods, "Enzyme-linked...

"The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein." International Immunology, December 1998;10(12):1789-1799.
February 15, 1999... Kmieciak, D.; Bednarek, I.; Takiguchi, M.; Wasik, T.J.; Bratosiewicz, J.; Wierzbicki, A.; Teppler, H.; Pientka, J.; Hsu, S.H.; Kaneko, Y.; Kozbor, D. According to the authors' abstract of an article published in International Immunology,...

"Plasmodium: Immunization with Carboxyl-Terminal Regions of MSP-1 Protects Against Homologous But Not Heterologous Blood-stage Parasite Challenge." Experimental Parasitology, January 1999;91(1):78-85.
February 15, 1999... Rotman, H.L.; Daly, T.M.; Long, C.A. According to the authors' abstract of an article published in Experimental Parasitology, "A leading candidate for a vaccine targeted at the erythrocytic stages of plasmodial parasite development is the...

General Expression Vectors for Production of Hydrophobically Tagged Immunogens for Direct ISCOM Incorporation.
February 15, 1999... Andersson, C.; Sandberg, L.; Murby, M.; Sjolander, A.; Lovgrenbengtsson, K.; Stahl, S. According to the authors' abstract of an article published in Journal of Immunological Methods, "A new general strategy for the production of...

"Antibody Response to 1995-1996 Influenza Vaccine in Institutionalized and Non-Institutionalized Elderly Women." Gerontology, January-February 1999;45(1):31-38.
February 15, 1999... Iorio, A.M.; Alatri, A.; Camilloni, B.; Neri, M.; Baglio, G.; Donatelli, I. According to the authors' abstract of an article published in Gerontology, "BACKGROUND: Concern about poor responsiveness to influenza vaccination by...

T-Cell Memory Seen As Key to HIV Disease, AIDS Vaccine.
February 22, 1999... Don't forget memory. For more than a decade, immunologic studies of HIV disease have focused on the dynamics of effector CD8(+) T cells. But understanding the much smaller pool of HIV specific memory CD8(+) T cells - virtually invisible...

"Self Vaccination" Via Intermittent Drug Therapy?
February 22, 1999... Don't try this at home - yet. A daring new treatment strategy hopes that intermittent treatment with highly active antiretroviral therapy (HAART) can lead to permanent immune control of the virus. The strategy comes from several poorly...

CD8(+) T Cells Crucial For HIV Control.
February 22, 1999... Monkey experiments dramatically demonstrate that CD8(+) T-cell responses determine the course of HIV disease. The studies were presented in a session devoted to cell-mediated immunity at the 6th Conference on Retroviruses and Opportunistic...

Variable AIDS Progression Linked to MHC Gene Differences.
February 22, 1999... Small genetic differences may determine whether a person progresses rapidly or slowly to AIDS. The suggestion comes from a study of a single family of macaque monkeys experimentally infected with SIVmac251, a pathogenic strain of simian...

Recombinant Protein Protects against P. Vivax Infection.
February 22, 1999... A yeast-expressed recombinant protein, combined with block copolymer and T-helper epitopes, may protect against malaria, researchers reported. Merozoite surface protein 1 is a candidate for blood-stage vaccines against parasites that cause...