Vaccine Weekly articles from February 1998

Vaccine Weekly archives from February 1998

Adenovirus vaccine induces potent CTL responses. (cytotoxic T-lymphocyte)
February 2, 1998... A recombinant adenovirus (rAd) vaccine encoding the T-cell epitopes of several oncogenes safely protected mice against lethal tumor challenge. The study demonstrates that tad can elicit cytotoxic T-lymphocyte (CTL) responses against multiple...

Recessive gene protects against AIDS.
February 2, 1998... A recessive chemokine gene offers the strongest natural protection yet seen against AIDS. The gene, SDF1-3[prime]UTR-801G-A (SDF1-3[prime]A), encodes for a portion of the chemokine known as stromal-derived factor or SDF-1. It is the principal...

Outbreak among gay Australians underscores vaccination need. (hepatitis A virus)
February 2, 1998... An outbreak of hepatitis A virus among homosexual males living in Sydney, Australia highlights the need for the routine vaccination of gay men. "This outbreak provides further evidence that homosexual men are a risk group for hepatitis A,"...

DNA vaccine yields homing antibody for cancer immunotoxin. (deoxyribonucleic acid)
February 2, 1998... DNA vaccination of mice can yield high-affinity antibodies that recognize the native conformations of human protein epitopes. Isolation and cloning of one such antibody led to the construction of an immunotoxin that may provide a new treatment...

Oligomerized epitopes "superactivate" immune response.
February 2, 1998... Immune responses are triggered by the formation of clusters of T-cell-receptor (TCR), major histocompatibility complex (MHC), and peptide antigen complexes, a Harvard University study shows. This fact makes it possible to enormously optimize...

Signal-protein functions contained in small segments.
February 2, 1998... Discreet functions of the body's chemical messengers may be contained in small peptide segments. The groundbreaking discovery that small portions of the interleukin 10 (IL-10) molecule contain different properties of the whole chemokine...

Hong Kong bird flu: first step in deadly pandemic?
February 2, 1998... Imagine a lethal influenza virus capable of rapidly infecting tissues throughout the body, including the heart and brain. Imagine that humans have no immunity to this virus. The specter haunting world health is that such an influenza virus...

Enhancement, not repression, of infection realized from vaccine protocol.
February 2, 1998... Feline immunodeficiency virus (FIV) infection was enhanced, rather than suppressed, after DNA vaccination with the FIV envelope in a feline model of a human immunodeficiency virus (HIV) vaccination protocol. Several studies have hinted at the...

High levels of CTL and protection obtained. (cytotoxic T lymphocyte)
February 2, 1998... A synthetic peptide vaccine that induced cytotoxic T lymphocyte (CTL) responses protected mice against malaria. "To our knowledge, this is the first demonstration of protection against malaria by a synthetic peptide vaccine designed to induce...

Plasmodium Yoelii CSP is produced in bacteria. (cicumsporozoite surface protein)
February 2, 1998... An approach for purifying a recombinant malaria parasite protein may be useful in the production of protein products. Thomas Stratmann and colleagues, The Scripps Research Institute, La Jolla, California, expressed and purified a recombinant...

Is Erogel a miracle substance for HIV? (human immuno virus)
February 2, 1998... Is Erogel the miracle substance that will free us from HIV and every other sexually transmitted disease? Most definitely, wrote Rene Chun in an article in the current issue of Esquire - that is, according to retired United Methodist Reverend...

Rotary International mobilizes world's largest immunization effort.
February 2, 1998... Rotary Club members from the U.S. and around the world joined forces on January 16, 1998, in India to stem the outbreak of polio - still the leading crippler of children. On January 18, more than 125 million children were to be immunized in a...

No link found between contaminated polio vaccine and cancer.
February 2, 1998... Americans who were administered a polio vaccine that was contaminated with an ape virus are not at increased risk for cancer, National Cancer Institute researchers have established. Howard D. Strickler, MD, MPH, from the National Cancer...