Vaccine Weekly articles from August 2003

Vaccine Weekly archives from August 2003

Myopericarditis is potential adverse reaction to smallpox vaccination.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Clinicians involved in smallpox vaccination programs should be aware of myopericarditis as a potential adverse reaction, according to a report in the...

Revaccination with smallpox possible with diluted vaccine.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Adults can be revaccinated against smallpox relatively safely if the vaccine is diluted 10-fold, according to a report published in the Journal of the...

Lentiviral vaccine targets dendritic cells and induces CD8+ T cell responses.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- In vivo administration of a lentiviral vaccine targets dendritic cells and induces efficient CD8+ T cell responses. "The present study evaluates the potential of third-generation lentivirus vectors...

Naked plasmid DNA injection into solid tumors of mice characterized.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- A team of researchers in Japan has characterized the disposition and gene expression in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice. "Previous studies have...

DNA vaccines enhance cellular immune response to SIV Gag.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- An enhanced cellular immune response against SIV Gag was induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins. "Codon-optimized genes were synthesized...

Antibodies elicited by 11-valent pneumococcal vaccine.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Functional antibodies were stimulated by an 11-valent diphtheria-tetanus toxoid-conjugated pneumococcal vaccine. According to a study from Finland and the Philippines, "The aluminum-adjuvanted...

Novel adenovirus-based SIV vaccine effective in macaques.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A novel adenovirus-based vaccine against the simian version of HIV (SIV) has delivered promising results in a macaque model of infection, researchers in the...

Expression of tumor antigens in acute leukemias investigated.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Expression of serologically identified tumor antigens in acute leukemias has been investigated. According to published research from Germany, "Cancer/testis antigens (CTA) are an expanding family...

HLA-A2 peptides are targets of HLA-A2-restricted cytotoxic T cells.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Naturally occurring peptides associated with HLA-A2 in ovarian cancer cell lines were identified by mass spectrometry and determined to be targets of HLA-A2-restricted cytotoxic T cells. According...

Tumor escape strategies reviewed.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The methods by which tumors evade detection and elimination by the immune system have been outlined in a recent issue of the European Journal of Immunogenetics. According to recent research from...

Timing is everything for kids' successful immunization.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The timing of the third vaccination that children receive for diphtheria, tetanus and whooping cough predicts whether children will get a fourth and final dose of the vaccine on time, according to a new...

Antibodies against zona pellucida glycoproteins inhibit sperm-egg binding.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Antibodies against Escherichia coli-expressed epitopes of zona pellucida glycoproteins inhibit in vitro human sperm-egg binding. "To minimize ovarian dysfunction subsequent to immunization with...

FDA approves St. Jude safety trial for second part of three-part HIV vaccine.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- St. Jude Children's Research Hospital has received approval from the U.S. Food and Drug Administration (FDA) to begin testing another part of its HIV vaccine regimen. The hospital will now begin...

Scientists document increasing reports of second infection.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Evidence is growing that "superinfection" with more than one strain of HIV may be more common than previously thought, experts said at an international AIDS conference. Specialists say such cases,...

Interferon resistance gene needed for modified vaccinia virus Ankara replication.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified an interferon (IFN) resistance gene whose expression is critical for modified vaccinia virus Ankara (MVA) replication....

FDA approves Infanrix fifth dose indication.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline (GSK) announced that its combination vaccine, Infanrix (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed), received approval from the U.S. Food and Drug Administration...

Dendritic cells help prime T cells by immune-stimulating complexes in vivo.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Dendritic cells participate in the priming of antigen-specific CD4+ and CD8+ T lymphocytes by immune-stimulating complexes in vivo. "Immune-stimulating complexes (ISCOMS) are adjuvant vectors which...

Influenza T cell epitope induces influenza protection in mice.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The immunodominant influenza matrix T cell epitope recognized in humans induced influenza protection in HLA-A2/K-b transgenic mice. According to recent research from France, "The protective...

Vaccine makers settle with drug recipients.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The maker of the discontinued Lymerix Lyme disease vaccine has agreed to settle class-action lawsuits alleging that it could cause an arthritic condition in some people, but those who received the...

Cytokine response after measles challenge dependent on vaccine protein.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The cytokine response after a measles virus challenge was dependent upon the type of protein used in the vaccine. According to published research from the United States, "Measles is associated with...

Cardiologists advance search for routine vaccine to prevent heart attacks and strokes.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- In their quest for a vaccine that may one day routinely protect against heart attacks and strokes, cardiologists at Cedars-Sinai Medical Center and their colleagues in Sweden have isolated a key step in...

DNA vaccine with pneumococcal surface protein A elicits immune responses.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- A DNA vaccine containing pneumococcal surface protein A elicited protective humoral and cellular immune responses. "Streptococcus pneumoniae is a major public health problem and new strategies for...

Rotavirus protein NSP4 induces antibody responses during natural infection.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Rotavirus nonstructural protein NSP4 induced heterotypic antibody responses during natural infection in children. According to recent research from India, "Seroconversion of immunoglobulin A (IgA)...

Progress being made towards a vaccine for schistosomiasis.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Progress is being made towards a vaccine for schistosomiasis. "Schistosomiasis continues to be a significant health problem, especially in Africa. While the recent World Health Assembly resolution...

Heart Association comments on patients with dilated cardiomyopathy following vaccine.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The U.S. Centers for Disease Control and Prevention has reported that two patients contracted dilated cardiomyopathy (DCM) 3 months after receiving the smallpox vaccine. Smallpox vaccinations have not...

Study tests vaccine bandages.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- As questions continue to swirl around President Bush's national smallpox vaccination plan, Vanderbilt University Medical Center is launching a new smallpox bandage trial that will help answer questions...

Statement on smallpox vaccinations for emergency physicians released.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- A statement on smallpox vaccinations for emergency physicians has been released by the AAEM/SAEM Smallpox Vaccination Working Group. "On December 13, 2002, President Bush formally announced the...

Certain leukocyte IgG receptors affect immunity to Streptococcus pneumoniae.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Certain leukocyte IgG receptors affect vaccine-induced immunity to Streptococcus pneumoniae. According to a study from the Netherlands and Iceland, "Members of the leukocyte immunoglobulin (Ig) G...

Group B streptococcal vaccine candidates identified.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Novel protein vaccine candidates against Group B streptococcal infection have been identified using alkaline phosphatase fusions. "Using an alkaline phosphatase-based genetic screening method, we...

Antigenic cross-reactivity between measles and cowpea mosaic viruses found.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Antigenic cross-reactivity was found between measles and cowpea mosaic viruses. "Two nonrelated viruses, cowpea mosaic virus (wtCPMV) and measles virus (MV), were found to induce cross-reactive...

Company focuses on host immune response, not the virus.
August 6, 2003... 2003 AUG 6 - (NewsRx.com & NewsRx.net) -- GenoMed, Inc., (MED), a St. Louis, Missouri-based company, reaffirmed its approach to deadly viruses such as SARS, West Nile virus, and HIV. Dr. David Moskowitz, GenoMed's chairman and chief medical...

Focal and generalized folliculitis common after smallpox vaccination.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Focal and generalized folliculitis was noted in people immunized against smallpox for the first time, according to a report in the Journal of the...

Influenza vaccination increases risk of Guillain Barre syndrome.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Patients who receive influenza vaccination face a significantly increased risk of Guillain Barre syndrome, according to a report published in a...

Pneumococcal vaccination decreases atherosclerotic lesion formation.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Pneumococcal vaccination decreased atherosclerotic lesion formation, indicating molecular mimicry between Streptococcus pneumoniae and oxidized LDL. According to a study from the United States,...

Dendritic cell vaccines offer new hope for treatment of endocrine tumors.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines offer new hope for the treatment of metastasized endocrine malignancies. "Dendritic cells (DCs) are antigen-presenting cells that are involved in the induction of primary...

Comutation of HPV16 E6 and E7 genes in Thai cervical tumors found.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A comutation of the HPV16 E6 and E7 genes were found in the squamous cervical carcinomas of women in Thailand. "Infection with high-risk HPV16 is well associated with invasive cervical carcinomas....

Immunogenicity of DNA vaccines boosted by modified vaccinia virus Ankara.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Enhanced T-cell immunogenicity of plasmid DNA vaccines was boosted by recombinant modified vaccinia virus Ankara in humans. According to published research from England and the United States, "In...

Detrick vaccine tested.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Work done at the U.S. Army's research institute at Fort Detrick, Maryland, has led to several clinical trials across the country for a possible new anthrax vaccine. The new vaccine would require...

Anti-idiotype antibody elicits antibody response in breast cancer patients.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A strong, specific antibody response occurred in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides. According to recent research published in...

Dendritic cells prevent metastasis of HPV 16-associated tumors.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Bone marrow-derived dendritic cells exhibited anti-metastatic effects in mice carrying human papillomavirus 16-associated tumors. "Oncogenic, moderately immunogenic MK16/1/ IIIABC (MK16) cells...

Oncolytic adenoviral vector expressing GM-CSF exhibits anti-tumor activity.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- An oncolytic adenoviral vector expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) exhibited strong anti-tumor activity. "Oncolytic adenoviruses are being tested as biological...

RNA transfection of dendritic cells induces immunity against breast cancer.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Transfection of dendritic cells with RNA induced CD4- and CD8-mediated T cell immunity against breast cancer and revealed the immunodominance of presented T cell epitopes. "Transfection of...

Role of dendritic cells in chronic lymphocytic leukemia reviewed.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- The role of monocyte-derived dendritic cells in chronic lymphocytic leukemia has been reviewed in the journal Leukemia and Lymphoma. According to published research from France, "Chronic...

Vector constructed from chimeric SIV and HIV characterized.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A vpr vector constructed from chimeric simian and human immunodeficiency virus has been characterized. "Chimeric simian and human immunodeficiency viruses (SHIVs) are useful toot for investigating...

Vaccines to treat human papillomavirus-associated disease under development.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Therapeutic vaccines to treat human papillomavirus-associated disease are currently under development. "There is a high prevalence of diseases caused by human papillomavirus (HPV) infection....

Green algae extract boosts flu vaccine effectiveness in people 50-55.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A research team from Dalhousie University and Ocean Nutrition Canada have shown that taking a carbohydrate extract of a green algae in pill form, Respondin, can significantly boost the positive immune...

Recombinant influenza virus generated using baculovirus delivery vector.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A recombinant influenza virus has been generated using a baculovirus delivery vector. "A recombinant baculovirus vector containing mammalian cell-active promoters and transcription terminators was...

Many factors affect immunity to Streptococcus pneumoniae.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- The factors affecting production and efficacy of vaccines against Streptococcus pneumoniae are reviewed in the journal Current Opinion in Infectious Diseases. According to recent research from...

License agreement executed for rights to ricin vaccine technology.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- DOR BioPharma, Inc., announced it has executed an exclusive worldwide license agreement with the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) to license issued U.S....

Program to vaccinate health workers against smallpox is faltering.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- The number of health care workers vaccinated against smallpox varies widely across the country, a top federal health official said in July, offering the most detailed picture yet of the foundering...

Researchers look for guidance on vaccinating children against smallpox.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Researchers are looking for guidance on vaccinating children against smallpox in emergency situations. According to a study from the United States, "Following the terrorist attacks on 11 September...

'Molecular farming' may provide source of vaccine components.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- 'Molecular farming' may provide a source of vaccine components. According to recent research from Germany, "'Molecular farming' is the production of valuable recombinant proteins in transgenic...

Therapeutic vaccination to block receptor-ligand interactions possible.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- The development of a therapeutic vaccine to block receptor-ligand interactions is possible, say researchers in Switzerland. According to published research from Switzerland, "Many chronic diseases...

Vaccine immunity to pathogenic fungi overcomes requirement for CD4 help.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells. "Systemic fungal infections with primary and opportunistic pathogens...

Vaccination programs should seek to reduce probability of infection.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Vaccination programs that reduce the probability of infection are more likely to lead to eradication than are programs that slow growth rates in patients already affected. According to recent...

Current infectious diseases threats discussed.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Current emerging infectious disease threats are bringing a heightened sense of awareness of smallpox, severe acute respiratory syndrome (SARS), monkeypox, norovirus, HIV, and West Nile virus, health...

Hawaii firm develops vaccine.
August 13, 2003... 2003 AUG 13 - (NewsRx.com & NewsRx.net) -- A Hawaii research company has developed a vaccine using genetically engineered viral proteins to protect human beings from contracting the West Nile virus. David Watumull, president and chief...

Delivery and animal model affects immune response to Japanese encephalitis virus.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The delivery method and the animal model used affect the T helper cytokine immune response to Japanese encephalitis virus inoculation in mice. ...

Streptococcus pneumoniae peptides enhance vaccine efficacy.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Foreign and self-derived peptides increased the protective ability of vaccines prepared with whole parent proteins of Streptococcus pneumoniae,...

New vaccines against Alzheimer's targeting truncated beta-amyloid peptides.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- New vaccines against Alzheimer disease are targeting truncated beta-amyloid peptide species. According to published research from France, "Vaccination against human beta-amyloid peptide (A-beta)...

Emergency smallpox vaccination may not allow for informed consent.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Emergency smallpox vaccination may not allow for informed consent in the event of an attack. According to published research from the United States, "In the event of a widespread biological attack...

Plant-based vaccines getting closer to the market.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Plant-based vaccines are getting closer to commercial reality, according to a report in the International Journal for Parasitology. "Plant systems are reviewed with regard to their ability to...

Vector developed for purification of Mycobacterium tuberculosis proteins.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A modified vector for efficient purification of recombinant Mycobacterium tuberculosis proteins expressed in Escherichia coli has been constructed. "A major problem in assessing the vaccine and...

Roche announces positive results with enfuvirtide.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Fuzeon (enfuvirtide, formerly known as T-20), a drug that blocks the HIV virus from entering the human immune cell, could change the treatment options for pre-treated HIV patients. World experts...

Antigen specificity studied in autoimmune encephalomyelitis in DA rats.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Antigen specificity and TCR repertoire, and TCR-based DNA vaccine therapy in myelin basic protein-induced autoimmune encephalomyelitis were characterized in DA rats. According to a study from...

Adeno-interferon gamma product candidate receives orphan drug designation.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Transgene has announced that the European Commission has approved the designation of Transgene's immunotherapy product candidate Adeno-Interferon gamma (Ad-IFN gamma) as an Orphan Medicinal Product for...

Novel vaccine to be manufactured from live bacterium.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Cobra Biomanufacturing has announced an agreement with Advaxis, Inc., to supply clinical trials and, potentially, commercial supplies of the active ingredient for its Listeria monocytogenes-based...

CD80 and CD86 expression produces tumor vaccine better than either alone.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Dual expression of CD80 and CD86 produced a tumor vaccine superior to single expression of either molecule. According to recent research from the United States, "A murine model for neuroblastoma,...

Dendritic cell vaccine induces antigen-specific protective antitumor immunity.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity. "In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine...

Dendritic cell-based glioma immunotherapy reviewed.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A review of dendritic cell-based glioma immunotherapy has been published in a recent issue of the International Journal of Oncology. According to a study from Japan, "Despite advances in radiation...

Recent progress in tumor vaccine development reported.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A report on recent progress in tumor vaccine development has been published in the journal Expert Opinion on Investigational Drugs. "Immunotherapy offers an exciting opportunity to treat human...

Data say some states lax on vaccinations.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- About 75% of U.S. toddlers are getting vaccinated on time but pockets of the country are doing significantly worse, new government data show. In 2002, just 63% of toddlers in Colorado were getting...

More U.S. children are getting their shots.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- The number of children in the U.S. receiving immunizations remains at an all-time high, with significant increases in the coverage rates for varicella (chickenpox) and pnuemococcal conjugate vaccine,...

Databases and data mining for computational vaccinology reviewed.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A review of databases and data mining for computational vaccinology has been published recently. "Drugs and vaccines are keys to the effective fight against disease. While the pharmaceutical...

Antibiotic-resistant Streptococcus pneumoniae found in Malawian children.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Antibiotic-resistant Streptococcus pneumoniae was found in Malawian children. "Nasopharyngeal swabs were taken from 906 Malawian children younger than five years old visiting rural health clinics....

Single shot is speedy protection.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A new fast-acting Ebola vaccine protects cynomolgus macaque monkeys from infection within just 1 month, about six times faster than previous vaccines. This accelerated approach may provide an...

Vaccine research efforts for filoviruses reviewed.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A researcher has published a review of current research into developing vaccines for filoviruses in the International Journal for Parasitology. According to a study from the United States, "Ebola...

Vaccine maker reports net loss of $3.2M in second quarter.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Avant Immunotherapeutics, Inc., (AVAN) reported financial results for the second quarter ended June 30, 2003. The company reported a net loss of $3.2 million, or $.05 per share, for the second...

Cationic lipids may soon be used for DNA transfection in humans.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Advances in transfection using cationic lipids for DNA delivery still have some problems, but use in humans is close. According to recent research published in the journal Current Medicinal...

Positive results reported from first clinical trial of recombinant human gelatin.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced positive results from the first clinical safety study of recombinant human gelatin, finding the study material safe and well tolerated at all doses tested. The data...

Importance of CD4+ helper T-cells in antitumor immunity detailed.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- The importance of CD4+ helper T-cells in antitumor immunity has been detailed. "CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo,...

Mycobacterium leprae membrane fraction may be effective vaccine antigen.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- A fraction of the membrane from Mycobacterium leprae cells shows promise as immunogenic antigen for vaccine use. "The antigenicity of Mycobacterium leprae-derived cell membrane fraction was...

Phase I study of novel cholesterol management vaccine published.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Research published in the journal Atherosclerosis supports the feasibility, immunogenicity, and safety of an experimental vaccine approach to raising HDL cholesterol under development by AVANT...

TAP polymorphisms do not affect antibody levels after measles vaccination.
August 20, 2003... 2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Researchers have found no association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination. "The transporter...