Vaccine Weekly articles from August 1998

Vaccine Weekly archives from August 1998

Ethics and Vaccine: Consensus Elusive.
August 10, 1998... When 200 people from 30 countries convene to agree on ethical standards, consensus is hard to reach. The new ethical guidelines on HIV vaccine research will be published later this year. But in many cases the document merely will outline the...

HIV Lures Uninfected Cells To Their Doom.
August 10, 1998... HIV-1 issues a siren call to uninfected cells, luring them to lymphoid tissues crawling with virus. The AIDS virus docks to susceptible cells via specific chemokine receptors. Since chemokines act as cellular messengers that tell T cells when...

HIV Tat Selects Infecting Viral Variant.
August 10, 1998... HIV-1 has yet another amazing trick up its sleeve: its Tat protein can inhibit some strains of HIV. This seeming contradiction provides an answer to the long-standing question of exactly why, when a transmitting individual carries both...

Between What Is and What Can Be: The Real AIDS Gap.
August 10, 1998... Every five seconds, AIDS prevention fails. HIV infects 16,000 people every day. Most of these people soon will die from treatable diseases such as tuberculosis. A relative few, fortunate enough both to have access to state-of-the-art treatments...

Inoculations Begin in St. Louis AIDSVAX Phase III Trial.
August 10, 1998... Inoculation of volunteers in the first-ever Phase III human clinical testing of a vaccine against HIV began July 8, 1998, at the Center for Vaccine Development at St. Louis University School of Medicine in St. Louis, Missouri. The trial, which...

Without Improved Vaccine TB Epidemic Will Worsen.
August 10, 1998... A critical lack of ongoing research aimed at improving tuberculosis vaccination could worsen an anticipated TB epidemic in developing nations. "Given the rapid global increase in tuberculosis and the widespread use of bacillus Calmette-Guerin...

Attenuated Recombinant B. Pertussis Enhances Protection against Parasites.
August 10, 1998... Attenuated recombinant Bordetella pertussis strains may be suitable vectors for disease protection through one intranasal administration. Although single-dose mucosal immunization is best achieved by using attenuated live microorganisms, such...

New Peptide Antigens for Malaria Vaccines.
August 10, 1998... Two synthetic peptides may have potential for use in a multicomponent subunit vaccine against asexual blood stages of Plasmodium falciparum. The delineation of putatively protective and immunogenic epitopes in vaccine candidate proteins...

Vaccine Testing Gets Booster.
August 10, 1998... A new technique to visualize immune cell interactions could cut testing times for new vaccines from several weeks to 48 hours. Developed by researchers at the University of Minnesota in Rochester, the University of Glasgow in Scotland, and...

Melanoma DNA Vaccine Trial Initiated.
August 10, 1998... Vical Inc., San Diego, California, announced the initiation of a Phase I/II clinical trial to study the safety and potential efficacy of an experimental DNA vaccine for patients with metastatic melanoma. The trial is being sponsored by the U.S....

Plan To Speed Up AIDS Vaccine Development.
August 10, 1998... A global plan to speed up AIDS vaccine development was launched at the start of the 12th International AIDS Conference, held in Geneva, Switzerland, June 28 - July 3, 1998. The International AIDS Vaccine Initiative (IAVI) released its...

Potential Trial Participants: Be Open and Honest and Do No Harm.
August 10, 1998... Members of communities similar to those likely to be targeted for participation in HIV vaccine trials have specific concerns about how this research is carried out. They want full and honest disclosure about all aspects of the research and the...

Findings May Help Explain Immunity To HIV in Thai Female Prostitutes.
August 10, 1998... The production of both cytotoxic T lymphocytes B often called "killer T cells" B and HIV suppressive factors may have played a role in protecting highly exposed female sex workers in Thailand from HIV infection, according to data presented by the...

Kinetics of Cytomegalovirus In Vivo in FHV Infected Patients Versus Transplant Recipients Under Ganciclovir Therapy.
August 10, 1998... "Kinetics of Cytomegalovirus In Vivo in FHV Infected Patients Versus Transplant Recipients Under Ganciclovir Therapy." C. Payan, S. Konyoudyiam, J.M. Chennebault, F. Cogny, N. Ifrah, E. Pichard and F. Lunel. Laboraitoire de Virologie Chu Angers,...

Multi-Subtype Envelope-Based DNA and Protein Immunization Strategies for Broadening Immune Responses to HIV-1.
August 10, 1998... "Multi-Subtype Envelope-Based DNA and Protein Immunization Strategies for Broadening Immune Responses to HIV-1." S.W. Barnett, Y. Sun, H.S. Legg, T.C. VanCott, J.R. Mascola and F.M. Sinangil. Chiron Corporation, Emeryville, California....

Development of a Novel DNA Vaccine against Bovine Respiratory Syncytial Virus.
August 10, 1998... "Development of a Novel DNA Vaccine against Bovine Respiratory Syncytial Virus." D.S. Bautista and Y. Haj-Ahmad. Brock University St. Catharines, Ontario, Canada; Procyon, Biopharma Inc., London, Ontario, Canada. According to an abstract...

A Recombinant BCG Vaccine for HIV-1 Protects Cynomolgus Monkeys from SHIVMN Challenge.
August 10, 1998... "A Recombinant BCG Vaccine for HIV-1 Protects Cynomolgus Monkeys from SHIVMN Challenge." T. Nakasonel, K. Someya, Y. Ami, K. Shinora, H. Yamamotos, N. Yoshino, S. Ando, T. Asano, L. Yichen, K. Matsuo, H. Yoshikura, S. Yamazaki and M. Honda....

How Would Gay Men Decide Whether or Not to Participate an HIV Vaccine Efficacy Trial?
August 10, 1998... "How Would Gay Men Decide Whether or Not to Participate an HIV Vaccine Efficacy Trial?" R.B. Hays, S.M. Kegeles, B.W. Ralston and T. Slama. UCSF Center for AIDS Prevention Studies, San Francisco, California. According to an abstract submitted...

Regain of Fertility and Normality of Progeny Born During Below Protective Threshold Antibody Titers in Women Immunized with the HSD-hCG Vaccine.
August 10, 1998... Singh, M.; Das, S.K.; Suri, S.; Singh, O.; Talwar, G.P. "Regain of Fertility and Normality of Progeny Born During Below Protective Threshold Antibody Titers in Women Immunized with the HSD-hCG Vaccine." American Journal of Reproductive...

Neonatal Mouse Immunity Against Group B Streptococcal Infection by Maternal Vaccination with Recombinant Anti-Idiotypes.
August 10, 1998... Magliani, W.; Polonelli, L.; Conti, S.; Salati, A.; Rocca, P.F.; Cusumano, V.; Mancuso, G.; Teti, G. "Neonatal Mouse Immunity Against Group B Streptococcal Infection by Maternal Vaccination with Recombinant Anti-Idiotypes." Nature Medicine, June...

Antibodies to Nonrepeat Sequences of Antigen Pf155/RESA of Plasmodium falciparum Inhibit Parasite Growth in vitro.
August 10, 1998... Siddique, A.B.; Iqbal, J.; Ahlborg, N.; Flyg, B.W.; Perlmann, P.; Berzins, K. "Antibodies to Nonrepeat Sequences of Antigen Pf155/RESA of Plasmodium falciparum Inhibit Parasite Growth in vitro." Parasitology Research, June 1998;84(6):485-491....

Childhood Immunisation Today.
August 10, 1998... Eskola, J. "Childhood Immunisation Today." Drugs, June 1998;55(6):759-766. According to the author's abstract of an article published in Drugs, "Better knowledge of the pathogenesis of infections and host responses, and progress in...

Initiating the First DTP Vaccination Age-Appropriately: A Model for Understanding Vaccination Coverage.
August 10, 1998... "Initiating the First DTP Vaccination Age-Appropriately: A Model for Understanding Vaccination Coverage." Pediatrics, June 1998;101(6):970-974. According to the authors' abstract of an article published in Pediatrics, "OBJECTIVE: Our earlier...

Idiotypic Immunization Induces Immunity to Mutated p53 and Tumor Rejection.
August 10, 1998... Ruiz, P.J.; Wolkowicz, R.; Waisman, A.; Hirschberg, D.L.; Carmi, P.; Erez, N.; Garren, H.; Herkel, J.; Karpuj, M.; Steinman, L.; Rotter, V.; Cohen, I.R. "Idiotypic Immunization Induces Immunity to Mutated p53 and Tumor Rejection." Nature...

Epidemics of Aseptic Meningitis Due to Enteroviruses Following National Immunization Days in Bahrain.
August 10, 1998... Khalfan, S.; Aymard, M.; Lina, B.; Thouvenot, D.; Schuffenecker, I.; Foray, S.; Fernandes, E.; Baig, B. "Epidemics of Aseptic Meningitis Due to Enteroviruses Following National Immunization Days in Bahrain." Annals of Tropical Paediatrics, June...

Ethics and Vaccine: Consensus Elusive
August 10, 1998... When 200 people from 30 countries convene to agree on ethical standards, consensus is hard to reach. The new ethical guidelines on HIV vaccine research will be published later this year. But in many cases the document merely will outline the...

HIV Lures Uninfected Cells To Their Doom
August 10, 1998... HIV-1 issues a siren call to uninfected cells, luring them to lymphoid tissues crawling with virus. The AIDS virus docks to susceptible cells via specific chemokine receptors. Since chemokines act as cellular messengers that tell T cells when...

HIV Tat Selects Infecting Viral Variant
August 10, 1998... HIV-1 has yet another amazing trick up its sleeve: its Tat protein can inhibit some strains of HIV. This seeming contradiction provides an answer to the long-standing question of exactly why, when a transmitting individual carries both...

Editorial: Between What Is and What Can Be: The Real AIDS Gap
August 10, 1998... Every five seconds, AIDS prevention fails. HIV infects 16,000 people every day. Most of these people soon will die from treatable diseases such as tuberculosis. A relative few, fortunate enough both to have access to state-of-the-art treatments...

AIDS Vaccines Inoculations Begin in St. Louis AIDSVAX Phase III Trial
August 10, 1998... Inoculation of volunteers in the first-ever Phase III human clinical testing of a vaccine against HIV began July 8, 1998, at the Center for Vaccine Development at St. Louis University School of Medicine in St. Louis, Missouri. The trial, which...

Epidemiology (TB) Without Improved Vaccine TB Epidemic Will Worsen
August 10, 1998... A critical lack of ongoing research aimed at improving tuberculosis vaccination could worsen an anticipated TB epidemic in developing nations. "Given the rapid global increase in tuberculosis and the widespread use of bacillus Calmette-Guerin...

Immunology Attenuated Recombinant B. Pertussis Enhances Protection against Parasites
August 10, 1998... Attenuated recombinant Bordetella pertussis strains may be suitable vectors for disease protection through one intranasal administration. Although single-dose mucosal immunization is best achieved by using attenuated live microorganisms, such...

Malaria New Peptide Antigens for Malaria Vaccines
August 10, 1998... Two synthetic peptides may have potential for use in a multicomponent subunit vaccine against asexual blood stages of Plasmodium falciparum. The delineation of putatively protective and immunogenic epitopes in vaccine candidate proteins...

Vaccine Development Vaccine Testing Gets Booster
August 10, 1998... A new technique to visualize immune cell interactions could cut testing times for new vaccines from several weeks to 48 hours. Developed by researchers at the University of Minnesota in Rochester, the University of Glasgow in Scotland, and...

Cancer Vaccines Melanoma DNA Vaccine Trial Initiated
August 10, 1998... Vical Inc., San Diego, California, announced the initiation of a Phase I/II clinical trial to study the safety and potential efficacy of an experimental DNA vaccine for patients with metastatic melanoma. The trial is being sponsored by the U.S....

HIV Vaccines Plan To Speed Up AIDS Vaccine Development
August 10, 1998... A global plan to speed up AIDS vaccine development was launched at the start of the 12th International AIDS Conference, held in Geneva, Switzerland, June 28 - July 3, 1998. The International AIDS Vaccine Initiative (IAVI) released its...

HIV Vaccines Potential Trial Participants: Be Open and Honest and Do No Harm
August 10, 1998... Members of communities similar to those likely to be targeted for participation in HIV vaccine trials have specific concerns about how this research is carried out. They want full and honest disclosure about all aspects of the research and the...

Immunology Findings May Help Explain Immunity To HIV in Thai Female Prostitutes
August 10, 1998... The production of both cytotoxic T lymphocytes B often called "killer T cells" B and HIV suppressive factors may have played a role in protecting highly exposed female sex workers in Thailand from HIV infection, according to data presented by the...

Disease Associations "Kinetics of Cytomegalovirus In Vivo in FHV Infected Patients Versus Transplant Recipients Under Ganciclovir Therapy."
August 10, 1998... C. Payan, S. Konyoudyiam, J.M. Chennebault, F. Cogny, N. Ifrah, E. Pichard and F. Lunel. Laboraitoire de Virologie Chu Angers, Angers Cedex; Service de Maladies Infectieuses Chu Angers, Angers; Service de Nephrologie chu Angers, Angers; Service...

HIV Vaccines "Multi-Subtype Envelope-Based DNA and Protein Immunization Strategies for Broadening Immune Responses to HIV-1."
August 10, 1998... S.W. Barnett, Y. Sun, H.S. Legg, T.C. VanCott, J.R. Mascola and F.M. Sinangil. Chiron Corporation, Emeryville, California. According to an abstract submitted by the authors to the 12th World AIDS Conference, held June 28 - July 3, 1998, in...

DNA Vaccines (RSV) "Development of a Novel DNA Vaccine against Bovine Respiratory Syncytial Virus."
August 10, 1998... D.S. Bautista and Y. Haj-Ahmad. Brock University St. Catharines, Ontario, Canada; Procyon, Biopharma Inc., London, Ontario, Canada. According to an abstract submitted by the authors to the 98th General Meeting of the American Society for...

HIV Vaccines "A Recombinant BCG Vaccine for HIV-1 Protects Cynomolgus Monkeys from SHIVMN Challenge."
August 10, 1998... T. Nakasonel, K. Someya, Y. Ami, K. Shinora, H. Yamamotos, N. Yoshino, S. Ando, T. Asano, L. Yichen, K. Matsuo, H. Yoshikura, S. Yamazaki and M. Honda. Toyama, Shinjuku-ku, Tokyo; AIDS Research Center, NIID, Tokyo; Div. Experimental Animal...

Knowledge, Attitudes and Behavior "How Would Gay Men Decide Whether or Not to Participate an HIV Vaccine Efficacy Trial?"
August 10, 1998... R.B. Hays, S.M. Kegeles, B.W. Ralston and T. Slama. UCSF Center for AIDS Prevention Studies, San Francisco, California. According to an abstract submitted by the authors to the 12th World AIDS Conference, held June 28 - July 3, 1998, in Geneva,...

Contraception "Regain of Fertility and Normality of Progeny Born During Below Protective Threshold Antibody Titers in Women Immunized with the HSD-hCG Vaccine."
August 10, 1998... Singh, M.; Das, S.K.; Suri, S.; Singh, O.; Talwar, G.P. American Journal of Reproductive Immunology, June 1998;39(6):395-398. According to the authors' abstract of an article published in American Journal of Reproductive Immunology, "PROBLEM:...

Group B Streptococcus "Neonatal Mouse Immunity Against Group B Streptococcal Infection by Maternal Vaccination with Recombinant Anti-Idiotypes."
August 10, 1998... Magliani, W.; Polonelli, L.; Conti, S.; Salati, A.; Rocca, P.F.; Cusumano, V.; Mancuso, G.; Teti, G. Nature Medicine, June 1998;4(6):705-709. According to the authors' abstract of an article published in Nature Medicine, "We investigated...

Malaria Vaccines "Antibodies to Nonrepeat Sequences of Antigen Pf155/RESA of Plasmodium falciparum Inhibit Parasite Growth in vitro."
August 10, 1998... Siddique, A.B.; Iqbal, J.; Ahlborg, N.; Flyg, B.W.; Perlmann, P.; Berzins, K. Parasitology Research, June 1998;84(6):485-491. According to the authors' abstract of an article published in Parasitology Research, "Immune responses to the repeat...

Pediatrics "Childhood Immunisation Today."
August 10, 1998... Eskola, J. Drugs, June 1998;55(6):759-766. According to the author's abstract of an article published in Drugs, "Better knowledge of the pathogenesis of infections and host responses, and progress in biotechnology has paved the way for new...

Pediatrics "Initiating the First DTP Vaccination Age-Appropriately: A Model for Understanding Vaccination Coverage."
August 10, 1998... Ross, A.; Kennedy, A.B.; Holt, E.; Guyer, B.; Hou, W.; Hughart, N. Pediatrics, June 1998;101(6):970-974. According to the authors' abstract of an article published in Pediatrics, "OBJECTIVE: Our earlier research found that the strongest...

Vaccine Development "Idiotypic Immunization Induces Immunity to Mutated p53 and Tumor Rejection."
August 10, 1998... Ruiz, P.J.; Wolkowicz, R.; Waisman, A.; Hirschberg, D.L.; Carmi, P.; Erez, N.; Garren, H.; Herkel, J.; Karpuj, M.; Steinman, L.; Rotter, V.; Cohen, I.R. Nature Medicine, June 1998;4(6):710-712. According to the authors' abstract of an article...

Vaccine Safety "Epidemics of Aseptic Meningitis Due to Enteroviruses Following National Immunization Days in Bahrain."
August 10, 1998... Khalfan, S.; Aymard, M.; Lina, B.; Thouvenot, D.; Schuffenecker, I.; Foray, S.; Fernandes, E.; Baig, B. Annals of Tropical Paediatrics, June 1998;18(2):101-109. According to the authors' abstract of an article published in Annals of Tropical...

Support Slips For Live HIV Vaccine.
August 24, 1998... Nothing went right for Charles Farthing in his eloquent defense of testing a live HIV vaccine. In a debate at the 12th World AIDS Conference, everything seemed to work against the AIDS clinician and researcher who has volunteered to be the...

Avipox AIDS Vaccine Elicits Durable Anti-HIV CTLs.
August 24, 1998... More than half of the volunteers who received a candidate AIDS vaccine developed durable, HIV specific cytotoxic T-lymphocyte (CTL) responses. The vaccine is a canarypox virus engineered to express HIV genes. The virus is capable only of a...

CDC Meta-Analysis: AIDS Prevention Works, Saves Money.
August 24, 1998... With AIDS spreading so rapidly throughout the world, it comes as something of a shock to learn that AIDS prevention works. But it does: and researchers at the U.S. Centers for Disease Control and Prevention (CDC) have organized systems to...

Low-Molecular Weight Compounds Block HIV Binding.
August 24, 1998... Clinical trials already are underway to test a new drug that blocks HIV infection. In vitro studies of the drug suggest that when HIV acquires resistance to the drug, it may lose its ability to infect T cells. The drug is the bicyclam...

Russian Risk Factor: Organized Crime.
August 24, 1998... Organized crime actively fights Russian AIDS prevention efforts, a Moscow NGO officer says. The spread of Russia's mafia during the nation's transition from state socialism has been a major factor in the spread of AIDS, said Elena Pyroyshkina,...

Vaccinia-Based AIDS Vaccine Safe In Early Trials.
August 24, 1998... A live, recombinant vaccinia virus that expresses multiple HIV antigens is well tolerated by humans, early trial results show. The vaccine, dubbed TBC-3B by manufacturer Therion Biologics Corp., expresses the HIV env, gag, and pol genes. The...

Can Wyeth Hold Its Rotavirus Vaccine Lead?
August 24, 1998... As support for universal rotavirus vaccination grows, so does the competition. The imminent approval of Wyeth-Ayerst Laboratories' rotavirus vaccine (dubbed RotaShield in the U.S. and Rotamune abroad) promises the firm a generous return on its...

IgG Fc Receptor Blocks Effectiveness of Antibodies.
August 24, 1998... Study results may help explain why antibodies do not successfully modify herpes simplex virus (HSV) infection. HSV glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and...

Database Will Help In Developing Effective Vaccines.
August 24, 1998... Medical researchers around the world now can tap into the world's most comprehensive collection of genetic information about the influenza virus. The new database will help scientists understand how the flu bug mutates and will aid in the...

Genome Sequence Offers Clues To Better Diagnosis, Prevention, Treatment.
August 24, 1998... In a research breakthrough that paves the way for preventive vaccines as well as better diagnostic tests and treatments, scientists have sequenced the complete genome for Treponema pallidum, the bacterium that causes syphilis. The project,...

Bug Model Could Lead to HCV Vaccine.
August 24, 1998... Researchers may be one step closer to establishing an insect model that could further the development of a hepatitis C virus vaccine. Thomas F. Baumert and colleagues from the U.S. National Institutes of Health found that hepatitis C virus...

CDC: Childhood Vaccination Rates Hover at Highest Levels.
August 24, 1998... Immunizations of U.S. preschoolers stayed at their highest levels in 1997, with more than 90 percent receiving four of the six recommended vaccines, government health officials reported. The nationwide survey by the U.S. Centers for Disease...

Determination of Prevalent HIV-1 Subtypes in South Africa and the Construction of a gp120 DNA Vaccine.
August 24, 1998... "Determination of Prevalent HIV-1 Subtypes in South Africa and the Construction of a gp120 DNA Vaccine." J. van Harmelen, H. Bredell, L. Morris, E. van der Ryst, S. Lyons, D. York and C. Williamson. UCT Medical School, Anzio Road Observatory;...

Retroviral Vectors: Investigation of Receptor Utilization by Different Vector Pseudotypes and Application for Suicide Gene Transfer.
August 24, 1998... "Retroviral Vectors: Investigation of Receptor Utilization by Different Vector Pseudotypes and Application for Suicide Gene Transfer." W. Uckert. Max-Delbruck-Center for Molecular Medicine, Berlin, FRG. According to an abstract submitted by...

AVEG 031: Phase I Evaluation of a gag-pol Facilitated DNA Vaccine for HIV-1 Prevention.
August 24, 1998... "AVEG 031: Phase I Evaluation of a gag-pol Facilitated DNA Vaccine for HIV-1 Prevention." P. Goapfert, M. Mulligan, L. Corey, B. Graham, T. Evans, K. Weinhold, D. Stablein and R. Ginsberg. University of Alabama, Birmingham, AL; University of...

Chemokine Levels Modulated In Vivo by DNA Vaccines.
August 24, 1998... "Chemokine Levels Modulated In Vivo by DNA Vaccines." D. Weiner, K. Ugen, K.E. Ugen, J. Kim, R. Ciccarelli, S. Nylan and J. Boyer. Univ Pennsylvania, Philadelphia, Pennsylvania; USF College of Medicine, Tampa, Florida; Apollon, Malvern,...

Anti-MUC1 Class I Restricted CTLs in Metastatic Breast Cancer Patients Immunized with a Synthetic MUC1 Peptide.
August 24, 1998... Reddish, M.A.; Maclean, G.D.; Koganty, R.R.; Kanmitchell, J.; Jones, V.; Mitchell, M.S.; Longenecker, B.M. "Anti-MUC1 Class I Restricted CTLs in Metastatic Breast Cancer Patients Immunized with a Synthetic MUC1 Peptide." International Journal of...

Stabilization of Proteins and Peptides in Diagnostic Immunological Assays by the Molecular Chaperone Hsp25.
August 24, 1998... Ehrnsperger, M.; Hergersberg, C.; Wienhues, U.; Nichtl, A.; Buchner, J. "Stabilization of Proteins and Peptides in Diagnostic Immunological Assays by the Molecular Chaperone Hsp25." Analytical Biochemistry, June 1, 1998;259(2):218-225....

Polymeric Nanoparticles as Delivery System for Influenza Virus Glycoproteins.
August 24, 1998... "Polymeric Nanoparticles as Delivery System for Influenza Virus Glycoproteins." Journal of Controlled Release, June 1998;54(1):15-27. According to the authors' abstract of an article published in Journal of Controlled Release, "The objective...

Measles-Mumps-Rubella and Hepatitis B Vaccination Uptake in Adolescents: A Survey in Metropolitan Melbourne.
August 24, 1998... "Measles-Mumps-Rubella and Hepatitis B Vaccination Uptake in Adolescents: A Survey in Metropolitan Melbourne." Medical Journal of Australia, June 1, 1998;168(11):546-549. According to the authors' abstract of an article published in Medical...

Guideline for Infection Control in Health Care Personnel, 1998.
August 24, 1998... Bolyard, E.A.; Tablan, O.C.; Williams, W.W.; Pearson, M.L.; Shapiro, C.N.; Deitchman, S.D. "Guideline for Infection Control in Health Care Personnel, 1998." American Journal of Infection Control, June 1998;26(3):289-354. According to the...

Antibody Responses and Persistence in the Two Years after Immunization with Two Acellular Vaccines and One Whole-Cell Vaccine Against Pertussis.
August 24, 1998... Giuliano, M.; Mastrantonio, P.; Giammanco, A.; Piscitelli, A.; Salmaso, S.; Wassilak, S.G.F. "Antibody Responses and Persistence in the Two Years after Immunization with Two Acellular Vaccines and One Whole-Cell Vaccine Against Pertussis."...

Eliminating a Region of Respiratory Syncytial Virus Attachment Protein Allows Induction of Protective Immunity Without Vaccine-Enhanced Lung Eosinophilia.
August 24, 1998... Sparer, T.E.; Matthews, S.; Hussell, T.; Rae, A.J.; Garciabarreno, B.; Melero, J.A.; Openshaw, P.J.M. "Eliminating a Region of Respiratory Syncytial Virus Attachment Protein Allows Induction of Protective Immunity Without Vaccine-Enhanced Lung...

Clinically Relevant Vaccine-Vaccine Interactions: A Guide for Practitioners.
August 24, 1998... Gizurarson, S. "Clinically Relevant Vaccine-Vaccine Interactions: A Guide for Practitioners." Biodrugs, June 1998;9(6):443-453. The need for combination vaccines has been recognised for many years. Many children must have 9 or 12 injections in...

Conference Coverage (12th World AIDS) Support Slips For Live HIV Vaccine
August 24, 1998... Nothing went right for Charles Farthing in his eloquent defense of testing a live HIV vaccine. In a debate at the 12th World AIDS Conference, everything seemed to work against the AIDS clinician and researcher who has volunteered to be the...

Conference Coverage (12th World AIDS) Avipox AIDS Vaccine Elicits Durable Anti-HIV CTLs
August 24, 1998... More than half of the volunteers who received a candidate AIDS vaccine developed durable, HIV specific cytotoxic T-lymphocyte (CTL) responses. The vaccine is a canarypox virus engineered to express HIV genes. The virus is capable only of a...

Conference Coverage (12th World AIDS) CDC Meta-Analysis: AIDS Prevention Works, Saves Money
August 24, 1998... With AIDS spreading so rapidly throughout the world, it comes as something of a shock to learn that AIDS prevention works. But it does: and researchers at the U.S. Centers for Disease Control and Prevention (CDC) have organized systems to...

Conference Coverage (12th World AIDS) Low-Molecular Weight Compounds Block HIV Binding
August 24, 1998... Clinical trials already are underway to test a new drug that blocks HIV infection. In vitro studies of the drug suggest that when HIV acquires resistance to the drug, it may lose its ability to infect T cells. The drug is the bicyclam...

Conference Coverage (12th World AIDS) Russian Risk Factor: Organized Crime
August 24, 1998... Organized crime actively fights Russian AIDS prevention efforts, a Moscow NGO officer says. The spread of Russia's mafia during the nation's transition from state socialism has been a major factor in the spread of AIDS, said Elena Pyroyshkina,...

Conference Coverage (12th World AIDS) Vaccinia-Based AIDS Vaccine Safe In Early Trials
August 24, 1998... A live, recombinant vaccinia virus that expresses multiple HIV antigens is well tolerated by humans, early trial results show. The vaccine, dubbed TBC-3B by manufacturer Therion Biologics Corp., expresses the HIV env, gag, and pol genes. The...

Vaccine Marketplace Can Wyeth Hold Its Rotavirus Vaccine Lead?
August 24, 1998... As support for universal rotavirus vaccination grows, so does the competition. The imminent approval of Wyeth-Ayerst Laboratories' rotavirus vaccine (dubbed RotaShield in the U.S. and Rotamune abroad) promises the firm a generous return on its...

HSV-1 IgG Fc Receptor Blocks Effectiveness of Antibodies
August 24, 1998... Study results may help explain why antibodies do not successfully modify herpes simplex virus (HSV) infection. HSV glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and...

Influenza Vaccines Database Will Help In Developing Effective Vaccines
August 24, 1998... Medical researchers around the world now can tap into the world's most comprehensive collection of genetic information about the influenza virus. The new database will help scientists understand how the flu bug mutates and will aid in the...

Syphilis Genome Sequence Offers Clues To Better Diagnosis, Prevention, Treatment
August 24, 1998... In a research breakthrough that paves the way for preventive vaccines as well as better diagnostic tests and treatments, scientists have sequenced the complete genome for Treponema pallidum, the bacterium that causes syphilis. The project,...