Vaccine Weekly articles from April 2004

Vaccine Weekly archives from April 2004

High-mannose-type oligosaccharides bind to human antibody 2G12.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- High-mannose-type oligosaccharides bind to human antibody 2G12, which has implications for HIV-1 vaccine design. According to a study from the United States, "Human antibody 2G12 broadly...

Hepatitis C DNA vaccine induces strong DTH response in mice.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A hepatitis C virus core protein-expressing DNA vaccine induced a strong class I-binding peptide DTH response in mice. "The hepatitis C virus (HCV) core protein-encoding sequence (HCcAg) is the...

Microglial activation facilitates A-beta plaque removal.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Microglial activation facilitates A-beta plaque removal following intracranial anti-A beta antibody administration. According to a study from the United States, "The mechanisms by which anti-A-beta...

Bacteriophage-mediated nucleic acid immunization offers benefits.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Bacteriophage-mediated nucleic acid immunization offers benefits over naked DNA vaccines. "Whole bacteriophage lambda particles, containing reporter genes under the control of the cytomegalovirus...

Influenza A viruses obtained from Vero cells by reverse genetics.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- High-yielding influenza A viruses obtained from African green monkey kidney (Vero) cells by reverse genetics. "Influenza A viruses are the cause of annual epidemics of human disease with occasional...

Immunization attenuates psychoactive effects of nicotine.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Immunization attenuates the psychoactive effects of nicotine. "Despite the enormous health risks, people continue to smoke and use tobacco primarily as a result of nicotine addiction. As part of...

U.S. to stockpile new vaccine.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- The U.S. government is planning to stockpile enough doses of an experimental new anthrax vaccine to inoculate 25 million people. Studies designed to prove whether this new vaccine is safe are still...

FluMist maker announces plan to achieve $2 billion in revenues by 2009.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) announced that it expects to achieve $2 billion in total revenues by 2009, driven by investments in its pipeline and the continued growth of its currently marketed products. ...

Commercial agreement announced for cancer vaccine product candidate.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Prima BioMed Ltd, subsidiary CancerVac, and Biomira Inc. (BIOM) announced a commercial agreement for the development and commercialization of CancerVac's most advanced cancer vaccine product candidate....

Genaera extends alliance IL-9 alliance.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Genaera Corp. (GENR) and the Ludwig Institute for Cancer Research (LICR) announced a 2-year extension of a collaborative agreement on the joint discovery and development of novel genes and proteins as...

Phase II colorectal vaccine trial results updated.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) provided an update of data from the phase II Theratope vaccine colorectal study of 20 patients. A Kaplan-Meier Survival and Time to Disease Progression Curve of the 20...

$1M in grants to fund cytomegalovirus vaccine development.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Vical Incorporated (VICL) has received notification of funding of approximately $1 million for research and development related to the company's plasmid DNA vaccine against cytomegalovirus (CMV) under...

Trial results advance development of vaccine for travelers' diarrhea.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A clinical trial undertaken by the U.K. biotechnology company Microscience at the St. George's Vaccine Institute at St. George's Hospital Medical School in London, England has demonstrated the safety...

Biotechnology company completes $23.1M series B financing.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- VaxInnate Corporation has completed a $23.1 million, series B financing to advance the development of next-generation preventative vaccines and immune therapies for infectious disease and cancer. ...

Vaccine development helps drive company's 25% revenue increase in 2003.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- GenVec, Inc., (GNVC), announced financial results for the fourth quarter and year ended December 31, 2003. For the year ended December 31, 2003, GenVec reported a net loss of $21.3 million or $0.65...

Hepatitis A peptide covalently linked to liposomes.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A hepatitis A peptide has been covalently linked to liposomes. "In this work we have studied the conjugation of the immunogenic peptide sequence (110-121) belonging to the VP3 capsid protein of...

Self-reported hepatitis B vaccination status unreliable among drug users.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Self-reported hepatitis B virus infection and vaccination status among young drug users is unreliable. "Self-reported hepatitis B virus (HBV) infection status and immunization status were compared...

Expression by DNA-transfected DCs occurs through terminal differentiation.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells (DCs) occurs through terminal differentiation. "Dendritic cells play a key role in the induction and...

Hepatitis C virus core protein thwarts effector cytotoxic T-cell differentiation.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus core protein thwarts effector cytotoxic T-cell differentiation. "In a companion study, we showed a dichotomy between the expansion of central memory (CCR7[superscript]+) hepatitis...

World health experts warn that major flu outbreak overdue.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A devastating outbreak of a new flu strain could happen at any time and cause widespread deaths, U.N. health officials told a meeting of global experts bracing for the next pandemic. "For the last...

Rhode Island doctor found guilty of diluting vaccines.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A Cranston, Rhode Island, doctor has been found guilty of product tampering and altering drugs for diluting vaccines he administered to his immigrant patients. A United States federal jury on March...

Geron Corp. inks agreement for therapeutic cancer-vaccine technology.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Geron Corp. (GERN) and Merix Bioscience, Inc., have executed an agreement under which Geron has acquired the exclusive right to use Merix's platform technology in therapeutic cancer vaccines using the...

P. falciparum parasitophorous vacuole membrane protein investigated.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Scientists have performed a functional analysis of Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16) during gametocytogenesis and gametogenesis by targeted gene disruption. ...

Replication kinetics of Chimerivax-DEN in Aedes aegypti determined.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Replication kinetics of the Chimerivax-DEN 1, 2, 3, 4 tetravalent virus mixture in Aedes aegypti were determined using real-time reverse transcriptase-polymerase chain reaction. According to recent...

MHC- and TCR-binding residues of myelin glycoprotein peptide characterized.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Scientists have characterized the MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. "Myelin oligodendrocyte glycoprotein (MOG) is a major experimental...

ACT antibody response low after failed pertussis vaccination.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Adenylate cyclase toxin (ACT) antibody response was low in patients who experienced failed Bordetella pertussis immunization. According to recent research from the United States, "Presence of...

Controversial polio vaccines are safe, Nigerian president says.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Independent tests on controversial polio vaccines used in Nigeria show they are safe, Nigeria's president said March 17, 2004, in a bid to ease Muslim fears the vaccines are contaminated with HIV and...

Bacterial clearance from respiratory tract requires complement component C3.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3. According to a study from the United States, "To assess the contribution of...

Vaccine may cause harmless skin rashes.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- People who have never received a smallpox vaccination may develop any of a variety of benign skin rashes a few days after getting vaccinated for smallpox that should not be confused with a more serious...

Risk of vaccinia transfer after smallpox vaccination low.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- The risk of vaccinia transfer to the hands of vaccinated persons after smallpox immunization is very low if the vaccination site is properly bandaged. According to published research from the United...

New TB vaccine now in Phase I tests.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- A genetically engineered vaccine aimed at preventing tuberculosis was administered to volunteers at St. Louis University, part of a clinical trial that is the first-ever human testing of the vaccine...

GM-CSF immobilized onto particulate vaccine carrier systems.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Researchers have developed a method to immobilize granulocyte-macrophage colony-stimulating factor (GM-CSF) onto particulate vaccine carrier systems. According to recent research published in the...

Vaccination for neurotropic disease recommended in children with brain tumors.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Researchers recommend immunization against vaccine-preventable potentially neurotropic diseases in children treated for malignant brain tumors with HIT-91 chemo- and radiotherapy. According to...

Vaccine improves antibody levels in hematopoietic cell transplant patients.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Recipient vaccination both before and early after hematopoietic cell transplantation increases protective antibody levels. "Allogeneic hematopoietic cell transplantation is followed by humoral...

Vaccine preservative has action similar to methylmercury in neurons.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Thimerosal, a preservative in vaccines, has an effect similar to methylmercury on the intracellular Ca[superscript]2+ concentration of rat cerebellar neurons. "The effect of thimerosal, an...

Vaccinia virus infections treated with ether lipid esters of cidofovir.
April 7, 2004... 2004 APR 7 - (NewsRx.com & NewsRx.net) -- Cowpox and vaccinia virus infections in mice were treated with ether lipid esters of cidofovir. According to recent research from the United States, "Four newly synthesized ether lipid esters of...

German starts clinical development of a new TB vaccine.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- With some 2.5 million deaths and 9 million new cases annually, tuberculosis (TB), along with HIV/AIDS, is responsible for the greatest number of infectious disease victims worldwide. Of particular...

Interfering with virus defense systems may lead to novel vaccines.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Novel vaccines for some viruses may be possible due to research into the way viruses block our bodies' natural defense mechanisms, scientists from the University of St. Andrews announced at the Society...

Mouse model mimics real-world plague infection.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- An experimental plague vaccine proved 100% effective when tested in a new mouse model for plague infection developed by scientists at Rocky Mountain Laboratories (RML), part of the National Institute...

Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer. According to a study from Taiwan, "intravesical immunotherapy with live Mycobacterium bovis bacillus Calmette-Guerin (BCG)...

Breast cancer vaccine well tolerated and safe in clinical trial patients.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Pharmexa announced that data from the first clinical trial in the U.S. with the HER-2 Protein AutoVac vaccine show that the vaccine is well tolerated and safe and that it induces significant HER-2...

Therapeutics company earns milestone payment.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Valentis Inc. (VLTS) has earned a milestone payment from Genencor International, Inc. (GCOR), which resulted from Genencor's initiation of subject dosing in a phase I clinical trial of its DNA-based...

Merix Bioscience announces cancer vaccines agreement.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Merix Bioscience, a Durham, North Carolina-based company pioneering therapeutic cancer vaccines, has signed a joint licensing agreement with California-based Geron Corp. The agreement could propel...

Geospiza Finch Sequencing Center available for DNA sequencing data management.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Wyeth (WYE) has completed the roll-out of Geospiza Finch Sequencing Center Enterprise Edition across its many Discovery sites, helping scientists and researchers at large enterprises like Wyeth manage...

Biotech company reports 2003 net loss of $11.0 million.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Lipid Sciences, Inc., (LIPD) reported results for the fourth quarter and the year ended December 31, 2003. Lipid Sciences is a development-stage biotechnology company engaged in the research and...

AIDS vaccine to be tested on humans.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers for the University of Massachusetts (UMass) Medical School said they will begin human testing of an AIDS vaccine which attacks aggressively the virus that causes the disease. The...

MVA-HPV-IL2 vaccine shows activity in phase II HPV clinical trial.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Transgene (TRGNY) announced encouraging results from the phase II clinical trial of its MVA-HPV-IL2 vaccine candidate in patients with human papilloma virus (HPV)-related disease. "The data we...

Chemokine gene modification of dendritic cells improves antitumor activity.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Chemokine gene modification of dendritic cells improves antitumor activity. "Previous animal studies conducted in our laboratory have shown that tumor antigen-pulsed dendritic cells (TP-DC) can...

Stress blunts response to flu shots.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Even modest stress reduces the effect of flu vaccine, a finding that may shed light on how stress increases vulnerability to infectious diseases, a new study says. Part of the effect was due to the...

Nebraska researcher to study possible nicotine vaccine.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- After years of research, a biochemist at the University of Nebraska Medical Center has been awarded a national grant to study a possible nicotine vaccine. Sam Sanderson, PhD, an associate professor...

Muslim Nigerian state won't join immunization campaign.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- A mainly Muslim state in northern Nigeria says it won't join a nationwide polio immunization campaign because the alternative vaccines it ordered from abroad have not arrived. Kano is the only...

Biotech company and Chinese CDC provide update on vaccine development.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Sinovac Biotech Ltd. (SNVBF) announced that the Center for Disease Control of China and Sinovac are jointly working on the latest key science-technology project of the National "Tenth Five-Year-Plan"...

Health officials urge suspension of vaccine use.
April 14, 2004... 2004 APR 14 - (NewsRx.com & NewsRx.net) -- Health officials are recommending that West Virginia children suspend the use of the third and fourth doses of the vaccine Prevnar because of a shortage of the drug. However, children with...

Needle-free skin patch vaccination method for anthrax developed.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists have developed a needle-free skin patch vaccination method for anthrax. "Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI)...

Efficacy of tuberculosis DNA vaccine varies with method of DNA introduction.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo. "A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium...

Assays with extended incubation phases needed to monitor HIV vaccine trials.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- The first generation of candidate HIV-1 vaccines can induce antibodies able to neutralize primary isolates in assays with extended incubation phases. According to published research from Belgium,...

Fatal human influenza A subtype H5N1 disease re-emerges.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Fatal human influenza A subtype H5N1 disease has re-emerged. According to recent research published in the journal Lancet, "Human disease associated with influenza A subtype H5N1 re-emerged in...

Live sporozoite vaccine under chloroquine therapy protects against malaria.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Protective T cell immunity against malaria liver stage occurred after vaccination with live sporozoites under chloroquine treatment. According to recent research from France and Brazil, "In this...

DtaP vaccine causes hypersensitivity to aluminum in children.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- An aluminum adsorbed diphtheria-tetanus/acellular pertussis (DtaP) vaccine caused persistent hypersensitivity to aluminum in children. According to recent research published in the journal Vaccine,...

Lactic acid bacteria and allergen induce immune response in allergy model.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. According to a study from Austria and France,...

Guardsman who refused anthrax vaccine discharged from Army.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- An Ohio National Guardsman has been discharged from the Army for refusing another order to be vaccinated against anthrax, this time while in Kuwait. Specialist Kurt Hickman, 20, of Granville,...

Issues surrounding the MMR vaccine and autism discussed.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers discuss the issues surrounding the measles-mumps-rubella (MMR) vaccine and autism in a recent issue of the journal Vaccine. According to recent research from the United States, "Media...

Vaccination of infected flocks could backfire without proper surveillance.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Vaccinating chickens may be the only way out of the bird flu nightmare in Asia. But it could also lead to the evolution of new strains, the latest research shows, increasing the risk of a human...

Immunogenicity of recombinant BCG vaccine strains investigated.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the immunogenicity of recombinant BCG vaccine strains overexpressing components of the antigen 85 complex of Mycobacterium tuberculosis. According to a study from...

Exemestane and aromatase inhibitors play role in breast cancer management.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Exemestane and aromatase inhibitors play a role in the management of advanced breast cancer. "In metastatic breast cancer, orally-active, potent, selective third-generation nonsteroidal inhibitors...

Embrex opens biotech plant in Scotland County.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- A plant that will make vaccines for poultry was dedicated March 30, 2004, in Scotland County, [North Carolina,] starting with seven jobs and planning to expand to as many as 40 positions. Embrex...

Exosomes act as potent cell-free peptide-based vaccines.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Exosomes act as potent cell-free peptide-based vaccines. According to a study from an international team of researchers, "Ideal vaccines should be stable, safe, molecularly defined, and...

High efficiency of low-affinity epitopes in cancer therapy reported.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists report the high vaccination efficiency of low-affinity epitopes in antitumor immunotherapy. "Most of the human tumor-associated antigens (TAAs) characterized thus far are derived from...

Natural killer T-like cells induced by thymoma expressing alpha-fetoprotein.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- CD4+ murine natural killer T-like cells were induced by immunization with syngeneic thymoma expressing embryonic alpha-fetoprotein. According to a study from Japan, "In embryo, before the...

Peptide-based vaccines for cancer immunotherapy reviewed.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists review peptide-based vaccines for cancer immunotherapy in a recent issue of Expert Opinion on Biological Therapy. "One approach in the immunotherapy of cancer patients involves...

Bacteria-mediated DNA transfer in gene therapy and vaccination reviewed.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists review bacteria-mediated DNA transfer in gene therapy and vaccination in a recent issue of Expert Opinion on Biological Therapy. According to researchers in Germany, "The use of live...

Methylated CpG-containing plasmid activates immune system.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Methylated CpG-containing plasmid activates the immune system. According to published research from France, "Bacterial DNA differs from mammalian DNA by the presence of unmethylated...

Activation of dendritic cells translates innate into adaptive immunity.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Activation of dendritic cells translates innate into adaptive immunity. "Innate recognition of infection in vertebrates can lead to the induction of adaptive immune responses through activation of...

Danish study finds no link between childhood vaccinations and diabetes.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers have determined there is no link between childhood vaccines and the development of diabetes, the latest study to find no such connection. Using birth and medical registries, Danish...

Biologics company raises financing for working capital.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Microbix Biosystems, Inc., (MBX) announced that it has entered into an agreement to raise $500,000 in the form of an 8% convertible debenture, in a non-arms-length transaction with an existing...

Medical supply distributor reports increase in net loss.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Moore Medical Corp. (MMD), an Internet-enabled multichannel marketer and distributor of medical, surgical, and pharmaceutical products to healthcare practices and facilities in nonhospital settings...

FDA accepts IND for unique HIV vaccine.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- CytRx Corporation (CYTR), Advanced BioScience Laboratories (ABL) and the University of Massachusetts Medical School (UMMS) announced that the HIV vaccine formulation developed by the University of...

AIDS virus is vulnerable in initial stage of infection.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- In individuals newly infected with HIV, the virus that establishes infection is susceptible to inactivation by antibodies from the transmitting partner, according to a recent study by researchers at...

HIV-1 infection blocked via CCR5 and CXCR4 receptors.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- HIV-1 infection was blocked via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. "The identification of chemokine receptors as HIV-1 coreceptors has focused research on...

Signs of cerebral amyloid angiopathy-related inflammation reported.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers report the clinical manifestations of cerebral amyloid angiopathy-related inflammation in a recent issue of the Annals of Neurology. According to published research from the United...

Incomplete tolerance to the tumor-associated antigen MDM2 investigated.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists report the investigations of incomplete tolerance to the tumor-associated antigen MDM2 in a recent issue of International Immunology. "MDM2 is a tumor-associated antigen widely expressed...

New human influenza vaccine research and development project initiated.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Sinovac Biotech Ltd. (SNVBF) has initiated their Inactivated New Human Influenza (H5N1) Vaccine Research and Development Project. Based on the protocol, it is expected to finish pre-clinical...

Universal influenza vaccination in children not yet justified.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Universal influenza vaccination in children is not yet justified. According to recent research published in the journal Lancet Infectious Diseases, "Recent studies have suggested that pediatric...

IL-12 administration suppressed metastatic liver tumor unsusceptible to CTL.
April 21, 2004... 2004 APR 21 - (NewsRx.com & NewsRx.net) -- Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to cytotoxic T lymphocytes (CTL). "A cytokine gene therapy approach was conducted against metastatic lesions...