Vaccine Weekly articles from April 2000

Vaccine Weekly archives from April 2000

MAP Vaccine Tested for Safety and Immunogenicity in Phase I Trial.
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Immediate-type hypersensitivity reactions to a Plasmodium falciparum multi-antigen, CD peptide vaccine were exhibited in adult volunteers participating in a Phase I clinical trial, reported researchers from...

Genetic Vaccination with Self Protein Eradicates Melanoma in a Murine Model.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Genetic vaccination with a self tyrosinase-related protein 2 caused melanoma eradication but not autoimmune aggression, researchers from Italy reported. "'Self' melanocyte differentiation antigens are...

IL-2 Potentiates Immunologic Response of Dendritic-Cell-Based Tumor Vaccines.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Recombinant IL-2 potentiated the immunologic responsiveness of dendritic cell (DC)-based tumor vaccination, reported researchers from the United States. "Dendritic cells can elicit potent immune responses...

Interleukin-2 Enhances Therapeutic Anticancer Vaccines.
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Interleukin (IL)-2 can enhance the therapeutic efficacy of anticancer vaccines, suggested a study from the United States. "The purpose of our efforts is to trigger the immune destruction of established...

Childhood Vaccination Rates Affected by Several Factors.
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- A variety of factors influence childhood vaccination rates, according to a study in a recent issue of Archives of Pediatrics & Adolescent Medicine. "Controlling vaccine-preventable diseases by achieving...

Intranasal Vaccine Safe, Efficacious.
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Researchers from the United States conducted a study to test the efficacy of nasal vaccination of an influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. St. Louis University,...

Vaccine Safe in Renal Transplant Recipients.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Pneumococcal vaccination is safe in renal transplant recipients, according to researchers in Turkey. "Streptococcus pneumoniae, a common pathogen leading to pneumonia, is a cause of morbidity and mortality...

Testing for Specific Immunoglobulin G Antibody in Urine Possible.
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- A new study has determined that rubella-specific immunoglobulin G antibody can be obtained from urine samples. "In Japan, rubella vaccination is generally done once during a lifetime, and the vaccination...

HPV-E5 Protein Targeted by Peptide Vaccine.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- The E5 protein of the human papillomavirus (HPV) is a potential target for a novel prophylactic peptide-based vaccine for cervical cancer, researchers from the United States reported. "There are active...

Synthetic, Microencapsulated Peptide Vaccine Under Development.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Researchers from the United Kingdom have evaluated in mice a novel microencapsulated peptide vaccine against hepatitis B. "A 48-amino-acids-long, synthetic peptide (S121/48) representing residues 121-167...

Cellular Responses to T-Cell Epitopes Evaluated in Cameroon.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Researchers from Cameroon and the United States compared cellular responses to conserved and variant T-cell epitopes with vaccine potential in children and adults in a Cameroon village. "Cellular and...

Phase II Clinical Trial for Oncophage Cancer Vaccine Announced.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Antigenics Inc., New York, New York, announced that the company has initiated a Phase II clinical trial testing Oncophage cancer vaccine in patients with non-Hodgkin's lymphoma, the fifth most common cancer in...

Experts Want to See Improved Rates of Varicella Immunization.(Brief Article)(Statistical Data Included)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Five years after its licensure by the U.S. Food and Drug Administration (FDA), the varicella (chickenpox) vaccine is recommended by all major vaccine policy-making organizations in the U.S., and is required...

Phase I SBIR Grant for MHC Class II Enhanced Cancer Vaccines Announced.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Antigen Express, Inc. (AgExp), Worcester, Massachusetts, announced that it has received a $173,000 Small Business Innovative Research (SBIR) grant from the U.S. National Institutes of Health (NIH) to support...

Alliance Formed To Discover and Develop Therapeutic Monoclonal Antibodies.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Corixa Corp., Seattle, Washington, announced a collaboration with Abgenix, Inc. to discover and develop human monoclonal antibodies against selected targets from Corixa's library of proprietary autoimmune...

New Vaccines Expected to Bolster Adult Immunization Sales.(Brief Article)(Statistical Data Included)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- The U.S. market for vaccines totaled $2.0 billion in 1999, growing 8.6% annually from 1994, according to a recent study published by Kalorama Information, a publisher of market research. Sales are expected...

Valproate and Hepatitis C Virus Lead to Fatality.(Brief Article)
April 5, 2000... 2000 APR 5 - (NewsRx.com) -- Valproate therapy is used to treat seizure disorders. Researchers at the American University of Beirut report that a young child died while taking this therapy when he acquired hepatitis A from his sister. ...

Vaccine Candidates Identified by Expression Library Immunization.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Expression library immunization can be used to identify individual vaccine candidates, reported researchers from the United States. "Expression library immunization was used to directly identify...

Therapy Combines Transduced Interleukin-12 Cells with Systemic Interleukin-18.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Researchers from Japan have evaluated a cancer therapy combining the transduction of cells with interleukin-12 given as a vaccine with systemic interleukin-18 administration. "We introduced the...

Vaccine May Make Booster.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- The widely used chickenpox vaccine seems to reactivate itself when an individual's immunity lessens, possibly creating its own booster mechanism, researchers have discovered. The vaccine, called Oka, was...

Results of Vaccines Studied in vitro Don't Always Reflect in vivo Responses.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- In vitro analysis of Vibrio cholerae vaccines does not always correlate with in vivo responses, suggested research from the United States. "The optimal promoter for in vivo expression of heterologous...

Immune System Cell Has Potent Ability to Fight HIV.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Duke University Medical Center researchers have discovered a potent ability of specific immune system cells to fight against HIV. Scientists have long known that immune system cells known as "killer CD8"...

Efficacy of Protein Vaccine Explored in Monkeys.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- The vaccine efficacy of recombinant Plasmodium falciparum merozoite surface protein 1 was evaluated in an animal study. "Protection against a lethal challenge infection of Plasmodium falciparum was...

Effects of Paternal Lymphocyte Immunization Evaluated in Patients.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- The effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR V beta and V gamma repertoire were evaluated in patients with recurrent spontaneous abortions. "The mechanism of...

BCG-Vaccinated Children Develop Reactivity and Sensitization to Other Mycobacteria.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Children who were vaccinated with bacille Calmette-Guerin at birth develop tuberculin reactivity and sensitization to Mycobacterium scrofulaceum and M. fortuitum, researchers from Finland report. "Since...

Synthetic Peptide Immunogens Elicit Polyclonal and Monoclonal Antibodies.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- According to a study from Canada, synthetic peptide immunogens can elicit polyclonal and monoclonal antibodies (MAbs) specific for epitopes made up of amino acids necessary for fibronectin binding. "A...

Modified Dendritic Cell Vaccine Effective in Murine Model.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Dendritic cells (DCs) modified by targeted adenoviral vectors acted as an effective vaccine in a murine model of human cervical cancer, reported researchers from the United States. "Increasingly, DC are...

Development of Potential Preventive Vaccine Pursued.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- The Immune Response Corp. (IMNR), Carlsbad, California, announced data from preclinical animal studies of a potential new vaccine consisting of the company's HIV immunogen, Remune (whole-killed HIV depleted...

Low Immunization Rate Among Health Care Workers Associated with Outbreak.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- In a recent study concerning influenza outbreak in a hospital setting, researchers reported that close to half of health care workers did not want to be vaccinated and this may have been a contributing factor...

Microspheres Used for Fast-Enhanced Immunogenicity.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Antigens presented by microspheres evoked higher immune responses in vivo than did free antigen in a recent study. "The purpose of this study was to compare the immune responses of mice to intranasal...

Salmonella typhi Is a Delivery Vehicle for Helicobacter pylori Antigens.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Salmonella typhi is a novel delivery vehicle for Helicobacter pylori antigens, reported researchers from the United Kingdom. "Attenuated Salmonella typhi (deltaaro and deltahtrA) have been shown by...

E. coli Toxin to Enter Clinical Trials.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Select Therapeutics (SLPU), a Cambridge, Massachusetts-based biotechnology company developing cancer therapies, announced it has completed financial arrangements enabling it to move forward into clinical...

Alliance Expanded to Grant Access to MPL Adjuvant Formulation.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Corixa Corp. (CRXA), Seattle, Washington, and Wyeth Lederle Vaccines, Radnor, Pennsylvania, a business unit of American Home Products Corp. (AHP), announced the companies have expanded Wyeth Lederle's access...

Alliance Plans to Develop Human Papillomavirus Vaccine.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Schering AG, Berlin, Germany, and MediGene AG, Munich, Germany, announced the formation of a world-wide strategic alliance to develop and commercialize MediGene's Viral Vaccine for the treatment of...

Multi-Center Autologous Therapeutic Cancer Vaccine Trial.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Avax Technologies, Inc. (AVXT), Kansas City, Missouri, announced that it has initiated a multi-center Phase II study of M-Vax, an autologous therapeutic cancer vaccine, in patients with Stage IV melanoma who...

Passive and Active Immunoprophylaxis Pursued for Hepatitis Prevention.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- The U.S. National Institutes of Health Hepatitis Viruses Section (HVS) is working on a number of vaccines for the prevention of hepatitis A, B, C, and E. Among its projects, HVS has developed candidate...

Immunodepletion of Antibodies Increases Adenovirus Efficiency.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- Passive immunization with adenovirus (Ad) antibody-depleted serum increases transduction efficiency of Ad vector in a murine model, reported researchers from the United States. "Ad vectors are capable of...

Tuberculosis Foundation Selects Core Research Scientists.(Brief Article)(Statistical Data Included)
April 12, 2000... 2000 APR 12 - (NewsRx.com) -- In an initial step towards the development of a new vaccine to prevent tuberculosis (TB), the Sequella Global Tuberculosis Foundation has named 13 researchers to the Core Scientist Program of its Tuberculosis...

Targeted Polymerized Liposomes Evaluated For Mucosal Delivery.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Targeted polymerized liposomes may be the oral vaccine delivery method of the future, suggested researchers from the United States. "A variety of micro- and nano-particulate systems have been proposed as...

Engrafting Costimulator Molecules Is Alternative to Transfection.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- The engraftment of costimulator molecules onto tumor cell surfaces with chelator lipids is an alternative to gene transfection for cancer vaccines, researchers from Australia reported. "The genetic...

Human Anti-Idiotypic Antibody Evaluated as Treatment.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Researchers from England evaluated the human anti-idiotypic antibody, 105AD7, in a clinical trial of colon cancer. "Thirty-five patients received 105AD7 human anti-idiotype vaccination prior to surgery...

Neonatal Immune Responses are Similar to Conventional Vaccines.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- According to a study from the United States, neonatal immune responses to DNA vaccines are similar to responses induced by conventional vaccines. "Virus infections are devastating to neonates, and the...

Oncogene Breakpoint Fusion Peptide Vaccine Generates Specific Responses.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Vaccination with bcr-abl oncogene breakpoint fusion peptides generated specific immune responses in patients with chronic myelogenous leukemia, reported a study from the United States. "Chronic...

Costimulatory Molecules Important for Post-Vaccination Protective Immunity.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Protective antiviral immunity after peptide vaccination requires 4-1BB costimulation, according to a recent report. "Peptide vaccination induces T-cell activation and cytotoxic T-cell development," wrote...

Maturation and Trafficking of Monocyte-Derived Dendritic Cells Explored.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Understanding of the maturation and trafficking of monocyte-derived dendritic cells (DC) is necessary to develop DC-based vaccines, suggested researchers from the United States. "Human dendritic cells...

Modified Gag Gene May Be a Better Delivery System.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Researchers at the Chiron Corporation may have identified a way to modify the Gag gene so that it could serve as a vehicle for gene vaccine delivery in HIV infected patients, according to a report of a study...

Vaccine in Mouse Model Improves Relapse-Free Survival.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Avax Technologies, Inc., announced the presentation of pre-clinical data on its AC Vaccine technology, an autologous cell cancer vaccine, at the 91st Annual Meeting of the American Association for Cancer...

Infection Does Not Alter Vaccine Effectiveness.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Current human papillomavirus (HPV) infection should not alter the effectiveness of HPV vaccines, suggested researchers from the United States. "Current therapeutic vaccine strategies for HPV-induced...

Vaccine May Help Prevent Associated Cancers.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Vaccination-acquired cell mediated immunity (CMI) may help prevent and treat human papillomavirus (HPV)-associated cancers, researchers from the United States reported. "Although most immunoprophylactic...

Hospital Sets Benchmark for Staff Flu Shots.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- As a result of an Ontario hospital's efforts to increase staff influenza vaccinations, a benchmark 84% response rate was achieved. Because flu vaccines among health care workers not only protect patients...

Vaccination Rates Increase for U.S. Health Care Workers.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Researchers from the U.S. Centers for Disease Control and Prevention in Atlanta, Georgia, recently conducted a study on the trends of influenza vaccination (IV) among health care workers (HCWs). F.J....

Clinical Data on Cancer Vaccine Presented.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Antigenics Inc. (AGEN), New York, New York, announced the release of data from a Phase I/II melanoma clinical trial of the company's cancer vaccine, Oncophage. Dr. Omar Eton, M.D. Anderson Cancer Center...

Vaccine Induces T-Cell Mediated Immune Reactions.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Avax Technologies, Inc., announced at the 91st annual meeting of the American Association for Cancer Research (AACR), that M-Vax, a cancer vaccine made from the patient's own tumor cells, induces T-cell...

Microsphere-Entrapped Antigens May Be Viable Delivery System.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Antigens entrapped in microspheres have potential as an oral vaccine delivery system, researchers from the United Kingdom suggested. "Entrapment of subunit antigens in biodegradable microspheres for oral...

Organization Emphasizes There's No Scientific Link to Immunization.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- The following statement was issued by the organization, Parents of Kids with Infectious Diseases: [helv] The national [U.S.] parent advocacy organization, PKIDs (Parents of Kids with Infectious Diseases),...

Novel Antibody Reported for Vaccine Delivery.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Immunomedics, Inc. (IMMU) announced that its scientists reported progress in cancer vaccine development at the 91st Annual Meeting of the American Association for Cancer Research, held in San Francisco,...

Progress in Gene Therapy Announced.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Genetronics Biomedical Limited (GEB; Toronto), San Diego, California, reported results of the extension of its platform technology, electroporation, into gene therapy. The company announced the signing of...

DNA Vaccine Introduced To Treat Melanoma in Animals.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- Bioject Medical Technologies Inc. (BJCT), Portland, Oregon, and the Animal Medical Center, New York, New York, announced the introduction of a DNA-based vaccine treatment for melanoma in animals. Previous...

Pneumococcal Vaccine Becomes Available.(Brief Article)(Statistical Data Included)
April 19, 2000... 2000 APR 19 - (NewsRx.com) -- The U.S. Food and Drug Administration's recent approval of a new vaccine developed specifically for infants and toddlers is expected to have a significant impact in the number of cases of pneumococcal...