Vaccine Weekly articles from April 1999

Vaccine Weekly archives from April 1999

IOM Announces Priorities for New Vaccines.
April 12, 1999... There are several surprises among the seven vaccines ranked as the highest priorities for development in the United States by the U.S. Institute of Medicine (IOM). Included at the top of the wish list are therapeutic vaccines for diabetes,...

AIDSVax Phase III Trials: Results Some 3 Years Away.
April 12, 1999... It's easy to overinterpret the large-scale efficacy trials of the VaxGen HIV vaccine (AIDSVax) that recently began with great media fanfare. Politicians point to the trial as an example of Something Being Done. Proponents of traditional...

Antibodies Bad For AIDS Vaccine?
April 12, 1999... Monkey studies suggest that prime/boost HIV vaccines may actually be harmful. The most successful candidate HIV vaccine approaches at eliciting anti-HIV antibodies use the so-called prime/boost technique. This approach begins with one or...

Hepatitis B Vaccine Adverse Events: Reporting Artifact?
April 12, 1999... The extraordinary reliability of health-care workers may be a problem for hepatitis B (HB) vaccine safety studies. Preliminary data from a U.S. Centers for Disease Control and Prevention (CDC) study show that adults report adverse events...

Strong Promoter Needed for Humoral, Not T-Cell Response.
April 12, 1999... A strong promoter is sometimes good, sometimes irrelevant. Developers of DNA vaccines generally want to increase expression of antigenic genes by linking them to strong promoter sequences. In the test tube, this seems best for all vaccines,...

Combined Flu/HBV Vaccine Effective in Alaskan Study.
April 12, 1999... A combined influenza/hepatitis B virus vaccine given to infants at 2, 4, and 12-15 months appeared to be effective in an Alaskan study. The U.S. Centers for Disease Control and Prevention's (CDC's) Artic Investigations Program examined the...

Experience with HBV Vaccine in Israel is Positive.
April 12, 1999... A report from Israel offers further evidence that routine immunization of infants against hepatitis B is both efficacious and cost effective. The report found, however, that the targeted screening of high-risk populations is not...

Multisubunit Vaccine: Wave of the Future?
April 12, 1999... Multisubunit immunization may be the wave of the future for tuberculosis vaccines. The development of more effective antituberculosis vaccines would assist in the control of the global problem of infection with Mycobacterium tuberculosis....

Findings May Help in Developing Better Serologic Diagnostic Assays.
April 12, 1999... Only some virulence factors may be expressed and/or immunogenic during Yersinia pestis infection, researchers suggested. The available information concerning the nature and extent of the immune response to the virulence determinants of...

Scientists Prepare Defense Against Germ Warfare.
April 12, 1999... More than 350 scientists from around the world gathered for the 2nd Annual Conference on Vaccine Research in Bethesda, Maryland, during March 1999, to address major issues in vaccination. Topics ranged from vaccines against major global...

Vaccines May Provide Treatment Option for Cancer.
April 12, 1999... Vaccines traditionally have been designed to generate immune responses that have a protective effect against specific infections. In the future, however, researchers believe vaccine use will expand from disease prevention to include...

Australia Ready for Human Vaccine Trials.
April 12, 1999... Human trials of Australian HIV vaccines could begin within months and eventually include thousands of people in Southeast Asia, researchers said. Trials of the vaccines, which have already protected monkeys against HIV when exposed to the...

First Trial of HIV Vaccine Begins in Thailand.
April 12, 1999... Clinical trials of an HIV vaccine began in Thailand with six volunteers receiving the first of seven shots they will get over the next year. The six volunteers, all intravenous drug users, were the first of 2,500 people in the country to...

Researchers Find Way To Immunize Against Fatal Bacterium.
April 12, 1999... Collaborating researchers from the Medical College of Wisconsin and the University of California at San Francisco have developed an alternative to antibiotics in the fight against a virulent class of microbes that continue to kill hundreds of...

Immune Reponse Seen with Intranasal Virus Vaccine.
April 12, 1999... Another needleless route for immunization is being explored for childhood respiratory illnesses. The second most common cause of croup, bronchiolitis, and pneumonia in infants, after respiratory syncytial virus (RSV), is parainfluenza...

Findings Challenge Notion of Withholding Food To Fight Virus.
April 12, 1999... Malnutrition slows recovery from rotaviral infection, scientists said. Their research, which challenges the long-accepted approach of withholding food to rest the bowels of infants and animals infected with the virus, documents what...

No-Needle Vaccination May Be Possible with Transcutaneous Immunization.
April 12, 1999... With a few notable exceptions, such as the oral polio vaccine, most vaccines are given by injection. One potential route of administration is transcutaneous immunization, in which an antigen and an adjuvant are applied to the skin surface....

The Design and Synthesis of Novel Saponin Analogs as Potential Cancer Vaccine Adjuvants and Their Evaluation In an In Vivo Murine Model.
April 12, 1999... Cancer Vaccines "The Design and Synthesis of Novel Saponin Analogs as Potential Cancer Vaccine Adjuvants and Their Evaluation In an In Vivo Murine Model." R.D. May, R.C. Reynolds, A.K. Pathak, L.E. Gundy, Y.Y. Maxuitenko, L.A. Kraus, M.S....

Immunologic Effects of Granulocyte Macrophage-Colony Stimulating Factor Transfected Autologous Tumor Cell Vaccines in Melanoma.
April 12, 1999... Cancer Vaccines "Immunologic Effects of Granulocyte Macrophage-Colony Stimulating Factor Transfected Autologous Tumor Cell Vaccines in Melanoma." G.S. Hogge, R.R. Dubielzig, M.R. Albertini, N.-S. Sun and E.G. MacEwen. University of...

Tumor Vaccines Containing Reconstituted Tumor Membranes.
April 12, 1999... Cancer Vaccines "Tumor Vaccines Containing Reconstituted Tumor Membranes." Peter E. Jensen. Emory University, Atlanta, Georgia. NIH GRANT NUMBER: IR55CA72474-01A1. GRANT EXPIRES: September 14, 1999. PRINCIPLE INVESTIGATOR: Peter E....

WT1: A New Leukemia and Cancer Antigen.
April 12, 1999... Cancer Vaccines "WT1: A New Leukemia and Cancer Antigen." A. Gaiger, V. Reese, P. Sleath, M.L. Disis and M.A. Cheever. Corixa Corp, Seattle; University of Washington, Seattle; University of Vienna. According to an abstract submitted by...

Immunotherapy of Myasthenia Gravis.
April 12, 1999... Myasthenia Gravis (Immunotherapy) "Immunotherapy of Myasthenia Gravis." James E. Blalock. University of Alabama at Birmingham, Birmingham, Alabama. NIH GRANT NUMBER: 5R01AI37670-02. GRANT EXPIRES: March 31, 2002. PRINCIPLE...

Chronic Stress in Elderly Carers of Dementia Patients and Antibody Response to Influenza Vaccination.
April 12, 1999... Influenza Vedhara, K.; Cox, N.K.M.; Wilcock, G.K.; Perks, P.; Hunt, M.; Anderson, S.; Lightman, S.L.; Shanks, N.M. "Chronic Stress in Elderly Carers of Dementia Patients and Antibody Response to Influenza Vaccination." Lancet, February 20,...

Effectiveness of Influenza Vaccine in Health Care Professionals - A Randomized Trial.
April 12, 1999... Influenza Wilde, J.A.; Mcmillan, J.A.; Serwint, J.; Butta, J.; Oriordan, M.A.; Steinhoff, M.C. "Effectiveness of Influenza Vaccine in Health Care Professionals - A Randomized Trial." JAMA - Journal of the American Medical Association,...

First Rotavirus Vaccine Licensed: Is There Really a Need?
April 12, 1999... Rotavirus Glass, R.I.; Bresee, J.S.; Parashar, U.D.; Holman, R.C.; Gentsch, J.R. "First Rotavirus Vaccine Licensed: Is There Really a Need?" Acta Paediatrica, January 1999;88(Suppl. 42):2-8. According to the authors' abstract of an...

Heterologous Protein Secretion in Lactococcus lactis: A Novel Antigen Delivery System.
April 12, 1999... Vaccine Delivery Langella, P.; Leloir, Y. "Heterologous Protein Secretion in Lactococcus lactis: A Novel Antigen Delivery System." Brazilian Journal of Medical and Biological Research, February 1999;32(2):191-198. According to the...

Pathogenicity Island 2 Mutants of Salmonella typhimurium Are Efficient Carriers for Heterologous Antigens and Enable Modulation of Immune Responses.
April 12, 1999... Vaccine Delivery Medina, E.; Paglia, P.; Nikolaus, T.; Muller, A.; Hensel, M.; Guzman, C.A. "Pathogenicity Island 2 Mutants of Salmonella typhimurium Are Efficient Carriers for Heterologous Antigens and Enable Modulation of Immune...

Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins as Antigens and Adjuvants.
April 12, 1999... Vaccine Delivery Glenn, G.M.; Schartonkersten, T.; Vassell, R.; Matyas, G.R.; Alving, C.R. "Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins as Antigens and Adjuvants." Infection and Immunity, March...

Nobel Laureate Foresees CMI Vaccines.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Vaccines that elicit cell mediated immunity (CMI) are on the way, predicted 1996 Nobel Prize winner Peter C. Doherty. Doherty and colleague Rolf M. Zinkernagel jointly won medicine's top honor...

Sequence-Reactive Antibodies Induced by HVR1 HCV.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cross-reactive antibodies to the hypervariable region 1 of hepatitis C virus are inducible by a single peptide immunization. Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) is known to...

Flu Vaccine May Protect Children from Asthma.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Influenza vaccination may protect children against asthma, suggest intriguing data from the U.S. Centers for Disease Control and Prevention (CDC). It is suspected that some 85 percent of asthma...

1999 State of the AIDS Vaccine: Good, Not Great.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Progress toward an AIDS vaccine has been good, but not very good. That's the assessment of Margaret I. "Peggy" Johnston, and she should know: now assistant director for AIDS vaccines at the...

Hepatitis E Vaccine Safe, Immunogenic in Phase I Test.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A relatively simple hepatitis E vaccine has sailed through a Phase I clinical trial with flying colors. Hepatitis E virus (HEV) is a small, positive-stranded RNA virus. Endemic in Asia, Africa,...

UNAIDS Descries "AIDS Exceptionalism".
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Is AIDS the exception to established norms of vaccine-development? No, says Jose Esparza of the Joint United Nations Program on HIV/AIDS (UNAIDS). He suggested that the development of an HIV...

March 29/April 5, 1999 Issue.(Correction Notice)
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The story "Close Call with Killer Flu in '97," which ran in the March 29/April 5, 1999 issue of this newsletter, contained an error. Due to a mistyped word, one paragraph incorrectly suggested...

Vaccine Might Work Against Peanut Allergy.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers said they had taken the first step toward making a vaccine against peanut allergy, the most common cause of death from food allergies. They said they used DNA from peanuts to help...

Orphan Drug Status Received for M-Vax Vaccine.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Avax Technologies, Inc., Kanasas City, Missouri, announced that its investigational proprietary Autologous Cell (AC) vaccine for the treatment of Stage 3 melanoma, known as M-Vax, received Orphan...

Legislation Introduced To Fight Infectious Disease on World TB Day.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- California Representative Nancy Pelosi introduced the Lifesaving Vaccine Technology Act, legislation that would provide a tax credit for research and development on vaccines for the world's most...

Interim Phase I Trial Results Released for Vaccine Adjuvant.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Corixa Corp., Seattle, Washington, announced that its proprietary vaccine adjuvant, Leishmania elongation Initiation Factor (LeIF) has been used in humans to increase the efficacy of a T-cell vaccine...

Second Multicenter GVAX Phase I/II Trial Initiated.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cell Genesys, Inc., Foster City, California, announced that it has initiated a second multicenter, Phase I/II clinical trial of GVAX cancer vaccine for prostate cancer in approximately 40 patients...

Data Supporting Malaria and Hepatitis Vaccine Development Reported.
April 19, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Epimmune Inc., San Diego, California, announced that it has published data concerning its approach to vaccine development in three journals. The data were reported in Vaccine (Franke et al., "Pan...

The Design and Synthesis of Novel Saponin Analogs as Potential Cancer Vaccine Adjuvants and Their Evaluation In an In Vivo Murine Model.
April 19, 1999... Cancer Vaccines "The Design and Synthesis of Novel Saponin Analogs as Potential Cancer Vaccine Adjuvants and Their Evaluation In an In Vivo Murine Model." R.D. May, R.C. Reynolds, A.K. Pathak, L.E. Gundy, Y.Y. Maxuitenko, L.A. Kraus, M.S....

Immunologic Effects of Granulocyte Macrophage-Colony Stimulating Factor Transfected Autologous Tumor Cell Vaccines in Melanoma.
April 19, 1999... Cancer Vaccines "Immunologic Effects of Granulocyte Macrophage-Colony Stimulating Factor Transfected Autologous Tumor Cell Vaccines in Melanoma." G.S. Hogge, R.R. Dubielzig, M.R. Albertini, N.-S. Sun and E.G. MacEwen. University of...

Tumor Vaccines Containing Reconstituted Tumor Membranes.
April 19, 1999... Cancer Vaccines "Tumor Vaccines Containing Reconstituted Tumor Membranes." Peter E. Jensen. Emory University, Atlanta, Georgia. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: IR55CA72474-01A1. GRANT EXPIRES: September...

WT1: A New Leukemia and Cancer Antigen.
April 19, 1999... Cancer Vaccines "WT1: A New Leukemia and Cancer Antigen." A. Gaiger, V. Reese, P. Sleath, M.L. Disis and M.A. Cheever. Corixa Corp, Seattle; University of Washington, Seattle; University of Vienna. (CW HENDERSON PUBLISHER...

Immunotherapy of Myasthenia Gravis.
April 19, 1999... Myasthenia Gravis (Immunotherapy) "Immunotherapy of Myasthenia Gravis." James E. Blalock. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 5R01AI37670-02. GRANT...

Chronic Stress in Elderly Carers of Dementia Patients and Antibody Response to Influenza Vaccination.
April 19, 1999... Influenza Vedhara, K.; Cox, N.K.M.; Wilcock, G.K.; Perks, P.; Hunt, M.; Anderson, S.; Lightman, S.L.; Shanks, N.M. "Chronic Stress in Elderly Carers of Dementia Patients and Antibody Response to Influenza Vaccination." Lancet, February 20,...

Effectiveness of Influenza Vaccine in Health Care Professionals - A Randomized Trial.
April 19, 1999... Influenza Wilde, J.A.; Mcmillan, J.A.; Serwint, J.; Butta, J.; Oriordan, M.A.; Steinhoff, M.C. "Effectiveness of Influenza Vaccine in Health Care Professionals - A Randomized Trial." JAMA - Journal of the American Medical Association,...

First Rotavirus Vaccine Licensed: Is There Really a Need?
April 19, 1999... Rotavirus Glass, R.I.; Bresee, J.S.; Parashar, U.D.; Holman, R.C.; Gentsch, J.R. "First Rotavirus Vaccine Licensed: Is There Really a Need?" Acta Paediatrica, January 1999;88(Suppl. 42):2-8. (CW HENDERSON PUBLISHER www.newsfile.com) --...

Heterologous Protein Secretion in Lactococcus lactis: A Novel Antigen Delivery System.
April 19, 1999... Vaccine Delivery Langella, P.; Leloir, Y. "Heterologous Protein Secretion in Lactococcus lactis: A Novel Antigen Delivery System." Brazilian Journal of Medical and Biological Research, February 1999;32(2):191-198. (CW HENDERSON...

Pathogenicity Island 2 Mutants of Salmonella typhimurium Are Efficient Carriers for Heterologous Antigens and Enable Modulation of Immune Responses.
April 19, 1999... Vaccine Delivery Medina, E.; Paglia, P.; Nikolaus, T.; Muller, A.; Hensel, M.; Guzman, C.A. "Pathogenicity Island 2 Mutants of Salmonella typhimurium Are Efficient Carriers for Heterologous Antigens and Enable Modulation of Immune...

Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins as Antigens and Adjuvants.
April 19, 1999... Vaccine Delivery Glenn, G.M.; Schartonkersten, T.; Vassell, R.; Matyas, G.R.; Alving, C.R. "Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins as Antigens and Adjuvants." Infection and Immunity, March...

Window of Opportunity for Malaria Vaccine.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A rare and fleeting alignment of political, economic, and scientific interests creates the opportunity to for a malaria vaccine. Recent breakthroughs suggest that a vaccine to protect travelers...

New Vaccine Strategy Pins Antigens To T-Cell Receptors.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A novel vaccine bends the ears of T cells and forces them to listen to the message it carries. The ears of the T cell are the T-cell receptor (TCR), the major histocompatibility complex class II...

Technique Takes Toxicity Out of Toxins.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A novel technique creates nontoxic toxins for use in vaccines. Antibodies to toxins are thought to protect against disease. Whole toxins are far more immunogenic than toxin subunits. But...

Transcutaneous Immunization Advances in Animal Studies.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An immunogenic cream may replace needles for administration of many vaccines. The technique is called transcutaneous immunization or TCI. It uses bacterial ADP-ribosylating exotoxins (bAREs) to...

New Killer Brain Virus Erupts in Malaysia, Singapore.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A previously unknown virus is killing people in Malaysia and Singapore, the U.S. Centers for Disease Control and Prevention (CDC) reports. As of April 4, 1999, there had been 112 deaths. The...

Virus-Modified Tumor Cells Make Safe Cancer Vaccine.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Newcastle disease virus provides a safe and efficient way to produce cancer vaccines. The production of tumor vaccines in human gene therapy is often limited by unsafe and inefficient vectors. A...

TB Vaccination Versus Prophylaxis Assessed.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Tuberculosis vaccination could prevent more active disease than preventive therapy in endemic areas with high anergy if the effectiveness of the vaccine is close to 90 percent, according to a...

Two Dose HBV Vaccine Shown to be Effective.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A new recombinant DNA hepatitis B vaccine was found to give protection after just two doses. Researcher P. Abraham and colleagues assessed the efficacy and safety of Shanvac-B, a new recombinant...

DNA Vaccination Yields Potent Transmission-Blocking Antibodies.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- DNA vaccination can result in potent transmission-blocking antibodies in mice, researchers indicated. Recent study findings also suggest that the Pfs25 gene should be included as part of a...

Ends-In Strategy May Be Applicable to Modify Plasmodial Genes.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An ends-in strategy may be widely applicable to modify plasmodial genes and to perform structure-function product analyses. The recent advent of gene-targeting techniques in malaria (Plasmodium)...

Vaccine Raises HDL, Reduces Atherosclerosis in Animals.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A novel vaccine approach shows promise for raising high density lipoprotein (HDL) or "good" cholesterol levels, and preventing atherosclerosis, according to preclinical research presented by...

HIV-VAC, Inc., Acquires Worldwide Rights to Vaccine.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- HIV-VAC, Inc., Collingwood, Ontario, Canada, has announced that it has acquired the worldwide rights to an HIV vaccine through an assignment of license agreement with Intracell Vaccines Limited. ...

Vaccine Proves Successful for Patients with Disease Spread to Two Lymph Node Areas.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A custom-made vaccine created from a patient's own cancer tumor cells appears effective in prolonging the survival of patients with malignant melanoma, the deadliest form of the skin cancer, spread...

GMK Vaccine Mechanism of Action Described.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Progenics Pharmaceuticals, Inc., presented new data on the mechanism of action of its proprietary GMK cancer vaccine in a poster session at the 90th annual meeting of the American Association for...

Trial Results of Cancer Vaccine Reported.
April 26, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cell Genesys, Inc., reported additional clinical data from the company's initial Phase I/II trial of GVAX prostate cancer vaccine consistent with previously reported interim results demonstrating...

Engerix B Vaccination in Children with Malignant Diseases.
April 26, 1999... Hepatitis Vaccination "Engerix B Vaccination in Children with Malignant Diseases." E. Zhukovskava, V. Gerein, N. Rusanova and E. Basharova. Zlialubina Medical Academy of Chelyabinsk, Russia; Kinderklinik of KKH Gummersbach, Germany ...

Recombinant Tumor Vaccine - CATBRM.
April 26, 1999... Cancer Vaccines "Recombinant Tumor Vaccine - CATBRM." Albert F. Lobuglio. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- GRANT NUMBER: 5U01CA61397-06. GRANT EXPIRES: July 31,...

Development of a Malaria Transmission Blocking Vaccine.
April 26, 1999... Malaria Vaccines "Development of a Malaria Transmission Blocking Vaccine." Nirbhay Kumar. Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218. (CW HENDERSON PUBLISHER www.newsfile.com) -- GRANT NUMBER:...

Induction of Specific CD8(+) T-Lymphocyte Responses Using a Human Papillomavirus-16 E6/E7 Fusion Protein and Autologous Dendritic Cells.
April 26, 1999... Cancer Vaccines Murakami, M.; Gurski, K.J.; Marincola, F.M.; Ackland, J.; Steller, M.A. "Induction of Specific CD8(+) T-Lymphocyte Responses Using a Human Papillomavirus-16 E6/E7 Fusion Protein and Autologous Dendritic Cells." Cancer...

Phase II Prostate Cancer Vaccine Trial: Report of a Study Involving 37 Patients With Disease Recurrence Following Primary Treatment.
April 26, 1999... Cancer Vaccines Murphy, G.P.; Tjoa, B.A.; Simmons, S.J.; Ragde, H.; Rogers, M.; Elgamal, A.; Kenny, G.M.; Troychak, M.J.; Salgaller, M.L.; Boynton, A.L. "Phase II Prostate Cancer Vaccine Trial: Report of a Study Involving 37 Patients With...

Induction of Protective Immunity Against Dengue Virus Type 2: Comparison of Candidate Live Attenuated and Recombinant Vaccines.
April 26, 1999... Dengue Virus Velzing, J.; Groen, J.; Drouet, M.T.; Vanamerongen, G.; Copra, C.; Osterhaus, A.D.M.E.; Deubel, V. "Induction of Protective Immunity Against Dengue Virus Type 2: Comparison of Candidate Live Attenuated and Recombinant...

Protection of Macaques Against Intrarectal Infection by a Combination Immunization Regimen With Recombinant Simian Immunodeficiency Virus SIVmne gp160 Vaccines.
April 26, 1999... HIV Vaccines Polacino, P.; Stallard, V.; Montefiori, D.C.; Brown, C.R.; Richardson, B.A.; Morton, W.R.; Benveniste, R.E.; Hu, S.L. "Protection of Macaques Against Intrarectal Infection by a Combination Immunization Regimen With Recombinant...

Safety and Immunogenicity of Combined Diphtheria Tetanus Pertussis (Whole Cell and Acellular) Haemophilus influenzae b Conjugate Vaccines Administered to Indonesian Children.
April 26, 1999... Haemophilus influenzae Richie, E.; Punjabi, N.H.; Harjanto, S.J.; Wangsasaputral, F.; Sukandar, M.; Supriatman, M.; Simanjuntak, C.H.; Que, J.U.; Cryz, S.J. "Safety and Immunogenicity of Combined Diphtheria Tetanus Pertussis (Whole Cell...

A Novel Influenza Subunit Vaccine Composed of Liposome-Encapsulated Haemagglutinin/Neuraminidase and IL-2 or GM-CSF. I. Vaccine Characterization and Efficacy Studies in Mice.
April 26, 1999... Influenza Babai, I.; Samira, S.; Barenholz, Y.; Zakayrones, Z.; Kedar, E. "A Novel Influenza Subunit Vaccine Composed of Liposome-Encapsulated Haemagglutinin/Neuraminidase and IL-2 or GM-CSF. I. Vaccine Characterization and Efficacy...

Human Antibody Responses to Mature and Immature Forms of Viral Envelope in Respiratory Syncytial Virus infection: Significance for Subunit Vaccines.
April 26, 1999... Respiratory Syncytial Virus Sakurai, H.; Williamson, R.A.; Crowe, J.E.; Beeler, J.A.; Poignard, P.; Bastidas, R.B.; Chanock, R.M.; Burton, D.R. "Human Antibody Responses to Mature and Immature Forms of Viral Envelope in Respiratory...