Vaccine Weekly articles from April 1998

Vaccine Weekly archives from April 1998

Protective Mucosal Immunity From PCLUS HIV Vaccine.
April 27, 1998... An improved peptide-cluster HIV vaccine protected against rectal challenge in a mouse model of HIV infection. The protection was the first demonstration that local administration of an artificial peptide-based vaccine elicited long-lasting, HIV...

HIV DNA Vaccine Safe in Humans, Protective in Monkeys.
April 27, 1998... An experimental HIV DNA vaccine protected nonhuman primates against challenge with a chimeric simian/human immunodeficiency virus (SHIV). Combined with mounting safety data from preliminary human clinical trials, the new findings propel DNA...

Unprecedented Protection with Prime/Boost Malaria Vaccine.
April 27, 1998... An effective malaria vaccine - possibly capable of treating as well as preventing disease - may be closer to reality than previously thought possible. Mice primed with a malarial DNA vaccine and boosted with recombinant, live, attenuated...

Quantity of Latent Virus Correlates with Reactivation.
April 27, 1998... The quantity of latent virus DNA correlates with - and may be an important determinant of - the site-specific patterns and rates of reactivation of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). HSV-1 and HSV-2 have well-characterized...

DNA TB Vaccination Shows Promise.
April 27, 1998... DNA tuberculosis vaccination offers promise for inducing immunity against tuberculosis, according to a new report. Researcher Oliver Denis and colleagues found that fundamental differences exist in the immune response sensitization that occurs...

HSV-Specific T Cells Contribute to Vaginal Immunity.
April 27, 1998... Vaginal T cells play a major role in mucosal immunity to herpes simplex virus type 2 (HSV-2). In mice, intravaginal (IVAG) inoculation of wild-type HSV-2 causes epithelial infection followed by lethal neurological illness. IVAG inoculation of...

Clinical Study of Cancer Treatment Vaccine Commences.
April 27, 1998... Cytokine Networks, Inc. (CNI), Seattle, Washington, announced that the U.S. Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for the commencement of a clinical trial of a cancer treatment vaccine....

Preclinical Data Publication on Potential Preventative Vaccine Announced.
April 27, 1998... The Immune Response Corp., Carlsbad, California, announced the publication of the company's preclinical data in Vaccine (1998, Vol. 16, No. 7) entitled, "Whole-killed gp120-depleted HIV-1 antigen in a murine model for prophylactic vaccination."...

New Immune System Measurement Helps in Virus Fight.
April 27, 1998... Improved techniques for measuring the body's immune response are giving researchers insights that could help them in the fight to develop vaccines against HIV and cancer, scientists said. While making advances in learning about viruses and...

Researchers Say HIV May Target Gut.
April 27, 1998... HIV may head straight for the gut early on in infection - which could mean that research into ways to fight it has been looking in the wrong place, researchers said. Tests on monkeys show that SIV destroys immune cells in the intestines first,...

Extremely Premature Infants Should Adhere to Normal Immunization Schedule.
April 27, 1998... Results of a new study confirm that premature and low-birth weight infants should receive their immunizations at the same ages recommended for healthy, full-term babies. The study, which validates current practice, represents the first...

Vaccine Against Pneumococcal Disease Safe And Effective.
April 27, 1998... An experimental vaccine to protect children against pneumococcal disease has been shown to be safe and effective at stimulating the immune system to fight against the disease, according to a study published in the April 1998 issue of Pediatrics....

PNCRM7 Vaccine Might Work Against Ear Infections.
April 27, 1998... A vaccine that might work against ear infections is safe in babies and does stimulate their immune systems, researchers said. If it works as planned the vaccine, being developed by American Home Products Wyeth-Lederle division, would be the...

Optimistic Future Painted for Therapeutic Vaccine Manufacturers.
April 27, 1998... Viruses are difficult to treat because they mutate, rendering initially effective drugs useless against new viral strains. By targeting only the highly conserved areas of viral protein, protein-based or deoxyribonucleic acid (DNA) therapeutic...

Protective Tumor Immunity in a Murine Melanoma Model.
April 27, 1998... "Protective Tumor Immunity in a Murine Melanoma Model." C.K. Donawho, M.W. Pride, C.D. Bucana and M.L. Kripke. Departments of Immunology and Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; Wyeth Lederle Vaccines and...

A Novel Strategy for Identification of Tumor Associated MHC Class II Antigens.
April 27, 1998... "A Novel Strategy for Identification of Tumor Associated MHC Class II Antigens." F. Korangy, D. Golgher, J. Mautner and D. Pardoll. Johns Hopkins University, School of Medicine, Department of Oncology, Baltimore, Maryland. According to an...

Recombinant Mycobacterium bovis-BCG Producing the N-Terminal Half of SIVmac251 Env Antigen Induces Neutralizing Antibodies and CTL Responses in Mice and Guinea Pigs.
April 27, 1998... "Recombinant Mycobacterium bovis-BCG Producing the N-Terminal Half of SIVmac251 Env Antigen Induces Neutralizing Antibodies and CTL Responses in Mice and Guinea Pigs." E.M. Lim, M. Lagranderie, R. Le Grand, J. Rauzier, M. Gheorghiu, B. Gicquel...

Intragastric Compared to Oral Administration of BCG Induces Identical Immune Responses Without Side Effects.
April 27, 1998... "Intragastric Compared to Oral Administration of BCG Induces Identical Immune Responses Without Side Effects." M. Lagranderie, A.M. Balazuc and G. Marchal. Institute Pasteur Paris, Paris, France. According to an abstract submitted by the...

RAP-PCR as a Means of Determining Vaccine Leads in Mycobacteria.
April 27, 1998... "RAP-PCR as a Means of Determining Vaccine Leads in Mycobacteria." J. Bedwell, S. Kairo and P. Tyler. National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, United Kingdom. According to an abstract...

A Novel and Efficient Method for Synthetic Carbohydrate Conjugate Vaccine Preparation: Synthesis of Sialyl Tn KLH Conjugate Using a 4-(4-N-maleimidomethyl) cyclohexane-1-carboxyl Hydrazide (MMCCH) Linker Arm.
April 27, 1998... Ragupathi, G.; Koganty, R.R.; Qiu, D.X.; Lloyd, K.O.; Livingston, P.O. "A Novel and Efficient Method for Synthetic Carbohydrate Conjugate Vaccine Preparation: Synthesis of Sialyl Tn KLH Conjugate Using a 4-(4-N-maleimidomethyl)...

Characterization of a Mouse Monoclonal IgG3 Antibody to the Tumor-associated Globo H Structure Produced by Immunization With a Synthetic Glycoconjugate.
April 27, 1998... Kudryashov, V.; Ragupathi, G.; Kim, I.J.; Breimer, M.E.; Danishefsky, S.J.; Livingston, P.O.; Lloyd, K.O. "Characterization of a Mouse Monoclonal IgG3 Antibody to the Tumor-associated Globo H Structure Produced by Immunization With a Synthetic...

Vaccination With an Attenuated Creutzfeldt-Jakob Disease Strain Prevents Expression of a Virulent Agent.
April 27, 1998... "Vaccination With an Attenuated Creutzfeldt-Jakob Disease Strain Prevents Expression of a Virulent Agent." Proceedings of the National Academy of Sciences of the United States of America, March 3, 1998;95(5):2520-2525. According to the...

Safety and Immunogenicity of Hepatitis A Vaccine in Patients With Chronic Liver Disease.
April 27, 1998... Keeffe, E.B.; Iwarson, S.; Mcmahon, B.J.; Lindsay, K.L.; Koff, R.S.; Manns, M.; Baumgarten, R.; Wiese, M.; Fourneau, M.; Safary, A.; Clemens, R.; Krause, D.S. "Safety and Immunogenicity of Hepatitis A Vaccine in Patients With Chronic Liver...

Prediction of Response to Hepatitis B Vaccine in Health Care Workers: Whose Titers of Antibody to Hepatitis B Surface Antigen Should Be Determined After a Three-dose Series, and What are the Implications in Terms of Cost-effectiveness?
April 27, 1998... "Prediction of Response to Hepatitis B Vaccine in Health Care Workers: Whose Titers of Antibody to Hepatitis B Surface Antigen Should Be Determined After a Three-dose Series, and What are the Implications in Terms of Cost-effectiveness?."...

Evaluation of a Candidate Human Immunodeficiency Virus Type 1 (HIV 1) Vaccine in Macaques: Effect of Vaccination with HIV-1 gp120 on Subsequent Challenge With Heterologous Simian Immunodeficiency Virus-HIV-1 Chimeric Virus.
April 27, 1998... Stott, E.J.; Almond, N.; Kent, K.; Walker, B.; Hull, R.; Rose, J.; Silvera, P.; Sangster, R.; Corcoran, T.; Lines, J.; Silvera, K.; Luciw, P.; Murphycorb, M.; Momin, P.; Bruck, C. "Evaluation of a Candidate Human Immunodeficiency Virus Type 1...

Decline of Measles-Specific Immunoglobulin M Antibodies after Primary Measles, Mumps, and Rubella Vaccination.
April 27, 1998... Helfand, R.F.; Gary, H.E.; Atkinson, W.L.; Nordin, J.D.; Keyserling, H.L.; Bellini, W.J. "Decline of Measles-Specific Immunoglobulin M Antibodies after Primary Measles, Mumps, and Rubella Vaccination." Clinical and Diagnostic Laboratory...

Efficacy of a Food Plant-based Oral Cholera Toxin B Subunit Vaccine.
April 27, 1998... "Efficacy of a Food Plant-based Oral Cholera Toxin B Subunit Vaccine." Nature Biotechnology, March 1998;16(3):292-297. According to the authors' abstract of an article published in Nature Biotechnology, "Transgenic potatoes were engineered to...