Science Progress articles from March 2002

Science Progress archives from March 2002

Introduction: Microbial disease; recent studies show that novel extracellular components can enhance microbial resistance to lethal host chemicals and increase virulence.
March 22, 2002... This volume, in the main, covers a range of topics related to infectious disease caused by organisms which are, at present, or permanently, in the news. Many of these organisms are of substantial public concern, because of major health problems...

Helicobacter: A paradigm shift in peptic ulcer disease and more?
March 22, 2002... There are many diseases where the cause is unknown and this makes a specific treatment difficult. In many cases all that can be achieved is amelioration of the illness. Peptic ulcer disease was one such condition no more that 20 years ago. The...

Inflammatory bowel disease: Is the intestine a Trojan horse?
March 22, 2002... Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the intestines that is clinically heterogenous. The cause(s) of IBD are currently unknown but the mechanisms of injury are immunological. Increasingly there is an...

Methicillin resistance in Staphylococcus aureus: Mechanisms and modulation.
March 22, 2002... Staphylococcus aureus is a major pathogen both within hospitals and in the community. Methicillin, a [beta]-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs) that are involved in tile synthesis of peptidoglycan, an...

Prospects for generating new antibiotics.
March 22, 2002... A plethora of human pathogens are now resistant to all clinically significant antibiotics causing a crisis, in the treatment and management of infectious diseases, but also presenting a clear danger to future public health. If drug resistance...

Resistance to antifolates in Plasmodium falciparum, the causative agent of tropical malaria.
March 22, 2002... Every year there are 270 million clinical attacks of malaria and 2 million deaths, caused by the protozoan Plasmodium falciparum. Most of these cases occur in Africa. Chloroquine-resistance has led to reliance on anti-malarial antifolates, in...