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The road to Yellowstone - and beyond.
January 1, 1995... KEY WORDS: microbial ecology, thermophiles, biotechnology, history, limnology
CONTENTS
Introduction Beginnings First Professional Work First Academic Appointment Indiana University Steps Toward Microbial Ecology Friday Harbor Laboratories...
Mechanisms for the prevention of damage to DNA in spores of Bacillus species.
January 1, 1995... KEY WORDS: UV resistance, heat resistance, DNA-binding protein, UV photochemistry, DNA depurination
CONTENTS
INTRODUCTION ENVIRONMENT OF SPORE DNA SPORE RESISTANCE TO OXIDIZING AGENTS, HEAT, AND DESICCATION Mechanisms of Spore Killing by...
Genetics, physiology, and evolutionary relationships of the genus Buchnera: intracellular symbionts of aphids.
January 1, 1995... KEY WORDS: endosymbionts, genome analysis, tryptophan biosynthesis, gene amplification, evolutionary relationships, coevolution, mutualism
CONTENTS
INTRODUCTION GENERAL PROPERTIES OF APHIDS ULTRASTRUCTURE, LOCATION. AND TRANSMISSION OF...
Physiological implications of sterol biosynthesis in yeast.
January 1, 1995... KEY WORDS: yeast, Saccharomyces, sterols, ergosterol
CONTENTS
INTRODUCTION STEROL BIOSYNTHESIS AND REGULATION
Biosynthetic Pathways
Sites of Regulation
Ergosterol Features and Regulation STEROL METABOLISM
Effect of...
The structure and replication of kinetoplast DNA.
January 1, 1995... KEY WORDS: kDNA, mitochondrial DNA, DNA network, Trypanosoma, Crithidia
CONTENTS
INTRODUCTION THE MOLECULAR COMPONENTS OF kDNA
Maxicircles
Minicircles STRUCTURE OF THE kDNA NETWORK
The Isolated Network
The kDNA...
How Salmonella survive against the odds.
January 1, 1995... KEY WORDS: environmental stress, stress and virulence, stress responses
CONTENTS
INTRODUCTION VOYAGES THROUGH THE NATURAL ENVIRONMENT AND THROUGH AN ANIMAL HOST SALMONELLA STRESS SURVIVAL STRATEGIES
Starvation Stress Response
...
The mechanisms of Trypanosoma cruzi invasion of mammalian cells.
January 1, 1995... KEY WORDS: protozoan, parasite, intracellular, antigen, attachment, signaling
CONTENTS
INTRODUCTION LIFE-CYCLE STAGES INVASION OF PHAGOCYTIC AND NONPHAGOCYTIC HOST CELLS
Amastigote Invasion of Macrophages
Lysosome Recruitment...
Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics.
January 1, 1995... KEY WORDS: biosynthesis, enzymes, polyketide cyclases, secondary metabolites, Streptomyces
CONTENTS
INTRODUCTION POLYKETIDE SYNTHASES: STRUCTURE AND FUNCTION
Type I Multifunctional Enzyme Systems
Type II Multienzyme Systems
...
Nonopsonic phagocytosis of microorganisms.
January 1, 1995... KEY WORDS: phagocytic receptors, opsonins, adhesins, lectins
CONTENTS
INTRODUCTION LECTINOPHAGOCYTOSIS MEDIATED BY BACTERIAL SURFACE LECTINS
Type 1 Fimbriae of Enterobacteriaceae
Other Fimbrial ant Nonfimbrial Adhesins of...
Peptides as weapons against microorganisms in the chemical defense system of vertebrates.
January 1, 1995... KEY WORDS: antimicrobial peptides, molecular immunity, cytotoxicity, cell membrane
CONTENTS
INTRODUCTION DEFENSINS AND [Beta]-DEFENSINS
Defensins and [Beta]-Defensins: Endogenous Antibiotics of Myeloid-Derived
Cells
...
CO dehydrogenase. (carbon monoxide)
January 1, 1995... KEY WORDS: carbon monoxide, acetate, carbon cycle, aerobic, anaerobic
CONTENTS
INTRODUCTION AEROBES
Microbiology and Physiology
The CO Dehydrogenase from Pseudomonas carboxydovorans PHOTOTROPHIC ANAEROBES
Microbiology and...
Nitrogenase structure and function: a biochemical-genetic perspective.
January 1, 1995... KEY WORDS: Fe protein, MoFe protein, P clusters, FeMo cofactor, MgATP, signal transduction, mutagenesis
CONTENTS
INTRODUCTION OVERVIEW ASSIGNMENT OF MoFe PROTEIN METALLOCLUSTER DOMAINS
Assignment 1
Assignment 2
Assignment...
Conjugative transposition.
January 1, 1995... KEY WORDS: conjugattion, transposition, recombination, resistance, antibiotic, integrase
CONTENTS
INTRODUCTION
General Properties
Simple ant Compound Transposons
Drug Resistance
Broad Distribution
Use in...
Cellulose degradation in anaerobic environments.
January 1, 1995... KEY WORDS: cellulase, cellulose fermentation, microbial interactions, cellulolytic microoganisms, carbon cycle
CONTENTS
INTRODUCTION THE SUBSTRATE CELLULOLYTIC ENZYME SYSTEMS OF ANAEROBES CELLULOSE DEGRADATION IN SOILS. SEDIMENTS, AND...
New mechanisms of drug resistance in parasitic protozoa.
January 1, 1995... KEY WORDS: P-glycoproteins, drug transport, chemotherapeutic targets, parasitic diseases
CONTENTS
INTRODUCTION AN OVERVIEW OF DRUG RESISTANCE IN PARASITIC PROTOZOA P-GLYCOPROTEINS AND RELATED TRAFFIC ATPases
Mammalian P-Glycoproteins...
Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology - a trip of over 50 years.
January 1, 1995... KEY WORDS: sewage-associated viruses, cell cultures, nucleic acid hybridization, public health concerns, sewage-polluted waters, shellfish
CONTENTS
INTRODUCTION ENVIRONMENTAL VIROLOGY AND PUBLIC HEALTH CONCERNS
Poliovirus: Early...
How bacteria sense and swim.
January 1, 1995... KEY WORDS: motility, chemotaxis, protein phosphorylation, membrane receptors, molecular motors
CONTENTS
DESCRIPTION OF THE PHENOMENON THE CHEMOSENSORY PATHWAY
Structure and Function of the Protein Components
Other Factors in...
Biodegradation of nitroaromatic compounds.
January 1, 1995... KEY WORDS: nitroaromatic compounds, TNT, explosives, biodegradation, dioxygenase, biotransformation
CONTENTS
INTRODUCTION CHEMISTRY OF THE AROMATIC NITRO GROUP ANAEROBIC BIODEGRADATION
Sulfate-Reducing Bacteria
Clostridium...
Biocatalytic syntheses or aromatics from D-glucose: renewable microbial sources of aromatic compounds.
January 1, 1995... KEY WORDS: chemical manufacture, environment, amino acid, biosynthesis, common pathway
CONTENTS
Introduction Traditional Approaches for Increasing Aromatic Biosynthesis Substrate-Limited Aromatic Biosynthesis Impediments to Carbon Flow...
The regulation of methane oxidation in soil.
January 1, 1995... KEY WORDS: methanotrophy, methylotrophy, soil, methanotroph ecology
CONTENTS
INTRODUCTION METHANOTROPH BACTERIA PHYSIOLOGY AND BIOCHEMISTRY OF METHANE OXIDATION
Ribulose Monophosphate Pathway
Serine Pathway ECOLOGY OF METHANE...
Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.
January 1, 1995... KEY WORDS: natural products, squalene synthase inhibitors, cholesterol biosynthesis inhibitors, fungi, antifungals
CONTENTS
INTRODUCTION AND DISCOVERY
Rationale
Screening
Discovery of the Zaragozic Acids ZARAGOZIC ACIDS,...
Prospects for new interventions in the treatment and prevention of mycobacterial disease.
January 1, 1995... KEY WORDS: tuberculosis, vaccines, drugs, mycobacteria, immunity
CONTENTS
INTRODUCTION
Tuberculosis
Other Mycobacterial Diseases BASIC BIOLOGY OF MYCOBACTERIAL INFECTION
Stage 1. Initial Uptake of Bacteria
Stage 2....
Development and application of herpes simplex virus vectors for human gene therapy.
January 1, 1995... KEY WORDS: gene-transfer vector, latency, promoter, cancer, central nervous system
CONTENTS
INTRODUCTION
Gene Therapy Vectors: An Overview
The Niche of HSV in Gene Transfer THE HSV LIFE CYCLE
Molecular Biology of Lytic...
Microbial biofilms.
January 1, 1995... KEY WORDS: sessile bacterial communities, [Sigma] factor, phenotype change, mass transfer, consortia
CONTENTS
DEFINITION INTRODUCTION DISTRIBUTION AND UBIQUITY OF BIOFILMS THE STRUCTURE OF BIOFILMS
As Revealed by Confocal Scanning...
Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli.
January 1, 1995... KEY WORDS: transcription regulation, DNA-binding proteins, chromosome structure
CONTENTS
INTRODUCTION THE LEUCINE-RESPONSIVE REGULATORY PROTEIN Lrp AS A REGULATOR
Patterns of Regulation by Lrp
Regulation of Lrp Synthesis
...
Microbiology to 10,500 meters in the deep sea.
January 1, 1995... KEY WORDS: high pressure, microbial ecology, growth physiology, membranes, PTk diagram
CONTENTS
INTRODUCTION DEEP-SEA HABITATS METHODS OF SAMPLING FOR MICROBIOLOGY HIGH PRESSURE LABORATORY TECHNIQUES
Pressure Vessels
Colony...
Viral vectors in gene therapy.
January 1, 1995... KEY WORDS: gene therapy, adenovirus vectors, AAV vectors, retrovirus vectors, cationic lipids
CONTENTS
INTRODUCTION OVERALL GOALS OF GENE THERAPY CATEGORIES OF VIRUS CONSIDERED
Retroviruses
Adenoviruses
Adeno-Associated...