Annual Review of Genetics articles

Recent articles from Annual Review of Genetics

Ira Herskowitz (1946-2003).(Obituary)
January 1, 2003... On April 28, 2003, the genetics community lost one of its most creative and talented members when Ira Herskowitz succumbed to pancreatic cancer, at age 56. Ira's career intersected the activities of Annual Review of Genetics and its editors in many ways. He authored two outstanding...

Transposon-based strategies for microbial functional genomics and proteomics.
January 1, 2003... Key Words transposon, mutagenesis, bacteria, pentapeptide scanning, signature-tagged mutagenesis Abstract Transposons are mobile genetic elements that can relocate from one genomic location to another. As well as modulating gene expression and contributing to genome plasticity and...

Error-prone DNA polymerases: when making a mistake is the only way to get ahead (1).
January 1, 2003... Key Words translesion polymerase, somatic hypermutation, untargeted mutagenesis, nonhomologous end joining, polymerase recruitment Abstract Cells have high-fidelity polymerases whose task is to accurately replicate the genome, and low-fidelity polymerases with specialized functions....

Genetics of hair and skin color.
January 1, 2003... Key Words melanin, melanocortin 1 receptor (MC1R), eumelanin, pheomelanin, red hair Abstract Differences in skin and hair color are principally genetically determined and are due to variation in the amount, type, and packaging of melanin polymers produced by melanocytes secreted into...

Thiol-based regulatory switches.
January 1, 2003... Key Words redox reactions, cysteine, metal coordination, transcriptional regulation, disulfide bonds Abstract Thiol-based regulatory switches play central roles in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-disulfide redox balance. Protein...